Türkiye'de Geranium Macrorrhizum L. (Geraniaceae) Metanol Ekstresinin Biyolojik ve Antimikrobiyal Aktivitesinin Belirlenmesi

Yıl 2019, Cilt: 12 Sayı: 1, 241 - 252, 24.03.2019

Yasemin Karafakıoglu

https://doi.org/10.18185/erzifbed.443982

Öz

 Dünyanın değişik bölgelerinde
Geranium türleri, ağrı kesici, kan dindirici, antihemoroidal, antidiyabetik,
ateş düşürücü, antidiyareik, kan temizleyici ve gastrointestinal sistem
rahatsızlıklarının tedavisinde kullanılmaktadır. Bu çalışma da Balıkesir ili’nden
toplanan Geranium macrorrhizum türünün
metanol ekstresinde biyolojik ve antimikrobiyal aktivite çalışmaları
yapılmıştır.

“Geranium macrorrhizum metanol ekstresinde”, numunenin toplam fenolik
içerik miktarı 130.18 µg GAE / 1g kuru örnek olarak bulunmuştur. Geranium macrorrhizum metanol ekstresinde,
toplam flavonoid içerik miktarı 55,56 ± 1,20 mg QE/g kuru numune olarak
belirlenmiştir. Geranium macrorrhizum
(Geraniaceae)’nın metanol ekstresinde ABTS radikal giderme aktivitesi 5.80 ±
0,55 lC50 (μg/mL) olarak bulunmuştur. DPPH radikali olarak antioksidan aktivitesi 10,05
μg/mL olarak belirlenmiştir. Geranium
macrorrhizum metanol ekstresi için en duyarlı bakterinin Klebsiella
pneumoniae ATCC700603 (13 mm) olduğu tespit edilmiştir. Elde edilen bulgular Geranium macrorrhizum bitkisinin tıbbi
bitki olarak değerlendirilebileceğini göstermektedir.

İleri
araştırmalarda G. macrorrhizum’un
içerdiği kimyasal bileşenlerin belirlenmesinin yanı sıra in situ ve in vivo testler ile etki mekanizmalarının daha detaylı
araştırılmasının gerekli olduğu sonucuna varılmıştır.

Anahtar Kelimeler

Geranium macrorrhizum, Geraniaceae, Toplam Fenolik İçerik

Kaynakça

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