Evaluation of Electrocardiographic and Echocardiographic Findings In Patients Diagnosed with Polycythemia Vera and Essential Thrombocythemia

Yıl 2024, Cilt: 34 Sayı: 1, 51 - 56, 29.02.2024

Bahattin Engin Kaya , Sinan Demircioğlu , Atakan Tekinalp , Ahmet Lütfü Sertdemir , Mustafa Çağrı Ergün , Ali Kürşat Tuna , Şerif Ahmet Kandemir , Abdullah İçli , Özcan Çeneli

https://doi.org/10.54005/geneltip.1342363

Öz

Background/Aims: Polycythemia vera (PV) and essential thrombocythemia (ET) are chronic myeloproliferative diseases. Along with the increase in myeloproliferative cell lines, they can cause various clinical outcomes such as arterial and venous thrombosis, pulmonary hypertension, and myocardial infarction. This study was designed to evaluate the cardiac effects of these diseases via electrocardiography and echocardiography.
Methods: A total of 50 patients with a diagnosis of PV, 50 patients with a diagnosis of ET, and 50 healthy individuals as a control group were included in this study. Data on patient demographics were recorded in all subjects. All patients and control subjects had electrocardiography (ECG) recordings and routine transthoracic echocardiographic examination. Pulse wave velocity (PWV) was assessed with a Holter blood pressure device.
Results: In total, 50 PV patients, 50 ET patients, and 50 control group were included in the study. The demographic characteristics of the PV, ET and control groups were similar. The PR interval was significantly shorter in control subjects than in PV and ET patients (p:0.007, p:0.024). Although the measured values were within normal limits, diastolic posterior wall thickness was significantly lower in the control group compared to PV and ET patients (p:0.019, p:0.009). PWV was significantly higher in ET patients compared to the control group (p:0.012).
Conclusion: In this study, evaluating the effects of PV and ET on electrocardiography and transthoracic echocardiography; ECG parameters used to predict ventricular arrhythmias (QT, QTc, Tp-Te, Tp-Te/QT) and Pulmonary Artery Pressure showed no significant change, in opposition to existing literature. Nonetheless, similar to previous publications, PV and ET were found to negatively affect the diastolic function parameters on transthoracic echocardiography. While the aortic stiffness was significantly higher in ET patients compared to the control group, no significant difference was noted between PV patients and control subjects in terms of aortic stiffness.

Anahtar Kelimeler

Polycythemia vera, Essential thrombocythemia, electrocardiography, echocardiography

Polistemi Vera ve Esansiyel Trombositemi Tanısı Alan Hastalarda Elektrokardiyografik ve Ekokardiyografik Bulgularının Değerlendirilmesi

Öz

Amaç: Polisitemia vera (PV) ve Esansiyel trombositemi (ET) kronik myeloproliferatif hastalıklardır. Myeloproliferatif seride artışla beraber arterial ve venöz trombozlar, pulmoner hipertansiyon, miyokarda infarktüsü gibi çeşitli klinik sonuçlar oluşturabilmektedirler. Çalışmamızda bu hastalıkların kalp üzerine etkilerini elektrokardiyografi ve ekokardiyografi ile değerlendirme amaçlanmıştır.
Gereç ve Yöntem: Çalışmamıza PV tanılı 50 hasta ET tanılı 50 hasta ve kontrol grubu olarak sağlıklı 50 kişi alındı. Hasta demografik bilgilerine ilişkin veriler tüm deneklerde kaydedildi. Tüm hastalara ve kontrollere elektrokardiyografi (EKG) kayıtları ve rutin transtorasik ekokardiyografik inceleme yapıldı. Nabız dalga hızı (PWV), bir Holter kan basıncı cihazı ile değerlendirildi.
Bulgular: Çalışmaya toplam 50 PV hastası, 50 ET hastası ve 50 kontrol grubu dahil edildi. PV, ET ve kontrol gruplarının demografik özellikleri benzerdi. PR aralığı, kontrol olgularında PV ve ET hastalarına göre anlamlı olarak daha kısaydı (p = 0.007, p = 0.024). Ölçülen değerler normal sınırlarda olmasına rağmen kontrol grubunda diyastolik arka duvar kalınlığı PV ve ET hastalarına göre anlamlı olarak düşüktü (p = 0,019, p = 0,009). PWV, ET hastalarında kontrol grubuna göre anlamlı olarak yüksekti (p = 0.012).
Sonuç: Ventriküler aritmileri öngörmek için kullanılan EKG parametreleri (QT, QTc, Tp-Te, Tp-Te/QT) ve Pulmoner Arter Basıncı mevcut literatürün aksine anlamlı bir değişiklik göstermedi. Bununla birlikte, önceki yayınlara benzer şekilde, transtorasik ekokardiyografide PV ve ET’nin diyastolik fonksiyon parametrelerini olumsuz etkilediği bulundu. Aort sertliği ET hastalarında kontrol grubuna göre anlamlı olarak yüksek bulunurken, PV hastaları ile kontrol grubu arasında aort sertliği açısından anlamlı fark saptanmadı.

Anahtar Kelimeler

Polisitemia vera, Esansiyel trombositemi, elektrokardiyografi, ekokardiyografi, Pulse Wave Velosite

Kaynakça

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