KENGER (GUNDELIA TOURNEFORTII L.) BİTKİSİNİN FARKLI KISIMLARININ BİYOAKTİF, SİTOTOKSİK VE ANTİDİYABETİK POTANSİYELİNİN IN VITRO DEĞERLENDİRİLMESİ

Öz

Bu çalışma, kenger bitkisinin kökleri (TR), gövde ve yaprakları (TSL) ile çiçeklerinin (TF) fizikokimyasal özelliklerini, biyoaktif bileşiklerini, sitotoksisite ve antidiabetik potansiyelini incelemeyi amaçlamıştır. Sonuçlar, en yüksek ham protein (%13.91), ham yağ (%15.50), toplam fenolik içeriği (214.64 mg GAE/g), toplam monomerik antosiyanin içeriği (1132.96 mg/g), ABTS (25.48 mg TE/g), CUPRAC (203.92 mg TE/g) ve FRAP (32.63 µmol Fe²⁺E/g) aktiviteleri açısından en zengin kısmının TF olduğunu göstermiştir. Magnezyum, potasyum ve kalsiyum gibi mineraller tüm bitki kısımlarında belirgin miktarda bulunmuştur. TF, aynı zamanda en yüksek α-glukozidaz (%61.99) ve α-amilaz (%54.92) inhibisyonu göstererek güçlü antidiabetik potansiyele işaret etmiştir. Tüm örneklerde sitotoksisite zayıf bulunmuş olup HEK-293 ve Caco-2 hücrelerine karşı IC50 değerleri 1049.76-1641.08 μg/mL arasında değişmiştir. Bu bulgular, kenger bitkisinin biyoaktif ve besin öğeleri açısından en zengin kısmının TF olduğunu göstermektedir.

Anahtar Kelimeler

• Gundelia tournefortii L. bitkisi
• biyoaktif özellikler
• antidiyabetik potansiyel
• antiproliferatif özellikler
• mineral içeriği.

Destekleyen Kurum

Yoktur.

Etik Beyan

Yoktur

Teşekkür

Yoktur

AN IN VITRO ASSESSMENT OF THE BIOACTIVE, CYTOTOXIC, AND ANTIDIABETIC POTENTIAL OF DIFFERENT PARTS OF TUMBLEWEED (GUNDELIA TOURNEFORTII L.)

Öz

This study aimed to investigate the physicochemical properties, bioactive compounds, cytotoxicity, and antidiabetic potential of the tumbleweed plant’s roots (TR), stems & leaves (TSL), and flowers (TF). Results indicated TF as the richest part in bioactive compounds and antioxidant capacity, with the highest crude protein (13.91%), crude oil (15.50%), total phenolic content (214.64 mg GAE/g), total monomeric anthocyanin content (1132.96 mg/g), ABTS (25.48 mg TE/g), CUPRAC (203.92 mg TE/g), and FRAP (32.63 µmol Fe²⁺E/g) activities. Mineral contents varied, with Mg, K, and Ca present in significant amounts across all parts. TF also showed the highest α-glucosidase (61.99%) and α-amylase (54.92%) inhibition, suggesting strong antidiabetic potential. Cytotoxicity was weak across samples, with IC50 values ranging from 1049.76 to 1641.08 μg/ mL against HEK-293 and Caco-2 cells. These findings highlight TF as the most bioactive and nutritionally rich part of the tumbleweed plant.

Anahtar Kelimeler

• Gundelia tournefortii L.
• bioactive properties
• antidiabetic potential
• antiproliferative characteristics
• mineral content.

Kaynakça

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