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Propolis üzerine ön klinik araştırmalar

Yıl 2015, Cilt: 31 Sayı: 3, 185 - 191, 01.06.2015

Öz

Propolis, son yıllarda sağlık üzerine etkileri en fazla araştırılan doğal ürünlerden biridir. Ancak, yapılan araştırmalar kimyasal analizlerin, laboratuvar ve hayvan deneyi çalışmalarının ötesine geçememiştir. Ülkemizde sağlığı korumak veya tedaviye destek amacıyla çok sayıda kişi bilinçli/bilinçsiz bir şekilde propolis kullanmaktadır. Bu derlemede, propolisin kimyasal yapısı ve standardizasyonu ile yapılan ön klinik araştırmalar özetlenmiştir. Ayrıca propolis için klinik çalışmaların gerekliliği ve önemi de vurgulanmıştır.

Kaynakça

  • Bankova, V.S., De Castro, S.L., Marcucci, M.C., Propolis: recent advances in chemistry and plant origin, Apidologie, 31, 3–15, 2000.
  • Sforcin, J. A., Bankova, V., Propolis: Is there a potential for the development of new drugs? J Ethnopharmacol, 133, 253–260, 2011.
  • Ghisalberti, E.L., Propolis: A Review, Bee World, 60(2), 59-84, 1979.
  • Castaldo, S., Capasso F., Propolis, an old remedy used in modern medicine, Fitoterapia, 73, 1–6, 2002.
  • Bankova, V., De Castro, S.L., Marcucci, M.C., Chemical diversity of propolis and the problem of standardization, J. Ethnopharmacol., 100, 114–117, 2005 a.
  • Sforcin, J.M., Propolis and the immune system: a review, J Ethnopharmacol., 113, 1–14, 2007.
  • Burdock, G.A., Review of the biological properties and toxicity of bee propolis (propolis), Food and Chem. Toxicol., 36, 347– 363, 1998.
  • Greenaway W., May J., Scaysbrook T., et al., Identification by gas chromatography mass spectrometry of 150 compounds in propolis, Z Naturforsch, 46c, 111-121, 1991.
  • Popova, M., Silici, S., Kaftanoglu, O., et al., Antibacterial activity of Turkish propolis and its qualitative and quantitative chemical composition, Phytomed., 12 (3), 221-228, 2005.
  • Campo Fernandez, M., Cuesta-Rubio, O., Rosado Perez, A. et al., GC–MS determination of isoflavonoids in seven red Cuban propolis samples, J Agric Food Chem., 56, 9927–9932, 2008.
  • Hernandez, I.M., Cuesta-Rubio, O., Fernandez, M.C., et al., Studies on the constituents of yellow Cuban propolis: GC–MS determination of triterpenoids and flavonoids, J Agric Food Chem., 58, 4725–4730, 2010.
  • Ozkok, D., Iscan, K., Silici, S., Effects of dietray propolis supplementation on performance and egg quality in laying hens. J. Anim. Vet. Adv., 12 (2), 269-275, 2013.
  • Kartal, M., Kaya, S., Kurucu, S., GC-MS Analysis of propolis samples from two diferent regions of Turkey, Z. Naturforsch., 57, 905-909, 2002.
  • Gencay, Ö., Sorkun, K., Microscopic analysis of propolis samples collected from east Anatolia (Kemaliye-Erzincan) FABAD J. Pharm. Sci., 31,192197, 2006.
  • Sorkun, K., Süer, B., Salih, B., Determination of chemical composition of Turkish propolis, Z. Naturforsch, 56c, 666-668, 2001.
  • Silici S., Kutluca, S., Chemical composition and antibacterial activity of propolis collected by three different races of honeybees in the same region, J. Ethnopharmacol., 99, 69-73, 2005a.
  • Silici, S., Unlu, M., Vardar-Unlu, G., Antibacterial activity and phytochemical evidence for the plant origin of Turkish propolis from different regions, World J Microbiol Biotechnol., 23 (12), 1797-1803, 2007.
  • Uzel, A., Sorkun, K., Önçağ, Ö., et al., Chemical compositions and antimicrobial activities of four different Anatolian propolis samples, Microbiol Res., 160, 189-195, 2005.
  • Velikova, M., Bankova, V., Sorkun, K.. et al., Chemical composition and biological activity of propolis from Turkish and Bulgarian origin, Mellifera, 1-1, 57-59, 2000.
  • Mohammadzadeh, S., Shariatpanahi, M., Hamedi, M., et al., Chemical composition, oral toxicity and antimicrobial activityof Iranian propolis, Food Chem., 103,1097–1103, 2007.
  • Gülçin, I., Bursal,E., Sehitoğlu, M.H., et al., Polyphenols contents and antioxidant activity of lyophilized aqueus extract of propolis from Erzurum, Turkey, Food Chem. Toxicol., 48, 2227-2238, 2010.
  • Vardar-Ünlü, G., Silici, S., Ünlü, M., Composition and in vitro antimicrobial activity of Populus buds and poplar-type propolis, World J Microbiol Biotechnol., 24 (7), 1011-1017, 2008.
  • Doğan, M. Silici, S., Saraymen, R., Element content of propolis from different regions of Turkey, Acta Alimentaria, 35 (1), 127-130, 2006.
  • Özcan, M., Antifungal properties of propolis, Grasas y Aceites, 50 (5), 395-398, 1999.
  • Özcan, M., Ünver, A., Ceylan, D.A., et al., Inhibitory effect of pollen and propolis extracts, Nahrung/Food, 48 (3), 188-194, 2004.
  • Koç, A.N., Silici, S., Ayangil, D., A.N., et al., Comparison of in vitro activities of antifungal drugs and ethanolic extract of propolis against Trichophyton rubrum and T. mentagrophytes by using a microdilution assay, Mycoses, 48, 205-210, 2005.
  • Silici, S., Koc, A.N., Ayangil, D., et al., Antifungal activities of propolis collected by different races of honeybees against yeasts isolated from patients with superficial mycoses, J Pharmacol Sci., 99 (1), 39-44, 2005b.
  • Silici, S., Koç, A.N., Mıstık, S., Comparision of ın vıtro actıvıtıes of antifungal drugs and propolis against yeasts isolated from patients with superficial mycoses, Ann. Microbiol, 57(2), 269-272, 2007.
  • Koç, A.N., Silici, S., Comparative study of in vitro methods used to analyse the antifungal activity of propolis against Trichophyton rubrum and T. mentagrophytes, Ann. Microbiol, 58(3), 543-547, 2008.
  • Öksüz, H., Duran, N., Tamer, C., et al., Effect of propolis in the treatment of experimental Staphylococcus aureus keratitis in rabbits, Opthalmic Res., 37, 328-334, 2005.
  • Sagdıc, O., Silici, S., Yetim, H., Fate of Escherichia coli and E.coli 0157:H7 in apple juice treated with propolis extract, Ann. Microbiol, 57(3), 345-348, 2007.
  • Eraslan, G., Kanbur, M., Silici, S. et al., Evaluation of propolis effects on some biochemical parameters in rats treated with sodium fluoride, Pest Biochem Physiol., 88 (3), 273-283, 2007.
  • Eraslan, G., Kanbur, M., Silici, S., et al., Effects of cypermethrin on some biochemical changes in rats: The protective role of propolis, Exp. Anim., 57(5), 453-460,
  • Kanbur, M., Eraslan, G., Silici, S., Antioxidant effect of propolis against exposure to propetamphos in rats. Ecotox Environ Safe., 72(3), 909-915, 2009.
  • Çetin, E., Kanbur, M., Silici, S., et al., Propetamphos induced changes in hematological and biochemical parameters of female rats: protective role of propolis, Food Chem Toxicol., 48 (7), 1806-1810, 2010a.
  • Yonar, M.E., Yonar, S.M, Ural, M.Ş., et al., Protective role of propolis in chlorpyrifos-induced changes in the haematological parameters and the oxidative/ antioxidative status of Cyprinus carpio carpio, Food Chem Toxicol, 50 (8), 2703-2708, 2012.
  • Ozkul, Y., Silici, S., Eroğlu, E., The anticarcinogenic effect of propolis in human lymphocytes culture, Phytomed., 12(10), 742-747, 2005.
  • Eroğlu, H.E., Ozkul, Y., Tatlisen, A et al., Anticarcinogenic and antimitotic effects of Turkish propolis and mitomycin-C on tissue cultures of bladder cancer, Natural Product Res., 22(12), 1060-1066, 2008.
  • Çam, Y., Koc, A.N., Silici, S., et al., Treatment of dermatophytosis in young cattle with propolis and Whitfield’s ointment, Vet. Record., 165 (2), 57-58, 2009.
  • Ozbilge, H., Kaya, E.G., Albayrak, S., et al., Antileishmanial activities of ethanolic extract of Kayseri propolis, African J Microbiol Res., 4 (7), 556-560, 2010.
  • Çetin, E. Silici, S., Cetin, N., Effects of diets containing different concentrations of propolis on hematological and immunological variables in laying hens, Poultry Sci., 89 (8), 1703-1708, 2010b.
  • Yonar, M.E., Yonar, S.M., Silici, S., Protective effect of propolis against oxidative stress and immunosuppression induced by oxytetracycline in rainbow trout (Oncorhynchus mykiss, W.), Fish and Shelfish Immunol., 31 (2), 318-325, 2011.
  • Yonar, S.M., Ural, M.Ş., Silici, S., et al., Malathioninduced changes in the haematological profile, the immun response, and the oxidative/antioxidant status of Cyprinus carpio carpio: Protective role of propolis, Ecotoxicol Environ Safe., 102, 202-209, 2014.
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  • Arslan, S., Silici, S., Percin, D. et al., Antimicrobial activity of poplar propolis on mutans streptococci and caries development in rats, Turk J. Biol., 36 (1), 65-73, 2012b.
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  • Seven, I., Tatlı-Seven, P., Silici, S., Effects of dietary Turkish propolis as alternative to antibiotic on growth and laying performances, nutrient digestibility and egg quality in laying hens under heat stress, Revue Méd. Vét., 162 (4), 186-191, 2011.
  • Silici, S., Koc, A.N., Mutlu-Sarıgüzel, F., et al., Mould inhibition in different fruit juices by propolis, Arch Lebensmittelhyg., 56, 73-96, 2005c.
  • Koç, A.N., Silici, S.,Mutlu-Sarıgüzel, F., et al., Antifungal activity of propolis in four different fruit juices, Food Technol Biotechnol., 45 (1), 57-61, 2007.
  • Özcan, M., Ozcan, M., Ayar, A., Effect of propolis extracts on butter stability, J Food Quality, 26(1), 65-73, 2003.
  • Popova, M.P., Bankova, V.S., Bogdanov, S., et al., Chemical characteristics of poplar type propolis of different geographic origin, Apidologie, 38, 306-311, 2007.
  • Sforcin, J.M., Fernandes Jr., A., Lopes, C.A.M., et al., Seasonal effect on Brazilian propolis antibacterial activity, J Ethnopharmacol., 73, 243–249, 2000.
  • Sforcin, J.M., Fernandes Jr., A., Lopes, C.A.M., et al., Seasonal effect of Brazilian propolis on Candida albicans and Candida tropicalis, J Venom Anim Toxins., 7, 139– 144, 2001.
  • Freitas, S.F., Shinohara, L., Sforcin, J.M., et al., In vitro effects of propolison Giardia duodenalis trophozoites,
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  • Jasprica, I., Mornar, A., Debeljak, Z. et al., In vivo study of propolis supplementation effects on anti-oxidative status and red blood cells, J Ethnopharmacol., 110, 548554, 2007a.
  • Sforcin, J. A., Bankova, V., Propolis: Is there a potential for the development of new drugs?, J Ethnopharmacol., 133, 253–260, 2011.
  • Orsatti, C.L., Missima, F., Pagliarone, A.C., et al., Propolis immunomodulatory action in vivo on Toll-like receptors 2 and 4 expression and on pro-inflammatory cytokines production in mice, Phytotherapy Res., 24, 1141–1146, 2010.
  • Orsi, R.O., Sforcin, J.M., Rall, V.L.M., et al., Susceptibility profile of Salmonella against the antibacterial activity of propolis produced in two regions of Brazil, J Venom Anim Toxins., 11, 109–116, 2005.
  • Orsolic, N., Sver, L., Terzic, S., et al., Peroral application of water-soluble derivative of propolis (WSDP) and its related polyphenolic compounds and their influence on immunological and antitumor activity, Vet Res Commun., 29, 575–593, 2005.
  • Bassani-Silva, S., Sforcin, J.M., Amaral, A.S., et al., Propolis effect in vitro on canine transmissible venereal tumor cells, Rev Port Ciênc Vet., 102, 261–265, 2007.
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  • Sforcin, J.M., Funari, S.R.C., Novelli, E.L.B., Serum biochemical determinations of propolis-treated rats, J Venom Anim Toxins., 1, 31-7, 1995.
  • Sforcin, J.M., Novelli, E.L.B., Funari, S.R.C., Seasonal effect of Brazilian propolis on seric biochemical variables, J Venom Anim Toxins., 8, 244–254, 2002.
  • Jasprica, I., Bojic, M., Mornar, A et al., Evaluation of antioxidative activity of Croatian propolis samples using DPPH and ABTS stable free radical assays, Molecules, 12, 1006-1021, 2007b.
  • Cuesta, A., Rodriguez,A., Angeles, M., et al., In vivo effects of propolis, a honeybee product, on gilthead seabream innate immune responses, Fish & Selfish Immun.,18(1), 71-80, 2005.
  • Walgrave, S.E., Warshaw, E.M., Glesne, L.A., Allergic contact dermatitis from propolis, Dermatitis, 16, 209-215, 2005.
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  • Gardana, C., Scaglianti, M., Pietta, P. et al., Analysis of the polyphenolic fraction of propolis from different sources by liquid chromatography-tandem mass spectrometry, J Pharm Biomed Anal., 45, 390–399, 2007.
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  • Mani, F., Damasceno, H.C.R., Novelli, E.L.B., et al., Propolis: effect of different concentrations, extracts and intake period on seric biochemical variables, J Ethnopharmacol., 105, 95–98, 2006.
  • Kolankaya, D., Selmanoğlu, G., Sorkun, K., et al., Protective effects of Turkish propolis on alcohol-induced serum lipid changes and liver injury in male rats, Food Chem., 78, 213-217, 2002
  • Russo, A., Cardile, V., Sanchez, F., et al., Chilean propolis: antioxidant activity and antiproliferative action in human tumor cell lines, Life Sci., 76, 545-58, 2004.
  • Kumazawa, S., Hamasaka, T., Nakayama, T et al., Antioxidant activity of propolis of various geographic origins, Food Chem., 84, 329-339, 2004.
  • Isla, M.I., Nieva Moreno, M.I., Sampietro, A.R., et al., Antioxidant activity of Argentine propolis extracts, J Ethnopharmacol., 76, 165-170, 2001.
  • Ahn, M.R., Kumazawa, S., Hamasaka, T. et al., Antioxidant activity and constituents of propolis ollected in various areas of Korea, J. Agric. Food Chem., 52, 7286-7292, 2004.
  • Banskota, A.H., Tezuka, Y., Adnyana, I.K., Biological evaluation of propolis from Brazil, Peru, the Netherlands and China, J. Ethnopharmacol., 72, 239246, 2000.
  • Gonzalez, R., Remirez, D., Rodriguez, S., et al., Hepatoprotective effects of propolis extract on paracetamol-induced liver damage in mice, Phytother Res., 8 (4), 229-232, 1994.
  • Gonzalez, R., Corcho, I., Remirez, D., et al., Hepatoprotective effects of propolis extract on carbon tetrachloride-induced liver injury in rats, Phytother Res., 9 (2), 114-117, 1995.
  • Lin, S.C., Lin, Y.H., Chan, C.F., et al., The hepatoprotective and therapeutic effects of propolis ethanol extract on chronic alcohol-induced liver injuries, Am J Chin Med., 25 (3/4), 325-332, 1997.
  • Ramadan, A., Soliman, G., Mahmoud, et al., Evaluation of the safety and antioxidant activities of Crocus sativus and Propolis ethanolic extracts, J Saudi Chem Soc., 16, 13–21, 2012.
  • Banskota, A.H., Tezuka, Y., Kadota, S., Recent progress in pharmacological research of propolis, Phytother. Res., 15, 561–571, 2001.
  • Bratter, C., Tregel, M., Liebenthal, C. et al., Prophylaktische wirkungen von propolis zur immunstimulation: eine klinische pilotstudie, Forschende Komplementarmedizin, 6, 256–260, 1999.
  • Özen, T., Kılıç, A., Bedir, O., et al., In vitro activity of Turkish propolis samples against anaerobic bacteria causing oral cavity infections, Kafkas Univ Vet Fak Dergisi, 16(2), 293-298, 2010.
  • Khayyal, M.T., El-Ghazaly, M.A., El-Khatib, A.S., et al., A clinical pharmacological study of the potential beneficial effects of a propolis food product as an adjuvant in asthmatic patient, Fundam Clin Pharmacol., 17(1), 93-102

Pre-clinical studies on propolis

Yıl 2015, Cilt: 31 Sayı: 3, 185 - 191, 01.06.2015

Öz

Propolis is one of the most investigated natural products for their effects on health in recent years. However, these investigations did not go beyond the chemical analysis, in vitro and animal studies. In our country, a lot of people use propolis either consciously or unconsciously as an adjuvant to medical therapy or prophylactic purposes. In this review, chemical structure, standardization, and pre-clinical studies of propolis are summarized. Moreover, the necessity and importance of clinical studies for propolis are also emphasized.

Kaynakça

  • Bankova, V.S., De Castro, S.L., Marcucci, M.C., Propolis: recent advances in chemistry and plant origin, Apidologie, 31, 3–15, 2000.
  • Sforcin, J. A., Bankova, V., Propolis: Is there a potential for the development of new drugs? J Ethnopharmacol, 133, 253–260, 2011.
  • Ghisalberti, E.L., Propolis: A Review, Bee World, 60(2), 59-84, 1979.
  • Castaldo, S., Capasso F., Propolis, an old remedy used in modern medicine, Fitoterapia, 73, 1–6, 2002.
  • Bankova, V., De Castro, S.L., Marcucci, M.C., Chemical diversity of propolis and the problem of standardization, J. Ethnopharmacol., 100, 114–117, 2005 a.
  • Sforcin, J.M., Propolis and the immune system: a review, J Ethnopharmacol., 113, 1–14, 2007.
  • Burdock, G.A., Review of the biological properties and toxicity of bee propolis (propolis), Food and Chem. Toxicol., 36, 347– 363, 1998.
  • Greenaway W., May J., Scaysbrook T., et al., Identification by gas chromatography mass spectrometry of 150 compounds in propolis, Z Naturforsch, 46c, 111-121, 1991.
  • Popova, M., Silici, S., Kaftanoglu, O., et al., Antibacterial activity of Turkish propolis and its qualitative and quantitative chemical composition, Phytomed., 12 (3), 221-228, 2005.
  • Campo Fernandez, M., Cuesta-Rubio, O., Rosado Perez, A. et al., GC–MS determination of isoflavonoids in seven red Cuban propolis samples, J Agric Food Chem., 56, 9927–9932, 2008.
  • Hernandez, I.M., Cuesta-Rubio, O., Fernandez, M.C., et al., Studies on the constituents of yellow Cuban propolis: GC–MS determination of triterpenoids and flavonoids, J Agric Food Chem., 58, 4725–4730, 2010.
  • Ozkok, D., Iscan, K., Silici, S., Effects of dietray propolis supplementation on performance and egg quality in laying hens. J. Anim. Vet. Adv., 12 (2), 269-275, 2013.
  • Kartal, M., Kaya, S., Kurucu, S., GC-MS Analysis of propolis samples from two diferent regions of Turkey, Z. Naturforsch., 57, 905-909, 2002.
  • Gencay, Ö., Sorkun, K., Microscopic analysis of propolis samples collected from east Anatolia (Kemaliye-Erzincan) FABAD J. Pharm. Sci., 31,192197, 2006.
  • Sorkun, K., Süer, B., Salih, B., Determination of chemical composition of Turkish propolis, Z. Naturforsch, 56c, 666-668, 2001.
  • Silici S., Kutluca, S., Chemical composition and antibacterial activity of propolis collected by three different races of honeybees in the same region, J. Ethnopharmacol., 99, 69-73, 2005a.
  • Silici, S., Unlu, M., Vardar-Unlu, G., Antibacterial activity and phytochemical evidence for the plant origin of Turkish propolis from different regions, World J Microbiol Biotechnol., 23 (12), 1797-1803, 2007.
  • Uzel, A., Sorkun, K., Önçağ, Ö., et al., Chemical compositions and antimicrobial activities of four different Anatolian propolis samples, Microbiol Res., 160, 189-195, 2005.
  • Velikova, M., Bankova, V., Sorkun, K.. et al., Chemical composition and biological activity of propolis from Turkish and Bulgarian origin, Mellifera, 1-1, 57-59, 2000.
  • Mohammadzadeh, S., Shariatpanahi, M., Hamedi, M., et al., Chemical composition, oral toxicity and antimicrobial activityof Iranian propolis, Food Chem., 103,1097–1103, 2007.
  • Gülçin, I., Bursal,E., Sehitoğlu, M.H., et al., Polyphenols contents and antioxidant activity of lyophilized aqueus extract of propolis from Erzurum, Turkey, Food Chem. Toxicol., 48, 2227-2238, 2010.
  • Vardar-Ünlü, G., Silici, S., Ünlü, M., Composition and in vitro antimicrobial activity of Populus buds and poplar-type propolis, World J Microbiol Biotechnol., 24 (7), 1011-1017, 2008.
  • Doğan, M. Silici, S., Saraymen, R., Element content of propolis from different regions of Turkey, Acta Alimentaria, 35 (1), 127-130, 2006.
  • Özcan, M., Antifungal properties of propolis, Grasas y Aceites, 50 (5), 395-398, 1999.
  • Özcan, M., Ünver, A., Ceylan, D.A., et al., Inhibitory effect of pollen and propolis extracts, Nahrung/Food, 48 (3), 188-194, 2004.
  • Koç, A.N., Silici, S., Ayangil, D., A.N., et al., Comparison of in vitro activities of antifungal drugs and ethanolic extract of propolis against Trichophyton rubrum and T. mentagrophytes by using a microdilution assay, Mycoses, 48, 205-210, 2005.
  • Silici, S., Koc, A.N., Ayangil, D., et al., Antifungal activities of propolis collected by different races of honeybees against yeasts isolated from patients with superficial mycoses, J Pharmacol Sci., 99 (1), 39-44, 2005b.
  • Silici, S., Koç, A.N., Mıstık, S., Comparision of ın vıtro actıvıtıes of antifungal drugs and propolis against yeasts isolated from patients with superficial mycoses, Ann. Microbiol, 57(2), 269-272, 2007.
  • Koç, A.N., Silici, S., Comparative study of in vitro methods used to analyse the antifungal activity of propolis against Trichophyton rubrum and T. mentagrophytes, Ann. Microbiol, 58(3), 543-547, 2008.
  • Öksüz, H., Duran, N., Tamer, C., et al., Effect of propolis in the treatment of experimental Staphylococcus aureus keratitis in rabbits, Opthalmic Res., 37, 328-334, 2005.
  • Sagdıc, O., Silici, S., Yetim, H., Fate of Escherichia coli and E.coli 0157:H7 in apple juice treated with propolis extract, Ann. Microbiol, 57(3), 345-348, 2007.
  • Eraslan, G., Kanbur, M., Silici, S. et al., Evaluation of propolis effects on some biochemical parameters in rats treated with sodium fluoride, Pest Biochem Physiol., 88 (3), 273-283, 2007.
  • Eraslan, G., Kanbur, M., Silici, S., et al., Effects of cypermethrin on some biochemical changes in rats: The protective role of propolis, Exp. Anim., 57(5), 453-460,
  • Kanbur, M., Eraslan, G., Silici, S., Antioxidant effect of propolis against exposure to propetamphos in rats. Ecotox Environ Safe., 72(3), 909-915, 2009.
  • Çetin, E., Kanbur, M., Silici, S., et al., Propetamphos induced changes in hematological and biochemical parameters of female rats: protective role of propolis, Food Chem Toxicol., 48 (7), 1806-1810, 2010a.
  • Yonar, M.E., Yonar, S.M, Ural, M.Ş., et al., Protective role of propolis in chlorpyrifos-induced changes in the haematological parameters and the oxidative/ antioxidative status of Cyprinus carpio carpio, Food Chem Toxicol, 50 (8), 2703-2708, 2012.
  • Ozkul, Y., Silici, S., Eroğlu, E., The anticarcinogenic effect of propolis in human lymphocytes culture, Phytomed., 12(10), 742-747, 2005.
  • Eroğlu, H.E., Ozkul, Y., Tatlisen, A et al., Anticarcinogenic and antimitotic effects of Turkish propolis and mitomycin-C on tissue cultures of bladder cancer, Natural Product Res., 22(12), 1060-1066, 2008.
  • Çam, Y., Koc, A.N., Silici, S., et al., Treatment of dermatophytosis in young cattle with propolis and Whitfield’s ointment, Vet. Record., 165 (2), 57-58, 2009.
  • Ozbilge, H., Kaya, E.G., Albayrak, S., et al., Antileishmanial activities of ethanolic extract of Kayseri propolis, African J Microbiol Res., 4 (7), 556-560, 2010.
  • Çetin, E. Silici, S., Cetin, N., Effects of diets containing different concentrations of propolis on hematological and immunological variables in laying hens, Poultry Sci., 89 (8), 1703-1708, 2010b.
  • Yonar, M.E., Yonar, S.M., Silici, S., Protective effect of propolis against oxidative stress and immunosuppression induced by oxytetracycline in rainbow trout (Oncorhynchus mykiss, W.), Fish and Shelfish Immunol., 31 (2), 318-325, 2011.
  • Yonar, S.M., Ural, M.Ş., Silici, S., et al., Malathioninduced changes in the haematological profile, the immun response, and the oxidative/antioxidant status of Cyprinus carpio carpio: Protective role of propolis, Ecotoxicol Environ Safe., 102, 202-209, 2014.
  • Arslan, S., Yazici, R.A., Görücü, J. et al., Comparison of the effects of Er, Cr: YSGG laser and different cavity disinfection agents on microleakage of current adhesives, Lasers Med. Sci., 27(4), 805-11, 2012a.
  • Arslan, S., Silici, S., Percin, D. et al., Antimicrobial activity of poplar propolis on mutans streptococci and caries development in rats, Turk J. Biol., 36 (1), 65-73, 2012b.
  • Denli, M., Cankaya, S. Silici, S., et al., Effect of dietary addition of Turkish propolis on the growth performance, carcass characteristics and serum variables of quail (Coturnix coturnix japonica, AJAS, 18 (6), 848-854, 2005.
  • Seven, I., Tatlı-Seven, P., Silici, S., Effects of dietary Turkish propolis as alternative to antibiotic on growth and laying performances, nutrient digestibility and egg quality in laying hens under heat stress, Revue Méd. Vét., 162 (4), 186-191, 2011.
  • Silici, S., Koc, A.N., Mutlu-Sarıgüzel, F., et al., Mould inhibition in different fruit juices by propolis, Arch Lebensmittelhyg., 56, 73-96, 2005c.
  • Koç, A.N., Silici, S.,Mutlu-Sarıgüzel, F., et al., Antifungal activity of propolis in four different fruit juices, Food Technol Biotechnol., 45 (1), 57-61, 2007.
  • Özcan, M., Ozcan, M., Ayar, A., Effect of propolis extracts on butter stability, J Food Quality, 26(1), 65-73, 2003.
  • Popova, M.P., Bankova, V.S., Bogdanov, S., et al., Chemical characteristics of poplar type propolis of different geographic origin, Apidologie, 38, 306-311, 2007.
  • Sforcin, J.M., Fernandes Jr., A., Lopes, C.A.M., et al., Seasonal effect on Brazilian propolis antibacterial activity, J Ethnopharmacol., 73, 243–249, 2000.
  • Sforcin, J.M., Fernandes Jr., A., Lopes, C.A.M., et al., Seasonal effect of Brazilian propolis on Candida albicans and Candida tropicalis, J Venom Anim Toxins., 7, 139– 144, 2001.
  • Freitas, S.F., Shinohara, L., Sforcin, J.M., et al., In vitro effects of propolison Giardia duodenalis trophozoites,
  • Phytomed., 13,170–175, 2006.
  • Harborne J.B., Williams C.A., Advances in flavonoid research since 1992, Phytochem, 55, 481–504, 2000.
  • Havsteen, B.H., Flavonoids, a class of natural products of high pharmacological potency, Biochem Pharmacol., 32, 1141–1448, 1983.
  • Kühnau, J., The flavonoids. A class of semi-essential food components: their role in human nutrition, World Rev Nutr Diet, 24, 117-191, 1976.
  • Hertog, M.G.L., Hollman, P.C., Katan, M.B., Intake of potentially anticarcinogenic flavonoids and their determinants in adults in Netherlands, Nutr Cancer Int J., 20, 21-29, 1993.
  • Williams, R.J., Spencer, J.P.E., Rice-Evans, C.A., Flavonoids: antioxidants or signaling molecules? Free Radical Biol Med., 36, 838-849, 2004.
  • Rice-Evans, C.A., Miller, N.J., Paganga, N., Structure antioxidant activity relationship flavonoids and phenolic acids, Free Radical Biol Med., 20, 933-956, 1996.
  • Cao, G., Sofic, E., Prior, R.L. et al., Antioxidant and prooxidant behavior of flavonoids: structure activity relationships, Free Radical Biol Med., 22, 749-760, 1997.
  • Jasprica, I., Mornar, A., Debeljak, Z. et al., In vivo study of propolis supplementation effects on anti-oxidative status and red blood cells, J Ethnopharmacol., 110, 548554, 2007a.
  • Sforcin, J. A., Bankova, V., Propolis: Is there a potential for the development of new drugs?, J Ethnopharmacol., 133, 253–260, 2011.
  • Orsatti, C.L., Missima, F., Pagliarone, A.C., et al., Propolis immunomodulatory action in vivo on Toll-like receptors 2 and 4 expression and on pro-inflammatory cytokines production in mice, Phytotherapy Res., 24, 1141–1146, 2010.
  • Orsi, R.O., Sforcin, J.M., Rall, V.L.M., et al., Susceptibility profile of Salmonella against the antibacterial activity of propolis produced in two regions of Brazil, J Venom Anim Toxins., 11, 109–116, 2005.
  • Orsolic, N., Sver, L., Terzic, S., et al., Peroral application of water-soluble derivative of propolis (WSDP) and its related polyphenolic compounds and their influence on immunological and antitumor activity, Vet Res Commun., 29, 575–593, 2005.
  • Bassani-Silva, S., Sforcin, J.M., Amaral, A.S., et al., Propolis effect in vitro on canine transmissible venereal tumor cells, Rev Port Ciênc Vet., 102, 261–265, 2007.
  • Kaneeda, J., Nishina, T., Safetiness of propolis. Acute toxicity, Honeybee Sci., 15, 29-33, 1994.
  • Sforcin, J.M., Funari, S.R.C., Novelli, E.L.B., Serum biochemical determinations of propolis-treated rats, J Venom Anim Toxins., 1, 31-7, 1995.
  • Sforcin, J.M., Novelli, E.L.B., Funari, S.R.C., Seasonal effect of Brazilian propolis on seric biochemical variables, J Venom Anim Toxins., 8, 244–254, 2002.
  • Jasprica, I., Bojic, M., Mornar, A et al., Evaluation of antioxidative activity of Croatian propolis samples using DPPH and ABTS stable free radical assays, Molecules, 12, 1006-1021, 2007b.
  • Cuesta, A., Rodriguez,A., Angeles, M., et al., In vivo effects of propolis, a honeybee product, on gilthead seabream innate immune responses, Fish & Selfish Immun.,18(1), 71-80, 2005.
  • Walgrave, S.E., Warshaw, E.M., Glesne, L.A., Allergic contact dermatitis from propolis, Dermatitis, 16, 209-215, 2005.
  • Cho, E., Lee, J.D., Cho, S.H. et al., Systemic contact dermatitis from propolis ingestion, Ann Dermatol., 23, 8588, 2011.
  • Shinmei, Y., Yano, H., Kagawa, Y., et al., Effect of Brazilian propolis on sneezing and nasal rubbing in experimental allergic rhinitis of mice, Int Immunopharmacol., 31, 688–693, 2009.
  • Gardana, C., Scaglianti, M., Pietta, P. et al., Analysis of the polyphenolic fraction of propolis from different sources by liquid chromatography-tandem mass spectrometry, J Pharm Biomed Anal., 45, 390–399, 2007.
  • Lee, S.Y., Lee, D.R., You, C.E., et al., Autosensitization dermatitis associated with propolis-induced allergic contact dermatitis, J Drugs Dermatol., 5, 458-460, 2006.
  • Hausen, B.M., Evaluation of the main contact allergens in propolis (1995 to 2005), Dermatitis, 16,127–129, 2005.
  • Çelikel, S., Karakaya, G., Yurtsever, N. et al., Bee and bee products allergy in Turkish beekeepers: determination of risk factors for systemic reactions, Allergol Immunopathol., 34, 180-184, 2006.
  • Mani, F., Damasceno, H.C.R., Novelli, E.L.B., et al., Propolis: effect of different concentrations, extracts and intake period on seric biochemical variables, J Ethnopharmacol., 105, 95–98, 2006.
  • Kolankaya, D., Selmanoğlu, G., Sorkun, K., et al., Protective effects of Turkish propolis on alcohol-induced serum lipid changes and liver injury in male rats, Food Chem., 78, 213-217, 2002
  • Russo, A., Cardile, V., Sanchez, F., et al., Chilean propolis: antioxidant activity and antiproliferative action in human tumor cell lines, Life Sci., 76, 545-58, 2004.
  • Kumazawa, S., Hamasaka, T., Nakayama, T et al., Antioxidant activity of propolis of various geographic origins, Food Chem., 84, 329-339, 2004.
  • Isla, M.I., Nieva Moreno, M.I., Sampietro, A.R., et al., Antioxidant activity of Argentine propolis extracts, J Ethnopharmacol., 76, 165-170, 2001.
  • Ahn, M.R., Kumazawa, S., Hamasaka, T. et al., Antioxidant activity and constituents of propolis ollected in various areas of Korea, J. Agric. Food Chem., 52, 7286-7292, 2004.
  • Banskota, A.H., Tezuka, Y., Adnyana, I.K., Biological evaluation of propolis from Brazil, Peru, the Netherlands and China, J. Ethnopharmacol., 72, 239246, 2000.
  • Gonzalez, R., Remirez, D., Rodriguez, S., et al., Hepatoprotective effects of propolis extract on paracetamol-induced liver damage in mice, Phytother Res., 8 (4), 229-232, 1994.
  • Gonzalez, R., Corcho, I., Remirez, D., et al., Hepatoprotective effects of propolis extract on carbon tetrachloride-induced liver injury in rats, Phytother Res., 9 (2), 114-117, 1995.
  • Lin, S.C., Lin, Y.H., Chan, C.F., et al., The hepatoprotective and therapeutic effects of propolis ethanol extract on chronic alcohol-induced liver injuries, Am J Chin Med., 25 (3/4), 325-332, 1997.
  • Ramadan, A., Soliman, G., Mahmoud, et al., Evaluation of the safety and antioxidant activities of Crocus sativus and Propolis ethanolic extracts, J Saudi Chem Soc., 16, 13–21, 2012.
  • Banskota, A.H., Tezuka, Y., Kadota, S., Recent progress in pharmacological research of propolis, Phytother. Res., 15, 561–571, 2001.
  • Bratter, C., Tregel, M., Liebenthal, C. et al., Prophylaktische wirkungen von propolis zur immunstimulation: eine klinische pilotstudie, Forschende Komplementarmedizin, 6, 256–260, 1999.
  • Özen, T., Kılıç, A., Bedir, O., et al., In vitro activity of Turkish propolis samples against anaerobic bacteria causing oral cavity infections, Kafkas Univ Vet Fak Dergisi, 16(2), 293-298, 2010.
  • Khayyal, M.T., El-Ghazaly, M.A., El-Khatib, A.S., et al., A clinical pharmacological study of the potential beneficial effects of a propolis food product as an adjuvant in asthmatic patient, Fundam Clin Pharmacol., 17(1), 93-102
Toplam 95 adet kaynakça vardır.

Ayrıntılar

Diğer ID JA79DB84TT
Bölüm Makaleler
Yazarlar

Sibel Silici Bu kişi benim

Yayımlanma Tarihi 1 Haziran 2015
Yayımlandığı Sayı Yıl 2015 Cilt: 31 Sayı: 3

Kaynak Göster

APA Silici, S. (2015). Propolis üzerine ön klinik araştırmalar. Erciyes Üniversitesi Fen Bilimleri Enstitüsü Fen Bilimleri Dergisi, 31(3), 185-191.
AMA Silici S. Propolis üzerine ön klinik araştırmalar. Erciyes Üniversitesi Fen Bilimleri Enstitüsü Fen Bilimleri Dergisi. Haziran 2015;31(3):185-191.
Chicago Silici, Sibel. “Propolis üzerine ön Klinik araştırmalar”. Erciyes Üniversitesi Fen Bilimleri Enstitüsü Fen Bilimleri Dergisi 31, sy. 3 (Haziran 2015): 185-91.
EndNote Silici S (01 Haziran 2015) Propolis üzerine ön klinik araştırmalar. Erciyes Üniversitesi Fen Bilimleri Enstitüsü Fen Bilimleri Dergisi 31 3 185–191.
IEEE S. Silici, “Propolis üzerine ön klinik araştırmalar”, Erciyes Üniversitesi Fen Bilimleri Enstitüsü Fen Bilimleri Dergisi, c. 31, sy. 3, ss. 185–191, 2015.
ISNAD Silici, Sibel. “Propolis üzerine ön Klinik araştırmalar”. Erciyes Üniversitesi Fen Bilimleri Enstitüsü Fen Bilimleri Dergisi 31/3 (Haziran 2015), 185-191.
JAMA Silici S. Propolis üzerine ön klinik araştırmalar. Erciyes Üniversitesi Fen Bilimleri Enstitüsü Fen Bilimleri Dergisi. 2015;31:185–191.
MLA Silici, Sibel. “Propolis üzerine ön Klinik araştırmalar”. Erciyes Üniversitesi Fen Bilimleri Enstitüsü Fen Bilimleri Dergisi, c. 31, sy. 3, 2015, ss. 185-91.
Vancouver Silici S. Propolis üzerine ön klinik araştırmalar. Erciyes Üniversitesi Fen Bilimleri Enstitüsü Fen Bilimleri Dergisi. 2015;31(3):185-91.

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