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Evaluation of Myocardial Protection Efficacy of del Nido Cardioplegia: A Comparative Study with Intermittent Cold Blood Cardioplegia

Cilt: 36 Sayı: 2026 5 Ekim 2026
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Evaluation of Myocardial Protection Efficacy of del Nido Cardioplegia: A Comparative Study with Intermittent Cold Blood Cardioplegia

Öz

Aim: Effective myocardial protection is crucial for successful outcomes in open-heart surgery. Hyperkalemic solutions have traditionally been used, with improvements leading to various cardioplegia types. Del Nido cardioplegia , initially designed for pediatric use, is increasingly adopted in adult cardiac surgery. This study aims to evaluate the efficacy of del Nido cardioplegia in myocardial protection based on clinical, biochemical, and hemodynamic parameters.
Materials and Methods: Thirty patients who underwent coronary artery bypass grafting between July and September 2018 at our clinic were included. Patients had similar demographics. Del Nido Cardioplegia was used in 15 patients, and intermittent cold blood cardioplegia after crystalloid induction was used in the remaining 15 patients. Preoperative, intraoperative, and postoperative data were analyzed.
Results: No significant differences were observed between groups regarding demographic characteristics, comorbidities, or surgical technique (p>0.05). Pre- and postoperative values for ejection fraction, cardiac output, and cardiac index showed no statistical differences (p>0.05). Troponin I patterns were also similar (p>0.05). Cross-clamp and cardiopulmonary bypass times were significantly shorter in the del Nido Cardioplegia group (48.9±2.8 min and 70.2±2.2 min) compared to the blood cardioplegia group (55.5±2.9 min and 78±2.7 min) (p<0.001). The del Nido cardioplegia group also had a lower requirement for defibrillation post-clamp removal (p<0.001). No differences were found regarding postoperative complications or intensive care unit stay duration (p>0.05).
Conclusion: Del Nido cardioplegia provides effective myocardial protection comparable to blood cardioplegia and may offer advantages in surgical flow due to reduced perfusion times, supporting its safe use in adult coronary artery bypass graft procedures.

Anahtar Kelimeler

coronary artery bypass, myocardial protection, del Nido, blood cardioplegia

Destekleyen Kurum

The authors received no financial support for the research, authorship, and/or publication of this article.

Etik Beyan

Ethics committee approval was obtained from the 2011-KAEK-25 Ethics Committee (Approval No: 2018/07-21).

Kaynakça

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Kaynak Göster

APA
Kaymakci, E., Koç, M., Engin, M., Gucu, A., & Göncü, M. T. (2026). Evaluation of Myocardial Protection Efficacy of del Nido Cardioplegia: A Comparative Study with Intermittent Cold Blood Cardioplegia. Genel Tıp Dergisi, 36(2026), 1-7. https://doi.org/10.54005/geneltip.1861131
AMA
1.Kaymakci E, Koç M, Engin M, Gucu A, Göncü MT. Evaluation of Myocardial Protection Efficacy of del Nido Cardioplegia: A Comparative Study with Intermittent Cold Blood Cardioplegia. Genel Tıp Derg. 2026;36(2026):1-7. doi:10.54005/geneltip.1861131
Chicago
Kaymakci, Emre, Murat Koç, Mesut Engin, Arif Gucu, ve Mehmet Tuğrul Göncü. 2026. “Evaluation of Myocardial Protection Efficacy of del Nido Cardioplegia: A Comparative Study with Intermittent Cold Blood Cardioplegia”. Genel Tıp Dergisi 36 (2026): 1-7. https://doi.org/10.54005/geneltip.1861131.
EndNote
Kaymakci E, Koç M, Engin M, Gucu A, Göncü MT (01 Ekim 2026) Evaluation of Myocardial Protection Efficacy of del Nido Cardioplegia: A Comparative Study with Intermittent Cold Blood Cardioplegia. Genel Tıp Dergisi 36 2026 1–7.
IEEE
[1]E. Kaymakci, M. Koç, M. Engin, A. Gucu, ve M. T. Göncü, “Evaluation of Myocardial Protection Efficacy of del Nido Cardioplegia: A Comparative Study with Intermittent Cold Blood Cardioplegia”, Genel Tıp Derg, c. 36, sy 2026, ss. 1–7, Eki. 2026, doi: 10.54005/geneltip.1861131.
ISNAD
Kaymakci, Emre - Koç, Murat - Engin, Mesut - Gucu, Arif - Göncü, Mehmet Tuğrul. “Evaluation of Myocardial Protection Efficacy of del Nido Cardioplegia: A Comparative Study with Intermittent Cold Blood Cardioplegia”. Genel Tıp Dergisi 36/2026 (01 Ekim 2026): 1-7. https://doi.org/10.54005/geneltip.1861131.
JAMA
1.Kaymakci E, Koç M, Engin M, Gucu A, Göncü MT. Evaluation of Myocardial Protection Efficacy of del Nido Cardioplegia: A Comparative Study with Intermittent Cold Blood Cardioplegia. Genel Tıp Derg. 2026;36:1–7.
MLA
Kaymakci, Emre, vd. “Evaluation of Myocardial Protection Efficacy of del Nido Cardioplegia: A Comparative Study with Intermittent Cold Blood Cardioplegia”. Genel Tıp Dergisi, c. 36, sy 2026, Ekim 2026, ss. 1-7, doi:10.54005/geneltip.1861131.
Vancouver
1.Emre Kaymakci, Murat Koç, Mesut Engin, Arif Gucu, Mehmet Tuğrul Göncü. Evaluation of Myocardial Protection Efficacy of del Nido Cardioplegia: A Comparative Study with Intermittent Cold Blood Cardioplegia. Genel Tıp Derg. 01 Ekim 2026;36(2026):1-7. doi:10.54005/geneltip.1861131