Rosmarinik Asit ve Karvakrol Kombinasyonunun Diyabetik Yara İyileşmesi Modelinde Böbrek Oksidatif Stres Biyobelirteçleri Üzerine Modülatör Etkileri

Yıl 2025, Cilt: 6 Sayı: 2, 395 - 408, 29.11.2025

Bahar Şahin , Feyza Kökkaya , Elif Naz Gürsoy , Kübra Şener , Şule Coşkun Cevher

https://doi.org/10.63716/guffd.1798377

Öz

Diyabetik yara iyileşmesi, yalnızca lokal doku hasarıyla sınırlı kalmayıp uzak organlarda da oksidatif stres aracılı sistemik etkiler ortaya çıkarmaktadır. Bu çalışmada, güçlü fenolik bileşikler olan Rosmarinik Asit (RA) ve Karvakrol (CAR) kombinasyonunun diyabetik rat böbrek dokusunda oksidatif stres parametreleri üzerindeki etkileri araştırılmıştır. Streptozotosin (STZ, 60 mg/kg, i.p.) ile diyabet modeli oluşturulan 72 Wistar Albino erkek rat, kontrol, diyabet, Karbopol jel, RA+CAR topikal (3. ve 7. gün) ve intraperitoneal (3. ve 7. gün) gruplarına ayrılmıştır. Böbrek dokularında Malondialdehit (MDA), Nitrik Oksit (NOx) ve Glutatyon (GSH) düzeyleri spektrofotometrik yöntemlerle belirlenmiştir. RA+CAR kombinasyonunun, tedavisiz gruplara kıyasla böbrek dokusunda MDA ve NOx düzeylerini anlamlı olarak azalttığı ve GSH düzeylerinde istatistiksel olarak anlamlı artış sağladığı belirlenmiştir (p<0,05). En belirgin etki 7 günlük intraperitoneal uygulamada gözlenmiş olup, bu grupta parametrelerin kontrol grubuna benzer düzeyler sergilediği gözlemlenmiştir. Bu bulgular, RA ve CAR kombinasyonunun diyabetik yara modelinde yalnızca lokal değil, sistemik düzeyde de oksidatif stresi modüle ederek terapötik potansiyel sunduğunu ortaya koymaktadır.

Anahtar Kelimeler

diyabetik yara , antioksidan , rosmarinik asit , karvakrol , böbrek , oksidatif stres

Etik Beyan

G.Ü.ET-21.079

Destekleyen Kurum

TÜBİTAK

Teşekkür

Bu çalışma TÜBİTAK 2209/A- Üniversite Öğrencileri Yurt İçi Araştırma Projeleri Destek Programı kapsamında desteklenmiştir.

Kaynakça

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