TERMAL BOZUNMA YÖNTEMİYLE KÜP ŞEKLİNDEKİ MANYETİT NANOPARTİKÜLLERİN OLUŞUM SÜRECİ VE YÜZEY MODİFİKASYONU

Öz

Yaklaşık elli yıl önce bilim dünyasında yer almaya başlayan nanoteknoloji kavramı, popülerliğini kaybetmeden etkini arttırarak gelişmeye devam etmektedir. Nano boyuttaki malzemelerin olağan üstü özellikleri, sağlık, enerji, data depolama, ve biyomedikal vs., alanlarda insan hayatının refahını arttırmaktadır. Nanoparçacıklar bu uygulama alanlarının önemli unsurlarındandır. Özellikle manyetik nanoparçacıklar, eşsiz manyetik özellikleri sayesinde manyetik hedefleme, ve manyetik hipertermi tedavilerinde kanser tedavisi alanında kullanımları oldukça yaygındır. Manyetik nanoparçacıklarının şekil , boyut ve yüzey modifikasyonunu kanser tedavisi uygulamalarında oldukça önemli parametrelerdir. Bu çalışmada termal bozunma yöntemi kullanılarak homojen boyut aralığına sahip, küp şeklinde manyetit (Fe3O4) nanoparçacıklar üretilmiştir. Farklı deneysel parametrelerin (yüzey aktif madde, sıcaklık, reaksiyon süresi vs.) manyetit parçacıklarının şekil ve boyut oluşumundaki etkileri aynı çalışma içinde incelenmiştir. Son olarak, üretilen manyetit nanoparçacıklar biyomedikal amaçlı kullanacağı için yüzeyleri biyo uyumlu PVP (Polivinilpirolidon) ile kaplanarak hidrofilik hale getirilmişlerdir.

Anahtar Kelimeler

• Manyetik Nanoparçacık
• Termal Bozunma Metodu
• Nanoteknoloji

Destekleyen Kurum

ÖYP-DPT

Proje Numarası

BAP-08-11-DPT.2011K121010.

Teşekkür

Bu çalışma, Dr. Yeliz AKPINAR'ın doktora tezinden üretilmiş olup, TÜBİTAK- BİDEB 'ın (2211-Yurt İçi Lisansüstü Burs Programı)hibesi ve ÖYP-DPT'nin BAP-08-11-DPT.2011K121010 numaralı projesiyle desteklenmiştir. XRD ölçümlerindeki desteği için Prof. Dr. Ayşen YILMAZ'a (METU, Kimya Bölümü) teşekkür ederiz.

Formation Process of Cubic-Shaped Magnetite Nanoparticles by Thermal Decomposition Method and Their Surface Modification

Öz

The concept of nanotechnology, which began to appear in the scientific world approximately fifty years ago, continues to develop and increase its impact without losing its popularity. The extraordinary properties of nanoscale materials are improving the well-being of human life in fields such as health, energy, data storage, and biomedical applications. Nanoparticles are important elements in these application areas. Magnetic nanoparticles, in particular, are widely used in cancer treatment, especially in magnetic targeting and magnetic hyperthermia treatments, thanks to their unique magnetic properties. The shape, size, and surface modification of magnetic nanoparticles are very important parameters in cancer treatment applications. In this study, cube-shaped magnetite (Fe3O4) nanoparticles with a homogeneous size range were produced using the thermal decomposition method. The effects of different experimental parameters (surfactant, temperature, reaction time, etc.) on the shape and size formation of magnetite particles were investigated in the same study. Finally, since the produced magnetite nanoparticles will be used for biomedical purposes, their surfaces were coated with biocompatible PVP (Polyvinylpyrrolidone) to make them hydrophilic.

Anahtar Kelimeler

• Magnetic Nanoparticle
• Thermal Decomposition
• Nanotechnology

Destekleyen Kurum

ÖYP-DPT

Proje Numarası

BAP-08-11-DPT.2011K121010.

Teşekkür

This work was produced from PhD thesis of Dr. Yeliz AKPINAR, and this study was supported by TÜBİTAK-BİDEB awarding grant (2211A-Domestic Graduate Scholarship Program) and ÖYP-DPT through Project BAP-08-11-DPT.2011K121010. We are grateful to Prof. Dr. Ayşen YILMAZ (METU, Department of Chemistry) for her support in the XRD measurements.

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