STREPTOCOCCUS AGALACTİAE KLİNİK İZOLATLARINDA ANTİBİYOTİKLERE DUYARLILIK

Öz

Grup B streptokoklar (GBS), yenidoğanlarda, gebe kadınlarda ve alt hastalığı olan erişkinlerde önemli infeksiyon etkenlerinden biridir. GBS’ler penisiline duyarlıdır ve tanı konduğunda tedavide ilk seçenek penisilin olmalıdır. Duyarlı olduğu diğer antibiyotikler ampisilin, vankomisin, teikoplanin, birinci, ikinci ve üçüncü kuşak sefalosporinler, imipenem ve meropenemdir. GBS’lerdeki klindamisin ve eritromisin direnci % 15-20 oranında olup bu oran giderek artmaktadır. 30 Temmuz 2005 ile 04 Ekim 2006 tarihleri arasında Erciyes Üniversitesi Tıp Fakültesi Hastaneleri’ne başvuran hastalara ait klinik örneklerden izole edilen 131 S. agalactiae suşu çalışmaya alındı. Tüm GBS izolatlarının penisilin G, seftriakson ve vankomisine duyarlı olduğu saptanmıştır. GBS izolatlarında tetrasiklin, eritromisin ve klindamisin direnci sırasıyla % 90, % 14,5 ve % 13 oranlarında belirlenmiştir. Bölgemizde GBS suşlarında penisilin G ve seftriaksona direnç problemi yoktur ve bu antibiyotikler GBS infeksiyonlarında ilk tercih olma özelliklerini sürdürmektedir. Eritromisin direncinin geçmişteki çalışmalara oranla 2 kat arttığı tespit edilmiş olup, bu tür antibiyotikler beta-laktam alerjisi dışında tercih edilmemelidir

Anahtar Kelimeler

• Streptococcus agalactiae, antibiyotik duyarlılığı, serotiplendirme

Antibiotic Susceptibilities of Clinical Streptococcus agalactiae Isolates

Öz

Group B streptococci (GBS) is one of the leading couses of infection in newborns, in pregnant women, and in patients with underlying diseases. GBS are sensitive to penicilin, that’s why, penicilin must be the first choice in the treatment. Other antibiotics which GBS are sensitive to are; ampicillin, vancomycin, teicoplanin, first, second and third generation cephalosporins, imipenem and meropenem. Clindamycin and erythromycin resistance rates are 15-20 % and they are increasing worldwide. One hundred thirty one S.agalactiae strains, isolated from the clinical samples of patients applied to Erciyes University Medical Faculty Hospitals between the dates of 30th July 2005 and 4th October 2006, were included to the study. It was determined that all GBS isolates were susceptible to penicillin G, ceftriaxone and vancomycin. Among strains, tetracycline, erythromycin and clindamycin resistance rates were determined as 90 %, 14,5 % and 13 % respectively. In our region there is no resistance problem to penicillin G and ceftriaxone among GBS and they are still the first choice in GBS infections. It was determined that the erythromycin resistance doubled in comparison with the past studies and these kinds of antibiotics should not be preferred except for beta-lactam allergy

Anahtar Kelimeler

• Streptococus agalactiae, antibiotic susceptibly, serotyping

Kaynakça

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