Clinical, Epidemiological, and Antimicrobial Resistance Characteristics of Myroides spp. Isolates in a Tertiary University Hospital: A Retrospective Analysis of 106 Cases
Öz
Aim: Myroides spp. is a rare opportunistic pathogen causing infections that are difficult to treat due to its intrinsic and broad-spectrum antibiotic resistance. This study aimed to retrospectively
investigate the clinical and epidemiological characteristics and antimicrobial resistance profiles of multidrug-resistant Myroides spp. strains isolated in our hospital.
Methods: A total of 106 Myroides spp. isolates, obtained from various clinical specimens at the Necmettin Erbakan University Medical Microbiology Laboratory of Faculty of Medicine Hospital between June 2021 and June 2025, were retrospectively analyzed. Bacterial identification was performed using MALDI-TOF MS, and antibiotic susceptibility testing (AST) was conducted with an automated system (BD Phoenix™). The results were interpreted according to EUCAST criteria.
Results: The mean age of the 106 patients was 67.9 years, and 72.6% were male. The vast majority of isolates were obtained from intensive care units (78.3%) and urine samples (94.3%). All isolates
demonstrated 100% resistance to amikacin, ciprofloxacin, imipenem, levofloxacin, piperacillin/tazobactam, and ceftazidime. The resistance rate for tigecycline was found to be 89.3%.
Conclusion: Myroides spp. is a significant nosocomial pathogen in our institution, predominantly isolated from urinary tract samples in intensive care patients and exhibiting a profile nearing pan-resistance against the tested antimicrobial agents. The severely limited therapeutic options underscore the critical importance of diagnosis, surveillance, and the rigorous implementation of infection control measures for this rare pathogen.
Anahtar Kelimeler
Myroides spp., multidrug resistance, nosocomial infection, urinary tract infection, intensive care unit.
Destekleyen Kurum
Yazarlar bu makalenin araştırılması, yazarlığı ve/veya yayımlanması için hiçbir finansal destek almamıştır.
Etik Beyan
Çalışmamızın, hasta kimlik bilgilerini tamamen gizli tutan ve rutin laboratuvar kayıtlarına dayanan retrospektif tasarımından ötürü, kurumumuzdaki yaygın uygulamalara paralel olarak başlangıçta resmi bir etik kurul onayı alınmamıştır. Bununla birlikte, Genel Tıp Dergisi'nin yüksek etik standartlarına ve başvuru şartlarına tam uyum göstermek amacıyla, çalışmamız için resmi etik kurul başvuru sürecini başlatmış bulunmaktayız. Onay belgesinin, hakem değerlendirme süreci esnasında veya makalenin kabulünden önce tarafınıza sunulacağını taahhüt ederiz. Çalışmamızın Helsinki Deklarasyonu'nun etik ilkelerine uygun olarak yürütüldüğünü teyit ederiz.
Teşekkür
Yoktur.
Kaynakça
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