DENEYSEL KETOZİS OLUŞTURULAN KOYUNLARDA PARENTERAL LİPİT EMÜLSİYONLARININ TEDAVİ ÜZERİNE ETKİLERİNİN ARAŞTIRILMASI

Yıl 2017, Cilt: 26 Sayı: 2, 126 - 132, 01.07.2017

Reyda Kıyıcı Şıklaroglu Vehbi Güneş

Öz

Bu çalısmada, deneysel ketozis oluşturulan koyunlarda
% 20’lik total parenteral lipit emülsiyonları’nın (TPLE)
% 30 Dekstroz tedavisine karşı etkinliği araştırıldı.
Onsekiz adet gebe olmayan ve laktasyon dönemi dışındaki koyunlar her grupta 6 adet koyun olacak şekilde üç
gruba ayrıldı. Bütün gruplarda deneysel ketozis oluşturuldu. Bu amaçla koyunların herbirine üç gün boyunca
derialtı phlorhizin enjekte edildi (100 mg/kg) ve sınırlı
yem (toplam rasyonun ¼’ü) verildi. Tüm gruplarda
ketozise ait klinik belirtiler oluşturulduktan sonra birinci gruba kontrol amacıyla % 0,9 NaCl, ikinci gruba standart tedavi amacıyla % 30 Dekstroz ve üçüncü gruba %
20'lik TPLE damar içi yola uygulandı. Dekstroz uygulaması sonrasında NEFA düzeyleri önemli oranda azaldı.
Lipit emülsiyonu verilenlerde ise NEFA düzeylerindeki
artış istatistikî açıdan önemli bulunmadı (p=0.05). Bu
grupta trigliserid ve glukoz düzeyleri TPLE uygulamasını takiben diğer gruplara oranla yüksek bulundu. Koyunlarda ketozise ait klinik belirtiler yalnız lipit emülsiyonu verildikten sonra belirgin olarak düzeldi. Sonuç
olarak deneysel açlık ketozisi oluşturulan koyunlarda %
30’luk Dekstrozun NEFA düzeylerini azaltmasına rağmen, % 20 TPLE’nin glikoz ve trigliserid düzeylerinde
artış sağlayıp dekstroz uygulamalarına göre enerji açığını kapattığı belirlendi. Bu nedenle TPLE’nın, açlık
ketozisinin klinik belirtilerinin düzeltilmesinde etkili
olabileceği değerlendirildi.

Anahtar Kelimeler

Ketozis, Koyun, Yağ emülsiyonu

The Effects of Treatment With Total Parenteral Lipid Emultion in Sheep Experimentally Induced Starvation Ketosis

Öz

In this study, the effects of Total Parenteral Lipid
Emulsions (TPLE) and 30% Dekstroz was compared to
treatment of experimentally induced starvation ketosis
in sheep. Eighteen nonpregnant, nonlactating sheep
were randomly divided into 3 different study groups
each containing six sheep. Subcutan phloryzin (100 mg/
kg) was injected together with feed restriction (1/4 of
total ration) to induce the ketosis and lipid mobilisation.
After clinical symptoms for ketosis in all groups, for
control 0,9% NaCl in first group, 30% Dekstroz in
second group IV and 20% TPLE in third group IV were
administered to the each sheep in groups. Mean NEFA
levels was a tendency to decrease after dextrose
administration in group administered dextrose. In TPLE
group, mean NEFA levels were not siginificantly higher
after TPLE administraion (p=0.05). Mean triglyceride
and glucose levels in sheep given TPLE were
significantly higher than those of other groups. Clinical
signs was recovered after in group given TPLE only. In
conclusion, although 30% dextroz treatment was the
most effective in decreasing of NEFA level, 20% TPLE
inhibited clinical signs of starvation ketozis in sheep by
providing urgent energy demand with increase of
trigliserid and glucose levels. For this reason, TPLE was
evaluated to be effective in correcting the clinical
symptoms of fasting ketosis.

Anahtar Kelimeler

Fat Emulsion, Ketosis, Sheep

Kaynakça

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