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Inflammatory biomarkers as Predictors of Mortality in patients with hip fractures: A Comprehensive Analysis

Cilt: 36 Sayı: 2026 23 Haziran 2026
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Inflammatory biomarkers as Predictors of Mortality in patients with hip fractures: A Comprehensive Analysis

Öz

Aim: Hip fractures cause high mortality in older adults. This study examined the success of inflammatory markers detected at hospital admission in predicting long-term survival outcomes in elderly patients undergoing hip fracture surgery.
Materials and Methods: The retrospective cohort study analyzed 90 patients aged 65 years and older who received hip fracture surgery from 2016 through 2020. The patients were separated into two groups based on their one-year follow-up status: survivors (n=78) and deaths (n=12). The admission measurements included Neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR) and C-reactive protein/albumin ratio (CAR). The ROC analysis determined the optimal cut-off values. The Cox regression analysis evaluated the risk factors for mortality.
Results: One-year mortality was 13.3%. In ROC analysis, the area under the curve was 0.78 for CAR, 0.72 for NLR and 0.68 for MLR. The optimal cut-off value for CAR was 1.36 (sensitivity 83%, specificity 71%). In multivariate analysis, CAR≥1.36 (HR=2.18; p=0.006), advanced age (HR=1.06; p=0.003) and high comorbidity index (HR=1.25; p=0.032) were independent predictors of mortality.
Conclusions: On admission, CAR has a higher predictive value than other inflammatory markers in predicting mortality in hip fracture patients. This simple and easily calculated parameter can be used in risk assessment.

Anahtar Kelimeler

Biomarkers, C-Reactive Protein, Hip Fractures, Mortality

Etik Beyan

Sayı :E-95531838-050.99-98294 ………… Konu : Etik Kurul Kararı Sayın Op. Dr. Ali Can ÇİÇEK İlgi : Op. Dr. Ali Can ÇİÇEK’in 26.03.2024 tarih ve 98011 varide sayılı dilekçesi Op. Dr. Ali Can ÇİÇEK'in ilgi dilekçesi ile Op. Dr. Ali Can ÇİÇEK ve Op. Dr. Mehmet Fatih AKSAY'ın "Kalça Kırığı Olan Hastalarda Mortalitenin Belirleyicisi Olarak İnflamatuar Biyobelirteçler" başlıklı bilimsel araştırması Ağrı İbrahim Çeçen Üniversitesi Bilimsel Araştırmalar Etik Kurulunca incelenmiş olup, 28.03.2024 tarih ve 136 sayılı karar ile söz konusu araştırmaya izin verilmiştir.

Kaynakça

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Kaynak Göster

APA
Çiçek, A. C., & Aksay, M. F. (2026). Inflammatory biomarkers as Predictors of Mortality in patients with hip fractures: A Comprehensive Analysis. Genel Tıp Dergisi, 36(2026), 1-8. https://doi.org/10.54005/geneltip.1737233
AMA
1.Çiçek AC, Aksay MF. Inflammatory biomarkers as Predictors of Mortality in patients with hip fractures: A Comprehensive Analysis. Genel Tıp Derg. 2026;36(2026):1-8. doi:10.54005/geneltip.1737233
Chicago
Çiçek, Ali Can, ve Mehmet Fatih Aksay. 2026. “Inflammatory biomarkers as Predictors of Mortality in patients with hip fractures: A Comprehensive Analysis”. Genel Tıp Dergisi 36 (2026): 1-8. https://doi.org/10.54005/geneltip.1737233.
EndNote
Çiçek AC, Aksay MF (01 Haziran 2026) Inflammatory biomarkers as Predictors of Mortality in patients with hip fractures: A Comprehensive Analysis. Genel Tıp Dergisi 36 2026 1–8.
IEEE
[1]A. C. Çiçek ve M. F. Aksay, “Inflammatory biomarkers as Predictors of Mortality in patients with hip fractures: A Comprehensive Analysis”, Genel Tıp Derg, c. 36, sy 2026, ss. 1–8, Haz. 2026, doi: 10.54005/geneltip.1737233.
ISNAD
Çiçek, Ali Can - Aksay, Mehmet Fatih. “Inflammatory biomarkers as Predictors of Mortality in patients with hip fractures: A Comprehensive Analysis”. Genel Tıp Dergisi 36/2026 (01 Haziran 2026): 1-8. https://doi.org/10.54005/geneltip.1737233.
JAMA
1.Çiçek AC, Aksay MF. Inflammatory biomarkers as Predictors of Mortality in patients with hip fractures: A Comprehensive Analysis. Genel Tıp Derg. 2026;36:1–8.
MLA
Çiçek, Ali Can, ve Mehmet Fatih Aksay. “Inflammatory biomarkers as Predictors of Mortality in patients with hip fractures: A Comprehensive Analysis”. Genel Tıp Dergisi, c. 36, sy 2026, Haziran 2026, ss. 1-8, doi:10.54005/geneltip.1737233.
Vancouver
1.Ali Can Çiçek, Mehmet Fatih Aksay. Inflammatory biomarkers as Predictors of Mortality in patients with hip fractures: A Comprehensive Analysis. Genel Tıp Derg. 01 Haziran 2026;36(2026):1-8. doi:10.54005/geneltip.1737233