Metil Parathion’un Sıçanların İnce Bağırsak Dokusu Üzerine Etkisi ve Vitamin C ve E’nin Koruyucu Rolü

Öz

Organofosfatlı bir insektisit olan metil parathion zirai mücadelede sıklıkla kullanılmakta ve zehirlenmelere neden olmak-tadır. Bu çalışmada, metil parathion (0.28 mg/kg gün), vitamin C (200 mg/kg gün)+vitamin E (200 mg/kg gün), vitamin C (200 mg/kg gün)+vitamin E (200 mg/kg gün)+metil parathion (0.28 mg/kg gün) erkek sıçanlara oral gavaj yoluyla verildi. Muameleden 4 hafta ve 7 hafta sonra sıçanların ince bağırsaklarındaki histopatolojik değişiklikler ışık mikroskobuyla incelendi. Metil parathion mu-amelesinden 4 ve 7 hafta sonra ince bağırsaklardaki villuslarda genişleme tespit edildi. Buna ilaveten 7. hafta sonunda bazı bölgelerde infiltrasyon gözlendi. Vitamin C+vitamin E+metil parathion muamemeli grupta da 4 ve 7 hafta sonra sıçanların ince bağırsakla-rında villusların yapısının bozulduğu gözlendi. Sonuç olarak düşük doz metil parathion sıçanların ince bağırsaklarında histopatolojik değişikliklere neden olmaktadır. Vitamin C ve vitamin E’nin, metil parathionun ince bağırsaklarda meydana getirdiği patolojik değişiklikleri önleyemediği tespit edildi.

Anahtar Kelimeler

• Etlik Veterinerlik Mikrobiyoloji Dergisi
• Metil Parathion
• İnce Bağırsak
• Sıçan
• Doku
• Vitamin C
• Vitamin A
• Ayşe ÖĞÜTCÜ
• Yavuz ULUSOY
• Kevser KAHRAMAN
• Meltem UZUNHİSARCIKLI
• Fatma Gökçe UZUN
• Hakkı TAŞTAN
• 2007

Effect of Methyl Parathion on the Rat Small Intestine Tissue and Protective Role of Vitamın C and E

Öz

Methyl parathion, an organophosphorous insecticide, is widely used in agricultural control and causes poisoning. In the present study, methyl parathion (0.28 mg/kg day), vitamin C (200mg/kg day)+vitamin E(200 mg/kg day), vitamin C (200mg/kg day)+vitamin E (200 mg/kg day)+methyl parathion (0.28 mg/kg day) were given to male rats through gavage. Histopathological changes were investigated using light microscope 4 and 7 weeks after administration. After 4 and 7 weeks of methyl parathion exposure, dilatation was observed in intestinal villi. Addition to this, infiltration in some area was observed 7 weeks after. After 4 and 7 weeks of vitamins C+vitamin E+methyl parathion exposure, degenerative changes were detected in the intestinal villi. As a result, lower doses of methyl parathion caused histopathological changes in the rat small intestine. It’s determined that vi-tamin C and vitamin E haven’t prevented the pathological changes caused by methyl parathion in small intestine.

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