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Clinical, Epidemiological, and Antimicrobial Resistance Characteristics of Myroides spp. Isolates in a Tertiary University Hospital: A Retrospective Analysis of 106 Cases

Cilt: 36 Sayı: 2026 2 Şubat 2026
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Clinical, Epidemiological, and Antimicrobial Resistance Characteristics of Myroides spp. Isolates in a Tertiary University Hospital: A Retrospective Analysis of 106 Cases

Öz

Aim: Myroides spp. is a rare opportunistic pathogen causing infections that are difficult to treat due to its intrinsic and broad-spectrum antibiotic resistance. This study aimed to retrospectively investigate the clinical and epidemiological characteristics and antimicrobial resistance profiles of multidrug-resistant Myroides spp. strains isolated in our hospital. Methods: A total of 106 Myroides spp. isolates, obtained from various clinical specimens at the Necmettin Erbakan University Medical Microbiology Laboratory of Faculty of Medicine Hospital between June 2021 and June 2025, were retrospectively analyzed. Bacterial identification was performed using MALDI-TOF MS, and antibiotic susceptibility testing (AST) was conducted with an automated system (BD Phoenix™). The results were interpreted according to EUCAST criteria. Results: The mean age of the 106 patients was 67.9 years, and 72.6% were male. The vast majority of isolates were obtained from intensive care units (78.3%) and urine samples (94.3%). All isolates demonstrated 100% resistance to amikacin, ciprofloxacin, imipenem, levofloxacin, piperacillin/tazobactam, and ceftazidime. The resistance rate for tigecycline was found to be 89.3%. Conclusion: Myroides spp. is a significant nosocomial pathogen in our institution, predominantly isolated from urinary tract samples in intensive care patients and exhibiting a profile nearing pan-resistance against the tested antimicrobial agents. The severely limited therapeutic options underscore the critical importance of diagnosis, surveillance, and the rigorous implementation of infection control measures for this rare pathogen.

Anahtar Kelimeler

Myroides spp., multidrug resistance, nosocomial infection, urinary tract infection, intensive care unit.

Destekleyen Kurum

The authors received no financial support for the research, authorship, and/or publication of this article.

Etik Beyan

Due to the retrospective design of our study, which is based on the analysis of fully anonymized, routine laboratory data, a formal ethics committee approval was not initially sought, in line with common institutional practice. However, to ensure full compliance with the high ethical standards and submission requirements of The Journal of General Medicine, we have initiated the formal application process to obtain ethics committee approval for this study. We commit to providing the official approval document during the peer-review process or prior to the final acceptance of the manuscript. We affirm that our study was conducted in accordance with the ethical principles of the Declaration of Helsinki.

Teşekkür

None.

Kaynakça

  1. 1. Jonas N, Valerian DM, Henry S, Magembe E, Abednego R, Urio L, et al. Prevalence and antimicrobial susceptibility pattern of gram-negative bacteria contaminating the hands of patients’ visitors at regional referral hospitals in Dar-es-Salaam. PLoS One 2025; 20:e0320700.
  2. 2. Ming DS, Chen QQ, Chen XT. Analysis of resistance genes in pan-resistant Myroides odoratimimus clinical strain PR63039 using whole genome sequencing. Microb Pathog 2017; 112:114-117.
  3. 3. Gülmez A, Ceylan AN, Özalp O. An increasing threat in intensive care units: evaluation of multi-drug-resistant Myroides spp. infections and risk factors. J Hosp Infect 2023; 137:8–16.
  4. 4. Karvar Ş, Okumuş E, Tutan KN, Yeşilyurt AÖ. Clonal outbreak of Myroides odoratimimus in ICU patients: A descriptive analysis of pan-drug resistance and associated mortality. Diagn Microbiol Infect Dis 2025; 113:117066.
  5. 5. Lorenzin G, Piccinelli G, Carlassara L, Scolari F, Caccuri F, Caruso A, et al. Myroides odoratimimus urinary tract infection in an immunocompromised patient: An emerging multidrug-resistant micro-organism. Antimicrob Resist Infect Control 2018; 7:100.
  6. 6. Biswal D, Pandey S, Mangla S, Khan S, Arora A, Mehta V, et al. From obscurity to infamy: Myroides as an opportunistic Uropathogen - A clinical vignette and comprehensive review of literature. Indian J Med Microbiol 2025; 54:100811.
  7. 7. Beharrysingh R. Myroides bacteremia: A case report and concise review. IDCases 2017; 8:68-70.
  8. 8. Alabdely MH, Englund K, Shrestha NK. Clinical Features and Outcomes of Myroides Species Infections. Open Forum Infect Dis 2025; 12:ofaf049.
  9. 9. Pérez-Lazo G, Morales-Moreno A, Soto-Febres F, Jove-Químper H, Morales-Castillo L, Palomares-Reyes C, et al. First report of Myroides phaeus bacteraemia identified by Polymerase chain reaction and genetic sequencing. IDCases 2020; 19:e00695.
  10. 10. Schröttner P, Rudolph WW, Eing BR, Bertram S, Gunzer F. Comparison of VITEK2, MALDI-TOF MS, and 16S rDNA sequencing for identification of Myroides odoratus and Myroides odoratimimus. Diagn Microbiol Infect Dis 2014; 79:149-152.

Kaynak Göster

APA
Gülbay, S. R., Ağralı, M. Ş., & Doğan, M. (2026). Clinical, Epidemiological, and Antimicrobial Resistance Characteristics of Myroides spp. Isolates in a Tertiary University Hospital: A Retrospective Analysis of 106 Cases. Genel Tıp Dergisi, 36(2026), 1-6. https://doi.org/10.54005/geneltip.1805063
AMA
1.Gülbay SR, Ağralı MŞ, Doğan M. Clinical, Epidemiological, and Antimicrobial Resistance Characteristics of Myroides spp. Isolates in a Tertiary University Hospital: A Retrospective Analysis of 106 Cases. Genel Tıp Derg. 2026;36(2026):1-6. doi:10.54005/geneltip.1805063
Chicago
Gülbay, Sait Ramazan, Muhammet Şükrü Ağralı, ve Metin Doğan. 2026. “Clinical, Epidemiological, and Antimicrobial Resistance Characteristics of Myroides spp. Isolates in a Tertiary University Hospital: A Retrospective Analysis of 106 Cases”. Genel Tıp Dergisi 36 (2026): 1-6. https://doi.org/10.54005/geneltip.1805063.
EndNote
Gülbay SR, Ağralı MŞ, Doğan M (01 Şubat 2026) Clinical, Epidemiological, and Antimicrobial Resistance Characteristics of Myroides spp. Isolates in a Tertiary University Hospital: A Retrospective Analysis of 106 Cases. Genel Tıp Dergisi 36 2026 1–6.
IEEE
[1]S. R. Gülbay, M. Ş. Ağralı, ve M. Doğan, “Clinical, Epidemiological, and Antimicrobial Resistance Characteristics of Myroides spp. Isolates in a Tertiary University Hospital: A Retrospective Analysis of 106 Cases”, Genel Tıp Derg, c. 36, sy 2026, ss. 1–6, Şub. 2026, doi: 10.54005/geneltip.1805063.
ISNAD
Gülbay, Sait Ramazan - Ağralı, Muhammet Şükrü - Doğan, Metin. “Clinical, Epidemiological, and Antimicrobial Resistance Characteristics of Myroides spp. Isolates in a Tertiary University Hospital: A Retrospective Analysis of 106 Cases”. Genel Tıp Dergisi 36/2026 (01 Şubat 2026): 1-6. https://doi.org/10.54005/geneltip.1805063.
JAMA
1.Gülbay SR, Ağralı MŞ, Doğan M. Clinical, Epidemiological, and Antimicrobial Resistance Characteristics of Myroides spp. Isolates in a Tertiary University Hospital: A Retrospective Analysis of 106 Cases. Genel Tıp Derg. 2026;36:1–6.
MLA
Gülbay, Sait Ramazan, vd. “Clinical, Epidemiological, and Antimicrobial Resistance Characteristics of Myroides spp. Isolates in a Tertiary University Hospital: A Retrospective Analysis of 106 Cases”. Genel Tıp Dergisi, c. 36, sy 2026, Şubat 2026, ss. 1-6, doi:10.54005/geneltip.1805063.
Vancouver
1.Sait Ramazan Gülbay, Muhammet Şükrü Ağralı, Metin Doğan. Clinical, Epidemiological, and Antimicrobial Resistance Characteristics of Myroides spp. Isolates in a Tertiary University Hospital: A Retrospective Analysis of 106 Cases. Genel Tıp Derg. 01 Şubat 2026;36(2026):1-6. doi:10.54005/geneltip.1805063