Dosimetric Comparison of Inverse Planning Simulated Annealing and Manual Optimization for Intracavitary Cervix Brachytherapy
Öz
Background/Aims: Different optimization methods in brachytherapy treatment planning is used. The aim of this study is to evaluate dosimetric differences between manual optimization (MO) and inverse planning simulated annealing (IPSA) planning techniques commonly used in brachytherapy of cervical cancer.
Methods: Fifteen cervical cancer patients were included in this study. Nucletron standard tandem-ovoid (TO) applicators were used for treatment. High-risk clinical tumor volume (HR-CTV), bladder, rectum, and sigmoid contouring were performed according to GEC-ESTRO recommendations. Two plans were created for each patient using IPSA and MO techniques. While a dose of 700 cGy was prescribed to the target volume during the planning phase, an effort was made to protect the organs at risk in the best way possible. IPSA and MO planning techniques were compared via dose volume histogram (DVH).
Results: There was no significant difference between HR-CTV and CI values for MO and IPSA techniques. There was a significant difference between IPSA and MO techniques for the 2cm3 volume of the rectum (p= 0.002). It was observed that the bladder was better protected by the IPSA technique. There was a 6.26% dose difference between IPSA and MO for the bladder. A significant difference was found between IPSA and MO techniques for the 2cm3 volume of the sigmoid (p= 0.002). The IPSA technique was superior to the MO technique in terms of time.
Conclusions: The IPSA technique was superior to the MO technique in terms of protecting organs at risk (OARs). IPSA provides a faster and higher quality plan in cervical brachytherapy.
Anahtar Kelimeler
Destekleyen Kurum
This study was supported by the Scientific Research Projects (BAP) Grants Unit, Selcuk University, Konya, TURKEY
Proje Numarası
22301001
Kaynakça
- Viswanathan AN, Erickson BA. Three-Dimensional Imaging in Gynecologic Brachytherapy: A Survey of the American Brachytherapy Society. International Journal of Radiation Oncology*Biology*Physics. 2010;76(1):104-9.
- Mahantshetty U, Poetter R, Beriwal S, Grover S, Lavanya G, Rai B, et al. IBS-GEC ESTRO-ABS recommendations for CT based contouring in image guided adaptive brachytherapy for cervical cancer. Radiotherapy and Oncology. 2021;160:273-84.
- Viswanathan AN, Erickson B, Gaffney DK, Beriwal S, Bhatia SK, Lee Burnett O, et al. Comparison and Consensus Guidelines for Delineation of Clinical Target Volume for CT- and MR-Based Brachytherapy in Locally Advanced Cervical Cancer. International Journal of Radiation Oncology*Biology*Physics. 2014;90(2):320-8.
- Kim YJ, Kang H-C, Kim YS. Impact of intracavitary brachytherapy technique (2D versus 3D) on outcomes of cervical cancer: a systematic review and meta-analysis. Strahlentherapie und Onkologie. 2020;196(11):973-82.
- Gao M, Albuquerque K, Chi A, Rusu I. 3D CT-based volumetric dose assessment of 2D plans using GEC-ESTRO guidelines for cervical cancer brachytherapy. Brachytherapy. 2010;9(1):55-60.
- Kirisits C, Pötter R, Lang S, Dimopoulos J, Wachter-Gerstner N, Georg D. Dose and volume parameters for MRI-based treatment planning in intracavitary brachytherapy for cervical cancer. International Journal of Radiation Oncology*Biology*Physics. 2005;62(3):901-11.
- Jamema SV, Sharma S, Mahantshetty U, Engineer R, Shrivastava SK, Deshpande DD. Comparison of IPSA with dose-point optimization and manual optimization for interstitial template brachytherapy for gynecologic cancers. Brachytherapy. 2011;10(4):306-12.
- Morén B, Larsson T, Tedgren ÅC. Optimization in treatment planning of high dose‐rate brachytherapy — Review and analysis of mathematical models. Medical Physics. 2021;48(5):2057-82.
- Kannan RA, Gururajachar JM, Ponni A, Koushik K, Kumar M, Alva RC, et al. Comparison of manual and inverse optimisation techniques in high dose rate intracavitary brachytherapy of cervical cancer: A dosimetric study. Reports of Practical Oncology & Radiotherapy. 2015;20(5):365-9.
- Deist TM, Gorissen BL. High-dose-rate prostate brachytherapy inverse planning on dose-volume criteria by simulated annealing. Physics in Medicine and Biology. 2016;61(3):1155-70.