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FONKSİYONEL GIDA KAVRAMINA YENİ BİR BAKIŞ: POSTBİYOTİKLER

Yıl 2021, Cilt: 46 Sayı: 4, 872 - 882, 17.05.2021
https://doi.org/10.15237/gida.GD21035

Öz

Tüketicilerin fonksiyonel gıda ürünlerine olan talepleri son 20 yılda artmıştır. Bu eğilimin bir sonucu olarak, probiyotik gıda ürünleri pazarında hızlı bir büyüme gözlemlenmiştir. Ancak, probiyotik gıda ürünlerinin raf ömrü, bu pazarı ve tüketici taleplerini karşılamada sınırlayıcı bir faktördür. Bu noktada postbiyotikler, sağlık potansiyellerinin yanı sıra bu tür sınırları aşmak için yeni bir kavram olarak ortaya çıkmıştır. Kısaca postbiyotikler, mikroorganizmalar tarafından üretilen biyoaktif maddeler yani fermantasyon metabolitleridir. Mikrobiyal metabolitler, mikrobiyal hücreler ve bunların bileşenlerini içerebilirler. Çeşitli probiyotiklerden veya aktif olmayan formlarından elde edilebilirler. Son yıllarda, doğasını ve potansiyel sağlık yararlarını anlamak için giderek daha fazla sayıda araştırma yapılmaktadır. Bu çalışmanın amacı, içerikleri ve potansiyel sağlık yararları ile ilgili postbiyotikler üzerine yapılan güncel çalışmalar hakkında bilgi vermektir.

Destekleyen Kurum

Süleyman Demirel Üniversitesi BAP Komisyonu

Proje Numarası

FDK-2020-7481

Teşekkür

Çağlar Gökırmaklı 100/2000 YÖK Doktora Bursiyeri olarak Yükseköğretim Kurulu Başkanlığı'na teşekkür eder.

Kaynakça

  • Aguilar-Toalá, J.E., Garcia-Varela, R., Garcia, H.S., Mata-Haro, V., González-Córdova, A. F., Vallejo-Cordoba, B., Hernández-Mendoza, A. (2018). Postbiotics: An evolving term within the functional foods field. Trends Food Sci Technol, 75: 105-114. doi: 10.1016/j.tifs.2018.03.009 Akal C., Yetişemiyen A. (2020). Probiyotik ve prebiyotik tüketiminin laktoz intoleransı üzerine etkileri. GIDA, 45(2): 380-389. doi: 10.15237/gida.GD20016
  • Akdeniz-Oktay B., Özbaş, Z.Y. (2020). Fermente gıdaların insan sağlığı üzerindeki etkileri. GIDA, 45(6): 1215-1226 doi: 10.15237/gida.GD20105
  • Akdeniz V., Özer E., Akalın A.S. (2018). Helicobacter pylori enfeksiyonunda probiyotiklerin rolü. GIDA, 43(6): 943-956. doi: 10.15237/gida.GD18062
  • Anderson, R.C. (2019). Are postbiotics the long sought-after solution for a leaky gut?. J Nutr, 149(11):1873-1874. doi: 10.1093/jn/nxz171
  • Ang, C.Y., Sano M., Dan S., Leelakriangsak M., Lal T.M. (2020). Postbiotics applications as infectious disease control agent in aquaculture. Biocontrol Sci, 25(1): 1-7. doi: 10.4265/BIO.25.1
  • Arpa-Zemzemoğlu, T.E., Uludağ, E., Uzun, S. (2019). Üniversite öğrencilerinin probiyotik bilgi düzeyi ve tüketim durumlarının belirlenmesi. GIDA. 44(1): 118-130. doi: 10.15237/gida.GD18104
  • Ashwini, A., Ramya, H.N., Ramkumar, C., Reddy, K.R., Kulkarni, R.V., Abinaya, V., Raghu, A.V. (2019). Reactive mechanism and the applications of bioactive prebiotics for human health. J Microbiol Methods, 159, 128-137. doi: 10.1016/j.mimet.2019.02.019
  • Azizkhani, M., Saris, P.E.J., Baniasadi, M. (2020). An in-vitro assessment of antifungal and antibacterial activity of cow, camel, ewe, and goat milk kefir and probiotic yogurt. J. Food Meas Charact. doi: 10.1007/s11694-020-00645-4
  • Cuevas-González, P.F., Liceaga, A.M., Aguilar-Toalá, J.E. (2020). Postbiotics and paraprobiotics: From concepts to applications. Food Res Int, 136: 109502. doi: 10.1016/j.foodres.2020.109502
  • Chaluvadi S., Hotchkiss A. T., Yam K. L. (2015). Gut microbiota: Impact of probiotics, prebiotics, synbiotics, pharmabiotics, and postbiotics on human health. In: Probiotics, Prebiotics, and Synbiotics. Preedy, V., Watson, R. (ed.) 1st Edition. Academic Press, the US,, pp. 515–523. doi: 10.1016/B978-0-12-802189-7.00036-8
  • Collado, M.C., Vinderola, G., Salminen, S. (2019). Postbiotics: facts and open questions. A position paper on the need for a consensus definition. Benef Microbes, 10(7): 711-719. doi: 10.3920/BM2019.0015
  • Cortés-Martín, A., Selma, M.V., Tomás-Barberán, F.A., González-Sarrías, A., Espín, J.C. (2020). Where to look into the puzzle of polyphenols and health? The Postbiotics and gut microbiota associated with human metabotypes. Mol Nutr Food Res, 64: e1900952. doi: 10.1002/mnfr.201900952
  • Craighead, A.F., Caughey, A.B., Chaudhuri, A. et al. (2020). Cost-effectiveness of probiotics for necrotizing enterocolitis prevention in very low birth weight infants. J Perinatol, 40: 1652–1661. doi: 10.1038/s41372-020-00790-0
  • D’Angelo, C., Reale, M., Costantini, E. (2017). Microbiota and probiotics in health and HIV infection. Nutrients, 9(6): 615. doi: 10.3390/nu9060615
  • Davani-Davari D., Negahdaripour M., Karimzadeh I., Seifan M., Mohkam M., Masoumi S. J., Berenjian A., Ghasemi Y. (2019). Prebiotics: Definition, types, sources, mechanisms, and clinical applications. Foods(Basel, Switzerland), 8(3), 92. https://doi.org/10.3390/foods8030092
  • de Simone, C. (2019). The unregulated probiotic market. Clin Gastroenterol Hepatol, 17(5): 809-817.
  • Di Cagno, R., Mazzacane, F., Rizzello, C. G., Vincentini, O., Silano, M., Giuliani, G., Gobbetti, M. (2010). Synthesis of isoflavone aglycones and equol in soy milks fermented by food-related lactic acid bacteria and their effect on human intestinal Caco-2 cells. J Agric Food Chem, 58(19), 10338-10346.
  • Dunand, E., Burns, P., Binetti, A., Bergamini, C., Peralta, G.H., Forzani L., Reinheimer J., Vinderola G. (2019). Postbiotics produced at laboratory and industrial level as potential functional food ingredients with the capacity to protect mice against Salmonella infection. J Appl Microbiol, 127(1): 219–29. doi: 10.1111/jam.14276.
  • Erem, F. (2019). Probiyotik fırın ürünleri üretim yöntemleri. GIDA, 44(3): 430-441 doi: 10.15237/gida.GD19025
  • Erk, G., Seven, A., Akpınar A. (2019). Vegan ve vejetaryan beslenmede probiyotik bitkisel bazlı süt ürünlerinin yeri. GIDA, 44 (3): 453-462 doi: 10.15237/gida.GD18083
  • Farias, D. dP., de Araújo, F.F., Neri-Numa, I.A., Pastore, G.M. (2019). Prebiotics: Trends in food, health and technological applications. Trends Food Sci Technol, 93: 23-35. doi: 10.1016/j.tifs.2019.09.004
  • Delzenne, N.M., Bindels, L.B., (2019). Food for thought about manipulating gut bacteria. Nature, 577, 32-34. doi: 10.1038/d41586-019-03704-z Gökırmaklı, Ç., Güzel-Seydim, Z. B. (2020). Probiyotiklerin Kolon Mikrobiyotasına Etkileri: Güncel Çalışmalar, J Biotechnol and Strategic Health Res. 4(3): 212-224
  • Güneş, R., Palabıyık, İ., Kurultay, Ş. (2018). Şekerleme teknolojisinde fonksiyonel ürün üretimi. GIDA, 43(6): 984-1001 doi: 10.15237/gida.GD18088
  • Hikmetoglu, M., Sogut, E., Sogut, O., Gokirmakli, C., Guzel-Seydim, Z. B. (2020). Changes in carbohydrate profile in kefir fermentation. Bioact Carbohydr Diet Fibre, 23: 100220. doi: 10.1016/j.bcdf.2020.100220
  • Homayouni-Rad, A., Aghebati Maleki, L., Samadi Kafil, H., Abbasi, A. (2020). Postbiotics: A novel strategy in food allergy treatment. Crit Rev Food Sci Nutr, 61(3): 492-499 doi: 10.1080/10408398.2020.1738333
  • Izuddin, W. I., Loh, T. C., Samsudin, A. A., & Foo, H. L. (2018). In vitro study of postbiotics from Lactobacillus plantarum RG14 on rumen fermentation and microbial population. R Bras Zootec, 47: e20170255. doi: 10.1590/rbz4720170255
  • Kocsis, T., Molnár, B., Németh, Hegyi P., Szakács Z., Bálint A., Garami A., Soós A., Márta K., Solymár M. (2020). Probiotics have beneficial metabolic effects in patients with type 2 diabetes mellitus: A meta-analysis of randomized clinical trials. Sci Rep, 10: 11787 doi: 10.1038/s41598-020-68440-1
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A NEW INSIGHT OF THE FUNCTIONAL FOOD CONCEPT: POSTBIOTICS

Yıl 2021, Cilt: 46 Sayı: 4, 872 - 882, 17.05.2021
https://doi.org/10.15237/gida.GD21035

Öz

Consumer demands on functional food products have been increased for the last 20 years. As a result of this trend, rapid growth in the probiotic food products market was observed. However, the limited shelf-life of probiotic food products is a limiting factor in improving this market and meeting consumer demands. At this point, postbiotics have emerged as a novel concept to exceed these kinds of limits as well as their health potentials. Briefly, postbiotics are bioactive products produced by microorganisms, i.e. fermentation metabolites. They may contain microbial metabolites, microbial cells, and their components. They may obtain from various probiotics or their inactive forms. In recent years increasingly, various investigations have been carried out to understand their nature and potential health benefits. This study aims to review recent studies on postbiotics related to their nature and potential health benefits.

Proje Numarası

FDK-2020-7481

Kaynakça

  • Aguilar-Toalá, J.E., Garcia-Varela, R., Garcia, H.S., Mata-Haro, V., González-Córdova, A. F., Vallejo-Cordoba, B., Hernández-Mendoza, A. (2018). Postbiotics: An evolving term within the functional foods field. Trends Food Sci Technol, 75: 105-114. doi: 10.1016/j.tifs.2018.03.009 Akal C., Yetişemiyen A. (2020). Probiyotik ve prebiyotik tüketiminin laktoz intoleransı üzerine etkileri. GIDA, 45(2): 380-389. doi: 10.15237/gida.GD20016
  • Akdeniz-Oktay B., Özbaş, Z.Y. (2020). Fermente gıdaların insan sağlığı üzerindeki etkileri. GIDA, 45(6): 1215-1226 doi: 10.15237/gida.GD20105
  • Akdeniz V., Özer E., Akalın A.S. (2018). Helicobacter pylori enfeksiyonunda probiyotiklerin rolü. GIDA, 43(6): 943-956. doi: 10.15237/gida.GD18062
  • Anderson, R.C. (2019). Are postbiotics the long sought-after solution for a leaky gut?. J Nutr, 149(11):1873-1874. doi: 10.1093/jn/nxz171
  • Ang, C.Y., Sano M., Dan S., Leelakriangsak M., Lal T.M. (2020). Postbiotics applications as infectious disease control agent in aquaculture. Biocontrol Sci, 25(1): 1-7. doi: 10.4265/BIO.25.1
  • Arpa-Zemzemoğlu, T.E., Uludağ, E., Uzun, S. (2019). Üniversite öğrencilerinin probiyotik bilgi düzeyi ve tüketim durumlarının belirlenmesi. GIDA. 44(1): 118-130. doi: 10.15237/gida.GD18104
  • Ashwini, A., Ramya, H.N., Ramkumar, C., Reddy, K.R., Kulkarni, R.V., Abinaya, V., Raghu, A.V. (2019). Reactive mechanism and the applications of bioactive prebiotics for human health. J Microbiol Methods, 159, 128-137. doi: 10.1016/j.mimet.2019.02.019
  • Azizkhani, M., Saris, P.E.J., Baniasadi, M. (2020). An in-vitro assessment of antifungal and antibacterial activity of cow, camel, ewe, and goat milk kefir and probiotic yogurt. J. Food Meas Charact. doi: 10.1007/s11694-020-00645-4
  • Cuevas-González, P.F., Liceaga, A.M., Aguilar-Toalá, J.E. (2020). Postbiotics and paraprobiotics: From concepts to applications. Food Res Int, 136: 109502. doi: 10.1016/j.foodres.2020.109502
  • Chaluvadi S., Hotchkiss A. T., Yam K. L. (2015). Gut microbiota: Impact of probiotics, prebiotics, synbiotics, pharmabiotics, and postbiotics on human health. In: Probiotics, Prebiotics, and Synbiotics. Preedy, V., Watson, R. (ed.) 1st Edition. Academic Press, the US,, pp. 515–523. doi: 10.1016/B978-0-12-802189-7.00036-8
  • Collado, M.C., Vinderola, G., Salminen, S. (2019). Postbiotics: facts and open questions. A position paper on the need for a consensus definition. Benef Microbes, 10(7): 711-719. doi: 10.3920/BM2019.0015
  • Cortés-Martín, A., Selma, M.V., Tomás-Barberán, F.A., González-Sarrías, A., Espín, J.C. (2020). Where to look into the puzzle of polyphenols and health? The Postbiotics and gut microbiota associated with human metabotypes. Mol Nutr Food Res, 64: e1900952. doi: 10.1002/mnfr.201900952
  • Craighead, A.F., Caughey, A.B., Chaudhuri, A. et al. (2020). Cost-effectiveness of probiotics for necrotizing enterocolitis prevention in very low birth weight infants. J Perinatol, 40: 1652–1661. doi: 10.1038/s41372-020-00790-0
  • D’Angelo, C., Reale, M., Costantini, E. (2017). Microbiota and probiotics in health and HIV infection. Nutrients, 9(6): 615. doi: 10.3390/nu9060615
  • Davani-Davari D., Negahdaripour M., Karimzadeh I., Seifan M., Mohkam M., Masoumi S. J., Berenjian A., Ghasemi Y. (2019). Prebiotics: Definition, types, sources, mechanisms, and clinical applications. Foods(Basel, Switzerland), 8(3), 92. https://doi.org/10.3390/foods8030092
  • de Simone, C. (2019). The unregulated probiotic market. Clin Gastroenterol Hepatol, 17(5): 809-817.
  • Di Cagno, R., Mazzacane, F., Rizzello, C. G., Vincentini, O., Silano, M., Giuliani, G., Gobbetti, M. (2010). Synthesis of isoflavone aglycones and equol in soy milks fermented by food-related lactic acid bacteria and their effect on human intestinal Caco-2 cells. J Agric Food Chem, 58(19), 10338-10346.
  • Dunand, E., Burns, P., Binetti, A., Bergamini, C., Peralta, G.H., Forzani L., Reinheimer J., Vinderola G. (2019). Postbiotics produced at laboratory and industrial level as potential functional food ingredients with the capacity to protect mice against Salmonella infection. J Appl Microbiol, 127(1): 219–29. doi: 10.1111/jam.14276.
  • Erem, F. (2019). Probiyotik fırın ürünleri üretim yöntemleri. GIDA, 44(3): 430-441 doi: 10.15237/gida.GD19025
  • Erk, G., Seven, A., Akpınar A. (2019). Vegan ve vejetaryan beslenmede probiyotik bitkisel bazlı süt ürünlerinin yeri. GIDA, 44 (3): 453-462 doi: 10.15237/gida.GD18083
  • Farias, D. dP., de Araújo, F.F., Neri-Numa, I.A., Pastore, G.M. (2019). Prebiotics: Trends in food, health and technological applications. Trends Food Sci Technol, 93: 23-35. doi: 10.1016/j.tifs.2019.09.004
  • Delzenne, N.M., Bindels, L.B., (2019). Food for thought about manipulating gut bacteria. Nature, 577, 32-34. doi: 10.1038/d41586-019-03704-z Gökırmaklı, Ç., Güzel-Seydim, Z. B. (2020). Probiyotiklerin Kolon Mikrobiyotasına Etkileri: Güncel Çalışmalar, J Biotechnol and Strategic Health Res. 4(3): 212-224
  • Güneş, R., Palabıyık, İ., Kurultay, Ş. (2018). Şekerleme teknolojisinde fonksiyonel ürün üretimi. GIDA, 43(6): 984-1001 doi: 10.15237/gida.GD18088
  • Hikmetoglu, M., Sogut, E., Sogut, O., Gokirmakli, C., Guzel-Seydim, Z. B. (2020). Changes in carbohydrate profile in kefir fermentation. Bioact Carbohydr Diet Fibre, 23: 100220. doi: 10.1016/j.bcdf.2020.100220
  • Homayouni-Rad, A., Aghebati Maleki, L., Samadi Kafil, H., Abbasi, A. (2020). Postbiotics: A novel strategy in food allergy treatment. Crit Rev Food Sci Nutr, 61(3): 492-499 doi: 10.1080/10408398.2020.1738333
  • Izuddin, W. I., Loh, T. C., Samsudin, A. A., & Foo, H. L. (2018). In vitro study of postbiotics from Lactobacillus plantarum RG14 on rumen fermentation and microbial population. R Bras Zootec, 47: e20170255. doi: 10.1590/rbz4720170255
  • Kocsis, T., Molnár, B., Németh, Hegyi P., Szakács Z., Bálint A., Garami A., Soós A., Márta K., Solymár M. (2020). Probiotics have beneficial metabolic effects in patients with type 2 diabetes mellitus: A meta-analysis of randomized clinical trials. Sci Rep, 10: 11787 doi: 10.1038/s41598-020-68440-1
  • Maguire, M., Maguire, G. (2018). Gut dysbiosis, leaky gut, and intestinal epithelial proliferation in neurological disorders: Towards the development of a new therapeutic using amino acids, prebiotics, probiotics, and postbiotics. Rev Neurosci, 30(2): 179-201. doi: 10.1515/revneuro-2018-0024
  • Malagón-Rojas, J. N., Mantziari, A., Salminen, S., & Szajewska, H. (2020). Postbiotics for preventing and treating common infectious diseases in children: A systematic review. Nutrients, 12(2), 389. doi: http://dx.doi.org/10.3390/nu12020389
  • Marx, W., Scholey, A., Firth, J., D’Cunha, N. M., Lane, M., Hockey, M., Ashton M. M., Cryan J. F., O'Neil A., Naumovski N., Berk M., Dean O. M., Jacka F. (2020). Prebiotics, probiotics, fermented foods and cognitive outcomes: A meta-analysis of randomized controlled trials. Neurosci Biobehav Rev, 118: 472-484. doi: 10.1016/j.neubiorev.2020.07.036
  • Mayorgas, A. (2020). P840 Immunomodulatory effects of two different postbiotics on primary human cell culture. J Crohns Colitis, 14(Supplement 1): S650. doi: 10.1093/ecco-jcc/jjz203.968
  • McFarland, L.V., Evans, C.T., Goldstein, E.J.C. (2018). Strain-specificity and disease-specificity of probiotic efficacy: A systematic review and meta-analysis. Front Med, 5: 124. doi: 10.3389/fmed.2018.00124
  • Moradi, M., Mardani, K., Tajik, H. (2019). Characterization and application of postbiotics of Lactobacillus spp. on Listeria monocytogenes in vitro and in food models. LWT-Food Sci Technol, 111: 457-464. doi: 10.1016/j.lwt.2019.05.072
  • Myles, I.A. (2014). Fast food fever: Reviewing the impacts of the Western diet on immunity. Nutr J, 13: 61. doi: 10.1186/1475-2891-13-61
  • Nataraj, B.H., Ali, S.A., Behare, P.V., Yadav H. (2020). Postbiotics-parabiotics: the new horizons in microbial biotherapy and functional foods. Microb Cell Fact, 19: 168. doi: 10.1186/s12934-020-01426-w
  • Nuraida, L. (2015). A review: Health promoting lactic acid bacteria in traditional Indonesian fermented foods. Food Sci Hum Well, 4(2), 47-55. doi: 10.1016/j.fshw.2015.06.001
  • O’Toole, P.W., Marchesi, J.R., Hill, C. (2017). Next-generation probiotics: The spectrum from probiotics to live biotherapeutics. Nat Microbiol, 2: 17057. doi: 10.1038/nmicrobiol.2017.57
  • Öztürk-Oruç, S., Çakır, İ. (2019). Probiyotik kültürlerle fermente karpuz suyu üretimi üzerine bir araştırma. GIDA, 44(6): 1030-1041 doi: 10.15237/gida.GD19124
  • Öztürk, Z., Gündüz, G.T. (2018). Gıda kaynaklı patojenlerin inhibisyonunda probiyotik mikroorganizmaların kullanımı. GIDA, 43(4): 533-548. doi: 10.15237/gida.GD17112
  • Păcularu-Burada, B., Georgescu, L.A., Vasile, M.A., Rocha, J.M., Bahrim, G.E. (2020). Selection of wild lactic acid bacteria strains as promoters of postbiotics in gluten-free sourdoughs. Microorganisms. 8(5): 643. doi: 10.3390/microorganisms8050643
  • Paton, A., Morona, R., Paton, J. (2006). Designer probiotics for prevention of enteric infections. Nat Rev Microbiol, 4: 193–200. doi: https://doi.org/10.1038/nrmicro1349
  • Perricone, M., Bevilacqua, A., Altieri, C., Sinigaglia, M., Corbo, M. (2015). Challenges for the production of probiotic fruit juices. Beverages, 1(2): 95–103. doi: 10.3390/beverages1020095
  • Quigley, E.M. (2019). Prebiotics and probiotics in digestive health. Clin Gastroenterol Hepatol, 17(2), 333-344. doi: 10.1016/j.cgh.2018.09.028
  • Rad, A.H., Maleki, L.A., Kafil, H.S., Zavoshti, H.F., Abbasi, A. (2020a). Postbiotics as novel health-promoting ingredients in functional foods. Health Promot Perspect, 10(1): 3–4. doi: 10.15171/hpp.2020.02
  • Rad, A.H., Aghebati-Maleki, L., Kafil, H. S., Abbasi, A. (2020b). Molecular mechanisms of postbiotics in colorectal cancer prevention and treatment. Crit Rev Food Sci Nutr, 1-17. doi: 10.1080/10408398.2020.1765310
  • Reynés, B., Palou, M., Rodríguez, A.M., Palou, A. (2019). Regulation of adaptive thermogenesis and browning by prebiotics and postbiotics. Front Physiol, 9: 1908. doi: 10.3389/fphys.2018.01908
  • Roobab, U., Batool, Z., Manzoor, M.F., Shabbir, M.A., Khan, M.R., Aadil, R.M. (2020). Sources, formulations, advanced delivery and health benefits of probiotics. Curr Opin Food Sci, 32, 17-28. doi: 10.1016/j.cofs.2020.01.003
  • Sarkar, A., Lehto, S. M., Harty, S., Dinan, T. G., Cryan, J. F., & Burnet, P. W. (2016). Psychobiotics and the manipulation of bacteria–gut–brain signals. Trends Neurosci, 39(11), 763-781. doi: 10.1016/j.tins.2016.09.002
  • Sarkar, S. (2016). Efficacy of dead probiotic cells. Int J Food Sci Nutr Diet 5(2e): 1. doi: dx.doi.org/10.19070/2326-3350-160006e
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  • Şengün, İ.Y., Kırmızıgül, A., Özaydın, İ., Yarım, H. (2020). Tüketicilerin probiyotik ve prebiyotik gıdalara yönelik bilgi düzeyleri ve tüketim durumlarının belirlenmesi: İzmir/Bornova örneği. GIDA, 45(1): 103-114. doi: 10.15237/gida.GD19123
  • Singh, B., Mal, G., Marotta, F. (2017). Designer probiotics: Paving the way to living therapeutics. Trends Biotechnol, 35(8): 679-682. doi: 10.1016/j.tibtech.2017.04.001
  • Taverniti, V., Guglielmetti, S. (2011). The immunomodulatory properties of probiotic microorganisms beyond their viability (ghost probiotics: proposal of paraprobiotic concept). Genes Nutr, 6(3), 261–274. doi: 10.1007/s12263-011-0218-x
  • Tomasik, P., Tomasik, P. (2020). Probiotics, non-dairy prebiotics and postbiotics in nutrition. Appl Sci, 10: 1470. doi: 10.3390/app10041470
  • Tsai, Y.C., Cheng, L.H., Liu, Y.W., Jeng, O.J., Lee, Y.K. (2021). Gerobiotics: Probiotics targeting fundamental aging processes. Biosci Microbiota Food Health, 40(1): 1–11. doi:10.12938/bmfh.2020-026
  • Wargo, J.A. (2020). Modulating gut microbes. Science, 369(6509): 1302-1303. doi: 10.1126/science.abc3965
  • Wegh, C.A.M., Geerlings, S.Y., Knol, J., Roeselers, G., Belzer, C. (2019). Postbiotics and their potential applications in early life nutrition and beyond. Int J Mol Sci, 20(19): 4673. doi: 10.3390/ijms20194673
  • Xiao, J., Wang, T., Xu, Y. Gu X., Li D., Niu K., Wang T., Zhao J., Zhou R., Wang H.L. (2020). Long-term probiotic intervention mitigates memory dysfunction through a novel H3K27me3-based mechanism in lead-exposed rats. Transl Psychiatry. 10: 25. doi: 10.1038/s41398-020-0719-8
  • Yang, J.J., Yu, D., Xiang, Y.B. et al. (2020). Association of dietary fiber and yogurt consumption with lung cancer risk: A pooled analysis. JAMA Oncol, 6(2): e194107. doi: 10.1001/jamaoncol.2019.4107
  • Zhang, Y., Gu, Y., Ren, H. et al. (2020). Gut microbiome-related effects of berberine and probiotics on type 2 diabetes (the PREMOTE study). Nat Commun, 11: 5015. https://doi.org/10.1038/s41467-020-18414-8
Toplam 60 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Gıda Mühendisliği
Bölüm Makaleler
Yazarlar

Çağlar Gökırmaklı 0000-0002-2572-8589

Bilgenur Üçgül Bu kişi benim 0000-0002-6834-5086

Zeynep Seydim 0000-0002-1536-6545

Proje Numarası FDK-2020-7481
Yayımlanma Tarihi 17 Mayıs 2021
Yayımlandığı Sayı Yıl 2021 Cilt: 46 Sayı: 4

Kaynak Göster

APA Gökırmaklı, Ç., Üçgül, B., & Seydim, Z. (2021). FONKSİYONEL GIDA KAVRAMINA YENİ BİR BAKIŞ: POSTBİYOTİKLER. Gıda, 46(4), 872-882. https://doi.org/10.15237/gida.GD21035
AMA Gökırmaklı Ç, Üçgül B, Seydim Z. FONKSİYONEL GIDA KAVRAMINA YENİ BİR BAKIŞ: POSTBİYOTİKLER. GIDA. Mayıs 2021;46(4):872-882. doi:10.15237/gida.GD21035
Chicago Gökırmaklı, Çağlar, Bilgenur Üçgül, ve Zeynep Seydim. “FONKSİYONEL GIDA KAVRAMINA YENİ BİR BAKIŞ: POSTBİYOTİKLER”. Gıda 46, sy. 4 (Mayıs 2021): 872-82. https://doi.org/10.15237/gida.GD21035.
EndNote Gökırmaklı Ç, Üçgül B, Seydim Z (01 Mayıs 2021) FONKSİYONEL GIDA KAVRAMINA YENİ BİR BAKIŞ: POSTBİYOTİKLER. Gıda 46 4 872–882.
IEEE Ç. Gökırmaklı, B. Üçgül, ve Z. Seydim, “FONKSİYONEL GIDA KAVRAMINA YENİ BİR BAKIŞ: POSTBİYOTİKLER”, GIDA, c. 46, sy. 4, ss. 872–882, 2021, doi: 10.15237/gida.GD21035.
ISNAD Gökırmaklı, Çağlar vd. “FONKSİYONEL GIDA KAVRAMINA YENİ BİR BAKIŞ: POSTBİYOTİKLER”. Gıda 46/4 (Mayıs 2021), 872-882. https://doi.org/10.15237/gida.GD21035.
JAMA Gökırmaklı Ç, Üçgül B, Seydim Z. FONKSİYONEL GIDA KAVRAMINA YENİ BİR BAKIŞ: POSTBİYOTİKLER. GIDA. 2021;46:872–882.
MLA Gökırmaklı, Çağlar vd. “FONKSİYONEL GIDA KAVRAMINA YENİ BİR BAKIŞ: POSTBİYOTİKLER”. Gıda, c. 46, sy. 4, 2021, ss. 872-8, doi:10.15237/gida.GD21035.
Vancouver Gökırmaklı Ç, Üçgül B, Seydim Z. FONKSİYONEL GIDA KAVRAMINA YENİ BİR BAKIŞ: POSTBİYOTİKLER. GIDA. 2021;46(4):872-8.

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