PERİODONTAL HASTALIK İLE DİYABET ARASINDA ÇİFT YÖNLÜ İLİŞKİ

Öz

Diyabet, hayatın uzunluğunu ve kalitesini 3 Erciyes Üniversitesi Diş Hekimliği Fakültesi Restoratif Diş Tedavisi Anabilim Dalı, Kayseri2 Beytepe Asker Hastanesi, Diş Servisi, Endodonti Bölümü, Ankaraetkileyen birçok major komplikasyonlarla kendini gösteren bir sistemik hastalıktır. Periodontal hastalık (periodontitis) bu komplikasyonlardan birisidir. Son çalışmalar periodontal hastalığın sadece lokalize oral enfeksiyon terimiyle açıklanamaya

Anahtar Kelimeler

• Diyabet, periodontitis, periodonsiyum

The Two-Way Relatıonshıp Between Perıodontal Dısease And Dıabetes

Öz

Diabetes mellitus is a systemic disease with several major complications affecting both the quality and length of life. One of these complications is periodontal disease (periodontitis). Recent data indicate that periodontitis is much more than a localized oral infection and may cause changes in systemic physiology. The interrelationships between periodontitis and diabetes provide an example of systemic disease predisposing to oral infection, and once that infection is established, the oral infection exacerbates systemic disease

Anahtar Kelimeler

• Diabetes, periodontitis, periodontium

Kaynakça

1. Demmer RT, Papapanou PN. Epidemiolo- gic patterns of chronic and aggressive periodontitis. Periodontol 2000. 2010; : 28-44.
2. Mealey BL. Periodontal implications: medically compromised patients. Ann Periodontol 1996; 1: 256–321.
3. Nishimura F, Takahashi K, Kurihara M. et al. Periodontal disease as a complication of diabetes mellitus. Ann Periodontol ; 3: 20–29. Offenbacher S. Periodontal disease: Pat- hogenesis. Ann Periodontol 1996; 1: 821 –878.
4. Forbes JM, Cooper ME. Mechanisms of diabetic complications. Physiol Rev ; 93: 137-188. Ali D, Kunzel C. Diabetes mellitus: Update and relevance for dentistry. Dent Today ; 30: 45-46. Krolewski AS, Warram JH, Rand LI, et al. Epidemiologic approach to the etiology of type I diabetes mellitus and its compli- cations. N Engl J Med 1987; 317: 1390
5. Altuntaş Y. Diabetes Mellitus’un tanımı, tes Mellitus Kitabı. Nobel Tıp Kitabevleri, 128 Reaven GM, Hollenbec CB, Chen YD. Rela- tionship between glucose tolerance, in- sulin secretion and insulin action in non- obese individuals with varying degrees of glucose tolerance. Diabetologia 1989; : 52-59.
6. Golay A, Felber JP, Jequier E, et al. Meta- bolic basis of obesity and non-insulin dependent diabetes mellitus. Diab Metab Rev 1988; 4: 727-747.
7. Porte D. Beta cells in type II Diabetes Mellitus. Diabetes 1991; 40: 166-180.
8. Mitrakou A, Kelly D, Mokan M, et al. Role of reduced suppression of glucose pro- duction and diminished early insulin release in impaired glucose tolerance, N Engl J Med 1992; 326: 22-29.

9. Taylor GW. Bidirectional interrelations- hips between diabetes and periodontal diseases: An epidemiologic perspective. Ann Periodontol 2001; 6: 99-112.
10. Coustan D. Gestational diabetes. Diabetes Care 1993; 16: 8-15.
11. Nathan DM. The pathophysiology of dia- betic complications: How much does the glucose hypotesis explain? Ann Intern Med 1996; 124: 86-89.
12. Mandrup PT. Recent advances-Diabetes. Br Med J 1998; 316: 1221-1225.
13. Klein BE. Overview of epidemiologic stu- dies of diabetic retinopathy. Ophthalmic Epidemiol 2007; 14: 179-183.
14. Tousoulis D, Kampoli AM, Stefanadis C. Diabetes mellitus and vascular endothe- lial dysfunction: current perspectives. Curr Vasc Pharmacol. 2012; 10: 19-32.
15. Wu M, Lyons TJ. Treatment approaches for diabetes and dyslipidemia. Horm Res Paediatr. 2011; 76: 76-80.
16. Brownlee M. Glycosylation diabetic complications. Diabetes 1994; 43: 836
17. Schmidt AM, Hori O, Brett J. Cellular re- ceptors for adveanced glycosylation end products. Implications for induction of oxidant stres and cellular dysfunction in the pathogenesis of vascular lesions. At- heroscler Thromb 1994; 14: 1521-1528.
18. Esposito C, Gerlach H, Brett J. Endothelial receptor-mediated binding of glucose- reased monolayer permeability and mo- dulation of cell surface coagulant proper- ties. J Exp Med 1992; 170: 1387-1407.
19. Schmidt AM, Hori O, Cao R. RAGE, a novel cellular receptor for advenced glycosyla- tion end products. Diabetes 1996; 45: 77 80.
20. Klokkevold PR, Mealey BL, Carranza FA. ders on the periodontium, In: Carranza’s Clinical Periodontology, (9th ed). Phila- delphia, WB Saunders Co. 2002; pp 204
21. Murrah VA. Diabetes mellitus and associ- ated oral manifestations: A review. J Oral Pathol 1985; 14: 271-281.
22. Mealey BL, Ocampo GL. Diabetes Mellitus and Periodontal Disease. Periodontology 2007; 44: 127-153.
23. Manouchehr-Pour M, Bissada NF. Perio- dontal disease in juvenile and adult dia- betic patients: A review. J Am Dent Assoc ; 107: 766-770. Oliver RC, Tervonen T. Diabetes-a risk factor for periodontitis in adults? J Perio- dontol 1994; 65: 530-538.
24. Grossi SG, Genco RJ. Periodontal disease and diabetes mellitus: A two-way relati- onship. Ann Periodontol 1998; 3: 51-61.
25. Goteiner D, Vogel R, Deasy M, et al. Perio- dontal and caries experience in children with insulin-dependent diabetes melli- tus. J Am Dent Assoc 1986; 113: 277-279.
26. Harrison R, Bowen WH. Periodontal he- alth, dental caries, and metabolic control in insulin-dependent diabetic children and adolescents. Pediatr Dent 1987; 9: 286. de Pommereau V, Dargent-Pare C, Robert
27. JJ, et al. Periodontal status in insulin- dependent diabetic adolescents. J Clin Periodontol 1992; 19: 628-632.
28. Soskolne WA, Klinger A. The relationship between periodontal diseases and diabe- tes: An overview. Ann Periodontol 2001; : 91-98.
29. Cianciola LJ, Park BH, Bruck E, et al. Pre- valence of periodontal disease in insulin- dependent diabetes mellitus (juvenile diabetes). J Am Dent Assoc 1982; 104: 660.
30. Seppälä B, Ainamo J. Periodontal conditions in insulin-dependent diabetes mellitus. J Clin Periodontol 1992; 19: 24
31. Shlossman M, Knowler WC, Pettitt DJ, et al. Type 2 diabetes mellitus and perio- dontal disease. J Am Dent Assoc 1990; : 532-536.
32. Emrich LJ, Shlossman M, Genco RJ. Perio- dontal disease in non-insulin dependent diabetes mellitus. J Periodontol 1991; 62: 131.
33. Nelson RG, Shlossman M, Budding LM, et al. Periodontal disease and NIDDM in Pima Indians. Diabetes Care 1990; 13: 840.
34. Taylor GW, Burt BA, Becker MP, et al. Non-insulin dependent diabetes mellitus and alveolar bone loss progression over years. J Periodontol 1998; 69: 76-83.
35. Tervonen T, Oliver RC. Long-term control of diabetes mellitus and periodontitis. J Clin Periodontol 1993; 20: 431-435.
36. Aldridge JP, Lester V, Watts TLP, et al. Single-blind studies of the effects of imp- roved periodontal health on metabolic control in type I diabetes mellitus. J Clin Periodontol 1995; 22: 271-275.
37. Thorstensson H, Hugoson A. Periodontal disease experience in adult long- duration insulin-dependent diabetics. J Clin Periodontol 1993; 20: 352-358.
38. Löe H. Periodontal disease: The sixth complication of diabetes mellitus. Diabe- tes Care 1993; 16: 329-334.
39. Karjalainen KM, Knuuttila MLE, von Dick- hoff KJ. Association of the severity of pe- riodontal disease with organ complicati- ons in Type I diabetic patients. J Perio- dontol 1994; 65: 1067-1072.
40. Thorstensson H, Kuylenstierna J, Hugo- son A. Medical status and complications in relation to periodontal disease expe- rience in insulin-dependent diabetes. J Clin Periodontol 1996; 23: 194-202.
41. Finestone AJ, Boorujy SR. Diabetes melli- tus and periodontal disease. Diabetes ; 16: 336-340. Collin HL, Uusitupa M, Niskanen L, et al. with non-insulin dependent diabetes mellitus. J Periodontol 1998; 69: 962
42. Taylor GW, Burt BA, Becker MP, et al. Se- vere periodontitis and risk for poor glyce- mic control in patients with non-insulin dependent daibetes mellitus. J Periodon- tol 1996; 67: 1085-1093.
43. Grossi SG. Treatment of Periodontal dise- ase and control of diabetes: An assess- ment of the evidence and need for future research. Ann Periodontol 2001; 6: 138
44. Seppälä B, Ainamo J. A site-by- site follow-up study on the effect of cont- rolled versus poorly controlled insulin- dependent diabetes mellitus. J Clin Perio- dontol 1994; 21: 161-165.
45. Alridge JP, Lester V, Watts TLP, et al. Single-blind studies of the effects of imp- roved periodontal health on metabolic control in Type I diabetes mellitus. J Clin Periodontol 1995; 22: 271-275.
46. Smith GT, Greenbaum CJ, Johnson BD, et al. Short-term responses to periodontal therapy in insulin-dependent diabetic patients. J Periodontol 1996; 67: 794
47. Christgau M, Palitzsch KD, Schmalz G, et al. Healing response ton on-surgical peri- odontal therapy in patients with diabetes mellitus: Clinical, microbiological and immunologic results. J Clin Periodontol ; 25: 112-124. Grossi SG, Skrepcinski FB, DeCaro T, et al. Treatment of periodontal disease in dia- betics reduces glycated hemoglobin. J Periodontol 1997; 68: 713-719.
48. Miller LS, Manwell MA, Newbold D, et al. The relationship between reduction in control: A report of 9 cases. J Periodontol ; 63: 843-848. Iwamoto Y, Nishimura F, Nakagawa M, et al. The effect of antimicrobial periodontal treatment on circulating tumor necrosis factor-alpha and glycated hemoglobin level in patients with type 2 diabetes. J Periodontol 2001; 72: 774-778.
49. Sasaki T, Ramamurthy NS, Yu Z, et al. Tetracycline administration increases protein synthesis and secretion in perio- tocin-induced diabetic rats. J Periodont Res 1992; 27: 631-639. king periodontal disease progression by inhibiting tissue-destructive enzymes: A potential therapeutic role for tetracycli- logs. J Periodontol 1993; 64: 819-827.
50. Mattila KJ, Nieminen MS, Valtonen VV. Association between dental health and acute myocardial infarction. Br Med J ; 298: 779-781. Offenbacher S, Katz V, Fertik G. Periodon- tal infection as a risk factor for preterm low birth weight. J Periodontol 1996; 67: 1113.