APTAMER TABANLI TANIMLAMA YÖNTEMİ VE GIDA GÜVENLİĞİNDEKİ UYGULAMALARI

Melike Canpolat; Zülal Kesmen

doi:10.15237/gida.GD23145

Derleme

BibTex

RIS

Kaynak Göster

APTAMER BASED IDENTIFICATION METHOD AND ITS APPLICATIONS IN FOOD SAFETY

Yıl 2024, , 536 - 553, 15.06.2024

Melike Canpolat , Zülal Kesmen

https://doi.org/10.15237/gida.GD23145

Öz

Aptamers are single-stranded, short, synthetic nucleic acid sequences. Aptamers, which show high affinity and specific binding to various target molecules, are used for the sensitive detection of various risk factors such as pathogenic microorganisms, biotoxins, allergens, pesticides and heavy metals that may be present in foods. The selection of aptamers specifically binding to molecules that pose a risk in terms of food safety is carried out through a process called SELEX. The selected aptamer interacts specifically with the target molecule and this interaction is measured using electrochemical, optical, or other biosensor techniques. There is a growing interest in aptamer-based methods with high specificity and sensitivity, which provide faster results compared to conventional methods used in food analysis. This review summarized the general properties of aptamers and their production by the SELEX principle and given examples of their applications in food safety.

Anahtar Kelimeler

Aptamer, SELEX, biosensor, biomarker molecule, contamination, food safety

Kaynakça

Ahmadi, N., Pourghobadi, Z., Zare, H. (2021). A highly sensitive FRET biosensor based on aptamer-modified nanocrystals for determination of lysozyme. Optik, 248, 168171. https://doi.org/ 10.1016/j.ijleo.2021.168171
Altalbawy, F. M., Ali, E., Mustafa, Y. F., Ibrahim, A. A., Mansouri, S., Bokov, D. O., Alsaalamy, A. (2024). Comprehensive review on biosensors based on integration of aptamer and magnetic nanomaterials for food analysis. Journal of the Taiwan Institute of Chemical Engineers, 157, 105410. https://doi.org/10.1016/j.jtice.2024.105410
Banerjee, D., Adhikary, S., Bhattacharya, S., Chakraborty, A., Dutta, S., Chatterjee, S., Rajak, P. (2023). Breaking boundaries: Artificial intelligence for pesticide detection and eco-friendly degradation. Environmental Research, 117601. https://doi.org/10.1016/ j.envres.2023.117601
Bilibana, M. P., Citartan, M., Fuku, X., Jijana, A. N., Mathumba, P., Iwuoha, E. (2022). Aptamers functionalized hybrid nanomaterials for algal toxins detection and decontamination in aquatic system: Current progress, opportunities, and challenges. Ecotoxicology and Environmental Safety, 232, 113249. https://doi.org/10.1016/ j.ecoenv.2022.113249
Bottari, F., Daems, E., de Vries, A. M., Van Wielendaele, P., Trashin, S., Blust, R., De Wael, K. (2020). Do aptamers always bind? The need for a multifaceted analytical approach when demonstrating binding affinity between aptamer and low molecular weight compounds. Journal of the American Chemical Society, 142(46), 19622-19630. https://doi.org/10.1021/jacs.0c08691
Brown, A., Brill, J., Amini, R., Nurmi, C., Li, Y. (2024). Development of Better Aptamers: Structured Library Approaches, Selection Methods, and Chemical Modifications. Angewandte Chemie International Edition, e202318665. https://doi.org/10.1002/ anie.202318665
Calabria, D., Zangheri, M., Pour, S. R. S., Trozzi, I., Pace, A., Lazzarini, E., Guardigli, M. (2022). Luminescent aptamer-based bioassays for sensitive detection of food allergens. Biosensors, 12(8), 644. https://doi.org/10.3390/ bios12080644
Chen, Q., Sheng, R., Wang, P., Ouyang, Q., Wang, A., Ali, S., Hassan, M. M. (2020). Ultra-sensitive detection of malathion residues using FRET-based upconversion fluorescence sensor in food. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 241, 118654. https://doi.org/10.1016/j.saa.2020.118654
Chen, Z., Luo, H., Gubu, A., Yu, S., Zhang, H., Dai, H., Zhang, G. (2023). Chemically modified aptamers for improving binding affinity to the target proteins via enhanced non-covalent bonding. Frontiers in Cell and Developmental Biology, 11, 1091809. https://doi.org/10.3389/ fcell.2023.1091809
Chinnappan, R., Eissa, S., Alotaibi, A., Siddiqua, A., Alsager, O. A., Zourob, M. (2020). In vitro selection of DNA aptamers and their integration in a competitive voltammetric biosensor for azlocillin determination in waste water. Analytica chimica acta, 1101, 149-156. https://doi.org/ 10.1016/j.aca.2019.12.023
Darmostuk, M., Rimpelova, S., Gbelcova, H., Ruml, T. (2015). Current approaches in SELEX: An update to aptamer selection technology. Biotechnology advances, 33(6), 1141-1161. https://doi.org/10.1016/ j.biotechadv.2015.02.008
DeRosa, M. C., Lin, A., Mallikaratchy, P., McConnell, E. M., McKeague, M., Patel, R., Shigdar, S. (2023). In vitro selection of aptamers and their applications. Nature Reviews Methods Primers, 3(1), 54. https://doi.org/10.1038/ s43586-023-00247-6
Drees, A., Trinh, T. L., Fischer, M. (2023). The Influence of Protein Charge and Molecular Weight on the Affinity of Aptamers. Pharmaceuticals, 16(3), 457. https://doi.org/ 10.3390/ph16030457
El-Sayed, R. A., Jebur, A. B., Kang, W., El-Demerdash, F. M. (2022). An overview on the major mycotoxins in food products: Characteristics, toxicity, and analysis. Journal of Future Foods, 2(2), 91-102. https://doi.org/10.1016/j.jfutfo.2022.03.002
Fadeev, M., O’Hagan, M. P., Biniuri, Y., Willner, I. (2022). Aptamer–Protein Structures Guide In Silico and Experimental Discovery of Aptamer–Short Peptide Recognition Complexes or Aptamer–Amino Acid Cluster Complexes. The Journal of Physical Chemistry B, 126(44), 8931-8939. https://doi.org/10.1021/acs.jpcb.2c05624
Fan, Y., Li, J., Amin, K., Yu, H., Yang, H., Guo, Z., Liu, J. (2023). Advances in aptamers, and application of mycotoxins detection: a review. Food Research International, 113022. https://doi.org/10.1016/j.foodres.2023.113022
Fei, A., Liu, Q., Huan, J., Qian, J., Dong, X., Qiu, B., Wang, K. (2015). Label-free impedimetric aptasensor for detection of femtomole level acetamiprid using gold nanoparticles decorated multiwalled carbon nanotube-reduced graphene oxide nanoribbon composites. Biosensors and Bioelectronics, 70, 122-129. https://doi.org/ 10.1016/j.bios.2015.03.028
Gao, S., Yang, G., Zhang, X., Lu, Y., Chen, Y., Wu, X., Song, C. (2022). β-Cyclodextrin polymer-based host–guest interaction and fluorescence enhancement of pyrene for sensitive isocarbophos detection. ACS omega, 7(15), 12747-12752. https://doi.org/10.1021/ acsomega.1c07295
Himanshu, J. K., Lakshmi, G. B. V. S., Verma, A. K., Ahlawat, A., Solanki, P. R. (2024). Development of aptasensor for chlorpyrifos detection using paper-based screen-printed electrode. Environmental Research, 240, 117478. https://doi.org/10.1016/j.envres.2023.117478
Hong, L., Pan, M., Xie, X., Liu, K., Yang, J., Wang, S., Wang, S. (2021). Aptamer-based fluorescent biosensor for the rapid and sensitive detection of allergens in food matrices. Foods, 10(11), 2598. https://doi.org/10.3390/ foods10112598
Huang, J., Wang, H., Dong, H., Liu, M., Geng, L., Sun, J., Guo, Y. (2024). Neonicotinoids: Advances in hazards of residues, screening of aptamers and design of aptasensors. Trends in Food Science & Technology, 104342. https://doi.org/ 10.1016/j.tifs.2024.104342
Jia, Y., Zhou, G., Wang, X., Zhang, Y., Li, Z., Liu, P., Zhang, J. (2020). A metal-organic framework/aptamer system as a fluorescent biosensor for determination of aflatoxin B1 in food samples. Talanta, 219, 121342. https://doi.org/10.1016/j.talanta.2020.121342
Jiang, X., Lv, Z., Rao, C., Chen, X., Zhang, Y., Lin, F. (2023). Simple and highly sensitive electrochemical detection of Listeria monocytogenes based on aptamer-regulated Pt nanoparticles/hollow carbon spheres nanozyme activity. Sensors and Actuators B: Chemical, 392, 133991. https://doi.org/10.1016/ j.snb.2023.133991
Kadam, U. S., Hong, J. C. (2022). Recent advances in aptameric biosensors designed to detect toxic contaminants from food, water, human fluids, and the environment. Trends in Environmental Analytical Chemistry, e00184. https://doi.org/10.1016/j.teac.2022.e00184
Kalita, J. J., Sharma, P., Bora, U. (2023). Recent developments in application of nucleic acid aptamer in food safety. Food Control, 145, 109406. https://doi.org/10.1016/j.foodcont.2022.109406
Kara, N., Ayoub, N., Ilgu, H., Fotiadis, D., Ilgu, M. (2023). Aptamers targeting membrane proteins for sensor and diagnostic applications. Molecules, 28(9), 3728. https://doi.org/10.3390/ molecules28093728
Khan, S., Hussain, A., Fahimi, H., Aliakbari, F., Bloukh, S. H., Edis, Z., Falahati, M. (2022). A review on the therapeutic applications of aptamers and aptamer-conjugated nanoparticles in cancer, inflammatory and viral diseases. Arabian Journal of Chemistry, 15(2), 103626. https://doi.org/10.1016/j.arabjc.2021.103626
Koerselman, M., Morshuis, L. C., Karperien, M. (2023). The use of peptides, aptamers, and variable domains of heavy chain only antibodies in tissue engineering and regenerative medicine. Acta Biomaterialia. 170, 1-14. https://doi.org/ 10.1016/j.actbio.2023.07.045
Komarova, N., Kuznetsov, A. (2019). Inside the black box: what makes SELEX better?. Molecules, 24(19), 3598. https://doi.org/10.3390/ molecules24193598
Kohlberger, M., Gadermaier, G. (2022). SELEX: Critical factors and optimization strategies for successful aptamer selection. Biotechnology and Applied Biochemistry, 69(5), 1771-1792. https://doi.org/10.1002/bab.2244
Lee, S. J., Cho, J., Lee, B. H., Hwang, D., Park, J. W. (2023). Design and prediction of aptamers assisted by in silico methods. Biomedicines, 11(2), 356. https://doi.org/10.3390/ bimedicines11020356
Li, L., Ma, R., Wang, W., Zhang, L., Li, J., Eltzov, E., Mao, X. (2023a). Group-targeting aptamers and aptasensors for simultaneous identification of multiple targets in foods. TrAC Trends in Analytical Chemistry, 117169. https://doi.org/10.1016/ j.trac.2023.117169
Li, M., Huang, R., Liao, X., Zhou, Z., Zou, L., Liu, B. (2023b). An inner filter effect-based fluorescent aptasensor for sensitive detection of kanamycin in complex samples using gold nanoparticles and graphene oxide quantum dots. Analytical Methods, 15(6), 843-848. https://doi.org/10.1039/d2ay01794f
Li, Y., Liu, W., Xu, H., Zhou, Y., Xie, W., Guo, Y., Ren, C. (2024). Aptamers combined with immune checkpoints for cancer detection and targeted therapy: A review. International Journal of Biological Macromolecules, 262 (2)130032. https://doi.org/10.1016/j.ijbiomac.2024.130032
Li, Z., Hu, B., Zhou, R., Zhang, X., Wang, R., Gao, Y., Wang, L. (2020). Selection and application of aptamers with high-affinity and high-specificity against dinophysistoxin-1. RSC advances, 10(14), 8181-8189. https://doi.org/ 10.1039/C9RA10600F
Lin, B., Xiao, F., Jiang, J., Zhao, Z., Zhou, X. (2023). Engineered aptamers for molecular imaging. Chemical Science. 14, 14039-14061. https://doi.org/10.1039/D3SC03989G
Liu, R., Zhang, Y., Ali, S., Haruna, S. A., He, P., Li, H., Chen, Q. (2021b). Development of a fluorescence aptasensor for rapid and sensitive detection of Listeria monocytogenes in food. Food Control, 122, 107808. https://doi.org/10.1016/ j.foodcont.2020.107808
Liu, S., Li, Q., Yang, H., Wang, P., Miao, X., Feng, Q. (2022). An in situ quenching electrochemiluminescence biosensor amplified with aptamer recognition-induced multi-DNA release for sensitive detection of pathogenic bacteria. Biosensors and Bioelectronics, 196, 113744. https://doi.org/10.1016/j.bios.2021.113744
Liu, Y., Wang, N., Chan, C. W., Lu, A., Yu, Y., Zhang, G., Ren, K. (2021a). The application of microfluidic technologies in aptamer selection. Frontiers in Cell and Developmental Biology, 9, 730035. https://doi.org/10.3389/fcell.2021.730035
Liu, W., Zhu, C., Gao, S., Ma, K., Zhang, S., Du, Q., Chi, Z. (2024). A biosensor encompassing fusarinine C-magnetic nanoparticles and aptamer-red/green carbon dots for dual-channel fluorescent and RGB discrimination of Campylobacter and Aliarcobacter. Talanta, 266, 125085. https://doi.org/10.1016/ j.talanta.2023.125085
Nasiri, M., Bahadorani, M., Dellinger, K., Aravamudhan, S., Vivero-Escoto, J. L., Zadegan, R. (2024). Improving DNA nanostructure stability: A review of the biomedical applications and approaches. International Journal of Biological Macromolecules, 129495. https://doi.org/10.1016/ j.ijbiomac.2024.129495
Ma, P., Guo, H., Ye, H., Zhang, Y., Wang, Z. (2023). Aptamer-locker probe coupling with truncated aptamer for high-efficiency fluorescence polarization detection of zearalenone. Sensors and Actuators B: Chemical, 380, 133356. https://doi.org/10.1016/ j.snb.2023.133356
Mahmoudian, F., Ahmari, A., Shabani, S., Sadeghi, B., Fahimirad, S., Fattahi, F. (2024). Aptamers as an approach to targeted cancer therapy. Cancer Cell International, 24(1), 1-22. https://doi.org/10.1186/s12935-024-03295-4
Mao, Z., Zhao, Y., Dong, J., Li, L., Zhou, Y. (2023). Electrochemiluminescent silica nanoparticles encapsulating structure-optimized iridium complex to sensitively detect acetamiprid residues in tea based on aptamer sensor. Sensors and Actuators B: Chemical, 394, 134480. https://doi.org/10.1016/j.snb.2023.134480
Manea, I., Casian, M., Hosu-Stancioiu, O., de-los-Santos-Álvarez, N., Lobo-Castañón, M. J., Cristea, C. (2024). A review on magnetic beads-based SELEX technologies: Applications from small to large target molecules. Analytica Chimica Acta, 342325. https://doi.org/10.1016/ j.aca.2024.342325
Mili, M., Bachu, V., Kuri, P. R., Singh, N. K., Goswami, P. (2024). Improving synthesis and binding affinities of nucleic acid aptamers and their therapeutics and diagnostic applications. Biophysical Chemistry, 107218. https://doi.org/ 10.1016/j.bpc.2024.107218
Mishra, A., Roy, S., Shaikh, N. I., Malave, P., Mishra, A., Alam, A., Hasan, M. R. (2023). Recent advances in multiplex aptasensor detection techniques for food-borne pathogens: A comprehensive review of novel approaches. Biosensors and Bioelectronics: X, 100417. https://doi.org/10.1016/j.biosx.2023.100417
Mohamad, N., Azizan, N. I., Mokhtar, N. F. K., Mustafa, S., Desa, M. N. M., Hashim, A. M. (2022). Future perspectives on aptamer for application in food authentication. Analytical Biochemistry, 114861. https://doi.org/10.1016/ j.ab.2022.114861
Musumeci, D., Montesarchio, D. (2023). G-Quadruplex-Based Aptamers in Therapeutic Applications. In Handbook of Chemical Biology of Nucleic Acids (pp. 1-26). Singapore: Springer Nature Singapore. https://doi.org/10.1007/978-981-16-1313-5_79-1
Ning, Y., Hu, J., Lu, F. (2020). Aptamers used for biosensors and targeted therapy. Biomedicine & Pharmacotherapy, 132, 110902. https://doi.org/ 10.1016/j.biopha.2020.110902
Oliveira, R., Pinho, E., Sousa, A. L., DeStefano, J. J., Azevedo, N. F., Almeida, C. (2022). Improving aptamer performance with nucleic acid mimics: de novo and post-SELEX approaches. Trends in Biotechnology, 40(5), 549-563. https://doi.org/ 10.1016/j.tibtech.2021.09.011
Onaş, A. M., Dascălu, C., Raicopol, M. D., Pilan, L. (2022). critical design factors for electrochemical aptasensors based on target-induced conformational changes: The case of small-molecule targets. Biosensors, 12(10), 816. https://doi.org/10.3390/bios12100816
Pan, M., Han, X., Chen, S., Yang, J., Wang, Y., Li, H., Wang, S. (2024). Paper-based microfluidic device for selective detection of peanut allergen Ara h1 applying black phosphorus-Au nanocomposites for signal amplification. Talanta, 267, 125188. https://doi.org/10.1016/ j.talanta.2023.125188
Qi, S., Duan, N., Khan, I. M., Dong, X., Zhang, Y., Wu, S., Wang, Z. (2022). Strategies to manipulate the performance of aptamers in SELEX, post-SELEX and microenvironment. Biotechnology advances, 55, 107902. https://doi.org/10.1016/j.biotechadv.2021.107902
Qian, S., Han, Y., Xu, F., Feng, D., Yang, X., Wu, X., Yuan, M. (2022). A fast, sensitive, low-cost electrochemical paper-based chip for real-time simultaneous detection of cadmium (Ⅱ) and lead (Ⅱ) via aptamer. Talanta, 247, 123548. https://doi.org/10.1016/j.talanta.2022.123548
Qiao, Z., Xue, L., Sun, M., Zhang, M., Chen, M., Xu, X., Wang, R. (2023). Highly sensitive detection of Salmonella based on dual-functional HCR-mediated multivalent aptamer and amplification-free Crispr/Cas12a system. Analytica Chimica Acta, 1284, 341998. https://doi.org/10.1016/j.aca.2023.341998
Rong, Y., Li, H., Ouyang, Q., Ali, S., Chen, Q. (2020). Rapid and sensitive detection of diazinon in food based on the FRET between rare-earth doped upconversion nanoparticles and graphene oxide. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 239, 118500. https://doi.org/10.1016/j.saa.2020.118500
Sawan, S., Errachid, A., Maalouf, R., Jaffrezic-Renault, N. (2022). Aptamers functionalized metal and metal oxide nanoparticles: Recent advances in heavy metal monitoring. TrAC Trends in Analytical Chemistry, 157, 116748. https://doi.org/10.1016/j.trac.2022.116748
Schmitz, F. R. W., Valério, A., de Oliveira, D., Hotza, D. (2020). An overview and future prospects on aptamers for food safety. Applied microbiology and biotechnology, 104, 6929-6939. https://doi.org/10.1007/s00253-020-10747-0
Scutarașu, E. C., Trincă, L. C. (2023). Heavy Metals in Foods and Beverages: Global Situation, Health Risks and Reduction Methods. Foods, 12(18), 3340. https://doi.org/10.3390/ foods12183340
Seelam, P. P., Mitra, A., Sharma, P. (2019). Pairing interactions between nucleobases and ligands in aptamer: ligand complexes of riboswitches: Crystal structure analysis, classification, optimal structures, and accurate interaction energies. RNA, 25(10), 1274-1290. https://doi.org/ 10.1261/rna.071530.119
Shen, Z., Xu, D., Wang, G., Geng, L., Xu, R., Wang, G., Sun, X. (2022). Novel colorimetric aptasensor based on MOF-derived materials and its applications for organophosphorus pesticides determination. Journal of Hazardous Materials, 440, 129707. https://doi.org/10.1016/ j.jhazmat.2022.129707
Sola, M., Menon, A. P., Moreno, B., Meraviglia-Crivelli, D., Soldevilla, M. M., Cartón García, F., Pastor, F. (2020). Aptamers against live targets: is in vivo SELEX finally coming to the edge? Molecular Therapy-Nucleic Acids, 21, 192-204. https://doi.org/10.1016/j.omtn.2020.05.025
Srinivasan, S., Ranganathan, V., McConnell, E. M., Murari, B. M., DeRosa, M. C. (2023). Aptamer-based colorimetric and lateral flow assay approaches for the detection of toxic metal ions, thallium (i) and lead (ii). RSC advances, 13(29), 20040-20049. https://10.1039/d3ra01658g
Su, L., Wang, S., Wang, L., Yan, Z., Yi, H., Zhang, D., Ma, Y. (2020). Fluorescent aptasensor for carbendazim detection in aqueous samples based on gold nanoparticles quenching Rhodamine B. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 225, 117511. https://doi.org/10.1016/j.saa.2019.117511
Sun, J., Liu, W., He, Z., Li, B., Dong, H., Liu, M., Sun, X. (2024). Novel electrochemiluminescence aptasensor based on AuNPs-ABEI encapsulated TiO2 nanorod for the detection of acetamiprid residues in vegetables. Talanta, 269, 125471. https://doi.org/10.1016/j.talanta.2023.125471
Sun, C., Su, R., Bie, J., Sun, H., Qiao, S., Ma, X., Zhang, T. (2018). Label-free fluorescent sensor based on aptamer and thiazole orange for the detection of tetracycline. Dyes and Pigments, 149, 867-875. https://doi.org/10.1016/ j.dyepig.2017.11.031
Svigelj, R., Dossi, N., Pizzolato, S., Toniolo, R., Miranda-Castro, R., de-Los-Santos-Álvarez, N., Lobo-Castañón, M. J. (2020). Truncated aptamers as selective receptors in a gluten sensor supporting direct measurement in a deep eutectic solvent. Biosensors and Bioelectronics, 165, 112339. https://doi.org/10.1016/j.bios.2020.112339
Tang, X., Zuo, J., Yang, C., Jiang, J., Zhang, Q., Ping, J., Li, P. (2023a). Current trends in biosensors for biotoxins (mycotoxins, marine toxins, and bacterial food toxins): principles, application, and perspective. TrAC Trends in Analytical Chemistry, 117144. https://doi.org/ 10.1016/j.trac.2023.117144
Tang, Y., Yuan, J., Zhang, Y., Khan, I. M., Ma, P., Wang, Z. (2023b). Lateral flow assays based on aptamers for food safety applications. Food Control, 110051. https://doi.org/10.1016/ j.foodcont.2023.110051
Teng, Y., Liu, S., Yang, S., Guo, X., Zhang, Y., Song, Y., Cui, Y. (2019). Computer-designed orthogonal RNA aptamers programmed to recognize Ebola virus glycoproteins. Biosafety and Health, 1(2), 105-111. https://doi.org/ 10.1016/j.bsheal.2019.11.001
Torregrosa, D., Jauset-Rubio, M., Serrano, R., Svobodová, M., Grindlay, G., O'Sullivan, C. K., Mora, J. (2023). Ultrasensitive determination of β-conglutin food allergen by means an aptamer assay based on inductively coupled plasma mass spectrometry detection. Analytica Chimica Acta, 1252, 341042. https://doi.org/10.1016/ j.aca.2023.341042
Uğurlu, Ö., Man, E., Gök, O., Ülker, G., Soytürk, H., Özyurt, C., Evran, S. (2023). A review of aptamer-conjugated nanomaterials for analytical sample preparation: Classification according to the utilized nanomaterials. Analytica Chimica Acta, 342001. https://doi.org/10.1016/ j.aca.2023.342001
Verdian, A., Fooladi, E., Rouhbakhsh, Z. (2019). Recent progress in the development of recognition bioelements for polychlorinated biphenyls detection: Antibodies and aptamers. Talanta, 202, 123-135. https://doi.org/ 10.1016/j.talanta.2019.04.059
Wang, B., Kobeissy, F., Golpich, M., Cai, G., Li, X., Abedi, R., Wang, K. K. (2024). Aptamer Technologies in Neuroscience, Neuro-Diagnostics and Neuro-Medicine Development. Molecules, 29(5), 1124. https://doi.org/ 10.3390/molecules29051124
Wang, L., Liu, G., Ren, Y., Feng, Y., Zhao, X., Zhu, Y., Chen, X. (2020). Integrating target-triggered aptamer-capped HRP@ metal–organic frameworks with a colorimeter readout for on-site sensitive detection of antibiotics. Analytical Chemistry, 92(20), 14259-14266. https://doi.org/ 10.1021/acs.analchem.0c03723
Wang, J., Chen, D., Huang, W., Yang, N., Yuan, Q., Yang, Y. (2023a). Aptamer‐functionalized field‐effect transistor biosensors for disease diagnosis and environmental monitoring. In Exploration, 3 (3), p. 20210027. https://doi.org/ 10.1002/EXP.20210027
Wang, T., Chen, C., Larcher, L. M., Barrero, R. A., Veedu, R. N. (2019). Three decades of nucleic acid aptamer technologies: Lessons learned, progress and opportunities on aptamer development. Biotechnology advances, 37(1), 28-50. https://doi.org/10.1016/j.biotechadv.2018.11.001
Wang, Y., He, D., Du, Z., Xu, E., Jin, Z., Wu, Z., Cui, B. (2022). Ultrasensitive Detection of Staphylococcal Enterotoxin B with an AuNPs@ MIL-101 Nanohybrid-Based Dual-Modal Aptasensor. Food Analytical Methods, 15, 1368–1376. https://doi.org/10.1007/s12161-021-02204-z
Wang, Y. L., Zeng, G. C., Lee, C. T., Lin, C. K., Kuo, T. H., Paulose, A. K., Hung, S. C. (2023b). Fabrication of Aptamer-based Field Effect Transistor Sensors for Detecting Mercury Ions. ECS Transactions, 111(3), 63. https://doi.org/10.1149/11103.0063ecst
Wei, W., Lin, H., Hao, T., Wang, S., Hu, Y., Guo, Z., Luo, X. (2021). DNA walker-mediated biosensor for target-triggered triple-mode detection of Vibrio parahaemolyticus. Biosensors and Bioelectronics, 186, 113305. https://doi.org/ 10.1016/j.bios.2021.113305
Wei, X., Ma, P., Mahmood, K. I., Zhang, Y., Wang, Z. (2023). A review: Construction of aptamer screening methods based on improving the screening rate of key steps. Talanta, 253, 124003. https://doi.org/10.1016/ j.talanta.2022.124003,
Wei, S., Su, Z., Bu, X., Shi, X., Pang, B., Zhang, L., Zhao, C. (2022). On-site colorimetric detection of Salmonella typhimurium. Science of Food, 6(1), 48. https://doi.org/10.1038/s41538-022-00164-0
Wolter, O., Mayer, G. (2017). Aptamers as valuable molecular tools in neurosciences. Journal of Neuroscience, 37(10), 2517-2523. https://doi.org/10.1523/JNEUROSCI.1969-16.2017
Xie, M., Zhao, F., Zhang, Y., Xiong, Y., Han, S. (2022). Recent advances in aptamer-based optical and electrochemical biosensors for detection of pesticides and veterinary drugs. Food Control, 131, 108399. https://doi.org/10.1016/ j.foodcont.2021.108399
Xu, Y., Cheng, N., Luo, Y., Huang, K., Chang, Q., Pang, G., Xu, W. (2022). An Exo III-assisted catalytic hairpin assembly-based self-fluorescence aptasensor for pesticide detection. Sensors and Actuators B: Chemical, 358, 131441. https://doi.org/10.1016/j.snb.2022.131441
Yadav, R., Berlina, A. N., Zherdev, A. V., Gaur, M. S., Dzantiev, B. B. (2020). Rapid and selective electrochemical detection of pb 2+ ions using aptamer-conjugated alloy nanoparticles. SN Applied Sciences, 2, 1-11. https://doi.org/ 10.1007/s42452-020-03840-6
Yalagandula, B. P., Mohanty, S., Goswami, P. P., Singh, S. G. (2024). Optimizations towards a nearly invariable WO3-functionalized electrochemical aptasensor for ultra-trace identification of arsenic in lake water. Sensors and Actuators B: Chemical, 398, 134730. https://doi.org/10.1016/j.snb.2023.134730
Yan, M., Wang, H., Li, M., Zhang, W., Du, H., Chen, Z., She, Y. (2023). Multicolor aptasensors for pesticide multiresidues detection in agricultural products using bioorthogonal surface-enhanced Raman scattering tags. Talanta, 265, 124800. https://doi.org/10.1016/ j.talanta.2023.124800
Yang, S., Li, C., Zhan, H., Liu, R., Chen, W., Wang, X., Xu, K. (2023). A label-free fluorescent biosensor based on specific aptamer-templated silver nanoclusters for the detection of tetracycline. Journal of Nanobiotechnology, 21(1), 22. https://doi.org/10.1186/s12951-023-01785-7
Yao, X., Shen, J., Liu, Q., Fa, H., Yang, M., Hou, C. (2020). A novel electrochemical aptasensor for the sensitive detection of kanamycin based on UiO-66-NH 2/MCA/MWCNT@ rGONR nanocomposites. Analytical Methods, 12(41), 4967-4976. https://doi.org/10.1039/D0AY01503B
Yu, H., Zhao, Q. (2022). Aptamer molecular beacon sensor for rapid and sensitive detection of ochratoxin A. Molecules, 27(23), 8267. https://doi.org/10.3390/molecules27238267
Yu, H., Zhao, Q. (2024). Sensitive electrochemical sensor for Cd2+ with engineered short high-affinity aptamer undergoing large conformation change. Talanta, 271, 125642.https://doi.org/10.1016/j.talanta.2024.125642
Zhang, H. L., Lv, C., Li, Z. H., Jiang, S., Cai, D., Liu, S. S., Zhang, K. H. (2023a). Analysis of aptamer-target binding and molecular mechanisms by thermofluorimetric analysis and molecular dynamics simulation. Frontiers in Chemistry, 11, 1144347. https://doi.org/10.3389/ fchem.2023.1144347
Zhang, J., Liu, X., Shi, W., Wei, Y., Wu, Z., Li, J., Xu, K. (2022). Rapid and sensitive detection of Escherichia coli O157: H7 based on silver nanocluster fluorescent probe. Journal of the Iranian Chemical Society, 19(4), 1339-1346. https://doi.org/10.1007/s13738-021-02384-9
Zhang, N., Chen, Z., Liu, D., Jiang, H., Zhang, Z. K., Lu, A., Zhang, G. (2021a). Structural biology for the molecular insight between aptamers and target proteins. International Journal of Molecular Sciences, 22(8), 4093. https://doi.org/ 10.3390/ijms22084093
Zhang, N., Lv, H., Wang, J., Yang, Z., Ding, Y., Zhao, B., Tian, Y. (2023b). An aptamer-based colorimetric/SERS dual-mode sensing strategy for the detection of sulfadimethoxine residues in animal-derived foods. Analytical Methods, 15(8), 1047-1053. https://doi.org/10.1039/d2ay01825j
Zhang, W., Wang, Y., Nan, M., Li, Y., Yun, J., Wang, Y., Bi, Y. (2021b). Novel colorimetric aptasensor based on unmodified gold nanoparticle and ssDNA for rapid and sensitive detection of T-2 toxin. Food Chemistry, 348, 129128. https://doi.org/10.1016/ j.foodchem.2021.129128
Zhao, L., Li, L., Zhao, Y., Zhu, C., Yang, R., Fang, M., Luan, Y. (2023). Aptamer-based point-of-care-testing for small molecule targets: From aptamers to aptasensors, devices and applications. TrAC Trends in Analytical Chemistry, 117408. https://doi.org/10.1016/j.trac.2023.117408
Zheng, Y., Shi, Z., Wu, W., He, C., Zhang, H. (2021). Label-free DNA electrochemical aptasensor for fumonisin B 1 detection in maize based on graphene and gold nanocomposite. Journal of Analytical Chemistry, 76, 252-257. https://doi.org/10.1134/S1061934821020167
Zhong, Z., Gao, R., Chen, Q., Jia, L. (2020). Dual-aptamers labeled polydopamine-polyethyleneimine copolymer dots assisted engineering a fluorescence biosensor for sensitive detection of Pseudomonas aeruginosa in food samples. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 224, 117417. https://doi.org/10.1016/j.saa.2019.117417
Zhou, E., Li, Q., Zhu, D., Chen, G., Wu, L. (2024a). Characterization of physicochemical and immunogenic properties of allergenic proteins altered by food processing: a review. Food Science and Human Wellness, 13(3), 1135-1151. https://doi.org/10.26599/FSHW.2022.9250095
Zhou, J., Zhang, C., Hu, C., Li, S., Liu, Y., Chen, Z., Deng, Y. (2024b). Electrochemical aptasensor based on black phosphorus-porous graphene nanocomposites for high-performance detection of Hg2+. Chinese Chemical Letters, 109561. https://doi.org/10.1016/j.cclet.2024.109561
Zhou, Y., Mahapatra, C., Chen, H., Peng, X., Ramakrishna, S., Nanda, H. S. (2020). Recent developments in fluorescent aptasensors for detection of antibiotics. Current Opinion in Biomedical Engineering, 13, 16-24. https://doi.org/ 10.1016/j.cobme.2019.08.003
Zhu, C., Feng, Z., Qin, H., Chen, L., Yan, M., Li, L., Qu, F. (2023). Recent progress of SELEX methods for screening nucleic acid aptamers. Talanta, 124998. https://doi.org/10.1016/ j.talanta.2023.124998
Zou, XM., Zou, J., Song, S., Guan-Hua, C. (2019). Screening of oligonucleotide aptamers and application in detection of pesticide and veterinary drug residues. Chinese Journal of Analytical Chemistry. Chinese Journal of Analytical Chemistry, 47(4), 488-499. https://doi.org/ 10.1016/S1872-2040(19)61153-9

APTAMER TABANLI TANIMLAMA YÖNTEMİ VE GIDA GÜVENLİĞİNDEKİ UYGULAMALARI

Yıl 2024, , 536 - 553, 15.06.2024

Melike Canpolat , Zülal Kesmen

https://doi.org/10.15237/gida.GD23145

Öz

Aptamerler, tek sarmallı, kısa, sentetik nükleik asit dizileridir. Çeşitli hedef moleküllere karşı yüksek afinite gösteren ve spesifik olarak bağlanan aptamerler, gıdalarda bulunabilecek patojen mikroorganizmalar, biyotoksinler, alerjenler, pestisitler ve ağır metaller gibi çeşitli risk faktörlerinin hassas bir şekilde tespiti için kullanılmaktadır. Gıda güvenliği açısından risk oluşturan moleküllere spesifik olarak bağlanan aptamerlerin seçilmesi SELEX adı verilen bir süreçle gerçekleştirilir. Seçilen aptamer, hedef molekül ile özgün olarak etkileşime girer ve bu etkileşim elektrokimyasal, optik veya diğer biyosensör teknikler kullanılarak ölçülür. Gıda analizlerinde kullanılan geleneksel yöntemlere kıyasla daha hızlı sonuçlar veren, yüksek özgüllüğe ve duyarlılığa sahip aptamer tabanlı yöntemlere duyulan ilgi giderek artmaktadır. Bu derlemede aptamerlerin genel özellikleri ve SELEX prensibiyle üretimleri özetlenmiş ve gıda güvenliği alanındaki uygulamalarına örnekler verilmiştir.

Anahtar Kelimeler

Aptamer, SELEX, biyobelirteç molekülü, biyosensör, kontaminasyon, gıda güvenliği

Kaynakça

Ahmadi, N., Pourghobadi, Z., Zare, H. (2021). A highly sensitive FRET biosensor based on aptamer-modified nanocrystals for determination of lysozyme. Optik, 248, 168171. https://doi.org/ 10.1016/j.ijleo.2021.168171
Altalbawy, F. M., Ali, E., Mustafa, Y. F., Ibrahim, A. A., Mansouri, S., Bokov, D. O., Alsaalamy, A. (2024). Comprehensive review on biosensors based on integration of aptamer and magnetic nanomaterials for food analysis. Journal of the Taiwan Institute of Chemical Engineers, 157, 105410. https://doi.org/10.1016/j.jtice.2024.105410
Banerjee, D., Adhikary, S., Bhattacharya, S., Chakraborty, A., Dutta, S., Chatterjee, S., Rajak, P. (2023). Breaking boundaries: Artificial intelligence for pesticide detection and eco-friendly degradation. Environmental Research, 117601. https://doi.org/10.1016/ j.envres.2023.117601
Bilibana, M. P., Citartan, M., Fuku, X., Jijana, A. N., Mathumba, P., Iwuoha, E. (2022). Aptamers functionalized hybrid nanomaterials for algal toxins detection and decontamination in aquatic system: Current progress, opportunities, and challenges. Ecotoxicology and Environmental Safety, 232, 113249. https://doi.org/10.1016/ j.ecoenv.2022.113249
Bottari, F., Daems, E., de Vries, A. M., Van Wielendaele, P., Trashin, S., Blust, R., De Wael, K. (2020). Do aptamers always bind? The need for a multifaceted analytical approach when demonstrating binding affinity between aptamer and low molecular weight compounds. Journal of the American Chemical Society, 142(46), 19622-19630. https://doi.org/10.1021/jacs.0c08691
Brown, A., Brill, J., Amini, R., Nurmi, C., Li, Y. (2024). Development of Better Aptamers: Structured Library Approaches, Selection Methods, and Chemical Modifications. Angewandte Chemie International Edition, e202318665. https://doi.org/10.1002/ anie.202318665
Calabria, D., Zangheri, M., Pour, S. R. S., Trozzi, I., Pace, A., Lazzarini, E., Guardigli, M. (2022). Luminescent aptamer-based bioassays for sensitive detection of food allergens. Biosensors, 12(8), 644. https://doi.org/10.3390/ bios12080644
Chen, Q., Sheng, R., Wang, P., Ouyang, Q., Wang, A., Ali, S., Hassan, M. M. (2020). Ultra-sensitive detection of malathion residues using FRET-based upconversion fluorescence sensor in food. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 241, 118654. https://doi.org/10.1016/j.saa.2020.118654
Chen, Z., Luo, H., Gubu, A., Yu, S., Zhang, H., Dai, H., Zhang, G. (2023). Chemically modified aptamers for improving binding affinity to the target proteins via enhanced non-covalent bonding. Frontiers in Cell and Developmental Biology, 11, 1091809. https://doi.org/10.3389/ fcell.2023.1091809
Chinnappan, R., Eissa, S., Alotaibi, A., Siddiqua, A., Alsager, O. A., Zourob, M. (2020). In vitro selection of DNA aptamers and their integration in a competitive voltammetric biosensor for azlocillin determination in waste water. Analytica chimica acta, 1101, 149-156. https://doi.org/ 10.1016/j.aca.2019.12.023
Darmostuk, M., Rimpelova, S., Gbelcova, H., Ruml, T. (2015). Current approaches in SELEX: An update to aptamer selection technology. Biotechnology advances, 33(6), 1141-1161. https://doi.org/10.1016/ j.biotechadv.2015.02.008
DeRosa, M. C., Lin, A., Mallikaratchy, P., McConnell, E. M., McKeague, M., Patel, R., Shigdar, S. (2023). In vitro selection of aptamers and their applications. Nature Reviews Methods Primers, 3(1), 54. https://doi.org/10.1038/ s43586-023-00247-6
Drees, A., Trinh, T. L., Fischer, M. (2023). The Influence of Protein Charge and Molecular Weight on the Affinity of Aptamers. Pharmaceuticals, 16(3), 457. https://doi.org/ 10.3390/ph16030457
El-Sayed, R. A., Jebur, A. B., Kang, W., El-Demerdash, F. M. (2022). An overview on the major mycotoxins in food products: Characteristics, toxicity, and analysis. Journal of Future Foods, 2(2), 91-102. https://doi.org/10.1016/j.jfutfo.2022.03.002
Fadeev, M., O’Hagan, M. P., Biniuri, Y., Willner, I. (2022). Aptamer–Protein Structures Guide In Silico and Experimental Discovery of Aptamer–Short Peptide Recognition Complexes or Aptamer–Amino Acid Cluster Complexes. The Journal of Physical Chemistry B, 126(44), 8931-8939. https://doi.org/10.1021/acs.jpcb.2c05624
Fan, Y., Li, J., Amin, K., Yu, H., Yang, H., Guo, Z., Liu, J. (2023). Advances in aptamers, and application of mycotoxins detection: a review. Food Research International, 113022. https://doi.org/10.1016/j.foodres.2023.113022
Fei, A., Liu, Q., Huan, J., Qian, J., Dong, X., Qiu, B., Wang, K. (2015). Label-free impedimetric aptasensor for detection of femtomole level acetamiprid using gold nanoparticles decorated multiwalled carbon nanotube-reduced graphene oxide nanoribbon composites. Biosensors and Bioelectronics, 70, 122-129. https://doi.org/ 10.1016/j.bios.2015.03.028
Gao, S., Yang, G., Zhang, X., Lu, Y., Chen, Y., Wu, X., Song, C. (2022). β-Cyclodextrin polymer-based host–guest interaction and fluorescence enhancement of pyrene for sensitive isocarbophos detection. ACS omega, 7(15), 12747-12752. https://doi.org/10.1021/ acsomega.1c07295
Himanshu, J. K., Lakshmi, G. B. V. S., Verma, A. K., Ahlawat, A., Solanki, P. R. (2024). Development of aptasensor for chlorpyrifos detection using paper-based screen-printed electrode. Environmental Research, 240, 117478. https://doi.org/10.1016/j.envres.2023.117478
Hong, L., Pan, M., Xie, X., Liu, K., Yang, J., Wang, S., Wang, S. (2021). Aptamer-based fluorescent biosensor for the rapid and sensitive detection of allergens in food matrices. Foods, 10(11), 2598. https://doi.org/10.3390/ foods10112598
Huang, J., Wang, H., Dong, H., Liu, M., Geng, L., Sun, J., Guo, Y. (2024). Neonicotinoids: Advances in hazards of residues, screening of aptamers and design of aptasensors. Trends in Food Science & Technology, 104342. https://doi.org/ 10.1016/j.tifs.2024.104342
Jia, Y., Zhou, G., Wang, X., Zhang, Y., Li, Z., Liu, P., Zhang, J. (2020). A metal-organic framework/aptamer system as a fluorescent biosensor for determination of aflatoxin B1 in food samples. Talanta, 219, 121342. https://doi.org/10.1016/j.talanta.2020.121342
Jiang, X., Lv, Z., Rao, C., Chen, X., Zhang, Y., Lin, F. (2023). Simple and highly sensitive electrochemical detection of Listeria monocytogenes based on aptamer-regulated Pt nanoparticles/hollow carbon spheres nanozyme activity. Sensors and Actuators B: Chemical, 392, 133991. https://doi.org/10.1016/ j.snb.2023.133991
Kadam, U. S., Hong, J. C. (2022). Recent advances in aptameric biosensors designed to detect toxic contaminants from food, water, human fluids, and the environment. Trends in Environmental Analytical Chemistry, e00184. https://doi.org/10.1016/j.teac.2022.e00184
Kalita, J. J., Sharma, P., Bora, U. (2023). Recent developments in application of nucleic acid aptamer in food safety. Food Control, 145, 109406. https://doi.org/10.1016/j.foodcont.2022.109406
Kara, N., Ayoub, N., Ilgu, H., Fotiadis, D., Ilgu, M. (2023). Aptamers targeting membrane proteins for sensor and diagnostic applications. Molecules, 28(9), 3728. https://doi.org/10.3390/ molecules28093728
Khan, S., Hussain, A., Fahimi, H., Aliakbari, F., Bloukh, S. H., Edis, Z., Falahati, M. (2022). A review on the therapeutic applications of aptamers and aptamer-conjugated nanoparticles in cancer, inflammatory and viral diseases. Arabian Journal of Chemistry, 15(2), 103626. https://doi.org/10.1016/j.arabjc.2021.103626
Koerselman, M., Morshuis, L. C., Karperien, M. (2023). The use of peptides, aptamers, and variable domains of heavy chain only antibodies in tissue engineering and regenerative medicine. Acta Biomaterialia. 170, 1-14. https://doi.org/ 10.1016/j.actbio.2023.07.045
Komarova, N., Kuznetsov, A. (2019). Inside the black box: what makes SELEX better?. Molecules, 24(19), 3598. https://doi.org/10.3390/ molecules24193598
Kohlberger, M., Gadermaier, G. (2022). SELEX: Critical factors and optimization strategies for successful aptamer selection. Biotechnology and Applied Biochemistry, 69(5), 1771-1792. https://doi.org/10.1002/bab.2244
Lee, S. J., Cho, J., Lee, B. H., Hwang, D., Park, J. W. (2023). Design and prediction of aptamers assisted by in silico methods. Biomedicines, 11(2), 356. https://doi.org/10.3390/ bimedicines11020356
Li, L., Ma, R., Wang, W., Zhang, L., Li, J., Eltzov, E., Mao, X. (2023a). Group-targeting aptamers and aptasensors for simultaneous identification of multiple targets in foods. TrAC Trends in Analytical Chemistry, 117169. https://doi.org/10.1016/ j.trac.2023.117169
Li, M., Huang, R., Liao, X., Zhou, Z., Zou, L., Liu, B. (2023b). An inner filter effect-based fluorescent aptasensor for sensitive detection of kanamycin in complex samples using gold nanoparticles and graphene oxide quantum dots. Analytical Methods, 15(6), 843-848. https://doi.org/10.1039/d2ay01794f
Li, Y., Liu, W., Xu, H., Zhou, Y., Xie, W., Guo, Y., Ren, C. (2024). Aptamers combined with immune checkpoints for cancer detection and targeted therapy: A review. International Journal of Biological Macromolecules, 262 (2)130032. https://doi.org/10.1016/j.ijbiomac.2024.130032
Li, Z., Hu, B., Zhou, R., Zhang, X., Wang, R., Gao, Y., Wang, L. (2020). Selection and application of aptamers with high-affinity and high-specificity against dinophysistoxin-1. RSC advances, 10(14), 8181-8189. https://doi.org/ 10.1039/C9RA10600F
Lin, B., Xiao, F., Jiang, J., Zhao, Z., Zhou, X. (2023). Engineered aptamers for molecular imaging. Chemical Science. 14, 14039-14061. https://doi.org/10.1039/D3SC03989G
Liu, R., Zhang, Y., Ali, S., Haruna, S. A., He, P., Li, H., Chen, Q. (2021b). Development of a fluorescence aptasensor for rapid and sensitive detection of Listeria monocytogenes in food. Food Control, 122, 107808. https://doi.org/10.1016/ j.foodcont.2020.107808
Liu, S., Li, Q., Yang, H., Wang, P., Miao, X., Feng, Q. (2022). An in situ quenching electrochemiluminescence biosensor amplified with aptamer recognition-induced multi-DNA release for sensitive detection of pathogenic bacteria. Biosensors and Bioelectronics, 196, 113744. https://doi.org/10.1016/j.bios.2021.113744
Liu, Y., Wang, N., Chan, C. W., Lu, A., Yu, Y., Zhang, G., Ren, K. (2021a). The application of microfluidic technologies in aptamer selection. Frontiers in Cell and Developmental Biology, 9, 730035. https://doi.org/10.3389/fcell.2021.730035
Liu, W., Zhu, C., Gao, S., Ma, K., Zhang, S., Du, Q., Chi, Z. (2024). A biosensor encompassing fusarinine C-magnetic nanoparticles and aptamer-red/green carbon dots for dual-channel fluorescent and RGB discrimination of Campylobacter and Aliarcobacter. Talanta, 266, 125085. https://doi.org/10.1016/ j.talanta.2023.125085
Nasiri, M., Bahadorani, M., Dellinger, K., Aravamudhan, S., Vivero-Escoto, J. L., Zadegan, R. (2024). Improving DNA nanostructure stability: A review of the biomedical applications and approaches. International Journal of Biological Macromolecules, 129495. https://doi.org/10.1016/ j.ijbiomac.2024.129495
Ma, P., Guo, H., Ye, H., Zhang, Y., Wang, Z. (2023). Aptamer-locker probe coupling with truncated aptamer for high-efficiency fluorescence polarization detection of zearalenone. Sensors and Actuators B: Chemical, 380, 133356. https://doi.org/10.1016/ j.snb.2023.133356
Mahmoudian, F., Ahmari, A., Shabani, S., Sadeghi, B., Fahimirad, S., Fattahi, F. (2024). Aptamers as an approach to targeted cancer therapy. Cancer Cell International, 24(1), 1-22. https://doi.org/10.1186/s12935-024-03295-4
Mao, Z., Zhao, Y., Dong, J., Li, L., Zhou, Y. (2023). Electrochemiluminescent silica nanoparticles encapsulating structure-optimized iridium complex to sensitively detect acetamiprid residues in tea based on aptamer sensor. Sensors and Actuators B: Chemical, 394, 134480. https://doi.org/10.1016/j.snb.2023.134480
Manea, I., Casian, M., Hosu-Stancioiu, O., de-los-Santos-Álvarez, N., Lobo-Castañón, M. J., Cristea, C. (2024). A review on magnetic beads-based SELEX technologies: Applications from small to large target molecules. Analytica Chimica Acta, 342325. https://doi.org/10.1016/ j.aca.2024.342325
Mili, M., Bachu, V., Kuri, P. R., Singh, N. K., Goswami, P. (2024). Improving synthesis and binding affinities of nucleic acid aptamers and their therapeutics and diagnostic applications. Biophysical Chemistry, 107218. https://doi.org/ 10.1016/j.bpc.2024.107218
Mishra, A., Roy, S., Shaikh, N. I., Malave, P., Mishra, A., Alam, A., Hasan, M. R. (2023). Recent advances in multiplex aptasensor detection techniques for food-borne pathogens: A comprehensive review of novel approaches. Biosensors and Bioelectronics: X, 100417. https://doi.org/10.1016/j.biosx.2023.100417
Mohamad, N., Azizan, N. I., Mokhtar, N. F. K., Mustafa, S., Desa, M. N. M., Hashim, A. M. (2022). Future perspectives on aptamer for application in food authentication. Analytical Biochemistry, 114861. https://doi.org/10.1016/ j.ab.2022.114861
Musumeci, D., Montesarchio, D. (2023). G-Quadruplex-Based Aptamers in Therapeutic Applications. In Handbook of Chemical Biology of Nucleic Acids (pp. 1-26). Singapore: Springer Nature Singapore. https://doi.org/10.1007/978-981-16-1313-5_79-1
Ning, Y., Hu, J., Lu, F. (2020). Aptamers used for biosensors and targeted therapy. Biomedicine & Pharmacotherapy, 132, 110902. https://doi.org/ 10.1016/j.biopha.2020.110902
Oliveira, R., Pinho, E., Sousa, A. L., DeStefano, J. J., Azevedo, N. F., Almeida, C. (2022). Improving aptamer performance with nucleic acid mimics: de novo and post-SELEX approaches. Trends in Biotechnology, 40(5), 549-563. https://doi.org/ 10.1016/j.tibtech.2021.09.011
Onaş, A. M., Dascălu, C., Raicopol, M. D., Pilan, L. (2022). critical design factors for electrochemical aptasensors based on target-induced conformational changes: The case of small-molecule targets. Biosensors, 12(10), 816. https://doi.org/10.3390/bios12100816
Pan, M., Han, X., Chen, S., Yang, J., Wang, Y., Li, H., Wang, S. (2024). Paper-based microfluidic device for selective detection of peanut allergen Ara h1 applying black phosphorus-Au nanocomposites for signal amplification. Talanta, 267, 125188. https://doi.org/10.1016/ j.talanta.2023.125188
Qi, S., Duan, N., Khan, I. M., Dong, X., Zhang, Y., Wu, S., Wang, Z. (2022). Strategies to manipulate the performance of aptamers in SELEX, post-SELEX and microenvironment. Biotechnology advances, 55, 107902. https://doi.org/10.1016/j.biotechadv.2021.107902
Qian, S., Han, Y., Xu, F., Feng, D., Yang, X., Wu, X., Yuan, M. (2022). A fast, sensitive, low-cost electrochemical paper-based chip for real-time simultaneous detection of cadmium (Ⅱ) and lead (Ⅱ) via aptamer. Talanta, 247, 123548. https://doi.org/10.1016/j.talanta.2022.123548
Qiao, Z., Xue, L., Sun, M., Zhang, M., Chen, M., Xu, X., Wang, R. (2023). Highly sensitive detection of Salmonella based on dual-functional HCR-mediated multivalent aptamer and amplification-free Crispr/Cas12a system. Analytica Chimica Acta, 1284, 341998. https://doi.org/10.1016/j.aca.2023.341998
Rong, Y., Li, H., Ouyang, Q., Ali, S., Chen, Q. (2020). Rapid and sensitive detection of diazinon in food based on the FRET between rare-earth doped upconversion nanoparticles and graphene oxide. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 239, 118500. https://doi.org/10.1016/j.saa.2020.118500
Sawan, S., Errachid, A., Maalouf, R., Jaffrezic-Renault, N. (2022). Aptamers functionalized metal and metal oxide nanoparticles: Recent advances in heavy metal monitoring. TrAC Trends in Analytical Chemistry, 157, 116748. https://doi.org/10.1016/j.trac.2022.116748
Schmitz, F. R. W., Valério, A., de Oliveira, D., Hotza, D. (2020). An overview and future prospects on aptamers for food safety. Applied microbiology and biotechnology, 104, 6929-6939. https://doi.org/10.1007/s00253-020-10747-0
Scutarașu, E. C., Trincă, L. C. (2023). Heavy Metals in Foods and Beverages: Global Situation, Health Risks and Reduction Methods. Foods, 12(18), 3340. https://doi.org/10.3390/ foods12183340
Seelam, P. P., Mitra, A., Sharma, P. (2019). Pairing interactions between nucleobases and ligands in aptamer: ligand complexes of riboswitches: Crystal structure analysis, classification, optimal structures, and accurate interaction energies. RNA, 25(10), 1274-1290. https://doi.org/ 10.1261/rna.071530.119
Shen, Z., Xu, D., Wang, G., Geng, L., Xu, R., Wang, G., Sun, X. (2022). Novel colorimetric aptasensor based on MOF-derived materials and its applications for organophosphorus pesticides determination. Journal of Hazardous Materials, 440, 129707. https://doi.org/10.1016/ j.jhazmat.2022.129707
Sola, M., Menon, A. P., Moreno, B., Meraviglia-Crivelli, D., Soldevilla, M. M., Cartón García, F., Pastor, F. (2020). Aptamers against live targets: is in vivo SELEX finally coming to the edge? Molecular Therapy-Nucleic Acids, 21, 192-204. https://doi.org/10.1016/j.omtn.2020.05.025
Srinivasan, S., Ranganathan, V., McConnell, E. M., Murari, B. M., DeRosa, M. C. (2023). Aptamer-based colorimetric and lateral flow assay approaches for the detection of toxic metal ions, thallium (i) and lead (ii). RSC advances, 13(29), 20040-20049. https://10.1039/d3ra01658g
Su, L., Wang, S., Wang, L., Yan, Z., Yi, H., Zhang, D., Ma, Y. (2020). Fluorescent aptasensor for carbendazim detection in aqueous samples based on gold nanoparticles quenching Rhodamine B. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 225, 117511. https://doi.org/10.1016/j.saa.2019.117511
Sun, J., Liu, W., He, Z., Li, B., Dong, H., Liu, M., Sun, X. (2024). Novel electrochemiluminescence aptasensor based on AuNPs-ABEI encapsulated TiO2 nanorod for the detection of acetamiprid residues in vegetables. Talanta, 269, 125471. https://doi.org/10.1016/j.talanta.2023.125471
Sun, C., Su, R., Bie, J., Sun, H., Qiao, S., Ma, X., Zhang, T. (2018). Label-free fluorescent sensor based on aptamer and thiazole orange for the detection of tetracycline. Dyes and Pigments, 149, 867-875. https://doi.org/10.1016/ j.dyepig.2017.11.031
Svigelj, R., Dossi, N., Pizzolato, S., Toniolo, R., Miranda-Castro, R., de-Los-Santos-Álvarez, N., Lobo-Castañón, M. J. (2020). Truncated aptamers as selective receptors in a gluten sensor supporting direct measurement in a deep eutectic solvent. Biosensors and Bioelectronics, 165, 112339. https://doi.org/10.1016/j.bios.2020.112339
Tang, X., Zuo, J., Yang, C., Jiang, J., Zhang, Q., Ping, J., Li, P. (2023a). Current trends in biosensors for biotoxins (mycotoxins, marine toxins, and bacterial food toxins): principles, application, and perspective. TrAC Trends in Analytical Chemistry, 117144. https://doi.org/ 10.1016/j.trac.2023.117144
Tang, Y., Yuan, J., Zhang, Y., Khan, I. M., Ma, P., Wang, Z. (2023b). Lateral flow assays based on aptamers for food safety applications. Food Control, 110051. https://doi.org/10.1016/ j.foodcont.2023.110051
Teng, Y., Liu, S., Yang, S., Guo, X., Zhang, Y., Song, Y., Cui, Y. (2019). Computer-designed orthogonal RNA aptamers programmed to recognize Ebola virus glycoproteins. Biosafety and Health, 1(2), 105-111. https://doi.org/ 10.1016/j.bsheal.2019.11.001
Torregrosa, D., Jauset-Rubio, M., Serrano, R., Svobodová, M., Grindlay, G., O'Sullivan, C. K., Mora, J. (2023). Ultrasensitive determination of β-conglutin food allergen by means an aptamer assay based on inductively coupled plasma mass spectrometry detection. Analytica Chimica Acta, 1252, 341042. https://doi.org/10.1016/ j.aca.2023.341042
Uğurlu, Ö., Man, E., Gök, O., Ülker, G., Soytürk, H., Özyurt, C., Evran, S. (2023). A review of aptamer-conjugated nanomaterials for analytical sample preparation: Classification according to the utilized nanomaterials. Analytica Chimica Acta, 342001. https://doi.org/10.1016/ j.aca.2023.342001
Verdian, A., Fooladi, E., Rouhbakhsh, Z. (2019). Recent progress in the development of recognition bioelements for polychlorinated biphenyls detection: Antibodies and aptamers. Talanta, 202, 123-135. https://doi.org/ 10.1016/j.talanta.2019.04.059
Wang, B., Kobeissy, F., Golpich, M., Cai, G., Li, X., Abedi, R., Wang, K. K. (2024). Aptamer Technologies in Neuroscience, Neuro-Diagnostics and Neuro-Medicine Development. Molecules, 29(5), 1124. https://doi.org/ 10.3390/molecules29051124
Wang, L., Liu, G., Ren, Y., Feng, Y., Zhao, X., Zhu, Y., Chen, X. (2020). Integrating target-triggered aptamer-capped HRP@ metal–organic frameworks with a colorimeter readout for on-site sensitive detection of antibiotics. Analytical Chemistry, 92(20), 14259-14266. https://doi.org/ 10.1021/acs.analchem.0c03723
Wang, J., Chen, D., Huang, W., Yang, N., Yuan, Q., Yang, Y. (2023a). Aptamer‐functionalized field‐effect transistor biosensors for disease diagnosis and environmental monitoring. In Exploration, 3 (3), p. 20210027. https://doi.org/ 10.1002/EXP.20210027
Wang, T., Chen, C., Larcher, L. M., Barrero, R. A., Veedu, R. N. (2019). Three decades of nucleic acid aptamer technologies: Lessons learned, progress and opportunities on aptamer development. Biotechnology advances, 37(1), 28-50. https://doi.org/10.1016/j.biotechadv.2018.11.001
Wang, Y., He, D., Du, Z., Xu, E., Jin, Z., Wu, Z., Cui, B. (2022). Ultrasensitive Detection of Staphylococcal Enterotoxin B with an AuNPs@ MIL-101 Nanohybrid-Based Dual-Modal Aptasensor. Food Analytical Methods, 15, 1368–1376. https://doi.org/10.1007/s12161-021-02204-z
Wang, Y. L., Zeng, G. C., Lee, C. T., Lin, C. K., Kuo, T. H., Paulose, A. K., Hung, S. C. (2023b). Fabrication of Aptamer-based Field Effect Transistor Sensors for Detecting Mercury Ions. ECS Transactions, 111(3), 63. https://doi.org/10.1149/11103.0063ecst
Wei, W., Lin, H., Hao, T., Wang, S., Hu, Y., Guo, Z., Luo, X. (2021). DNA walker-mediated biosensor for target-triggered triple-mode detection of Vibrio parahaemolyticus. Biosensors and Bioelectronics, 186, 113305. https://doi.org/ 10.1016/j.bios.2021.113305
Wei, X., Ma, P., Mahmood, K. I., Zhang, Y., Wang, Z. (2023). A review: Construction of aptamer screening methods based on improving the screening rate of key steps. Talanta, 253, 124003. https://doi.org/10.1016/ j.talanta.2022.124003,
Wei, S., Su, Z., Bu, X., Shi, X., Pang, B., Zhang, L., Zhao, C. (2022). On-site colorimetric detection of Salmonella typhimurium. Science of Food, 6(1), 48. https://doi.org/10.1038/s41538-022-00164-0
Wolter, O., Mayer, G. (2017). Aptamers as valuable molecular tools in neurosciences. Journal of Neuroscience, 37(10), 2517-2523. https://doi.org/10.1523/JNEUROSCI.1969-16.2017
Xie, M., Zhao, F., Zhang, Y., Xiong, Y., Han, S. (2022). Recent advances in aptamer-based optical and electrochemical biosensors for detection of pesticides and veterinary drugs. Food Control, 131, 108399. https://doi.org/10.1016/ j.foodcont.2021.108399
Xu, Y., Cheng, N., Luo, Y., Huang, K., Chang, Q., Pang, G., Xu, W. (2022). An Exo III-assisted catalytic hairpin assembly-based self-fluorescence aptasensor for pesticide detection. Sensors and Actuators B: Chemical, 358, 131441. https://doi.org/10.1016/j.snb.2022.131441
Yadav, R., Berlina, A. N., Zherdev, A. V., Gaur, M. S., Dzantiev, B. B. (2020). Rapid and selective electrochemical detection of pb 2+ ions using aptamer-conjugated alloy nanoparticles. SN Applied Sciences, 2, 1-11. https://doi.org/ 10.1007/s42452-020-03840-6
Yalagandula, B. P., Mohanty, S., Goswami, P. P., Singh, S. G. (2024). Optimizations towards a nearly invariable WO3-functionalized electrochemical aptasensor for ultra-trace identification of arsenic in lake water. Sensors and Actuators B: Chemical, 398, 134730. https://doi.org/10.1016/j.snb.2023.134730
Yan, M., Wang, H., Li, M., Zhang, W., Du, H., Chen, Z., She, Y. (2023). Multicolor aptasensors for pesticide multiresidues detection in agricultural products using bioorthogonal surface-enhanced Raman scattering tags. Talanta, 265, 124800. https://doi.org/10.1016/ j.talanta.2023.124800
Yang, S., Li, C., Zhan, H., Liu, R., Chen, W., Wang, X., Xu, K. (2023). A label-free fluorescent biosensor based on specific aptamer-templated silver nanoclusters for the detection of tetracycline. Journal of Nanobiotechnology, 21(1), 22. https://doi.org/10.1186/s12951-023-01785-7
Yao, X., Shen, J., Liu, Q., Fa, H., Yang, M., Hou, C. (2020). A novel electrochemical aptasensor for the sensitive detection of kanamycin based on UiO-66-NH 2/MCA/MWCNT@ rGONR nanocomposites. Analytical Methods, 12(41), 4967-4976. https://doi.org/10.1039/D0AY01503B
Yu, H., Zhao, Q. (2022). Aptamer molecular beacon sensor for rapid and sensitive detection of ochratoxin A. Molecules, 27(23), 8267. https://doi.org/10.3390/molecules27238267
Yu, H., Zhao, Q. (2024). Sensitive electrochemical sensor for Cd2+ with engineered short high-affinity aptamer undergoing large conformation change. Talanta, 271, 125642.https://doi.org/10.1016/j.talanta.2024.125642
Zhang, H. L., Lv, C., Li, Z. H., Jiang, S., Cai, D., Liu, S. S., Zhang, K. H. (2023a). Analysis of aptamer-target binding and molecular mechanisms by thermofluorimetric analysis and molecular dynamics simulation. Frontiers in Chemistry, 11, 1144347. https://doi.org/10.3389/ fchem.2023.1144347
Zhang, J., Liu, X., Shi, W., Wei, Y., Wu, Z., Li, J., Xu, K. (2022). Rapid and sensitive detection of Escherichia coli O157: H7 based on silver nanocluster fluorescent probe. Journal of the Iranian Chemical Society, 19(4), 1339-1346. https://doi.org/10.1007/s13738-021-02384-9
Zhang, N., Chen, Z., Liu, D., Jiang, H., Zhang, Z. K., Lu, A., Zhang, G. (2021a). Structural biology for the molecular insight between aptamers and target proteins. International Journal of Molecular Sciences, 22(8), 4093. https://doi.org/ 10.3390/ijms22084093
Zhang, N., Lv, H., Wang, J., Yang, Z., Ding, Y., Zhao, B., Tian, Y. (2023b). An aptamer-based colorimetric/SERS dual-mode sensing strategy for the detection of sulfadimethoxine residues in animal-derived foods. Analytical Methods, 15(8), 1047-1053. https://doi.org/10.1039/d2ay01825j
Zhang, W., Wang, Y., Nan, M., Li, Y., Yun, J., Wang, Y., Bi, Y. (2021b). Novel colorimetric aptasensor based on unmodified gold nanoparticle and ssDNA for rapid and sensitive detection of T-2 toxin. Food Chemistry, 348, 129128. https://doi.org/10.1016/ j.foodchem.2021.129128
Zhao, L., Li, L., Zhao, Y., Zhu, C., Yang, R., Fang, M., Luan, Y. (2023). Aptamer-based point-of-care-testing for small molecule targets: From aptamers to aptasensors, devices and applications. TrAC Trends in Analytical Chemistry, 117408. https://doi.org/10.1016/j.trac.2023.117408
Zheng, Y., Shi, Z., Wu, W., He, C., Zhang, H. (2021). Label-free DNA electrochemical aptasensor for fumonisin B 1 detection in maize based on graphene and gold nanocomposite. Journal of Analytical Chemistry, 76, 252-257. https://doi.org/10.1134/S1061934821020167
Zhong, Z., Gao, R., Chen, Q., Jia, L. (2020). Dual-aptamers labeled polydopamine-polyethyleneimine copolymer dots assisted engineering a fluorescence biosensor for sensitive detection of Pseudomonas aeruginosa in food samples. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 224, 117417. https://doi.org/10.1016/j.saa.2019.117417
Zhou, E., Li, Q., Zhu, D., Chen, G., Wu, L. (2024a). Characterization of physicochemical and immunogenic properties of allergenic proteins altered by food processing: a review. Food Science and Human Wellness, 13(3), 1135-1151. https://doi.org/10.26599/FSHW.2022.9250095
Zhou, J., Zhang, C., Hu, C., Li, S., Liu, Y., Chen, Z., Deng, Y. (2024b). Electrochemical aptasensor based on black phosphorus-porous graphene nanocomposites for high-performance detection of Hg2+. Chinese Chemical Letters, 109561. https://doi.org/10.1016/j.cclet.2024.109561
Zhou, Y., Mahapatra, C., Chen, H., Peng, X., Ramakrishna, S., Nanda, H. S. (2020). Recent developments in fluorescent aptasensors for detection of antibiotics. Current Opinion in Biomedical Engineering, 13, 16-24. https://doi.org/ 10.1016/j.cobme.2019.08.003
Zhu, C., Feng, Z., Qin, H., Chen, L., Yan, M., Li, L., Qu, F. (2023). Recent progress of SELEX methods for screening nucleic acid aptamers. Talanta, 124998. https://doi.org/10.1016/ j.talanta.2023.124998
Zou, XM., Zou, J., Song, S., Guan-Hua, C. (2019). Screening of oligonucleotide aptamers and application in detection of pesticide and veterinary drug residues. Chinese Journal of Analytical Chemistry. Chinese Journal of Analytical Chemistry, 47(4), 488-499. https://doi.org/ 10.1016/S1872-2040(19)61153-9

Toplam 106 adet kaynakça vardır.

Ayrıntılar

Birincil Dil	Türkçe
Konular	Gıda Biyoteknolojisi
Bölüm	Makaleler
Yazarlar	Melike Canpolat 0000-0003-0345-465X Zülal Kesmen 0000-0002-4505-6871
Yayımlanma Tarihi	15 Haziran 2024
Gönderilme Tarihi	26 Aralık 2023
Kabul Tarihi	30 Nisan 2024
Yayımlandığı Sayı	Yıl 2024

Kaynak Göster

APA	Canpolat, M., & Kesmen, Z. (2024). APTAMER TABANLI TANIMLAMA YÖNTEMİ VE GIDA GÜVENLİĞİNDEKİ UYGULAMALARI. Gıda, 49(3), 536-553. https://doi.org/10.15237/gida.GD23145
AMA	Canpolat M, Kesmen Z. APTAMER TABANLI TANIMLAMA YÖNTEMİ VE GIDA GÜVENLİĞİNDEKİ UYGULAMALARI. GIDA. Haziran 2024;49(3):536-553. doi:10.15237/gida.GD23145
Chicago	Canpolat, Melike, ve Zülal Kesmen. “APTAMER TABANLI TANIMLAMA YÖNTEMİ VE GIDA GÜVENLİĞİNDEKİ UYGULAMALARI”. Gıda 49, sy. 3 (Haziran 2024): 536-53. https://doi.org/10.15237/gida.GD23145.
EndNote	Canpolat M, Kesmen Z (01 Haziran 2024) APTAMER TABANLI TANIMLAMA YÖNTEMİ VE GIDA GÜVENLİĞİNDEKİ UYGULAMALARI. Gıda 49 3 536–553.
IEEE	M. Canpolat ve Z. Kesmen, “APTAMER TABANLI TANIMLAMA YÖNTEMİ VE GIDA GÜVENLİĞİNDEKİ UYGULAMALARI”, GIDA, c. 49, sy. 3, ss. 536–553, 2024, doi: 10.15237/gida.GD23145.
ISNAD	Canpolat, Melike - Kesmen, Zülal. “APTAMER TABANLI TANIMLAMA YÖNTEMİ VE GIDA GÜVENLİĞİNDEKİ UYGULAMALARI”. Gıda 49/3 (Haziran 2024), 536-553. https://doi.org/10.15237/gida.GD23145.
JAMA	Canpolat M, Kesmen Z. APTAMER TABANLI TANIMLAMA YÖNTEMİ VE GIDA GÜVENLİĞİNDEKİ UYGULAMALARI. GIDA. 2024;49:536–553.
MLA	Canpolat, Melike ve Zülal Kesmen. “APTAMER TABANLI TANIMLAMA YÖNTEMİ VE GIDA GÜVENLİĞİNDEKİ UYGULAMALARI”. Gıda, c. 49, sy. 3, 2024, ss. 536-53, doi:10.15237/gida.GD23145.
Vancouver	Canpolat M, Kesmen Z. APTAMER TABANLI TANIMLAMA YÖNTEMİ VE GIDA GÜVENLİĞİNDEKİ UYGULAMALARI. GIDA. 2024;49(3):536-53.

Makale Dosyaları

Tam Metin

GIDA Dergisi Creative Commons Atıf-Gayri Ticari 4.0 (CC BY-NC 4.0) Uluslararası Lisansı ile lisanslanmıştır.

GIDA / The Journal of FOOD is licensed under a Creative Commons Attribution-Non Commercial 4.0 International (CC BY-NC 4.0).

https://creativecommons.org/licenses/by-nc/4.0/