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A fatal side effect of piperacillin/tazobactam use: a case report.

Cilt: 3 Sayı: 3 28 Aralık 2021
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A fatal side effect of piperacillin/tazobactam use: a case report.

Öz

Drug-induced QT prolongation with T wave inversion is a complex regulatory and clinical problem due to the rarity of this potentially fatal adverse incident. A 68-year-old female patient was receiving piperacillin/tazobactam therapy for a complicated urinary tract infection. She has had normal ECG findings before the antibacterial therapy. After the treatment, the patient worsens due to long QT which is predisposed to torsades de pointes. As a result of the researches, it was understood that the cause of long QT was piperacillin/tazobactam. We aimed to present a rare case in which we detected drug-induced QTc prolongation with piperacillin/tazobactam in clinical practice.

Anahtar Kelimeler

Destekleyen Kurum

The authors declare no conflict of interest or any financial support.

Kaynakça

  1. :1. Goldenberg I, Moss AJ, Zareba W. QT interval: how to measure it and what is "normal". J Cardiovasc Electrophysiol. 2006;17(3):333-336. doi:10.1111/j.1540-8167.2006.00408.x
  2. 2. Antzelevitch C, Shimizu W. Cellular mechanisms underlying the long QT syndrome. Curr Opin Cardiol. 2002;17(1):43-51. doi:10.1097/00001573-200201000-00007
  3. 3. Woosley RL. QT Drug Lists by Risk Groups. AZ: Arizona Center for Research and Education on Therapeutics. Published 2009. Accessed September 1, 2021. http:// www.azcert.org/medical-pros/drug-lists/drug-lists.cfm
  4. 4. Katchman AN, Koerner J, Tosaka T, Woosley RL, Ebert SN. Comparative evaluation of HERG currents and QT intervals following challenge with suspected torsadogenic and nontorsadogenic drugs. J Pharmacol Exp Ther. 2006;316(3):1098-1106. doi:10.1124/jpet.105.093393
  5. 5. Poluzzi E, Raschi E, Motola D, Moretti U, De Ponti F. Antimicrobials and the risk of torsades de pointes: the contribution from data mining of the US FDA Adverse Event Reporting System. Drug Saf. 2010;33(4):303-314. doi:10.2165/11531850-000000000-00000
  6. 6. Panduranga P, Al-Mukhaini M, Rajarao MP. Multi-factorial causes of torsade de pointes in a hospitalised surgical patient. Sultan Qaboos Univ Med J. 2013;13(1):152-155. doi:10.12816/0003211
  7. 7. Piperacillin and tazobactam: Drug information. Published December 6, 2020. Accessed semtember 1, 2021. . https://www.uptodate.com/contents/piperacillin-and-tazobactam-drug-information search=piperacillin%20tazobactam&source=panel_search_result&selectedTitle=1~104&usage_type=panel&kp_tab=drug_general&display_rank=1#F210382

Ayrıntılar

Birincil Dil

İngilizce

Konular

Yoğun Bakım

Bölüm

Olgu Sunumu

Yayımlanma Tarihi

28 Aralık 2021

Gönderilme Tarihi

8 Eylül 2021

Kabul Tarihi

8 Kasım 2021

Yayımlandığı Sayı

Yıl 2021 Cilt: 3 Sayı: 3

Kaynak Göster

APA
Duyan, M., Günlü, S., Sarıdaş, A., Cander, B., & Solaç, Y. (2021). A fatal side effect of piperacillin/tazobactam use: a case report. Eurasian Journal of Critical Care, 3(3), 119-121. https://izlik.org/JA97WU47AK
AMA
1.Duyan M, Günlü S, Sarıdaş A, Cander B, Solaç Y. A fatal side effect of piperacillin/tazobactam use: a case report. Eurasian Journal of Critical Care. 2021;3(3):119-121. https://izlik.org/JA97WU47AK
Chicago
Duyan, Murat, Serhat Günlü, Ali Sarıdaş, Basar Cander, ve Yıldızhan Solaç. 2021. “A fatal side effect of piperacillin/tazobactam use: a case report”. Eurasian Journal of Critical Care 3 (3): 119-21. https://izlik.org/JA97WU47AK.
EndNote
Duyan M, Günlü S, Sarıdaş A, Cander B, Solaç Y (01 Aralık 2021) A fatal side effect of piperacillin/tazobactam use: a case report. Eurasian Journal of Critical Care 3 3 119–121.
IEEE
[1]M. Duyan, S. Günlü, A. Sarıdaş, B. Cander, ve Y. Solaç, “A fatal side effect of piperacillin/tazobactam use: a case report”., Eurasian Journal of Critical Care, c. 3, sy 3, ss. 119–121, Ara. 2021, [çevrimiçi]. Erişim adresi: https://izlik.org/JA97WU47AK
ISNAD
Duyan, Murat - Günlü, Serhat - Sarıdaş, Ali - Cander, Basar - Solaç, Yıldızhan. “A fatal side effect of piperacillin/tazobactam use: a case report”. Eurasian Journal of Critical Care 3/3 (01 Aralık 2021): 119-121. https://izlik.org/JA97WU47AK.
JAMA
1.Duyan M, Günlü S, Sarıdaş A, Cander B, Solaç Y. A fatal side effect of piperacillin/tazobactam use: a case report. Eurasian Journal of Critical Care. 2021;3:119–121.
MLA
Duyan, Murat, vd. “A fatal side effect of piperacillin/tazobactam use: a case report”. Eurasian Journal of Critical Care, c. 3, sy 3, Aralık 2021, ss. 119-21, https://izlik.org/JA97WU47AK.
Vancouver
1.Murat Duyan, Serhat Günlü, Ali Sarıdaş, Basar Cander, Yıldızhan Solaç. A fatal side effect of piperacillin/tazobactam use: a case report. Eurasian Journal of Critical Care [Internet]. 01 Aralık 2021;3(3):119-21. Erişim adresi: https://izlik.org/JA97WU47AK