Effects of Psychosocial Stress on Bone Health

Yıl 2020, Cilt: 3 Sayı: 2, 66 - 74, 31.08.2020

Mustafa Emre

https://doi.org/10.47141/geriatrik.727624

Öz

Summary: At the present time, it has been shown that physical stress stimulates the bone remodeling and affects the bone structure and function through complex mechanotransduction mechanisms. Recent research support the hypothesis that as well as physical stress, psychosocial stress (mental, behavioral, emotional) also affects the bone biology and eventually leads to osteoporosis, bone pain and increased risk of bone fracture. It has been considered that these effects originates from modulation of activity around the hypothalamic-pituitary-adrenal axis. In human and experimental animal studies, it has been reported that psychosocial stress brings about changes related to insulin-like growth factors, glucocorticoids, catecholamines, serotonin, GABA, brain-derived neurotrophic factor, receptor activator nuclear kappa ligand and release in cytokines (IL-1-6-11 -17, TNFα). This review summarises the current state of knowledge that psychosocial stress has a crucial role in structural adaptation of bone.

Keywords: Stress, osteoporosis, bone health

Anahtar Kelimeler

Stress, osteoporosis, bone health

Psikososyal Stresin Kemik Sağlığına Etkileri

Öz

Özet: Günümüzde, fiziksel stresin kemiğin yeniden şekillenmesini uyardığını ve karmaşık mekanotransdüksiyon mekanizmalarıyla kemik yapısını ve işlevini etkilediği gösterilmiştir. Son yapılan araştırmalar, fiziksel stresin yanı sıra psikososyal stresinde (zihinsel, davranışsal, duygusal) kemik biyolojisini etkilediği ve sonunda osteoporoza, kemik ağrılarına ve kemik kırık riskinin artmasına neden olduğu hipotezine zemin hazırlamıştır. Bu etkiler, muhtemelen hipotalamik-hipofiz-adrenal eksenindeki aktivitenin modülasyonu ile gerçekleştirildiği düşünülmektedir. İnsan ve deneysel hayvan çalışmalarında, psikososyal stresin insülin benzeri büyüme faktörleri, glukokortikoidler, katekolaminler, serotonin, GABA, beyin kaynaklı nörotrofik faktör, reseptör aktivatör nükleer kappa ligandı ve sitokinlerin (IL-1-6-11-17, TNFα) salınımında değişikliklere neden olduğu bildirilmiştir. Bu derlemede, psikososyal stresin kemiğin yapısal adaptasyonunda önemli bir oyuncu olduğuna dair mevcut bilgi durumu özetlenmiştir.

Anahtar kelimeler: Stres, osteoporoz, kemik sağlığı

Anahtar Kelimeler

Stres, osteoporoz, kemik sağlığı

Kaynakça

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