TAVŞANLARDA İÇME SUYU ILE KRONIK KLORPRIFOS ALIMININ ELEKTROKARDIYOGRAM ÜZERINE ETKISI

Öz

Bu çalışma, tavşanlarda içme suyu ile 125, 250 ve 375 ppm dozda klorprifos alımının bazı elektrokardiyografik parametreler üzerine etkisini incelemek amacıyla yapıldı. Araştırmada, 20 adet erkek Yeni Zelanda ırkı tavşan, biri kontrol olmak üzere dört eşit gruba ayrıldı. Kontrol grubuna 90 gün süreyle normal içme suyu verilirken deney gruplarına sırasıyla 125, 250 ve 375 ppm klorprifos içeren içme suyu verildi. Deneme sonunda hayvanların II. derivasyonları yazdırıldı. Elektrokardiyogramda 375 ppm klorprifos’un R ile T dalgası amplitüdünde ve T dalgası süresinde önemli bir artma, kalp atım sayısında ise önemli bir azalma oluşturduğu gözlendi. Ayrıca, aynı grupta sinus arrest tespit edildi. Diğer elektrokardiyografik parametrelerde ise önemli bir değişiklik belirlenmedi. Sonuçlar, tavşanlarda oral yolla verilen klorprifos’un bazı elektrokardiyografik parametreleri değiştirebile-ceğini gösterdi

Anahtar Kelimeler

• Elektrokardiyogram, klorprifos, tavşan

Effect of Chronic Chlorpyrifos Intake Via Drinking Water on the Electrocardiogram in Rabbits

Öz

The aim of this study is to investigate the effect of chronic chlorpyrifos intake through drinking water at the dosages of 125, 250 and 375 ppm of chlorpyrifos on the electrocardiogram in rabbits. In this study, 20 New Zealand male rabbits were divided equally into a control and three trial groups. For 90 days, the control group received normal drinking water and experimental groups were given drinking water containing 125, 250 and 375 ppm chlorpyrifos, respectively. At the end of the 90 days treatment period, lead II of animals was recorded. It was observed that 375 ppm chlorpyrifos caused a significant increase (p<0.05) in the amplitude of R and T wave, the duration of T wave, and a significant decrease (p<0.05) in the heart rate on the electrocardiogram. In addition, the sinus arrest was determined in the same group. No statistically significant change was recorded in the other electrocardiographic parameters. Our results show that oral chlorpyrifos may alter some electrocardiographic parameters in rabbits

Anahtar Kelimeler

• Chlorpyrifos, electrocardiogram, rabbit

Kaynakça

1. Kaya S . Pestisitler. In: Kaya S, Pirinçci İ, Bilgili A. (eds). Veteriner Hekimliğinde Toksikoloji. Medisan yayın evi, Ankara, 1998 pp 221-339.
2. Odenkirchen EW, Eisler R. Chlorpyrifos hazards to fisch, wildlife, intervertebrates: A synoptic review. http://www.pwrc.usgs.gov/ infobase/eisler/CHR_13_Chlorpyrifos.pdf. (Erişim tarihi: 12.10.2005). 3. Ray DE, Richards PG. The potential for toxic effects of chronic, low-dose exposure to organophosphates. Toxicol Let 2001, 120: 343-351.
3. Gordon CJ, Padnos BK. Prolonged elevation in blood pressure in the unrestrained rat exposed to chlorpyrifos. Toxicology, 2000, 146: 1-13.
4. Naidu KA, Visvanatha S, Krishnakumari MK. Cardiotoxic effects of dichlorvos in albino rats. Ind J Physiol Pharmac 1986, 31: 19-24.
5. Zoltani CK, Baskin SI. Simulation of acetylcholine cardiac overload caused by soman, a cholinesterase inhibitor. Comp Cardiol 2000, 27: 243-246.
6. Abraham S, Oz N, Sahar R, Kadar T. QT prolongation and cardiac lesions following acute organophosphate poisoning inrats. Proc West Pharmacol Soc 2001, 44: 185-186.
7. Aiuto LA, Pavlakis SG, Boxer RA. Life- threatening organophosphate induced delayed polyneuropathy in a child after accidental chlorpyrifos ingestion. J Pediatr 1993, 122: 658- 660.
8. Tafuri J, Roberts J. Organophosphate poisoning. Ann Emrg Med 1987, 16: 193-202.

9. Çetin N, Emre B. Anestezi edilmemiş tavşanlarda levamizol hidroklorit’in elektrokardiyogram üzerine etkileri. E Ü Sağ Bil Derg 2003, 12: 39-45
10. Rezekhani A, Rezaian G. Clinical electrocardiogram of laboratory White New Zealand Rabbits. J Appl Anim Res 1995, 7: 63-68.
11. Edward NJ. Bolton’s Handbook of canine and feline electrocardiography WB Saunders, Philadelphia 1987, pp 76-80.
12. Burch GE. A primer of electrocardiography. Lea & Febiger, Philadelphia 1960, pp 70- 81.
13. Ludomirsky A, Klein H, Sarelli P. Q-T prolongation and polymorhous (torsade de pointes) ventricular arrhythmias associated with organophosphorus insectiside poisoning. Am J Cardiol 1982, 49: 1654-1658.
14. Zoltani CK, Baskin SI. Organophosphate- modulated cardiac membrane currents: Computer study of the genesis of LQTS. Comp Cardiol 2002, 29: 693-696.
15. Caroline C. Journal of Pesticide Reform. Chlorpyrifos. chlorpyrifos.pdf. 1994 (Erişim tarihi: 13.12.2005).
16. Francic BM, Metcalf MR, Hansen LG. Toxicity of organophosphorus esters to laying hens after oral and dermal administration. J Environ Sci Health B 1985, 20:73-95.