YAŞA BAĞLI MAKULAR DEJENERASYON VE BESLENME

Yıl 2016, Cilt: 25 Sayı: 3, 161 - 164, 01.12.2016

Mustafa Özgür Nurcan Yabanci Ayhan

Öz

Yaşa bağlı makular dejenerasyon gelişmiş ülkelerde 65
yaş üstü bireylerde santral görme kaybının en önemli
nedenidir. Hastalığın tedavisi günümüzde hala tam olarak bilinmemekle birlikte, bazı besin ögelerinin diyetle
yeterli alımı ile hastalığın gelişme riski azalmakta ve
hastalığın ilerleyişi yavaşlamaktadır. Özellikle son yıllarda, antioksidan vitamin ve bileşiklerin, omega-3 ve
omega-6 elzem yağ asitlerinin, D vitaminin ve çinkonun
hastalığa etkilerini gösteren çalışmaların sayısı artmıştır. Bu derleme yazıda, yaşa bağlı makular dejenerasyon
ile beslenme ilişkisi ele alınmıştır

Anahtar Kelimeler

Yaşa bağlı makular dejenerasyon, beslenme, besin öğeleri

Age-Related Macular Degeneration and Nutrition

Öz

Age-related macular degeneration is the most important
cause of loss of central vision in over 65 years old in
developed country. Although the exact treatment of the
disease is still unknown, the risk of developing the disease reduced and its progression can be slowed down
through dietary intake of certain nutrients. Especially in
recent years, the number of the studies showing the
effect on the disease of antioxidant vitamins and components, omega-3 and omega-6 essential fatty acids, vitamin D and zinc on the disease has increased. This review article, discusses the relationship between nutrition and age-related macular degeneration

Anahtar Kelimeler

Age-related macular degeneration, nutrition, nutrients

Kaynakça

• 1. Lim LS, Mitchell P, Seddon JM, Holz FG, Wong TY. Age-related macular degeneration. Lancet 2012;379:1728-1738.
• 2. Boulton M. Ageing of the retina andretinal pigment epithelium. In: Holz FG, Pauleikhoff D, Spaide RF, Bird AC (eds), Verlag Berlin Heidelberg, 2013; pp 45-63.
• 3. Young RW. Pathophysiology of age-related macular degeneration. Sur Ophthalmol 1987;31(5):291- 306.
• 4. Mitchell P, Smith W, Attebo K, Wang JJ. Pevalence of age-related maculopathy in Australia. The Blue Mountains Eye Study. Ophthalmology 1995;102 (10):1450-1460.
• 5. Vingerling JR,Dielemans I, Hofman A, et al. The prevalance of age-related maculopathy in Rotterdam study. Ophthalmology 1995;102: 205- 210.
• 6. Klein R, Klein BE, Jensen SC, Meuer SM. The Fiveyear incidence and progression of age-related maculopathy: The Beaver Dam Eye Study. Ophthalmology 1997;104(1):7-21.
• 7. Klein R, Cruickshanks KJ, Nash SD, et al. The prevalence of age-related macular degeneration and associated risk factors: The Beaver Dam Offspring Study. Arch Ophthalmol 2010;128 (6):750-756.
• 8. Schachat AP, Hyman L, Leske MC, Connel AM, Wu SY. Features of age-related maculopathy in a black population: The Barbados Eye Study Group. Arch Ophthalmol 1995;113: 728-735.
• 9. Age-Related Eye Disease Study Research Group. Risk factors for the incidence of advanced agerelated macular degeneration in the age-related eye disease study (AREDS). AREDS Report No. 19. Ophthalmology 2005;112(4):533-539.
• 10. Saksens NTM, Fleckenstein M, SchmitzValckenberg S, et al. Macular dystrophies mimicking age-related macular degeneration. Prog Retin Eye Res 2014;39:23-57.
• 11. Knudtson MD, Klein R, Klein BE. Alcohol consumption and the 15 year cumulative incidence of age-related macular degeneration. Am J Ophthalmol 2007;143(6):1026-1029.
• 12. Singh A. Systemic changes in neovascular agerelated macular degeneration. Dan Med J 2014;61 (6):B4872.
• 13. Prasad AS. Discovery of human zinc deficiency: its impact on human health and disease. Adv Nutr 2013;4:176-190.
• 14. De Velasco PC, Sandre PC, Tavares Do Carmo Mg, et al. A critical period for omega-3 nutritional supplementation in the development of the rodent visual system. Brain Res 2015;1615:106-115.
• 15. Akuffo KO, Nolan JM, Howard AN, et al. Sustained supplementation and monitored response with differing carotenoid formulations in early agerelated macular degeneration. Eye 2015:1-11.
• 16. Fu Z, Lofqvist CA, Shao Z, et al. Dietary Omega-3 polyunsaturated fatty acids decrease retinal neovascularization by adipose–endoplasmic reticulum stress reduction to increase adiponectin. Am J Clin Nutr 2015;101:879-888.
• 17. Goldberg J, Flowerdew G, Smith E, Brody JA, Tso MO. Factors associated with age-related macular degeneration. An analysis of data from the first national health and nutrition examination survey. Am J Epidemiol 1988;128:700-710.
• 18. Age-Related Eye Disease Study Research Group. There relationship of dietary carotenoid and vitamin A, E, and C intake with age-related macular degeneration in a case-control study: AREDS Report No. 22. Arch Ophthalmol 2007;125:1225- 1232.
• 19. Bone RA, Landrum JT, Hime GW, Cains A, Zamor J. Stereochemistry of the human macular carotenoids. Invest Ophthalmol Vis Sci 1993;34 (6):2033-2040.
• 20. Age-Related Eye Disease Study Research Group. A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss AREDS Report No. 8. Arch Ophthalmol 2001;119(10):1417-1436.
• 21. Brustolin S, Giugliani R, Felix TM. Genetics of homocysteine metabolism and associated disorders. Braz J Med Biol Res 2010;43:1-7.
• 22. Kamburoglu G, Gumus K, Kadayifcilar S, Eldem B. Plasma Homocysteine, Vitamin B12 and folate levels in age-related macular degeneration. Graefes Arch Clin Exp Ophthalmol 2006;244:565-569.
• 23. Rochtchina E, Wang JJ, Flood VM, Mitchell P. Elevated serum homocysteine, low serum vitamin B12, folate, and age-related macular degeneration: The Blue Mountains Eye Study. Am J Ophthalmol 2007;143(2):344-346.
• 24. Christen WG, Glynn RJ, Chew EY, Albert CM, Manson JE. Folic acid, pyridoxine, and cyanocobalamin combination treatmentand agerelated macular degeneration in women the women's antioxidant and folic acid cardiovascular study. Arch Intern Med 2009;169(4):335-341.
• 25. Millen AE, Voland R, Sondel SA, et al. Vitamin D status and early age-related macular degeneration in postmenopausal women. Arch Ophthalmol 2011;129(4):481-489.
• 26. Baysal A. Beslenme (12nd ed). Hatipoğlu Yayınevi, Ankara, 2009, pp:135-137.
• 27. Harman D. Free radical theory of aging: An update: increasing the functional life span. Ann N Y Acad Sci 2006;1067:10-21.
• 28. Newsome DA, Swartz M, Leone NC, Elston RC, Miller E. Oral zinc in macular degeneration. Arch Ophthalmol 1988;106:192-198.
• 29. Yildirim Z, Ucgun NI, Yildirim F. The role of oxidative stress and antioxidants in the pathogenesis of age-related macular degeneration. Clinics 2011;66(5):743-746.
• 30. Kim E, Han K, Jee D. Inverse relationship between high blood 25- hydroxyvitamin D and late stage of age-related macular degeneration in a representative Korean population. IOVS 2014;55:4823-4831.
• 31. Mares-Perlman JA, Bradly WE, Klein R, et al. Serum antioxidants and age-related macular degeneration in a population-based case-control study. Arch Ophthalmol 1995;113(12):1518-1523.
• 32. Smith W, Mitchell P, Leader SR. Dietary fat and fish ıntake and age-related maculopathy. Arch Ophthalmol 2000;118(3):401-404.
• 33. Topouzis F, Anastasopoulos E, Augood C, et al. Association of diabetes with age-related macular degeneration in the eureye study. Br J Ophthalmol 2009;93:1037-1041.
• 34. Heuberger RA, Mares-Perlman JA, Klein R, et al. Relationship of dietaryfattoagerelatedmaculopathy in the Third National Health and Nutrition Examination Survey. Arch Ophthalmol 2001;119:1833-1838.
• 35. Baur JA, Pearson KJ, Price NL, et al. Resveratrol improves health and survival of mice on a highcalorie diet. Nature 2006;444:337-342.
• 36. 36. Bola C, Bartlett H, Eperjesi F. Resveratrol and the eye: activity and molecular mechanisms. Graefes Arch Clin Exp Ophthalmol 2014;252:699- 713.
• 37. Jenkins DJA, Kendall CWC, Augustin LSA, et al. Glycemic index: overview of implications in health and disease. Am J Clin Nutr 2002; 76(suppl):266- 273.
• 38. Chiu CJ, Milton RC, Klein R, et al. Dietary carbohydrate and the progression of age-related macular degeneration: A prospective study from the Age-Related Eye Disease Study. Am J Clin Nutr 2007;86:1210-1218.
• 39. Chiu CJ, Hubbard LD, Armstrong J, et al. Dietary glycemic index and carbohydrate in relation to early age-related macular degeneration. Am J Clin Nutr 2006 ;83(4):880-886.
• 40. Chiu CJ, Milton RC, Klein R, et al. Dietary compound score and risk of age-related macular degeneration in the age-related eye disease study. Ophtalmology 2009;116(5):939-946.