EXAMINATION OF NEUTROPHIL/LYMPHOCYTE (NLR), MONOCYTE/LYMPHOCYTE (MLR), AND PLATELET/LYMPHOCYTE (PLR) RATIOS BETWEEN ALZHEIMER'S DISEASE AND VASCULAR DEMENTIA

Öz

Background: The present study aims to investigate whether proinflammatory marker ratios in whole blood differ in these two dementia diseases. Materials and Methods: This study will involve Alzheimer's disease (AD) and vascular dementia (VaD) patients who were treated as outpatients in the outpatient clinic and inpatients in the ward of the Neurology Department of Adnan Menderes University Hospital. The patients’ diagnoses will be scanned in the hospital information system. The admission blood results of patients who presented between January 2018 and September 2020 will be included, and the patients’ hemogram results will be scanned retrospectively. Neutrophil/lymphocyte, monocyte/lymphocyte, and platelet/lymphocyte ratios in the hemogram results will be calculated and recorded. Results: In the AD-VaD comparison of the patients participating in the study, a significant difference was identified between the variability of platelet/lymphocyte (PLR) and NLRs (NLR) (p<0.001). Moreover, a significant difference was found between the mean ages of patients with vascular dementia and those with Alzheimer's dementia (p<0.0001). Conclusion: While proinflammatory markers obtained secondary to inflammation are significant in AD since it is a chronic and progressive process, the use of these markers is limited due to the gradual course after an acute event in vascular dementia. Furthermore, there is a need for additional studies on peripheral blood cells to identify the potential prodromal biomarkers of AD.

Anahtar Kelimeler

• Alzheimer
• NLR
• proinflammatory markers
• vascular dementia

Kaynakça

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