Etlik Piliçlerde Kullanılan Çeşitli Veteriner İlaçlarının Kalıntıları Üzerine Pişirme, Dondurma ve Benzeri İşlemlerinin Etkilerinin Araştırılması -Kinolon Grubu Bazı Antibakteriyellerin incelenmesi
Bu araştırma, hayvan hastalıklarının tedavisinde sıklıkla kullanılan sulfonamid grubu
ilaçlardan sulfadimetoksin, sulfakinoksalin ve sulfadoksinin etlik piliçlerin göğüs, but ve
karaciğer dokularındaki kalıntıları üzerine çeşitli pişirme işlemlerinin (ızgara, tuzlu ve tuzsuz
haşlama)ve derin dondurucuda (-1 8°C) farklı sürelerde bekletmenin etkilerini belirlemek
amacıyla yapılmıştır.
Yapılan analizler sonucunda farklı pişirme işlemlerinin sulfadimetoksin, sulfakinoksalin
ve sulfadoksin kalıntıları üzerinde belirgin bir azalmaya neden olduğu, derin dondurucuda
farklı sürelerde bekletmede ise sülfadoksin için sadece but dokusunda, sülfakinoksalin için ise
sadece göğüs dokusunda 20 günlük saklama ile istatistikse~ olarak önemli bir azalma (p<0.05)
bulunmuştur.
ASCALONE V (1980). Assay of trimethoprim,
sulfamethoxazole and its N4-acetyl
metabolile in biological fluids by high-pressure
liquid chromatography. High Resolution
Chromatogr Commun, 3:261-264.
BAYDAN E (1996). Türkiye'de veteriner
ilaçlarımn dünü ve bugünü. Türk Vet Hek
Derg, 8: 4-5.
BEVILL RF (1984). Factors influencing the
occurrence of drug residues in animal tissues
after the use of antimicrobial agents in animal
feeds. JAVMA, ı 85: ı ı24- I 126.
BOlSON JO ET AL (1992). Effect ofcoldtenıperature
storage on stability of benzylpenicillin
residues in plasma and tissues of
food-producing animals. JAOAC
International, 75: 974-978.
EPSTEIN RL ET AL (ı 988). lnfluence of
heat and cure preservatives on residues of
sulfamethazine, chloramphenicol, and cyromazine
in muscle tissue. J Agric Food Chem,
36:1009-0ı2.
HASSETT T ET AL (1990). The effect of
cooking on drug residues in nıeat and offal.
EuroResidue Conference on Residues of
Veterinary Oru gs in Food, pp.2 I I -2 ı 5.
INGLlS JM AND KATZ SE (ı978).
Determination of streptomycin residues in
eggs and stability of residues after cooking
J Ass oc Off Anal C hem, 6 ı: ı 098-1102.
KATZ SE AND LEVINE PR (1978).
Determination of neomycin residues in eggs
and stability of residues after cooking J
Assoc Off Anal Ch em, 61: 1 ı 03-1106.
KAYA S (2000). Kemoterapötikler. İçinde:
Veteriner Uygulamalı Farmakoıoji (Eds.S.
Kaya, i. Pirinçci, A. Bilgili) Cilt2, Baskı2.
Medisan Yayınevi. Seri 42, Ankara.
Kaya S VE ARK (1992). Mezbahadan
sağlanan Siğır et, karaciğer ve böbrek örneklerinde
antibiyotik kalıntıları. AÜ Vet Fak
Derg, 39:13-29.
LASHEV LD AND MIHAILOV R (1994).Pharmacokinetics
ofsulphamethaxazole and
tremethoprim administered intravenously
and orally to japanese quails. J Vet
Pharmacol Ther, 17:327-30.
LI T, QIAO GL, HU GZ, MENG FD, QIU
YS, ZHANG XY, GUO WX, YlE HL, LI
SF AND LI SY ( 1995). Comparative plasma
and tissue pharmacokinetics and drug
residue profi/es of different chemotherapeutants
in fowls and rabbits. J Vet Phar:macol
Ther, 18: 260-73.
LOSCHER W, FASSEENDER CP,
WEISSING M AND KIETZMANN M
( 1990). Drug plasma !eve/s fallawing admin~
istration of trimethoprim and sulphonamide
combinations to broilers. J Vet Pharmacol
Ther, 13: 309-ı9.
NOUWS JFM (1981). Tolerances and
· detection of antimicrobial residues in slaughtered
animals. Are für Lebensmitteıhygi, 32:
92-ı40.
NOUWS JFM AND ZIV G (ı976). The
effect ofstorage at 4°C on antibiotic residues
in kidney and meat tissues of dairy cows.
Tijdschr Diergeneesk, ıoı: ıı45.
O'BRIEN JJ ET AL (1980). Antibiotic
residues in meat: cooking and cold storage
effects. Vet Re c, 106: 365.
ÖZKAZANÇ N VE KAYA S (1983).
Hayvanların pişmemiş yenilebilir dokularında
sulfonamid analizi. Ankara Üniv Vet Fak
Derg, 30: 624-638 . .
ROSE MD ET AL (1995). The effect of
cooking on veterinGJ·y drug residues in food:
Clenbuterol. Food Add Contamin, 12: 67-
76.
ROSE MD ET AL (ı 995). The effect of
cooking on veterinary drug residues in food :
Levamisole. Food Add Contamin, 12: 185-ı94 .
WAGNER lG (1975). Fundamentals of
Clinical Pharmacokineties. Ist Ed. Drug
Intelligence Publications, Ine., Hamilton,
lllionis.
THE EFFECTS OF COOKING, FREEZlNG AND SOME SIMILAR PROCESSES ON THE VETERINARY DRUG RESIDUES IN BROILER TISSUES- Research of some antibacterials group of quinolone
This study was performed to determine effect of different cooking processed and different
stocking time at -1 8°C on sulfadimethoxine, sulfaquinoxaline, and sulfadoxine residues in
broiler tissues.
The tissues have been processed by grilling and boiling in water with salt and without
salt (both tissue and its gravy). After cooking processed sulfadimethoxine, sulfaquinoxaline
and sulfadoxine levels in tissue were measured (as ppm). The results of analysis indicated that
the sulfadimethoxine, sulfaquinoxaline and sulfadoxine residues of in the poultry tissues significantly
decreased after the different cooking procedures. But sulfadimethoxine,- sulfaquinoxaline
and sulfadoxine residues of in the poultry tissues didn't decrease different stocking
time at -1 8°C
ASCALONE V (1980). Assay of trimethoprim,
sulfamethoxazole and its N4-acetyl
metabolile in biological fluids by high-pressure
liquid chromatography. High Resolution
Chromatogr Commun, 3:261-264.
BAYDAN E (1996). Türkiye'de veteriner
ilaçlarımn dünü ve bugünü. Türk Vet Hek
Derg, 8: 4-5.
BEVILL RF (1984). Factors influencing the
occurrence of drug residues in animal tissues
after the use of antimicrobial agents in animal
feeds. JAVMA, ı 85: ı ı24- I 126.
BOlSON JO ET AL (1992). Effect ofcoldtenıperature
storage on stability of benzylpenicillin
residues in plasma and tissues of
food-producing animals. JAOAC
International, 75: 974-978.
EPSTEIN RL ET AL (ı 988). lnfluence of
heat and cure preservatives on residues of
sulfamethazine, chloramphenicol, and cyromazine
in muscle tissue. J Agric Food Chem,
36:1009-0ı2.
HASSETT T ET AL (1990). The effect of
cooking on drug residues in nıeat and offal.
EuroResidue Conference on Residues of
Veterinary Oru gs in Food, pp.2 I I -2 ı 5.
INGLlS JM AND KATZ SE (ı978).
Determination of streptomycin residues in
eggs and stability of residues after cooking
J Ass oc Off Anal C hem, 6 ı: ı 098-1102.
KATZ SE AND LEVINE PR (1978).
Determination of neomycin residues in eggs
and stability of residues after cooking J
Assoc Off Anal Ch em, 61: 1 ı 03-1106.
KAYA S (2000). Kemoterapötikler. İçinde:
Veteriner Uygulamalı Farmakoıoji (Eds.S.
Kaya, i. Pirinçci, A. Bilgili) Cilt2, Baskı2.
Medisan Yayınevi. Seri 42, Ankara.
Kaya S VE ARK (1992). Mezbahadan
sağlanan Siğır et, karaciğer ve böbrek örneklerinde
antibiyotik kalıntıları. AÜ Vet Fak
Derg, 39:13-29.
LASHEV LD AND MIHAILOV R (1994).Pharmacokinetics
ofsulphamethaxazole and
tremethoprim administered intravenously
and orally to japanese quails. J Vet
Pharmacol Ther, 17:327-30.
LI T, QIAO GL, HU GZ, MENG FD, QIU
YS, ZHANG XY, GUO WX, YlE HL, LI
SF AND LI SY ( 1995). Comparative plasma
and tissue pharmacokinetics and drug
residue profi/es of different chemotherapeutants
in fowls and rabbits. J Vet Phar:macol
Ther, 18: 260-73.
LOSCHER W, FASSEENDER CP,
WEISSING M AND KIETZMANN M
( 1990). Drug plasma !eve/s fallawing admin~
istration of trimethoprim and sulphonamide
combinations to broilers. J Vet Pharmacol
Ther, 13: 309-ı9.
NOUWS JFM (1981). Tolerances and
· detection of antimicrobial residues in slaughtered
animals. Are für Lebensmitteıhygi, 32:
92-ı40.
NOUWS JFM AND ZIV G (ı976). The
effect ofstorage at 4°C on antibiotic residues
in kidney and meat tissues of dairy cows.
Tijdschr Diergeneesk, ıoı: ıı45.
O'BRIEN JJ ET AL (1980). Antibiotic
residues in meat: cooking and cold storage
effects. Vet Re c, 106: 365.
ÖZKAZANÇ N VE KAYA S (1983).
Hayvanların pişmemiş yenilebilir dokularında
sulfonamid analizi. Ankara Üniv Vet Fak
Derg, 30: 624-638 . .
ROSE MD ET AL (1995). The effect of
cooking on veterinGJ·y drug residues in food:
Clenbuterol. Food Add Contamin, 12: 67-
76.
ROSE MD ET AL (ı 995). The effect of
cooking on veterinary drug residues in food :
Levamisole. Food Add Contamin, 12: 185-ı94 .
WAGNER lG (1975). Fundamentals of
Clinical Pharmacokineties. Ist Ed. Drug
Intelligence Publications, Ine., Hamilton,
lllionis.
Baydan, E., Akkaya, R., Traş, B., Bilgili, A., vd. (2002). Etlik Piliçlerde Kullanılan Çeşitli Veteriner İlaçlarının Kalıntıları Üzerine Pişirme, Dondurma ve Benzeri İşlemlerinin Etkilerinin Araştırılması -Kinolon Grubu Bazı Antibakteriyellerin incelenmesi. Etlik Veteriner Mikrobiyoloji Dergisi, 13(1), 56-76.