Tümör-Bağışıklık Hücre Etkileşimlerini Araştırmak İçin Biyomühendisliksel Yöntemler

Tuğba Topal; Zehra Ece Uzun

doi:10.63716/guffd.1768168

Tümör-Bağışıklık Hücre Etkileşimlerini Araştırmak İçin Biyomühendisliksel Yöntemler

Öz

Son yıllarda, immün hücrelerin tümör organoidleri ile birlikte kültürlenmesine yönelik artan bir ilgi bulunmaktadır. Bu yaklaşım, tümörler ile immün sistem arasındaki karmaşık etkileşimlere dair önemli bilgiler elde edilmesini sağlamıştır. Bu çalışmada, tümör mikro çevresi içerisinde yer alan immün hücrelerle olan etkileşimlerin modellenmesine yönelik olarak geliştirilen tümör–immün sistem hücresi organoidlerine dair mevcut gelişmeler ele alınmaktadır. Tümörün oluşumu, tümör mikro çevresinin temel bileşenleri ve bu çevrede yer alan başlıca immün hücre türleri hakkında genel bir çerçeve sunulmuştur. Özellikle hücre dışı matriksin biyokimyasal ve mekanik özelliklerinin; hücreler arası sinyalleşme, hücre göçü ve immün hücrelerin tümöre erişimi üzerindeki etkileri değerlendirilmektedir. Üç boyutlu kültür yöntemleriyle oluşturulan organoid modellerin geliştirilmesi, hastadan türetilmiş örneklerin kullanımı ve organ-on-a-chip gibi ileri teknolojilere dayalı yaklaşımlar sayesinde, tümör–immün sistem etkileşimlerinin daha fizyolojik koşullarda modellenmesi mümkün hale gelmektedir. Son olarak, bu modellerin klinik araştırmalarda kullanımı, tümör biyolojisinin anlaşılmasına katkıları ve gelecekteki potansiyel uygulama alanları tartışılmaktadır.

Anahtar Kelimeler

Kaynakça

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Ayrıntılar

Birincil Dil

Türkçe

Konular

Hücre Gelişimi, Proliferasyon ve Ölümü, Biyokimya ve Hücre Biyolojisi (Diğer), Nanobiyoteknoloji, Hayvan Fizyolojisi - Hücre

Bölüm

Derleme

Yazarlar

Tuğba Topal ^*
0000-0002-8865-9656
United States

Zehra Ece Uzun
0009-0007-7581-3478
Türkiye

Yayımlanma Tarihi

29 Kasım 2025

Gönderilme Tarihi

18 Ağustos 2025

Kabul Tarihi

9 Kasım 2025

Yayımlandığı Sayı

Yıl 2025 Cilt: 6 Sayı: 2

DOI

https://doi.org/10.63716/guffd.1768168

IZ

https://izlik.org/JA92NA33MA

Kaynak Göster

RIS / Bibtex

APA

Topal, T., & Uzun, Z. E. (2025). Tümör-Bağışıklık Hücre Etkileşimlerini Araştırmak İçin Biyomühendisliksel Yöntemler. Gazi Üniversitesi Fen Fakültesi Dergisi, 6(2), 343-374. https://doi.org/10.63716/guffd.1768168

AMA

1.Topal T, Uzun ZE. Tümör-Bağışıklık Hücre Etkileşimlerini Araştırmak İçin Biyomühendisliksel Yöntemler. GÜFFD. 2025;6(2):343-374. doi:10.63716/guffd.1768168

Chicago

Topal, Tuğba, ve Zehra Ece Uzun. 2025. “Tümör-Bağışıklık Hücre Etkileşimlerini Araştırmak İçin Biyomühendisliksel Yöntemler”. Gazi Üniversitesi Fen Fakültesi Dergisi 6 (2): 343-74. https://doi.org/10.63716/guffd.1768168.

EndNote

Topal T, Uzun ZE (01 Kasım 2025) Tümör-Bağışıklık Hücre Etkileşimlerini Araştırmak İçin Biyomühendisliksel Yöntemler. Gazi Üniversitesi Fen Fakültesi Dergisi 6 2 343–374.

IEEE

[1]T. Topal ve Z. E. Uzun, “Tümör-Bağışıklık Hücre Etkileşimlerini Araştırmak İçin Biyomühendisliksel Yöntemler”, GÜFFD, c. 6, sy 2, ss. 343–374, Kas. 2025, doi: 10.63716/guffd.1768168.

ISNAD

Topal, Tuğba - Uzun, Zehra Ece. “Tümör-Bağışıklık Hücre Etkileşimlerini Araştırmak İçin Biyomühendisliksel Yöntemler”. Gazi Üniversitesi Fen Fakültesi Dergisi 6/2 (01 Kasım 2025): 343-374. https://doi.org/10.63716/guffd.1768168.

JAMA

1.Topal T, Uzun ZE. Tümör-Bağışıklık Hücre Etkileşimlerini Araştırmak İçin Biyomühendisliksel Yöntemler. GÜFFD. 2025;6:343–374.

MLA

Topal, Tuğba, ve Zehra Ece Uzun. “Tümör-Bağışıklık Hücre Etkileşimlerini Araştırmak İçin Biyomühendisliksel Yöntemler”. Gazi Üniversitesi Fen Fakültesi Dergisi, c. 6, sy 2, Kasım 2025, ss. 343-74, doi:10.63716/guffd.1768168.

Vancouver

1.Tuğba Topal, Zehra Ece Uzun. Tümör-Bağışıklık Hücre Etkileşimlerini Araştırmak İçin Biyomühendisliksel Yöntemler. GÜFFD. 01 Kasım 2025;6(2):343-74. doi:10.63716/guffd.1768168