Ratların Akciğer Dokusu Üzerine Nikel Oksit’in Toksik Etkisi ve Resveratrol’ün Koruyucu Rolü

Müzeyyen Aybüke Yayla; Çağlar Adıgüzel

doi:10.63716/guffd.1759695

Ratların Akciğer Dokusu Üzerine Nikel Oksit’in Toksik Etkisi ve Resveratrol’ün Koruyucu Rolü

Öz

Nikel oksit (NiO) endüstride sıklıkla kulanılan bir geçiş metalidir. Yaygın kullanımına bağlı olarak halk sağlığı ve çevre sorunları meydana gelmiştir. Resveratrol (RES) antioksidan aktiviteleri güçlü olan bir fenolik bileşikdir. Şu anki çalışma NiO’nun ratların akciğer dokusundaki yarattığı oksidatif ve histopatolojik hasara karşı RES’in koruyucu rolünü araştırmıştır. Çalışmada 4 grup (her grupta 6 hayvan) oluşturulmuştur. Kontrol grubu, RES grubu (10 mg/kg v.a.), NiO grubu (10 mg/kg v.a.) ve RES+NiO grubu. 28 günlük oral gavaj uygulaması sonrası NiO uygulanan ratların akciğer dokularındaki, nikel birikimi ve MDA miktarı konrol grubuna göre anlamlı bir yükselme göstermiştir (p<0,05). SOD, CAT, GPx ve GST gibi antioksidanlarda ise anlamlı bir azalma meydana gelmiştir (p<0,05). Ayrıca NiO uygulanan gruptaki ratların akciğer dokularında ciddi histopatolojik değişiklikler gözlenmiştir. RES ve NiO’nun beraber uygulandığı grupta nikel birikiminde ve MDA düzeyinde anlamlı bir azalma, antioksidan aktivitelerde ise anlamlı bir artma meydana gelmiştir. Aynı zamanda histopatolojik incelemede iyileşmeler gözlenmiştir. Bu sonuçlar RES’in önemli bir takviye gıda olduğunu göstermektedir.

Anahtar Kelimeler

Etik Beyan

Hayvan deneyleri ile ilgili tüm süreçler Gazi Üniversitesi Hayvan Deneyleri Yerel Etik Kurulu tarafından onaylanmıştır (Etik Kurul No: G.U.ET-24.135).

Teşekkür

Çalışmamızın hayvan deneyleri kısmını FYL-2024-9656 no’lu pojeden destekleyen Gazi Üniversitesi Bilimsel Araştırma Projeleri birimine teşekkür ederiz. Bu çalışma, Gazi Üniversitesi Fen Bilimleri Enstitüsü Biyoloji Anabilim Dalında, “Nikel Oksit'in Rat Akciğer Dokusu Üzerine Toksik Etkisi ve Resveratrol'ün Koruyucu Etkisi” isimli yüksek lisans tezinden türetilmiştir.

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Ayrıntılar

Birincil Dil

Türkçe

Konular

Hayvan Fizyolojisi - Hücre

Bölüm

Araştırma Makalesi

Yazarlar

Müzeyyen Aybüke Yayla
0000-0002-4681-6887
Türkiye

Çağlar Adıgüzel ^*
0000-0003-3716-0051
Türkiye

Yayımlanma Tarihi

29 Kasım 2025

Gönderilme Tarihi

6 Ağustos 2025

Kabul Tarihi

18 Kasım 2025

Yayımlandığı Sayı

Yıl 2025 Cilt: 6 Sayı: 2

DOI

https://doi.org/10.63716/guffd.1759695

IZ

https://izlik.org/JA99XR33TD

Kaynak Göster

RIS / Bibtex

APA

Yayla, M. A., & Adıgüzel, Ç. (2025). Ratların Akciğer Dokusu Üzerine Nikel Oksit’in Toksik Etkisi ve Resveratrol’ün Koruyucu Rolü. Gazi Üniversitesi Fen Fakültesi Dergisi, 6(2), 384-394. https://doi.org/10.63716/guffd.1759695

AMA

1.Yayla MA, Adıgüzel Ç. Ratların Akciğer Dokusu Üzerine Nikel Oksit’in Toksik Etkisi ve Resveratrol’ün Koruyucu Rolü. GÜFFD. 2025;6(2):384-394. doi:10.63716/guffd.1759695

Chicago

Yayla, Müzeyyen Aybüke, ve Çağlar Adıgüzel. 2025. “Ratların Akciğer Dokusu Üzerine Nikel Oksit’in Toksik Etkisi ve Resveratrol’ün Koruyucu Rolü”. Gazi Üniversitesi Fen Fakültesi Dergisi 6 (2): 384-94. https://doi.org/10.63716/guffd.1759695.

EndNote

Yayla MA, Adıgüzel Ç (01 Kasım 2025) Ratların Akciğer Dokusu Üzerine Nikel Oksit’in Toksik Etkisi ve Resveratrol’ün Koruyucu Rolü. Gazi Üniversitesi Fen Fakültesi Dergisi 6 2 384–394.

IEEE

[1]M. A. Yayla ve Ç. Adıgüzel, “Ratların Akciğer Dokusu Üzerine Nikel Oksit’in Toksik Etkisi ve Resveratrol’ün Koruyucu Rolü”, GÜFFD, c. 6, sy 2, ss. 384–394, Kas. 2025, doi: 10.63716/guffd.1759695.

ISNAD

Yayla, Müzeyyen Aybüke - Adıgüzel, Çağlar. “Ratların Akciğer Dokusu Üzerine Nikel Oksit’in Toksik Etkisi ve Resveratrol’ün Koruyucu Rolü”. Gazi Üniversitesi Fen Fakültesi Dergisi 6/2 (01 Kasım 2025): 384-394. https://doi.org/10.63716/guffd.1759695.

JAMA

1.Yayla MA, Adıgüzel Ç. Ratların Akciğer Dokusu Üzerine Nikel Oksit’in Toksik Etkisi ve Resveratrol’ün Koruyucu Rolü. GÜFFD. 2025;6:384–394.

MLA

Yayla, Müzeyyen Aybüke, ve Çağlar Adıgüzel. “Ratların Akciğer Dokusu Üzerine Nikel Oksit’in Toksik Etkisi ve Resveratrol’ün Koruyucu Rolü”. Gazi Üniversitesi Fen Fakültesi Dergisi, c. 6, sy 2, Kasım 2025, ss. 384-9, doi:10.63716/guffd.1759695.

Vancouver

1.Müzeyyen Aybüke Yayla, Çağlar Adıgüzel. Ratların Akciğer Dokusu Üzerine Nikel Oksit’in Toksik Etkisi ve Resveratrol’ün Koruyucu Rolü. GÜFFD. 01 Kasım 2025;6(2):384-9. doi:10.63716/guffd.1759695