Orşektomi Sonrası Erkek Köpeklerde C-Reaktif Protein ve Serum Amiloid A

Yıl 2018, Cilt: 15 Sayı: 1, 37 - 40, 15.04.2018

Nejra Hadžimusić

Öz

Akut faz tepkisi doğuştan gelen bağışıklık sisteminin bir parçası olarak düşünülür. Akut faz yanıtı sırasında, akut

faz protein konsantrasyonları oluşur. Dolayısıyla, akut faz proteinleri doğuştan gelen bağışıklık tepkisinin bir parçasıdır

ve biyolojik fonksiyonu değişkendir, ancak genellikle patolojik hasarın savunulması ve homeostazın restorasyonu ile

ilgilidir. Bunların seviyeleri iltihap ve doku yaralanmasına tepki olarak dalgalanmaktadır. Köpeklerin ana akut faz proteinleri

C-reaktif protein (CRP) ve serum amyloid A'dır (SAA). Cerrahi travma, immünolojik ve hematolojik profiling pek

çok bölümünde etkili olur. Bu çalışmanın amacı, elektif orşiektomi uygulanan erkek köpeklerde CRP ve SAA'nın perioperative

dinamiklerini belirlemektir. Kan örnekleri ameliyat öncesi (Sıfırıncı gün), post-operatif birinci gün, üçüncü gün

ve yedinci gün vena jugularisten alındı. Sistemik inflamasyon belirteçleri olarak CRP ve SAA düzeylerini ölçmek için

ELISA testi kullanıldı. Çalışma, CRP ve SAA'nın hızla değiştiğini gösterdi. Pik CRP ve SAA konsantrasyonları ameliyattan

sonraki ilk gün tespit edildi. Postoperatif yedinci gündeki serum CRP konsantrasyonu fizyolojik aralıklardaiken,

SAA konsantrasyonu anlamlı derecede yüksek olduğu tespit edildi.

Anahtar Kelimeler

CRP, köpekler, orşiektomi, SAA

C-Reactive Protein and Serum Amyloid A in Male Dogs after Orchiectomy

Öz

The acute-phase response is considered part of the innate immune system. During acute phase response,

concentrations of acute phase proteins occur. Therefore, acute-phase proteins are part of the innate immune response

and its biological function, although variable, generally relate to defense to pathological damage and restoration of

homeostasis. Their levels fluctuate in response to inflammation and tissue injury. The main acute-phase proteins in

dogs are C-reactive protein (CRP) and serum amyloid A (SAA). Surgical trauma has effect on many parts of immunological

and hematological profile. The aim of this study was to determine the perioperative dynamics of CRP and SAA

in male dogs undergoing elective orchiectomy. Blood samples were collectedby jugular venipuncture in the following

order: before the surgery (day zero), on first (day one), third (day three) and seventh (day seven) postoperative day

(POD). As markers of systemic inflammation, CRP and SAA levels was determined by ELISA using commercial kits.

The study showed that the CRP and SAA changes rapidly. The peak CRP and SAA concentrations were detected on

the first day after surgery. Serum CRP concentration on the seventh postoperative day was within physiological ranges,

while SAA concentration was significantly higher. In conclusion, SAA and CRP measurements above basal levels

are clearly indicative of systemic inflammation in dogs.

Anahtar Kelimeler

CRP, dogs, orchiectomy, SAA

Kaynakça

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