SİGARA DUMANININ UTERUSA ETKİLERİ: HİSTOPATOLOJİK BİR ÇALIŞMA

Yıl 2008, Cilt: 17 Sayı: 2, 69 - 76, 01.06.2008

Zülal Ekincioğlu Gülcan Demir Dilek Güneş Dağ Hıdır Pekmez Niyazi Acer M.reşat Özercan

Öz

Bu çalışmada, sigara dumanına maruz
bırakılan sıçanların uteruslarında meydana gelen
histopatolojik değişikliklerin araştırılması
amaçlandı. Bu amaçla, 14 adet Wistar-albino cinsi
dişi sıçan iki eşit gruba ayrıldı. Grup I’deki
hayvanlar kontrol olarak kullanıldı. Grup II’deki
sıçanlar ise sigara dumanına maruz bırakıldı. 45
günlük deney süresi sonunda tüm sıçanlar
dekapitasyonla öldürülerek uterusları çıkarıldı.
Uterus doku örnekleri rutin histolojik işlemlerden
geçirilerek ışık mikroskobunda incelendi. Kontrol
sıçanlardan elde edilen uterus kesitleri normal
yapısal görünüm özellikleri sergiledi. Sigara
dumanına maruz bırakılan sıçanların uterus
kesitlerinin ışık mikroskobu ile yapılan
incelemesinde, duman inhalasyonunun uterusta doku
hasarına yol açtığı, endometriyum yüzey ve bez
epitel hücrelerinin boylarında azalmaya neden
olduğu belirlendi. Ayrıca, hücre çekirdekleri
belirgin ölçüde küçülmüş ve yassılaşmış
görünümlüydü. Elde edilen bulgular ışığında, sigara
dumanı inhalasyonunun sıçanların uteruslarında
histopatolojik düzeyde hasara neden olduğu
sonucuna varıldı.

Anahtar Kelimeler

Uterus, sigara, ışık mikroskobu

Influences of Cigarette Smoke on Uterus: A Histopathological Study

Öz

In this study, it was aimed to investigate
the histopathological changes in the uteri of rats
exposed to cigarette smoke. For this purpose, 14
female Wistar-albino rats were divided into two
equal groups. Animals in group I were used as
control. Rats in Group II were exposed to cigarette
smoke. At the end of 45 days experimental period,
all rats were killed by decapitation and their uteri
were removed. Following routine histological
procedures, uterus tissue specimens were examined
under a light microscope. The uterus sections of
control rats showed normal structural integrity.
Light microscopic examination of uterus specimens
from animals exposed to cigarette smoke revealed
that smoke inhalation caused tissue damage in the
uteri. It was observed decreases in height of surface
and glandular epithelial cells of rat endometrium.
Additionally, the cell nuclei appeared markedly
small and flat. In view of our findings herein, we
concluded that cigarette smoke inhalation causes
histopathologically damage in uterine tissue of ra

Anahtar Kelimeler

Uterus, cigarette, light microscope

Kaynakça

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