Kognitif Sağlıklı Yaşlılarda D Vitamini Depresyon ile İlişkili Olabilir mi?

Yıl 2022, Cilt: 5 Sayı: 1, 1 - 7, 30.04.2022

Açelya Gökdeniz Yıldırım Fatma Sena Dost

https://doi.org/10.47141/geriatrik.1086895

Öz

Amaç: Depresyon, yaşlılarda morbidite ve mortaliteye sebep olan geriatrik sendromlardan biridir. Depresyonun erken tanı ve tedavisi bireyin yaşam kalitesi için önemlidir. D vitamini depresyon patofizyolojisinde rol oynayan bir nörosteroid hormondur ve eksikliği yaşlılarda sık görülmektedir. Bu çalışmanın amacı, yaşlılarda sık görülen geriatrik sendromlardan biri olan depresyonun D vitamini ile ilişkisini değerlendirmektir.

Gereç ve Yöntemler: Çalışmaya 60 yaş ve üzeri 392 hasta alındı. Çalışmamız kesitsel retrospektif olarak dizayn edildi. Katılımcıların sosyodemografik verileri, komorbiditeleri, laboratuvar parametreleri, geriatrik depresyon ölçeği puanları, yürüme ve denge ölçeklerini içeren Ayrıntılı Geriatrik Değerlendirme verileri hasta takip dosyalarından incelenerek değerlendirildi. Elde edilen sonuçlarla prevelans analizi yapıldı.

Bulgular: D vitamini değerleri, depresyon tanısı olan grupta, depresyon tanısı olmayan gruptan anlamlı olarak düşüktü (p<0,01). Her iki grup yaş açısından benzerlik göstermekteydi. Depresyon tanısı alanlarda kadın cinsiyet oranı daha fazlaydı (p<0,01). Depresyon; düşme, malnutrisyon, kadın cinsiyet, düşük eğitim durumu ve ilaç sayısı ile ilişkili bulundu (p<0,001). Yaş ve cinsiyet faktörü düzeltildiğinde, depresyonun D vitamini ile ilişkisi ortadan kalktı.

Sonuç: Depresyon ve D vitamini arasında anlamlı bir ilişki bulunmaktadır. Depresyonu olan yaşlı bireylerde D vitamini değerlerini normalize etmek, oluşabilecek morbidite ve mortaliteyi önlemek için yapılan müdahalelerden biri olabilir. Bu konuda yapılacak destekleyici çalışmalara ihtiyaç vardır. 

Anahtar Kelimeler

D vitamini, geriatrik depresyon, geriatrik sendrom

Destekleyen Kurum

yok

Proje Numarası

3308-GOA

May Vitamin D Be Related to Depression in Cognitive Healthy Older Adults?

Öz

Aim: Depression is one of the geriatric syndromes that cause morbidity and mortality in the elderly. Early diagnosis and treatment of depression are essential for the individual's quality of life. Vitamin D is a neurosteroid hormone that plays a role in the pathophysiology of depression, and its deficiency is common in the elderly. This study aims to evaluate the relationship between depression, one of the most common geriatric syndromes in the elderly, and vitamin D.

Material and Methods: 392 patients aged 60 years and older were included in the study. It was designed as a cross-sectional retrospective. Comprehensive Geriatric Assessment data, including participants' sociodemographic data, comorbidities, laboratory parameters, geriatric depression scale scores, and gait and balance scales, were evaluated by examining patient follow-up files. A prevalence analysis was performed with the results obtained.

Results: Vitamin D values were significantly lower in the group with depression than those without depression (p<0.01). There was no significant age difference between the two groups. The female gender ratio was higher in those diagnosed with depression. Depression was associated with falling, malnutrition, female gender, low educational status, and the number of medications (p<0.001). The relation between depression and vitamin D disappeared when age and gender were adjusted.

Conclusions: There is a significant relationship between depression and vitamin D. Normalizing vitamin D values in elderly individuals with depression may be one of the interventions to prevent possible morbidity and mortality. Further studies are needed to support these results.

Anahtar Kelimeler

Vitamin D, geriatric depression, geriatric syndrome

Proje Numarası

3308-GOA

Kaynakça

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