Recent Advances in the Application Superovulation in Cattle

Yıl 2019, , 198 - 203, 01.12.2019

Uğur Kara , Tayfur Bekyürek

https://doi.org/10.32707/ercivet.648580

Öz

The purpose
of superovulation applications is to obtain the maximum number of fertilization
and transferable embryos. Differences
in ovarian functional responses in superovulated cattle and the
unpredictability of this condition negatively affect the profitability and
applicability of embryo transfer programs. Differential functional responses of donors to
superovulatory applications are due to differences in the stages of follicular
development on the ovaries at the onset of gonadotropin administration. The traditional superovulation methods which
initiated to be applied between 8-12 days of oestrus cycle the important
disadvantages such as the inability of the donors to get into practice at the
same time and at the same time as the cycle, have led practitioners to search
for alternative superovulation methods. Superovulation methods developed rapidly after the
use of purified pituitary extracts and intravaginal devices of progesterone
release. Superovulation can be applied to desired number of
donor animals at any time during the cycle determination of ovarian follicul
dynamic, controlling the exogenous follicular wave appearance and the
implementation of synchronization of the follicular wave based on removal of
the dominant follicle suppressive effect. Furthermore, the results obtained from these new
practical approaches developed are comparable to those obtained by traditional
superovulation methods. The
development of protocols in which simplified and optimal number of transferable
embryos can be obtained will contribute positively to the cost and
applicability of embryo production and transfer studies.

Anahtar Kelimeler

Folliculer wave, FSH, GnRH, estradiol, superovulation

İneklerde Süperovulasyon Uygulamalarında Son Gelişmeler

Öz

Süperovulasyon uygulamalarının amacı maksimum
sayıda fertilizasyon ve transfer edilebilir embriyo elde etmektir. Süperovulasyon
uygulanan sığırlarda ovaryum fonksiyonel cevabındaki farklılıklar ve bu durumun
önceden tahmin edilememesi embriyo transfer programlarının karlılığını ve uygulanabilirliğini
olumsuz etkilemektedir. Donörlerin süperovulasyon uygulamalarına verdikleri
fonksiyonel yanıt farklılıkları gonadotropin uygulamasının başlangıcında
ovaryumlar üzerindeki foliküler gelişim aşamalarındaki farklılıklardan
kaynaklanmaktadır. Östrus siklusunun 8-12. günleri arasında uygulamaya
başlanılan geleneksel süperovulasyon yöntemlerinin yoğun iş gücü gereksinimi ve
donörlerin aynı zaman ve siklus aşamasında uygulamaya alınamaması gibi önemli
dezavantajları uygulayıcıları alternatif süperovulasyon yöntemlerinin
geliştirilmesi arayışına yöneltmiştir.  Süperovulasyon
yöntemleri saflaştırılmış hipofiz ekstraktları ve progesteron salınımı yapan
intravaginal araçların kullanılmaya başlamasından sonra hızla gelişim
göstermiştir. Ovaryumun folikül dinamiğinin belirlenmesi, foliküler dalga
oluşumunun ekzojen kontrolü ve dominant folikülün baskılayıcı etkisinin ortadan
kaldırılmasını temel alan foliküler dalga senkronizasyonu uygulamalarının
gerçekleştirilmesi ile siklusun herhangi bir döneminde istenilen sayıda donör
hayvana aynı zamanda süperovulasyon uygulanabilmektedir. Ayrıca geliştirilen bu
yeni pratik yaklaşımlardan elde edilen sonuçlar geleneksel süperovulasyon
yöntemleri ile elde edilen sonuçlarla karşılaştırılabilir düzeydedir. Sadeleştirilmiş
ve optimum sayıda transfer edilebilir embriyo elde edilebilen protokollerin geliştirilmesi
embriyo üretimi ve transferi çalışmalarının maliyeti ve uygulanabilirliği
üzerine olumlu katkı sağlayacaktır.  

Anahtar Kelimeler

Foliküler dalga, FSH, GnRH, östradiol, süperovulasyon

Kaynakça

• 1. Adams GP, Matteri RL, Kastelic JP, Ko JCH, Ginther OJ. Association between surges of follicle stimulating hormone and the emergence of follicular waves in heifers. J Reprod Fertil 1992; 94: 177-88.
• 2. Adams GP, Kot K, Smith CA, Ginther OJ. Effect of the dominant follicle on regression of its subordinates. Can J Anim Sci 1993; 73: 267-75. 3. Adams GP. Control of ovarian follicular wave dynamics in cattle; Implications for synchronization and superstimulation. Theriogenology 1994; 4: 19-24.
• 4. Adams GP, Nasser LF, Bó GA, Garcia A, Del Campo MR, Mapletoft RJ. Superovulatory response of ovarian follicles of Wave 1 versus Wave 2 in heifers. Theriogenology 1994; 42: 1103-13.
• 5. Adams GP, Jaiswal R, Singh J, Mahli P. Progress in understanding ovarian follicular dynamics in cattle. Theriogenology 2008; 69: 72–80. 6. Alaçam E. Evcil Hayvanlarda Reprodüksiyon, Sun`i Tohumlama, Doğum ve İnfertilite (1.Baskı). Konya 1994: 1-385 s.
• 7. Akyol N. Sığır embriyo transferinde hormon kullanımı. Lalahan Hay Araşt Enst Derg 2001; 41(1): 95-105.
• 8. Alkemade S, Murphy B, Mapletoft R. Superovulation in the cow: effects of biological activity of gonadotropins. In: Proceedings of the 12th Annual Meeting of the American Embryo Transfer Association, Portland, Maine, 1993, pp. 1-19.
• 9. Andrade JC, Oliveira MA, Lima PF, Guido SI, Bartolomeu CC, Tenório Filho F, Pina VM, lunes-Souza TC, Paula NR, Freita JC. The use of steroid hormones in superovulation of Neloro donors at different stages of estrous cycle. Anim Reprod Sci 2003; 77: 117-25.
• 10. Armstrong DT. Recent advances in superovulation of cattle. Theriogenology 1993; 39: 7-24.
• 11. Ayaşan T, Hızlı H, Gök K, Kılıçalp N, Kara U, Çamlıdağ A, Karakozak E, Mutlu H, Çoban S, Seğmenoğlu MS. Effect of season upon the embryo quality in donor cows. J Fac Vet Med Univ Erciyes 2011; 8(3):181-86.
• 12. Ayaşan T, Hızlı H, Çamlıdağ A, Kara U, Gök K, Karakozak E, Çoban S, Mutlu H, Kılıçalp N, Seğmenoğlu MS. The determination of relationship between milk production and the quality of embryo of donor cows. Indian J Anim Sci 2011; 81(9): 912-14.
• 13. Ayaşan T, Asarkaya A, Hızlı H, Gök K, Tekgül A, Karakozak E, Kara U, Seğmenoğlu MS, Çoban S, Mutlu H, Kılıçalp N. The Effect of body condition score on embryo quality of holstein cows. J Fac Vet Med Univ Kafkas 2012; 18(1): 91-94.
• 14. Baracaldo MI, Martinez M, Adams GP, Mapletoft RJ. Superovulatory response following transvaginal follicle ablation in cattle. Theriogenology 2000; 53: 1239-50.
• 15. Barros CM, Barcelos ACZ, Gouvea LM, Meneghel M, Barcelos DS, Barcelos LN, Trinca LA. Improvement of a superovulatory protocol in Nelore cows: replacing the last two doses of pFSH by eCG. Reprod Fertil Dev 2008; 20: 152 (Abstract).
• 16. Bello NM, Steibel JP, Pursley JR. Optimizing ovulation to first GnRH improved outcomes to each hormonal injection of ovsynch in lactating dairy cows. J Dairy Sci 2006; 89: 3413-24.
• 17. Bergfelt DR, Lightfoot KC, Adams GP. Ovarian dynamics following ultrasound-guided transvaginal follicle ablation in heifers. Theriogenology 1994; 42: 895-907.
• 18. Bergfelt DR, Bó GA, Mapletoft RJ, Adams GP. Superovulatory response following ablation-induced follicular wave emergence at random stages of the estrous cycle in cattle. Anim Reprod Sci 1997; 49: 1-12.
• 19. Biancucci A, Sbaragli T, Comin A, Sylla L, Monaci M, Peric T, Stradaioli G. Reducing treatments in cattle superovulation protocols by combining a pituitary extract with a 5% hyaluronan solution: Is it able to diminish activation of the hypothalamic pituitary adrenal axis compared to the traditional protocol? Theriogenology 2016; 85: 914-21.
• 20. Bó GA, Carballo Guerrero D, Adams GP. Alternative approaches to setting up donor cows for superovulation. Theriogenology 2008; 69: 81-87.
• 21. Bó GA, Pierson RA, Mapletoft RJ. The effect of estradiol valerate on follicular dynamics and superovulatory response in cows with Syncro Mate B implants. Theriogenology 1991; 36: 169-83.
• 22. Bó GA, Guerre DC, Tríbulo A, Tríbulo H, Tríbulo R, Rogan D, Mapletoft RJ. New approaches to superovulation in the cow. Reprod Fertil Dev 2010; 22: 106-12.
• 23. Bó GA, Mapletoft RJ. Recent Advances in The Control of Follicular Development and Superovulation Protocols in Cattle, 28th Annual Meeting A.E.T.E., September,7-8, 2012; Saint Malo-France.
• 24. Bó GA, Baruselli P, Chesta P, Martins C. The timing of ovulation and insemination schedules in superstimulated cattle. Theriogenology 2006; 65: 89-101.
• 25. Bó GA, Adams GP, Pierson RA, Mapletoft RJ. Exogenous control of follicular wave emergence in cattle. Theriogenology 1995; 43: 31-40.
• 26. Bó GA, Mapletoft RJ. Historical perspectives and recent research on superovulation in cattle. Theriogenology 40th Anniversary Special Issue 2014; 81: 38-48.
• 27. Bó GA, Baruselli PS, Moreno D, Cutaia L, Caccia M, Tríbulo R, Tríbulo H, Mapletoft RJ. The control of follicular wave development for self-appointed embryo transfer programs in cattle. Theriogenology 2002; 57: 53-72.
• 28. Bó GA, Rogan DR, Mapletoft RJ. Pursuit of a method for single administration of pFSH for superstimulation in cattle: What we have learned. Theriogenology 2018; 112: 26-33.
• 29. Bova-Tech Ltd. Web Site, 2018, General İnformation Donors. http://www.bova-tech.com/general_donor_cows.php Erişim Tarihi: 28 Haziran 2018.
• 30. Caccia M, Tríbulo R, Tríbulo H, Bó GA. Effect of eCG pretreatment on superovulatory response in CIDR-B treated beef cattle. Theriogenology 2000; 53: 495.
• 31. Carballo Guerrero D, Tríbulo A, Tríbulo R, Tríbulo H, Bó GA. Superovulatory response in beef donors treated during the first follicular wave or four days after progesterone and estradiol administration. Reprod Fertil Dev 2010; 22: 358.
• 32. Carballo Guerrero D, Tribulo A, Tribulo R, Tribulo H, Bó GA. Superstimulation in the first follicular wave, without the use of estradiol in bonsmara cattle. Reprod Fertil Dev 2008; 20: 294 [abstract].
• 33. Dieleman S, Bevers M, Vos P, de Loos F. PMSG/anti-PMSG in cattle: a simple and efficient superovulatory treatment. Theriogenology 1993; 39: 25-42.
• 34. Galli C, Duchi R, Crotti G, Turini P, Ponderato N, Colleoni S, Lagutina I, Lazzari G. Bovine Embryo Technologies. Theriogenology 2003; 59: 599-616.
• 35. García GA, Tribulo A, Yapura J, Singh J, Mapletoft RJ. Lengthening the superstimulatory treatment protocol increases ovarian response and number of transferable embryos in beef cows. Theriogenology 2012; 78(2): 353-60.
• 36. Gonzalez A, Wang H, Carruthers T, Murphy B, Mapletoft R. Increased ovulation rates in PMSG-stimulated beef heifers treated with a monoclonal PMSG antibody. Theriogenology 1994;41: 1631-42.
• 37. Hızlı H, Ayaşan T, Gök K, Kara U, Kılıçalp N, Çamlıdağ A, Karakozak E, Seğmenoğlu MS, Mutlu H, Asarkaya A. The determination of relationship between age and the quality of embryo of donor cows. J Fac Vet Med Univ Kafkas 2011;17 (3): 493-97.
• 38. Hızlı H, Ayaşan T, Kılıçalp N, Kara U, Karakozak E, Özcan BD, Gök K, Çamlıdağ A, Çoban S, Mutlu H, Seğmenoğlu MS. The effects of repeated superovulations on the quality of embryo of donor cows and heifers. J Fac Vet Med Univ YY 2012; 23 (1): 11-14.
• 39. Ireland JJ, Ward F, Jimenez-Krassel F, Ireland JL, Smith GW, Lonergan P. Follicle numbers are highly repeatable within individual animals but are inversely correlated with FSH concentrations and the proportion of good-quality embryos after ovarian stimulation in cattle. Hum Reprod 2007; 22: 1687-95.
• 40. Ireland JJ, Smith GW, Scheetz D, Jimenez-Krassel F, Folger JK, Ireland JLH. Does size matter in females? An overview of the impact of the high variation in the ovarian reserve on ovarian function and fertility, utility of anti-mullerian hormone as a diagnostic marker for fertility and causes of variation in the ovarian reserve in cattle. Reprod Fertil Dev 2011; 23: 1-14.
• 41. Kara U, Bekyürek T. Östrus Senkronizasyonu ve Süperovulasyon Öncesi Gonadotropin Uygulamasını Takiben Kısa Süreli Ekzojen Progesteron Verilen ve Süperovulasyon Uygulanan Donörler ile Klasik Süperovulasyon Metodu Uygulanan Donörlerin Elde Edilen Embriyo Sayısı ve Kalitesi Yönünden Karşılaştırılması. Doktora Tezi, Erciyes Ünv Sağ Bil Ens, Kayseri 2018; s.1-124.
• 42. Kara U, Bekyürek T. The effect of double PGF2α administrations applied to donor before oestrus with synchronized CIDR on the number and quality of obtained embryos during embryo transfer in cattle. Journal of Health Sciences 2017; 26 (3): 204-10.
• 43. Kanagawa H, Shimohira I, Saitoh N. Manual of Bovine Embryo Transfer. National Livestock Breeding Center MAFF, JICA-Japan. 1995.
• 44. Kaymaz M. Yardımcı Üreme Teknikleri. Semacan A, Kaymaz M, Fındık M, Rişvanlı A, Köker A. eds. In: Çiftlik Hayvanlarında Doğum ve Jinekoloji. Malatya: Medipres Bölüm VI 2015; pp. 695-811.
• 45. Lane E, Austin E, Crowe M. Estrus synchronisation in cattle. Current options following the EU regulations restricting use of estrogenic compounds in food-producing animals: a review. Anim Reprod Sci 2008; 109: 1-16.
• 46. Mapletoft R, Bó GA. The evolution of improved and simplified superovulation protocols in cattle. Reprod Fertil Dev 2012; 24: 278-83.
• 47. Mapletoft RJ, Steward KB, Adams GP. Recent advaces in superovulation in cattle. Reprod Nutr Dev 2002; 42(6): 601-11.
• 48. Mapletoft, RJ. Embryo transfer in the cow: general procedures. Rev Sci Tech off int Epiz 1985;(4): 843-58.
• 49. Martinez MF, Adams GP, Bergfelt D. Effect of LH or GnRH on the dominant follicle of the first follicular wave in heifers. Anim Reprod Sci 1999; 57: 23-33.
• 50. Mihm M, Evans AC. Mechanisms for dominant follicle selection in monovulatory species: A comparison of morphological, endocrine and intraovarian events in cows, mares and women. Reprod Dom Anim 2008; 43 (Suppl 2): 48-56.
• 51. Mikel-Jenson A, Greve T, Madej A, Edqvist L. Endocrine profiles and embryo quality in the PMSG-PGF2α-treated cow. Theriogenology 1982;18: 33-34. 52. Monniaux D, Drouilhet L, Rico C, Estienne A, Jarrier P, Touzé JL. Regulation of anti-Mullerian hormone production in domestic animals. Reprod Fertil Dev 2013; 25: 1-16.
• 53. Murphy B, Martinuk S. Equine chorionic gonadotropin. Endocrine Rev 1991;12: 27-44.
• 54. Nabenishi H, Kitahara G, Takagi S, Yamazaki A, Osawa T. Relationship between plasma anti-Müllerian hormone concentrations during the rearing period and subsequent embryo productivity in Japanese black cattle. Domestic Animal Endocrinology 2017; 60: 19-24.
• 55. Nasser L, Sá Filho M, Reis E, Rezende C, Mapletoft R, Bó GA, Baruselli PS. Exogenous progesterone enhances ova and embryo quality following superstimulation of the first follicular wave in Nelore (Bos indicus) donors. Theriogenology 2011;76: 320-7.
• 56. Nasser L, Adams GP, Bó GA, Mapletoft RJ. Ovarian superstimulatory response relative to follicular wave emergence in heifers. Theriogenology 1993; 40: 713-24.
• 57. Reano I, Carballo D, Tribulo A, Tribulo P, Balla E, Bó GA. Efecto de la adicion de eCG a los tratamientos superovulatorios con Folltropin-V en la produccion de embriones de donantes de embriones. In 'Proceedings VIII Simposio Internacional de Reproduccion Animal - IRAC 2009', 2009; 1: 54 (Abstract).
• 58. Rico C, Drouilhet L, Salvetti P, Dalbiès-Tran R, Jarrier P, Touzé JL, Pillet E, Ponsart C, Fabre S, Monniaux D. Determination of anti-Mullerian hormone concentrations in blood as a tool to select holstein donor cows for embryo production: from the laboratory to the farm. Reprod Fertil Dev 2012; 24: 932-44.
• 59. Singh J, Domınguez M, Jaiswal R, Adams GP. A simple ultrasound test to predict the superstimulatory response in cattle. Theriogenology 2004; 62: 227-43.
• 60. Small JA, Colazo MG, Kastelic JP, Mapletoft RJ. Effects of progesterone pre-synchronization and eCG on pregnancy rates to GnRH-based, timed-AI in beef cattle. Theriogenology 2009; 71: 698-706.
• 61. Stoebel DP, Moberg GP. Repeated acute stress during the follicular phase and luteinizing hormone surge of dairy heifers. J Dairy Sci 1982; 65: 92-96.
• 62. Tríbulo A, Rogan D, Tribulo H, Tribulo R, Alasino RV, Beltramo D, Bianco I, Mapletoft R J, Bó GA. Superstimulation in beef cattle with a single intramuscular injection of Folltropin-V. Anim Reprod Sci 2011; 129: 7-13.
• 63. Wiley C, Jahnke M, Redifer C,. Gunn PJ, Dohlman T. Effects of endogenous progesterone during ovarian follicle superstimulation on embryo quality and quantity in beef cows, Theriogenology 2019; doi: 10.1016/j.theriogenology.2019.01.024.