Araştırma Makalesi

DECREASED SIRTUIN 1 GENE EXPRESSİON IN HUMAN EJACULATED SPERM IS ASSOCIATED WITH UNEXPLAINED INFERTILITY

Cilt: 36 Sayı: 2026 10 Şubat 2026
PDF İndir
EN TR

DECREASED SIRTUIN 1 GENE EXPRESSİON IN HUMAN EJACULATED SPERM IS ASSOCIATED WITH UNEXPLAINED INFERTILITY

Öz

Aims: The potential mechanisms underlying unexplained infertility, which is a condition in which couples experience infertility without an identifiable cause in both man and woman, have not yet been clarified. The present study aimed to investigate the role of Sirtuin 1 (SIRT1) gene in male infertility and unexplained infertility. Methods: A total of 50 couples who applied for infertility evaluation and treatment were included in the study. The couples' medical histories were taken and their fertility status was evaluated. Semen analysis results evaluated according to World Health Organization (WHO, 2010) criteria were divided into low and normal semen parameter groups in terms of sperm count and motility parameters. Couples were further categorized into three groups according to their fertility status; Non-infertility group (n=13): Couples without clinical infertility (no female and male factor (normal semen variables)). Male infertility group (n=19): Couples with clinical infertility (no female factor, with male factor (abnormal semen variables)). Unexplained infertility group (n=18): Couples with clinical infertility without an identifiable cause in male (normal semen variables) and female. Changes in SIRT1 gene expression between the groups were investigated using qPCR. Results: SIRT1 gene expression was not associated with sperm count and motility parameters. However, SIRT1 expression was observed to be significantly decreased in male infertility and, more importantly, in unexplained infertility groups, compared to the non-infertility group. Conclusions: Our study suggests that decreased SIRT1 may play a role in fertilization potential by affecting possibly different functions of sperm rather than count and motility parameters and may be one of the possible mechanisms underlying unexplained infertility.

Anahtar Kelimeler

Male infertility, Unexplained infertility, Semen parameters, Sirtuin 1 gene

Kaynakça

  1. 1. Gerrits T, Van Rooij F, Esho T, Ndegwa W, Goossens J, Bilajbegovic A, et al. Infertility in the Global South: Raising awareness and generating insights for policy and practice. Facts Views Vis Obgyn 2017; 9(1): 39-44.
  2. 2. Agarwal A, Baskaran S, Parekh N, Cho CL, Henkel R, Vij S, et al. Male infertility. Lancet 2021; 397(10271): 319-333. doi:10.1016/S0140-6736(20)32667-2
  3. 3. Practice Committee of the American Society for Reproductive Medicine. Electronic address: asrm@asrm.org; Practice Committee of the American Society for Reproductive Medicine. Evidence-based treatments for couples with unexplained infertility: a guideline. Fertil Steril 2020; 113(2): 305-322. doi:10.1016/j.fertnstert.2019.10.014
  4. 4. World Health Organization. WHO laboratory manual for the examination and processing of human semen, 5th edition, Geneva: World Health Organization 2010.
  5. 5. Barbagallo F, La Vignera S, Cannarella R, Mongioì LM, Garofalo V, Leanza C, et al. Obesity and Male Reproduction: Do Sirtuins Play a Role? Int J Mol Sci 2022; 23(2): 973. doi:10.3390/ijms23020973
  6. 6. Loganathan C, Kannan A, Panneerselvam A, Mariajoseph-Antony LF, Kumar SA, Anbarasu K, et al. The possible role of sirtuins in male reproduction. Mol Cell Biochem 2021; 476(7): 2857-2867. doi:10.1007/s11010-021-04116-2
  7. 7. Tatone C, Di Emidio G, Barbonetti A, Carta G, Luciano AM, Falone S, et al. Sirtuins in gamete biology and reproductive physiology: emerging roles and therapeutic potential in female and male infertility. Hum Reprod Update 2018; 24(3): 267-289. doi:10.1093/humupd/dmy003
  8. 8. McBurney MW, Yang X, Jardine K, Hixon M, Boekelheide K, Webb JR, et al. The mammalian SIR2alpha protein has a role in embryogenesis and gametogenesis. Mol Cell Biol 2003; 23(1): 38-54. doi:10.1128/MCB.23.1.38-54.2003
  9. 9. Kolthur Seetharam U, Teerds K, de Rooij DG, Wendling O, McBurney M, Sassone-Corsi P, et al. The histone deacetylase SIRT1 controls male fertility in mice through regulation of hypothalamic-pituitary gonadotropin signaling. Biol Reprod 2009; 80(2): 384-391. doi:10.1095/biolreprod.108.070193
  10. 10. Cavalcanti MC, Failling K, Schuppe HC, Bergmann M, Stalf T, Weidner W, et al. Validation of reference genes in human testis and ejaculate. Andrologia 2011; 43(5): 361-367. doi:10.1111/j.1439-0272.2010.01076.x

Kaynak Göster

APA
Dursunoğlu, D., Arıkoğlu, H., Göktürk, F., & Erkoç Kaya, D. (2026). DECREASED SIRTUIN 1 GENE EXPRESSİON IN HUMAN EJACULATED SPERM IS ASSOCIATED WITH UNEXPLAINED INFERTILITY. Genel Tıp Dergisi, 36(2026), 1-5. https://doi.org/10.54005/geneltip.1780224
AMA
1.Dursunoğlu D, Arıkoğlu H, Göktürk F, Erkoç Kaya D. DECREASED SIRTUIN 1 GENE EXPRESSİON IN HUMAN EJACULATED SPERM IS ASSOCIATED WITH UNEXPLAINED INFERTILITY. Genel Tıp Derg. 2026;36(2026):1-5. doi:10.54005/geneltip.1780224
Chicago
Dursunoğlu, Duygu, Hilal Arıkoğlu, Fatma Göktürk, ve Dudu Erkoç Kaya. 2026. “DECREASED SIRTUIN 1 GENE EXPRESSİON IN HUMAN EJACULATED SPERM IS ASSOCIATED WITH UNEXPLAINED INFERTILITY”. Genel Tıp Dergisi 36 (2026): 1-5. https://doi.org/10.54005/geneltip.1780224.
EndNote
Dursunoğlu D, Arıkoğlu H, Göktürk F, Erkoç Kaya D (01 Şubat 2026) DECREASED SIRTUIN 1 GENE EXPRESSİON IN HUMAN EJACULATED SPERM IS ASSOCIATED WITH UNEXPLAINED INFERTILITY. Genel Tıp Dergisi 36 2026 1–5.
IEEE
[1]D. Dursunoğlu, H. Arıkoğlu, F. Göktürk, ve D. Erkoç Kaya, “DECREASED SIRTUIN 1 GENE EXPRESSİON IN HUMAN EJACULATED SPERM IS ASSOCIATED WITH UNEXPLAINED INFERTILITY”, Genel Tıp Derg, c. 36, sy 2026, ss. 1–5, Şub. 2026, doi: 10.54005/geneltip.1780224.
ISNAD
Dursunoğlu, Duygu - Arıkoğlu, Hilal - Göktürk, Fatma - Erkoç Kaya, Dudu. “DECREASED SIRTUIN 1 GENE EXPRESSİON IN HUMAN EJACULATED SPERM IS ASSOCIATED WITH UNEXPLAINED INFERTILITY”. Genel Tıp Dergisi 36/2026 (01 Şubat 2026): 1-5. https://doi.org/10.54005/geneltip.1780224.
JAMA
1.Dursunoğlu D, Arıkoğlu H, Göktürk F, Erkoç Kaya D. DECREASED SIRTUIN 1 GENE EXPRESSİON IN HUMAN EJACULATED SPERM IS ASSOCIATED WITH UNEXPLAINED INFERTILITY. Genel Tıp Derg. 2026;36:1–5.
MLA
Dursunoğlu, Duygu, vd. “DECREASED SIRTUIN 1 GENE EXPRESSİON IN HUMAN EJACULATED SPERM IS ASSOCIATED WITH UNEXPLAINED INFERTILITY”. Genel Tıp Dergisi, c. 36, sy 2026, Şubat 2026, ss. 1-5, doi:10.54005/geneltip.1780224.
Vancouver
1.Duygu Dursunoğlu, Hilal Arıkoğlu, Fatma Göktürk, Dudu Erkoç Kaya. DECREASED SIRTUIN 1 GENE EXPRESSİON IN HUMAN EJACULATED SPERM IS ASSOCIATED WITH UNEXPLAINED INFERTILITY. Genel Tıp Derg. 01 Şubat 2026;36(2026):1-5. doi:10.54005/geneltip.1780224