DENEY HAYVANLARINDA ANKSİYETE MODELLERİ VE ANKSİYETENİN DEĞERLENDİRİLMESİ

Öz

Anksiyete çok farklı duyguları ve semptomları içeren emosyonel bir durumdur. Anksiyetenin 2 tipi vardır. Birincisi; bir olayla ilişkili olarak kişinin kendi kontrolü dışında, belirli bir süre ve şiddette ortaya çıkan ve fizyolojik koşullarda beklenen bir yanıttır, ikincisi ise süresi ya da şiddeti bakımından uygun olmayan ve fizyolojik koşullarda beklenmeyen bir yanıt şeklinde gelişebilir. Anksiyete çalışmalarında kullanılmak üzere deney hayvanlarında anksiyete oluşturmak ve anksiyeteyi veya anksiyete üzerinde çeşili ilaçların önleyici ya da tedavi edici etkisini araştırmak için çeşitli düzenekler ve testler geliştirilmiştir. Bunlar; yeni bir çevre uygulanmasına bağlı anksiyete oluşturma ve değerlendirme yöntemleri olan yükseltilmiş artı labirent ve deriveleri, yükseltilmiş T-labirent, açık alan, merdiven, sosyal izolasyon, yeni çevrenin beslenmeyi baskılaması, sosyal etkileşim, delikli kutu, yabancı bir kokuya maruz bırakma, ödüllendirme-cezalandırma uygulamasına dayanan şartlı zıtlaşma testleri ve cezalandırma uygulamasına dayanan savunmaya yönelik gömme, pasif sakınma, ayak şoku verme, sıcak tabaka, dört tabaka testleridir. Bu derlemede farklı koşullarda anksiyetenin oluşması ya da anksiyete tedavisinde kullanılacak ilaçların değerlendirilmesi amacı ile literatürde kullanılan deney hayvanı anksiyete modelleri ve bu modellerde anksiyeteyi değerlendirme yöntemleri bir arada verilerek, yöntemler arasında bir kıyaslama yapma imkanı sunulması amaçlanmıştır

Anahtar Kelimeler

• Anksiyete, anksiyete modelleri, hayvan davranışı

Anxiety Models in Experimental Animals and Evaluation of Anxiety

Öz

Anxiety is an emotional state of different feelings and symptoms. There are 2 types of anxiety: First one is a physiologically expected response, which occurs at a particular time and severity in an uncontrolled manner. Second one is a physiologically unexpected response, which occurs at an inappropriate time and severity. Several tests and equipments have been developed to form anxiety on experimental animals and to make investigations on anxiety or the prognostic or diagnostic effects of anxiety-related drugs. These are the methods for establishing and evaluating anxiety models in a new environment, such as elevated plus maze and derives, elevated T-maze, open field, staircase test, social isolation, novelty supressed feeding, social interaction, holeboard, predatory odor; operant conflict tests for rewardpunishment applications; and experiments with punishment procedures such as defensive burying, passive avoidance, foot shock, hot plate and four plate tests. These review, aimed to give all the methods on the anxiety models used in the literature for establishing anxiety and evaluating the effects of anxiety-related drugs and to compare these methods

Anahtar Kelimeler

• Anxiety, anxiety models, animal behavior

Kaynakça

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