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Impact of Platelet-Rich Fibrin Application on Postoperative Healing Following Tooth Extraction and Sequestrectomy in Patients Receiving Antiresorptive Therapy: A Retrospective Study

Cilt: 36 Sayı: 2026 22 Ocak 2026
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Impact of Platelet-Rich Fibrin Application on Postoperative Healing Following Tooth Extraction and Sequestrectomy in Patients Receiving Antiresorptive Therapy: A Retrospective Study

Öz

Aim: This study aimed to retrospectively evaluate the effects of Platelet-Rich Fibrin (PRF) application on postoperative healing following tooth extraction or sequestrectomy in patients with a history of antiresorptive drug use.
Materials and Methods: A total of 47 patients who underwent either tooth extraction (n = 33) or sequestrectomy (n = 14) with simultaneous PRF application were included. Patients were followed postoperatively at 1 week, 1 month, and 3 months. Wound closure status and presence of infection were clinically assessed. Demographic data, indications for drug use, and route of administration were also analyzed.
Results: In the sequestrectomy group, primary wound healing was achieved in 78.6% of patients at week 1, whereas only 6.1% of the tooth extraction group achieved primary wound healing. No signs of infection were observed in either group at the first-week follow-up. By month 3, complete mucosal healing was observed in all patients who underwent tooth extraction, and no cases of Medication-Related Osteonecrosis of the Jaws (MRONJ) development were recorded in this group. In contrast, two patients in the sequestrectomy group experienced recurrence of MRONJ, one of whom also showed signs of infection. PRF application was associated with low infection rates, successful mucosal closure, and the absence of new MRONJ cases in the extraction group.
Conclusions: PRF may serve as a beneficial adjunct in surgical management of patients receiving antiresorptive therapy by supporting wound healing and reducing complications. Further prospective, controlled studies are warranted to validate these findings.

Anahtar Kelimeler

Denosumab, Diphosphonates, Medication-Related Osteonecrosis of the Jaw, Platelet-Rich Fibrin, Wound Healing

Kaynakça

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Kaynak Göster

APA
Şengün, D. N., Kocamaz, Ö. F., Manav, Ö. C., & Kitap, M. C. (2026). Impact of Platelet-Rich Fibrin Application on Postoperative Healing Following Tooth Extraction and Sequestrectomy in Patients Receiving Antiresorptive Therapy: A Retrospective Study. Genel Tıp Dergisi, 36(2026), 1-6. https://doi.org/10.54005/geneltip.1773809
AMA
1.Şengün DN, Kocamaz ÖF, Manav ÖC, Kitap MC. Impact of Platelet-Rich Fibrin Application on Postoperative Healing Following Tooth Extraction and Sequestrectomy in Patients Receiving Antiresorptive Therapy: A Retrospective Study. Genel Tıp Derg. 2026;36(2026):1-6. doi:10.54005/geneltip.1773809
Chicago
Şengün, Dilara Nur, Ömer Faruk Kocamaz, Ömer Can Manav, ve Murat Cem Kitap. 2026. “Impact of Platelet-Rich Fibrin Application on Postoperative Healing Following Tooth Extraction and Sequestrectomy in Patients Receiving Antiresorptive Therapy: A Retrospective Study”. Genel Tıp Dergisi 36 (2026): 1-6. https://doi.org/10.54005/geneltip.1773809.
EndNote
Şengün DN, Kocamaz ÖF, Manav ÖC, Kitap MC (01 Ocak 2026) Impact of Platelet-Rich Fibrin Application on Postoperative Healing Following Tooth Extraction and Sequestrectomy in Patients Receiving Antiresorptive Therapy: A Retrospective Study. Genel Tıp Dergisi 36 2026 1–6.
IEEE
[1]D. N. Şengün, Ö. F. Kocamaz, Ö. C. Manav, ve M. C. Kitap, “Impact of Platelet-Rich Fibrin Application on Postoperative Healing Following Tooth Extraction and Sequestrectomy in Patients Receiving Antiresorptive Therapy: A Retrospective Study”, Genel Tıp Derg, c. 36, sy 2026, ss. 1–6, Oca. 2026, doi: 10.54005/geneltip.1773809.
ISNAD
Şengün, Dilara Nur - Kocamaz, Ömer Faruk - Manav, Ömer Can - Kitap, Murat Cem. “Impact of Platelet-Rich Fibrin Application on Postoperative Healing Following Tooth Extraction and Sequestrectomy in Patients Receiving Antiresorptive Therapy: A Retrospective Study”. Genel Tıp Dergisi 36/2026 (01 Ocak 2026): 1-6. https://doi.org/10.54005/geneltip.1773809.
JAMA
1.Şengün DN, Kocamaz ÖF, Manav ÖC, Kitap MC. Impact of Platelet-Rich Fibrin Application on Postoperative Healing Following Tooth Extraction and Sequestrectomy in Patients Receiving Antiresorptive Therapy: A Retrospective Study. Genel Tıp Derg. 2026;36:1–6.
MLA
Şengün, Dilara Nur, vd. “Impact of Platelet-Rich Fibrin Application on Postoperative Healing Following Tooth Extraction and Sequestrectomy in Patients Receiving Antiresorptive Therapy: A Retrospective Study”. Genel Tıp Dergisi, c. 36, sy 2026, Ocak 2026, ss. 1-6, doi:10.54005/geneltip.1773809.
Vancouver
1.Dilara Nur Şengün, Ömer Faruk Kocamaz, Ömer Can Manav, Murat Cem Kitap. Impact of Platelet-Rich Fibrin Application on Postoperative Healing Following Tooth Extraction and Sequestrectomy in Patients Receiving Antiresorptive Therapy: A Retrospective Study. Genel Tıp Derg. 01 Ocak 2026;36(2026):1-6. doi:10.54005/geneltip.1773809