Parkinson Hastalığının Tedavisinde Kullanılan Levodopa ve Benserazid Etken Maddelerinin Kemometrik Tayini

Yıl 2020, Cilt: 13 Sayı: 2, 669 - 676, 31.08.2020

Güzide Pekcan Ertokuş , Tahir Özer

https://doi.org/10.18185/erzifbed.690778

Cited By: 1

Öz

Bu çalışmada, Parkinson hastalığının tedavisinde kullanılan ilaç numunesindeki levodopa ve benserazid maddelerinin spektrofotometrik olarak kemometrik metotlarla tayini gerçekleştirilmiştir. Deneysel çalışmada maddelerin spektrofotometrik özellikleri belirlendikten sonra her bir maddenin uygun oranlarıyla karıştırılmasıyla yapay karışımların spektrum verileri incelenmiştir. En son aşamada tablet numunesi analizi yapılmıştır. Kemometrik yöntemlerden, temel bileşen regresyonu yöntemi (PCR) ve kısmi en küçük kareler yöntemi (PLS), sentetik karışım ve tablet numunesindeki miktar tayininde başarı ile uygulanmıştır. Hesaplanan veriler, istatistik olarak incelendiklerinde hem hesaplanan geri kazanım değerleri yüksek hem de standart sapmalar yeterince küçüktür. Uygulanan kemometrik yöntemler yardımıyla elde edilen sonuçlar son derece hızlı, basit ve güvenilir sonuçlardır.

Anahtar Kelimeler

Levodopa, Benserazid, PLS

Destekleyen Kurum

SÜLEYMAN DEMİREL ÜNİVERSİTESİ BİLİMSEL ARAŞTIRMA PROJELERİ

Proje Numarası

FYL-2018-6859

Teşekkür

Bu çalışma, Süleyman Demirel Üniversitesi Bilimsel Araştırma Projeleri Koordinasyon Birimi tarafından “FYL-2018-6859” kodlu proje ile desteklenmiştir.

Kaynakça

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