Antifungal Activity Of Lawsonia Inermis L. (Henna) Against Clinical Candida Isolates

Öz

  Lawsonia inermis L. (henna) is a much branched shrub or small tree, cultivated for its voluable leaves although stem, bark and roots have also been used in traditional medicine for over 9,000 years. In this study,  the antifungal activity of L. inermis was determined against clinical Candida isolates The study was carried out using 192 clinical isolates of Candida from six different species; 135 Candida albicans, 19 Candida parapsilosis, 17 Candida glabrata, 13 Candida tropicalis, 5 Candida krusei, 3 Candida kefyr. The anticandidal activities of L. inermis (henna) as paste form was determined by agar diffusion technique. The highest antifungal activity of henna was obtained against 68 (35.4%) clinical Candida isolates (≥20mm inhibition zone) and moderate activity also detected against 73 (38.0%) isolates (5-15 mm inhibition zone). Fifty-one (26.5%) isolates were resistance (no inhibition zone) to henna paste.

Anahtar Kelimeler

• Henna,Candida Species,Antifungal Activity

Antifungal Activity of Lawsonia Inermis L. (Henna) Against Clinical Candida Isolates

Öz

Kına (Lawsonia inermis L.), yaprakları, sürgünleri ve kökleri 9000 yıldan beri geleneksel tedavi için kullanılan, çok dallı çalı veya küçük ağaç formunda bir bitkidir. Bu çalışmada kınanın, klinik olarak izole edilen Candida türleri üzerine antifungal etkisi araştırılmıştır. Çalışma 6 farklı türe ait 192 klinik izolatla gerçekleştirilmiştir. İzolatların 135’i Candida albicans, 19’u Candida parapsilosis, 17’si Candida glabrata, 13’ü Candida tropicalis, 5’i Candida krusei ve 3’ü Candida kefyr türlerine aittir. Antikandidal aktivite, agar difüzyon tekniğiyle belirlenmiştir. En yüksek aktivite 68 (%35.4) Candida albicans izolatlarında 20mm den büyük inhibisyon zonuyla elde edilmiştir. Orta derecede aktivite ise yine aynı türe ait izolatlarda 73(%38.0) oran ve 5-15 mm inhibisyon zonuyla elde edilmiştir. İzolatlardan % 26’sı kınaya karşı dirençli ( inhibisyon zonu oluşmamış) bulunmuştur.

Anahtar Kelimeler

• Henna,Candida Species,Antifungal Etki

Kaynakça

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