The Relationship Between Structural Measurements of the Corpus Callosum and Disability in Patients with Multiple Sclerosis

Yıl 2022, , 433 - 438, 31.08.2022

Aysegul Demir , Fettah Eren , Süeda Ecem Yılmaz , Necat İslamoğlu

https://doi.org/10.54005/geneltip.1124013

Öz

Abstract
Purpose: The corpus callosum (CC) is the largest commissural pathway connecting both cerebral cortices.
Materials and Methods: Forty MS patients and 40 healthy controls were included in this research, which was planned as a prospective and case-control study. Disability was evaluated with the expanded disability rating scale. The number of attacks, disease duration, and MS disease subtype were determined. CC genu, truncus, splenium, and anterior-posterior diameters were measured in brain magnetic resonance imaging TSE/T1 sagittal sequence, and the corpus callosum index (CCI) was calculated using these measurements. The relationship of all these parameters with each other was examined.
Results: There were 40 patients (29 females, 11 males) with a mean age of 36.47±11.14 years in the study. In the CC morphometric measurements of the patients, the genu (mean±SD) was 11.46±1.60, truncus (median, min-max) 5.29 (4.6-6.52), splenium 11.09±1.82, anterior-posterior diameter 65.20 (63.64-67.22) and CCI was determined as 0.43±0.05 millimeters. The anterior-posterior diameter was smaller in MS patients (p=0.022). A negative correlation was determined between CCI and disease duration, the number of attacks, and EDSS scores in MS patients (p<0.05; r=-0.319; r=-0.316; r=-0.349; respectively). In the severe disability group, CC splenium, AP diameter, and CCI were lower (p=0.007; p=0.020; p=0.046; respectively).
Conclusion: In MS disease, the CC structure is affected, as in many central nervous system regions. The study results revealed that changes in the corpus callosum could be examined as a parameter in evaluating the disease process in MS patients.
Keywords: Multiple sclerosis; corpus callosum; morphometry; disability.

Anahtar Kelimeler

Multiple sclerosis, corpus callosum, morphometry, disability

Proje Numarası

yok

Kaynakça

• Referans1 Firat A, Tascioglu AB, Demiryurek MD et al. Evaluation of corpus callosum morphometry in patients with mesial temporal lobe epilepsy with hippocampal sclerosis. Surg Radiol Anat 2014;36:47-54.
• Referans2 Giedd JN, Rumsey JM, Castellanos FX et al. A quantitative MRI study of the corpus callosum in children and adolescents. Brain Res Dev Brain Res 1996;91:274-80. Referans3 Kurkcuoglu A, Zagyapan R, Pelin C. Stereological evaluation of temporal lobe/telencephalon volume in temporal lobe epilepsy using the Cavalieri principle. Turk Neurosurg 2010;20:358-63.
• Referans4 Sahin B, Ergur H. Assessment of the optimum section thickness for the estimation of liver volume using magnetic resonance images: a stereological gold standard study. Eur J Radiol 2006;57:96-101.
• Referans5 Barboriak DP, Padua AO, York GE, Macfall JR. Creation of DICOM--aware applications using ImageJ. J Digit Imaging 2005;18:91-9.