ADACAYI YAPRAKLARININ (SALVIA OFFICINALIS L.) KOLİNERJİK ETKİLERİ

Yıl 2014, , 275 - 281, 11.01.2015

Başar Altınterim

https://doi.org/10.18185/eufbed.25846

Öz

Öğrenme, bellek ve dikkat gibi algısal işlevler ön beyin tabanındaki kolinerjik nöronlarla ilişkilidir. Ön beyin tabanındaki kolinerjik sistemin öğrenmedeki rolü çok tartışılmıştır. Yakın zamanlarda yapılan çalışmalar genel öğrenmede ve hafıza mekanizmasında ön beyin tabanındaki kolinerjik sisteminin etkin bir rolü olduğunu desteklemektedir. Salvia ofŞcinalis L. (adaçayı) yaprakları iyi bir antioksidan olarak bilinir. Beyin fonksiyon bozukluğu, kanser, kalp hastalıkları ve immün sistem zayıflığı, serbest radikallerin neden olduğu hücresel yıkım gibi çoğu dejeneratif hastalıklarda kullanımı tavsiye edilmektedir. Diyetle alınması hastalıkların engellenmesinde bir antioksidan olarak önemli bir rol oynayabilir

Anahtar Kelimeler

Adaçayı, asetilkolin, kolinerjik etki

CHOLINERGIC EFFECTS OF SAGE (SALVIA OFFICINALIS L.) LEAVES

Öz

The cholinergic basal forebrain (CBF) has been implicated in cognitive functions including learning, memory, and attention. The role of the basal forebrain cholinergic system in learning has been widely debated. Early studies are supported a role for the basal forebrain cholinergic system in general learning and memory mechanisms. The leaves of Salvia officinalis L. (sage) are well known for their antioxidative properties. There is increasing evidence to suggest that many degenerative diseases, such as brain dysfunction, cancer, heart diseases, and weakened immune system, could be the result of cellular damage caused by free radicals, and antioxidants present in human diet may play an important role in disease prevention.

Anahtar Kelimeler

Sage, acetylcholine, cholinergic effect

Kaynakça

• Almkvist, O., Jelic, V., Amberla, K., Hellstrom-Lindahl, E., Meurling, L., Nordberg, A. 2001. Responder characteristics to a single oral dose of cholinesteraseinhibitor: a double-blind placebo-controlled study with tacrine in Alzheimer patients. Dement Geriatr Cogn Disord. 12: 22 –32.
• Bartus, R.T., Dean, R.L., Beer, B. and Lippa, A.S. 1982. The cholinergic hypothesis of geriatric memory dysfunction. Science. 217: 408 -414.
• Bigl, V., Woolf, N.J. and Butcher, L.L. 1982. Cholinergic projection from the basal forebrain to frontal, parietal, temporal, occipital, and cingulate cortices: A combined fluorescent tracer and acetylcholinesterase analysis. Brain Res. Bull. 8: 727-749.
• Bouaziz, M., Yangui, T., Sayadi, S., et al. 2009. Disinfectant properties of essential oils from Salvia officinalis L. cultivated inTunisia. Food and Chemical Toxicology. 47 (11): 2755–2760.
• Cho, H.M., Song, D.K., Suh, H.W., KimY.H. 1994. Serotonin uptake blocking activity from herb medicines. Neuropsychopharmacology. 10: 137.
• Chung, I.W., Chen, G., Manji, H., Kim, Y.S., Ahn, J.S., Potter, W.Z., et al. 1994. Binding of natural medicinal products to alpha 2 adrenergic receptors. Neuropsychopharmacology. 10: 137.
• Conner, J.M., Kulczycki, M. and Tuszynski, M.H. 2010. Unique Contributions of Distinct Cholinergic Projections to Motor Cortical Plasticity and Learning. Oxford Journals. Volume 20, Issue 11: pp. 2739-2748.
• Davies, P. and Maloney, A.J. 1976. Selective loss of central cholinergic neurons in Alzheimer's disease. Lancet. 2: 1403.
• DeKosky, S.T., Harbourgh, R.E., Schmitt, .FA., Bakay, R.A.E., Chui, H.C., Knopman, D.S., Reeder, T.M., Shetter, A.G., Senter, H.J., Markesbery, W.R. 1992. Cortical biopsy in Alzheimer's disease: diagnostic accuracy and neurochemical, neuropathological, and cognitive correlations. Ann Neurol 32: 625–632.
• Dhawan, B.N. 1994. Development of CNS active agents from plants. Neuropsychopharmacology. 10: 689.
• Eidi, M., Eidi, A., Bahar, M. 2006. Effects of Salvia officinalis L. (sage) leaves on memory retention and its interaction with the cholinergic system in rats. Nutrition. 22 (3): 321-6.
• Ellman, G., Courtney, K., Andres, V., Jr, Feather-Stone, Rm. 1961. A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem Pharmacol. 7: 88–95.
• Gold, P.E. 2002. Memory modulation: Regulating interactions between multiple memory systems. In Neuropsychology of memory, 3rd ed. (eds. L.R. Squire and D.L. Schacter), pp. 450 –462. Guilford Press, New York.
• Hefti, F., Weiner, W.J. 1986. Ann Neurol. 40: 346–354.
• Lehericy, S., Hirsch, E.C., Cervera-Pierot, P., Hersh, L.B., Bakchine, S., Piette, F., Duyckaerts, C., Hauw, J.J., Javoy-Agid, F., Agid, Y. 1993. Heterogeneity and selectivity of the degeneration of cholinergic neurons in the basal forebrain of patients with Alzheimer's disease. J. Comp. Neurol. 330: 15–31.
• Leung, A.Y., Foster, S. 1996. Encyclopaedia of common natural ingredients. Chichester: Wiley.
• Mantle, D., Pickering, A.T., Perry, E.K. 2000. Medicinal plant extracts for the treatment of dementia: a review of their pharmacology, efficacy and tolerability. CNS Drugs. 13: 201– 13.
• Orhan, İ., Kartal, M., Nazc, Q., Ejaz, A., Yilmaz, G., Kan, Y., Konuklugil, B., Şener, B., Choudhary, M.I. 2007. Antioxidant and anticholinesterase evaluation of selected Turkish Salvia species. Food Chemistry. Volume 103, Issue 4. Pages 1247–1254.
• Orhan, İ.E., Şenol, S., Öztürk, N., Akaydın G., Şener, B. 2012. Profiling of in vitro neurobiological effects and phenolic acids of selected endemic Salvia species. Food Chemistry. Volume 132, Issue 3, Pages 1360– 1367.
• Perry, N., Court, G., Bidet, N., Court, J., Perry, E. 1996. European herbs with cholinergic activities: potential in dementia therapy. Int J Geriatr Psychiatry. 11: 1063–9.
• Perry, N., Houghton, P.J., Jenner, P. 1997. Inhibition of erythrocyte acetylcholinesterase by droplet counter-current chromatography fractions of Salvia lavandulaefolia oil. J Pharm Pharmacol. 49: 34.
• Perry, N., Houghton, P.J., Jenner, P., Keith, A., Perry, E.K. 2002. Salvia lavandulaefolia essential oil inhibits cholinesterase in vivo. Phytomedicine. 9: 48-51.
• Rusted, J.M., Warburton, D.M. 1992. Facilitation of memory by posttrial administration of nicotine: evidence for an attentional explanation. Psychopharmacology 108 (4 ): 452-455.
• Sarter, M. and Bruno, J. 1997. Cognitive functions of cortical acetylcholine: Toward a unifying hypothesis. Brain Res. 23: 28 -46.
• Scheiderer, C.L., Mc Cutchen, E., Thacker, E.E., Kolasa, K., Ward, M.K., Parsons, D., Harrell, L.E., Dobrunz, L.E. and Mc Mahon, L.L. 2006. Sympathetic Sprouting Reinnervation That Prevents Loss of a Muscarinic Receptor- Drives Dependent Long-Term Depression at CA3–CA1 Synapses. The Journal of Neuroscience. 26 (14): 3745-3756. Cholinergic
• Scholey, A.B., Tildesley, N.T.J., Ballard, C.G., Wesnes, K.A., Tasker, A., Perry, E.K. and Kennedy, D.O. 2007. An extract of Salvia (sage) with anticholinesterase properties improves memory and attention in healthy older volunteers. Psychopharmacology. Volume 198, Number 1, 127-139.
• Tildesleya, N.T.J., Kennedya, D.O., Perryb, E.K., Ballardc, C.G., Savelevd, S., Wesnesa, K.A., Scholeya, A.B. 2003. Salvia lavandulaefolia (Spanish Sage) enhances memory in healthy young volunteers. Pharmacology, Biochemistry and Behavior. 75: 669-674.