A STUDY ON DIAGNOSTIC AND PROGNOSTIC ROLE OF PERIOSTIN IN RESPIRATORY SYSTEM DISEASE COMPLEX IN CALVES

Öz

The purpose of this study was to compare the amounts of serum amyloid a, haptoglobin, fibrinogen, and periostin in calves with respiratory system disease complex before and after treatment. Three groups were used in the study: an acute group (n=10) made up of calves with acute respiratory system disease complex symptoms, a chronic group made up of calves with chronic respiratory system disease complex symptoms, and a control group made up of disease-free, healthy calves. Before and after therapy (day 0, 7 and 14), clinical examinations were performed and blood samples were taken from the acute and chronic groups. Calves in the control group only had one clinical evaluation and blood sample collection. Results showed that both the acute and chronic groups exhibited clinical improvement after treatment. Before treatment, the concentrations of fibrinogen, serum amyloid A, and haptoglobin in the acute and chronic groups were significantly higher than those in the control group (p<0.001). On days 7 and 14, the serum periostin concentrations of the acute group were lower than those of the chronic group and control group (p<0.05). However, no significant difference was observed in serum periostin concentrations before and after treatment in both the acute and chronic groups (p>0.05). Additionally, a positive correlation was found between the respiratory system disease complex scores and the concentrations of serum amyloid A, haptoglobin, and fibrinogen. However, there was no significant correlation between periostin concentrations and respiratory system disease complex scores, as well as between fibrinogen, haptoglobin, and serum amyloid A concentrations (p>0.05).Based on the findings, it can be concluded that haptoglobin, serum amyloid A, and fibrinogen values, rather than periostin, play an important role in supporting the diagnosis and prognosis of respiratory system disease complex in calves.

Anahtar Kelimeler

• Calves
• Diagnostic
• Periostin
• Prognostic
• Respiratory system

BUZAĞILARDA SOLUNUM SİSTEMİ HASTALIK KOMPLEKSİNDE PERİOSTİNİN DİAGNOSTİK VE PROGNOSTİK ROLÜ ÜZERİNE BİR ÇALIŞMA

Öz

Bu çalışmada buzağılarda Solunum Sistemi Hastalıkları Kompleks’in de serum amiloidA, haptoglobin, fibrinojen ve periostin konsantrasyonlarının tedavi öncesi ve tedavi sonrası değişimlerinin araştırılması amaçlandı. Çalışmada üç grup kullanılmıştır: Akut solunum sistemi hastalığı kompleksi semptomları olan buzağılardan oluşan bir akut grup (n=10), kronik solunum sistemi hastalığı kompleksi semptomları olan buzağılardan oluşan bir kronik grup ve hastalıksız, sağlıklı buzağılardan oluşan bir kontrol grubu. Tedaviden önce ve sonra (0, 7 ve 14. günler), akut ve kronik gruplardan klinik muayeneler yapıldı ve kan örnekleri alındı. Kontrol grubundaki buzağılardan sadece bir klinik değerlendirme ve kan örneği alınmıştır. Sonuçlar hem akut hem de kronik grupların tedaviden sonra klinik iyileşme gösterdiğini ortaya koymuştur. Tedavi öncesinde, akut ve kronik gruplardaki fibrinojen, serum amiloidA ve haptoglobin konsantrasyonları kontrol grubundakilerden anlamlı derecede yüksekti (p<0.001). 7. ve 14. günlerde, akut grubun serum periostin konsantrasyonları kronik grup ve kontrol grubundan daha düşüktü (p<0.05). Ancak, hem akut hem de kronik gruplarda tedavi öncesi ve sonrası serum periostin konsantrasyonlarında anlamlı bir fark gözlenmemiştir (p>0.05). Ayrıca, solunum sistemi hastalığı kompleksi skorları ile serum amiloidA, haptoglobinve fibrihojen konsantrasyonları arasında pozitif bir korelasyon bulunmuştur. Ancak, periostin konsantrasyonları ile solunum sistemi hastalığı kompleksi skorları arasında ve ayrıca fibrinojen, haptoglobin ve serum amiloidA konsantrasyonları arasında anlamlı bir korelasyon bulunmamıştır (p>0.05).Bulgulara dayanarak, buzağılarda solunum sistemi hastalığı kompleksinin tanı ve prognozunu desteklemede periostin'den ziyade haptoglobin, serum amiloidA ve fibrinojen değerlerinin önemli bir rol oynadığı sonucuna varılabilir.

Anahtar Kelimeler

• Buzağı
• Diagnostik
• Periostin
• Prognostik
• Solunum Sistemi

Kaynakça

1. Gül Y. Geviş Getiren Hayvanların İç Hastalıkları, 3. Baskı, Malatya: Medipres Matbaacılık Yayıncılık Ltd Şti. 2012;258-263.
2. Güneş V, Onmaz AC, Ulusan M. Neonatal buzağıların solunum sistemi hastalıkları. Turkiye Klinikleri J Vet Sci. 2013; 4: 86-94.
3. Babcock A, Jones R, Langemeier M. Examining death loss in Kansas feedlots. Kansas State Univ. Beef Cattle Research–Report of Progress. 2006; 959:46-52.
4. Woolums AR. The Bronchopneumonias (Respiratory Disease Complex of Cattle, Sheep, and Goats). In: Smith BP Large Animal Internal Medicine. fifth Edition, Mosby, USA, 2015; pp: 583-616.
5. Dubrovsky SA, Van Eenennaam AL, Aly SS, et al. Preweaning cost of bovine respiratory disease (BRD) and cost-benefit of implementation of preventative measures in calves on California dairies: The BRD 10K study. J Dairy Sci. 2020; 103: 1583-1597. doi: 10.3168/jds.2018-15501. Epub 2019 Nov 20.
6. Eckersall PD. Recent advances and future prospects for the use of acute phase proteins as markers of disease in animals. Rev Med Vet-Toulouse. 2000;151(7):577-584.
7. Conner JG, Eckersall PD, Wiseman A, Bain RK, Douglas TA. Acute phase response in calves following infection with Pasteurella haemolytica, Ostertagia ostertagi and endotoxin administration. Res Vet Sci. 1989;47(2):203-207.
8. Gökce H , Bozukluhan K. Çiftlik hayvanlarında önemli akut faz proteinleri ve bunların veteriner hekimlik alanındaki kullanımı. Dicle Üniv Vet Fak Derg. 2009;1:1-14.

9. Moisá SJ, Aly SS, Lehenbauer TW, et al. Association of plasma haptoglobin concentration and other biomarkers with bovine respiratory disease status in pre-weaned dairy calves. J Vet Diagn Invest. 2019;31(1):40-46. doi: 10.1177/104063871880 7242. Epub 2018 Oct 17.
10. Yılmaz O, Gökçe G. Sığırlarda enfeksiyöz solunum sistemi hastalıkları kompleksinde (BRDC) klinik, hematoloji, biyokimya, oksidatif stres, akut faz proteinler üzerinde araştırmalar. Atatürk Üniv Vet Bil Derg. 2017;12(1):34-44. doi:10.17094/atauniv bd.309771
11. Okamoto M, Hoshino T, Kitasato Y, et al. Periostin, a matrix protein, is a novel biomarker for idiopathic interstitial pneumonias. Eur Respir J. 2011;37(5):1119-1127. doi:10.1183/09031936.0 0059810. Epub 2010 Dec 22. Erratum in: Eur Respir J. 2014 Sep;44(3):826.
12. McGuirk SM, Peek SF. Timely diagnosis of dairy calf respiratory disease using a standardized scoring system. Anim Health Res Rev. 2014;15(2):145-147. doi:10.1017/S1466252314000267. Epub 2014 Nov 20.
13. Silva BT, Henklein A, de Sousa MR. Vital parameters of Holstein calves from birth to weaning. Rev Bras Med Vet. 2016;38:299-304
14. Carrington CAP. The role of Mycoplasma Species in Bovine Respiratory Disease Complex in Feedlot Cattle in South Africa, [Doctoral thesis.].Pretoria, South Africa: Faculty of Veterinary Science, University of Pretoria, 2007.
15. Ellis JA. Bovine parainfluenza-3 virus. Vet Clin North Am: Food Anim Pract. 2010;26(3):575-593. doi:10.1016/j.cvfa.2010.08.002.
16. Horadagoda NU, Knox KM, Gibbs HA, et al. Acute phase proteins in cattle: Discrimination between acute and chronic inflammation. Vet Rec. 1999;144(16):437-441. doi:10.1136/vr.144.16.437.
17. Jawor P, Stefaniak T. Acute phase proteins in treatment of calves with respiratory tract inflammation. Folia Universitatis Agriculturae Stetinensis Zootechnica. 2006;48:51-56.
18. Sekin S, Elitok ÖM, Elitok B. Akut faz proteinlerden haptoglobulinin hastalıkların tanı ve ayrıcı tanısındaki önemi. YYU Vet Fak Derg. 1999;10(1-2):113-117.
19. Alsemgeest SP, Lambooy IE, Wierenga HK, et al. Influence of physical stress on the plasma concentration of serum amyloid-A (SAA) and haptoglobin (Hp) in calves. Vet Q. 1995;17(1):9-12. doi:10.1080/01652176.1995.9694521. PMID: 7610559.
20. Joshi V, Gupta VK, Bhanuprakash AG, Mandal RSK, Dimri U, Ajith Y. Haptoglobin and serum amyloid A as putative biomarker candidates of naturally occurring bovine respiratory disease in dairy calves. Microb Pathog. 2018;116:33-37.doi: 10.1016/j.micpath.2018.01.001. Epub 2018 Jan 9.
21. Gómez-Laguna J, Salguero FJ, Pallarés FJ, Rodríguez-Gómez IM, Barranco I, Carrasco L. Acute Phase Proteins as Biomarkers in Animal Health and Welfare. In: Francisco Veas (Ed). Acute Phase Proteins as Early Non-Specific Biomarkers of Human and Veterinary Diseases.1nd ed. Wallenwil, Switzerland:Intech-Ics AG; 2011.
22. Angen O, Thomsen J, Larsen LE, Larsen J, Kokotovic B, Heegaard PMH, Enemark JMD. Respiratory disease in calves: microbiological investigations on trans-tracheally aspirated bronchoalveolar fluid and acute phase protein response. Vet Microbiol. 2009;137(1-2):165-171. doi:10.1016/j.vet mic.2008.12.024. Epub 2009 Jan 4.
23. Arslan HH, Yavuz O, Nisbet C, Cenesiz S, Aksu DS. Comparative evaluation of the effects of florfenicol and tulathromycin on clinical recovery and acutep hase proteins in un differentiated natural bovine respiratory disease. Rev Med Vet. 2010;161(12):535-539.
24. Safi S. AcutePhaseProteins - Analysis, Clinical Applications and Potentials. In: Mahin Khatam (ed) Inflammatory Diseases-Immunopathology. Clinical and Pharmacological Bases, Chapter 17. Intech, 2012. doi 10.5772/19375
25. Coşkun A, Guzelbektes H, Simsek A, Aydogdu U, Sayın Z, Sen I. Haptoglobin and SAA concentrations and enzyme activities in bronchoalveolar lavage fluids from calves with bronchopneumonia. Rev Med Vet. 2012;163(12):615-620.
26. Kabu M, Elitok B, Kucukkurt I. Decetion of serum amyloid-A concentration in the calfclinically diagnosed with pneumonia, enteritis and pneumoenterites. Ciência Rural. 2016;46(2):293-299. doi:10.1590/0103-8478cr20150571.
27. Petersen HH, Nielsen JP, Heegaard PM. Application of acute phase protein measurements in veterinary clinical chemistry. Vet Res. 2004;35(2):163-187. doi:10.1051/vetres:2004002.
28. Hajimohammadi A, Nazifi S, Ansari-Lari M, Khoshmanzar MR, Bigdeli SM. Identifying relation ships among acute phase proteins (haptoglobin, serum amyloid A, fibrinogen, ceruloplasmin) and clinical findings in dairy calf diarrhea. Comp Clin Path. 2013;22(2):227-232. doi:10.1007/s00580-011-1390-5. Epub 2011 Dec 29.
29. Heegaard PM, Godson DL, Toussaint MJ, et al. The acute phase response of haptoglobin and serum amyloid A (SAA) in cattle under going experimental infection with Bovine respiratory syncytial virus. Vet Immunol Immunopathol. 2000;77(1-2):151-159. doi:10.1016/s0165-2427(00)00226-9.
30. Nikunen S, Härtel H, Orro T, et al. Association of bovine respiratory disease with clinical status and acute phase proteins in calves. Comp Immunol Microbiol Infect Dis. 2007;30(3):143-151. doi:10.1 016/j.cimid.2006.11.004. Epub 2007 Jan 26.
31. Özalp T, Erdoğan H. Neonatal ishalli buzağılarda 25 (OH) D3 konsantrasyonlarının araştırılması. Kocatepe Vet J. 2019;12(3):268-276. doi:10.306 07/kvj.532206.
32. Gruys E, Toussaint MJM, Niewold TA, Koopmans SJ. Acutephasere action and acutephase proteins. J ZhejiangUnivSci B. 2005;6(11):1045-1056. doi: 10. 1631/jzus.2005.B1045.
33. Saito A, Okazaki H, Sugawara I, Yamamoto K, Takizawa H. Potentialaction of IL-4 and IL-13 as fibrogenic factors on lung fibroblasts in vitro. Int Arch Allergy Immunol. 2003;132(2):168-176. doi: 10.1159/000073718.
34. Woodruff PG, Boushey HA, Dolganov GM, et al. Genome-wide profiling identifies epithelial cell genes associated with asthma and with treatment responsetocortico steroids. Proc Natl Acad Sci USA. 2007;104(40):15858-15863. doi:10.1073/pn as.0707413104. Epub 2007 Sep 26.
35. Woodruff PG, Modrek B, Choy DF, et al. T-helpertype 2-driven inflammation defines major subpheno types of asthma. Am J Respir Crit Care Med. 2009;180:388-395. doi:10.1164/rccm.20 0903-0392OC. Epub 2009 May 29. Erratum in: Am J Respir Crit Care Med. 2009 Oct 15;180(8):796.
36. Contié S, Voorzanger-Rousselot N, Litvin J, et al. Development of a new ELISA for serum periostin: evaluation of growth-related changes and bisphosphonate treatment in mice. Calcif Tissue Int. 2010;87(4):341-350. doi:10.1007/s00223-010-9391-y. Epub 2010 Jun 22.
37. Nagasaki T, Matsumoto H, Kanemitsu Y, et al. Integrating longitudinal information on pulmonary function and inflammation using asthma phenotypes. J Allergy Clin Immunol. 2014;133(5):1474-1477. doi:10.1016/j.jaci.2013. 12.1084. Epub 2014 Feb 26.
38. Conway SJ, Izuhara K, Kudo Y, et al. The role of periostin in tissue remodeling across health and disease. Cell Mol Life Sci. 2014;71(7):1279-1288. doi:10.1007/s00018-013-1494-y. Epub 2013 Oct 22.
39. Nuzzo PV, Rubagotti A, Argellati F, et al. Prognostic value of preoperative serum levels of periostin (PN) in early breast cancer (BCa). Int J Mol Sci. 2015;16(8):17181-17192. doi:10.3390/ijms1608 17181.
40. Fujitani H, Kasuga S, Ishihara T, et al. Age-related changes in serum periostin level in allergic and non-allergic children. Allergol Int. 2019;68:285-286. doi:10.1016/j.alit.2018.12.006. Epub 2019 Jan 31.
41. Ruiz-Campillo MT, Molina Hernandez V, Escamilla A, et al. Immune signatures of pathogenesis in the peritoneal compartment during early infection of sheep with Fasciola hepatica. Sci Rep 7, 2782 (2017). doi:10.1038/s41598-017-03094-0.
42. Mineshige T, Ogihara K, Kamiie J, et al. Increased expression of the stromal fibroblast-secreted periostin in canine squamous cell carcinomas. J Vet Med Sci. 2018;80(3):473-479. doi:10.1292/jvms. 17-0647. Epub 2018 Feb 6.
43. Fan Z, Shu S, Xu C, et al. Protein profiling of plasma proteins in dairy cows with subclinical hypocalcaemia. Ir Vet J. 2017;70:3. doi:10.1186/s13620-017-0082-0.