ASSESSMENT OF THE EFFICACY OF ADALIMUMAB TREATMENT IN HIDRADENITIS SUPPURATIVA: A SINGLE-CENTER STUDY

Yıl 2023, , 399 - 402, 04.12.2023

Eda Öksüm Solak

https://doi.org/10.34108/eujhs.1306589

Öz

Hidradenitis suppurativa (HS), is a chronic disease characterized by recurrent subcutaneous nodules, abscesses, and draining sinuses. Adalimumab is used for moderate to severe HS cases that do not respond to systemic treatments. The aim of our study was to evaluate the efficacy of adalimumab treatment in patients with HS who received treatment at our clinic. The medical records of patients aged 18 years and older who received adalimumab treatment for HS between 2016 and 2021 were retrospectively reviewed. When patients were evaluated in terms of Hidradenitis Suppurativa Clinical Response (HISCR) at the end of 3 months, 6 (31.6%) patients had achieved HISCR within 3 months. After 6 months of treatment, an additional 9 (47.4%) patients had reached the HISCR endpoint. At the end of 6 months, no response was observed in 4 patients (21.1%). Based on the data obtained from the study, adalimumab is considered to be an effective and safe treatment method for moderate to severe HS patients.

Anahtar Kelimeler

Adalimumab, Hidradenitis Suppurativa, Therapy, Drug, Efficiency

HİDRADENİTİS SÜPÜRATİVADA ADALİMUMAB TEDAVİSİNİN ETKİNLİĞİNİN DEĞERLENDİRİLMESİ: TEK MERKEZLİ BİR ÇALIŞMA

Öz

Hidradenitis süpürativa (HS), deri altında nodüller, apseler ve drene olan sinüslerin görülebildiği tekrarlayıcı bir hastalıktır. Adalimumab, sistemik tedavilere yanıt vermeyen orta ila şiddetli HS için kullanılmaktadır. Çalışmamızda kliniğimizde adalimumab tedavisi alan HS hastalarında etkinliği değerlendirmeyi amaçladık. Çalışmaya kliniğimize 2016-2021 yılları arasında başvuran, 18 yaşından büyük HS nedeniyle adalimumab tedavisi alan hastaların dosyaları retrospektif olarak taranmıştır. Hastalar 3 ay sonunda Hidradenitis Suppurativa Clinical Response (HiSCR) ile değerlendirildiğinde 6 (%31.6) hasta HiSCR’ye ulaşmıştı. Altı aylık tedavi sonrasında 9 (%47.4) hasta daha HiSCR değerine ulaşmıştı. Altı ayın sonunda 4 hastada (%21.1) tedaviye herhangi bir yanıt elde edilmedi.Çalışmadan elde edilen veriler neticesinde orta-şiddetli HS hastalarında adalimumabın etkili ve güvenli bir tedavi yöntemi olduğu düşünülmüştür.

Anahtar Kelimeler

Adalimumab, Hidradenitis Süpürativa, Tedavi, İlaç, Etkinlik

Kaynakça

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