DO GLYCEMIC INDEX AND GLYCEMIC LOAD EFFECT CANCER DEVELOPMENT?

Öz

The aim of this review article was examined the potential relationship between glycemic index, glycemic load and cancer. Glycemic index and/or glycemic load may affect glucose metabolism and cause the production of advanced glycation end products (AGE), dysbiosis development and insulin like growth factor (IGF) synthesis which may cause to cell proliferation and Deoxyribo Nnucleic Acid (DNA) damage and may increase risk of cancer. High dietary fiber intake is suggested to decrease these potential effects. Adequately consumptions of vegetables, fruits, whole grains, legumes and seeds have positive effects on these potential risk. For these beneficial effects, Mediterranean diet may be optimal dietary approach.

Anahtar Kelimeler

• Glycemic index
• glycemic load
• cancer

GLİSEMİK İNDEKS VE GLİSEMİK YÜK KANSER GELİŞİMİNDE ETKİLİ MİDİR?

Öz

Bu derleme yazıda glisemik indeks ve glisemik yükün kanser gelişimi üzerindeki potansiyel etkilerinin incelenmesi hedeflenmiştir. Glisemik indeks ve/veya glisemik yük değeri yüksek olan besinlerin; glukoz metabolizmasını etkileyerek ileri glikasyon son ürünlerinin oluşmasına, disbiyoz gelişmesine, insülin benzeri büyüme faktörü (insulin like growth factor, IGF) aracılığı ile hücre çoğalmasına ve Deoksiribo Nükleik Asit (DNA) hasarına neden olarak kanser gelişim riskini arttırıcı potansiyel etkiler gösterdiği mekanizmalar ile özetlenmiştir. Potansiyel olumsuz etkilerin en aza indirilmesi için glisemik içeriği düşük, posa içeriği yüksek olan karbonhidrat kaynaklarının tercih edilmesi önerilmektedir. Bu noktada uygun miktar ve sıklıkta sebze, meyve, tam tahıl, kurubaklagil ve yağlı tohum tüketimi önem arz etmektedir. Ek olarak bu önerileri karşılayabilmek adına Akdeniz diyeti optimal düzeyde benimsenmesi gereken bir beslenme modeli olarak önerilebilmektedir. 

Anahtar Kelimeler

• Glisemik indeks
• glisemik yük
• kanser

Kaynakça

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