Araştırma Makalesi
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TİYENİL-TİYAZOL-ARİL-TİYOÜRE HİBRİT MOLEKÜLLERİN SENTEZİ VE BİYOLOJİK AKTİVİTELERİNİN APOPTOTİK YOL ÜZERİNDEN ANTİ-KANSER ETKİLERİNİN ARAŞTIRILMASI

Yıl 2019, , 87 - 93, 20.09.2019
https://doi.org/10.34108/eujhs.493005

Öz

Tiyenil-tiyazol-aril-tiyoüre
türevleri (4a-4e) amino-4-(2-tiyenil)tiyazol ve fenilizotiyasiyanatların
reaksiyonları sonucu sentezlenmiştir. Sentezlenen bileşikler IR, 1H-NMR
ve kütle spektrumları ile karekterize edildi. Beş tiyoüre türevinin
anti-proliferatif etkileri A549 (KHDAK) hücrelerinde gerçek zamanlı hücre
analizörü xCELLigence sistemi ile incelendi. Gerçek zamanlı sistemde sitotoksik
olduğu gösterilmiş olan 2 tiyoürenin moleküler etki mekanizmaları,
mitokondriyal membran potansiyeli ΔψM spektrofotometrik olarak, sitokrom c
western blot methoduyla ve Bcl-2 ise qRT-PCR ile araştırılmıştır. 4e
diğerlerinden daha etkili bulunmuştur. 4e
IC50 değerleri 24 ve 48 saat için sırasıyla 29,6 µM ve 22,3 µM
olarak hesaplanmıştır. Bir triflorometil (-CF3) grubunu içeren 4e
molekülü bir anti-kanserojen madde olarak düşünülebilir ve daha ileri
araştırmalar yapılabilir.0000-0003-1761-188X
 

Kaynakça

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Toplam 34 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Eczacılık ve İlaç Bilimleri
Bölüm Araştırma Makalesi
Yazarlar

Şengül Dilem Doğan 0000-0003-1761-188X

Sümeyye Uğur Bu kişi benim

Ayşe Kübra Karaboğa Arslan Bu kişi benim

Ebru Öztürk Bu kişi benim

Ahmet Cumaoğlu

Mükerrem Betül Yerer

Yayımlanma Tarihi 20 Eylül 2019
Gönderilme Tarihi 6 Aralık 2018
Yayımlandığı Sayı Yıl 2019

Kaynak Göster

APA Doğan, Ş. D., Uğur, S., Karaboğa Arslan, A. K., Öztürk, E., vd. (2019). TİYENİL-TİYAZOL-ARİL-TİYOÜRE HİBRİT MOLEKÜLLERİN SENTEZİ VE BİYOLOJİK AKTİVİTELERİNİN APOPTOTİK YOL ÜZERİNDEN ANTİ-KANSER ETKİLERİNİN ARAŞTIRILMASI. Sağlık Bilimleri Dergisi, 28(2), 87-93. https://doi.org/10.34108/eujhs.493005
AMA Doğan ŞD, Uğur S, Karaboğa Arslan AK, Öztürk E, Cumaoğlu A, Yerer MB. TİYENİL-TİYAZOL-ARİL-TİYOÜRE HİBRİT MOLEKÜLLERİN SENTEZİ VE BİYOLOJİK AKTİVİTELERİNİN APOPTOTİK YOL ÜZERİNDEN ANTİ-KANSER ETKİLERİNİN ARAŞTIRILMASI. JHS. Eylül 2019;28(2):87-93. doi:10.34108/eujhs.493005
Chicago Doğan, Şengül Dilem, Sümeyye Uğur, Ayşe Kübra Karaboğa Arslan, Ebru Öztürk, Ahmet Cumaoğlu, ve Mükerrem Betül Yerer. “TİYENİL-TİYAZOL-ARİL-TİYOÜRE HİBRİT MOLEKÜLLERİN SENTEZİ VE BİYOLOJİK AKTİVİTELERİNİN APOPTOTİK YOL ÜZERİNDEN ANTİ-KANSER ETKİLERİNİN ARAŞTIRILMASI”. Sağlık Bilimleri Dergisi 28, sy. 2 (Eylül 2019): 87-93. https://doi.org/10.34108/eujhs.493005.
EndNote Doğan ŞD, Uğur S, Karaboğa Arslan AK, Öztürk E, Cumaoğlu A, Yerer MB (01 Eylül 2019) TİYENİL-TİYAZOL-ARİL-TİYOÜRE HİBRİT MOLEKÜLLERİN SENTEZİ VE BİYOLOJİK AKTİVİTELERİNİN APOPTOTİK YOL ÜZERİNDEN ANTİ-KANSER ETKİLERİNİN ARAŞTIRILMASI. Sağlık Bilimleri Dergisi 28 2 87–93.
IEEE Ş. D. Doğan, S. Uğur, A. K. Karaboğa Arslan, E. Öztürk, A. Cumaoğlu, ve M. B. Yerer, “TİYENİL-TİYAZOL-ARİL-TİYOÜRE HİBRİT MOLEKÜLLERİN SENTEZİ VE BİYOLOJİK AKTİVİTELERİNİN APOPTOTİK YOL ÜZERİNDEN ANTİ-KANSER ETKİLERİNİN ARAŞTIRILMASI”, JHS, c. 28, sy. 2, ss. 87–93, 2019, doi: 10.34108/eujhs.493005.
ISNAD Doğan, Şengül Dilem vd. “TİYENİL-TİYAZOL-ARİL-TİYOÜRE HİBRİT MOLEKÜLLERİN SENTEZİ VE BİYOLOJİK AKTİVİTELERİNİN APOPTOTİK YOL ÜZERİNDEN ANTİ-KANSER ETKİLERİNİN ARAŞTIRILMASI”. Sağlık Bilimleri Dergisi 28/2 (Eylül 2019), 87-93. https://doi.org/10.34108/eujhs.493005.
JAMA Doğan ŞD, Uğur S, Karaboğa Arslan AK, Öztürk E, Cumaoğlu A, Yerer MB. TİYENİL-TİYAZOL-ARİL-TİYOÜRE HİBRİT MOLEKÜLLERİN SENTEZİ VE BİYOLOJİK AKTİVİTELERİNİN APOPTOTİK YOL ÜZERİNDEN ANTİ-KANSER ETKİLERİNİN ARAŞTIRILMASI. JHS. 2019;28:87–93.
MLA Doğan, Şengül Dilem vd. “TİYENİL-TİYAZOL-ARİL-TİYOÜRE HİBRİT MOLEKÜLLERİN SENTEZİ VE BİYOLOJİK AKTİVİTELERİNİN APOPTOTİK YOL ÜZERİNDEN ANTİ-KANSER ETKİLERİNİN ARAŞTIRILMASI”. Sağlık Bilimleri Dergisi, c. 28, sy. 2, 2019, ss. 87-93, doi:10.34108/eujhs.493005.
Vancouver Doğan ŞD, Uğur S, Karaboğa Arslan AK, Öztürk E, Cumaoğlu A, Yerer MB. TİYENİL-TİYAZOL-ARİL-TİYOÜRE HİBRİT MOLEKÜLLERİN SENTEZİ VE BİYOLOJİK AKTİVİTELERİNİN APOPTOTİK YOL ÜZERİNDEN ANTİ-KANSER ETKİLERİNİN ARAŞTIRILMASI. JHS. 2019;28(2):87-93.