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Assessing ursolic acid contents of some commonly consumed herbs grown in Turkey

Yıl 2022, Cilt: 12 Sayı: 1, 301 - 308, 15.01.2022
https://doi.org/10.17714/gumusfenbil.931509

Öz

Ursolic acid is a triterpenoid compound in the plant kingdom and has important biological functions. In this study, ursolic acid contents of nine herbs including Anethum graveolens (dill), Camellia sinensis L. (green tea), Lepidium sativum L. (garden cress), Ocimum basilicum L. (sweet basil), Petroselinum crispum L. (parsley), Rosmarinus officinalis L. (rosemary), Salvia officinalis L. (sage), Thymus vulgaris L. (thyme) and Urtica dioica L. (nettle) were determined by High-Performance Liquid Chromatography (RP-HPLC-UV). Based on the results from the analysis of herbs, ursolic acid contents varied between 0.20% and 7.11%. The ursolic acid content was highest in rosemary and sage (7.11±0.20% and 6.63±0.27%, respectively), while the lowest content of ursolic acid was in nettle (0.20±0.10). It is expected from the results of this work to contribute to the knowledge on the nutritional value of commonly consumed herbs in Turkey and encourage their consumption as functional foods.

Kaynakça

  • Akbay, P., Basaran, A.A., Undeger, U. and Basaran, N. (2003). In vitro immunomodulatory activity of flavonoid glycosides from Urtica dioica L".Phytotherapy research, 17(1), 34-37.
  • AOAC (2000). Official methods of analysis of AOAC International, Gaithersburg, Md., Association of Official Analytical Chemists.
  • Ataie‐Jafari, A., Hosseini, S., Karimi, F. and Pajouhi, M. (2008). Effects of sour cherry juice on blood glucose and some cardiovascular risk factors improvements in diabetic women: A pilot study. Nutrition and Food Science, 38(4), 355-360.
  • Bakırel, T., Bakırel, U., Keleş, O. Ü., Ülgen, S. G. and Yardıbı, H. (2008). In vivo assessment of antidiabetic and antioxidant activities of rosemary (Rosmarinus officinalis) in alloxan-diabetic rabbits.Journal of ethnopharmacology, 116(1),64-73.
  • Bernatonıene, J., Cızauskaıte, U., Ivanauskas, L., Jakstas, V., Kalvenıene, Z. and Kopustınskıene, D. M. (2016). Novel approaches to optimize extraction processes of ursolic, oleanolic and rosmarinic acids from Rosmarinus officinalis leaves.Industrial Crops and Products, 84, 72-79.
  • Bourgeois, C., Leclerc, E.A., Corbin, C., Dossout, J., Serrano, V., Vanier, J-R., Seigneuret, J-M., Auguin, D., Pichon, C., Lainé, E. and Hano, C. (2016). Nettle (Urtica dioica) as source of antioxidant and anti-ageing for cosmetic applications".Comptes rendus Chimie, 19( 9),1090-1100.
  • Chan, E. W. C., Soh, E.Y., Tıe, P.P. and Law, Y.P. (2011). Antioxidant and antibacterial properties of green, black, and herbal teas of Camellia sinensis.Pharmacognosy Research, 3(4), 266-272.
  • Chopade, V., Phatak, A., Upaganlawar, A. and Tankar, A. (2008),"Green tea (Camellia sinensis): Chemistry, traditional, medicinal uses and its pharmacological activities-a review.Pharmacognosy Reviews, 2(3),157-162
  • Cimanga, R. K., Tona, G.L., Mesia, G.K., Kambu, O.K., Bakana, D.P., Kalenda, P.D.T., Penge, A.O., Muyembe, J.-J.T., Totté, J., Pieters, L. and Vlietinck, A. J. (2006). Bioassay-Guided isolation of antimalarial triterpenoid acids from the leaves of Morinda lucida.Pharmaceutical Biology,44(9), 677-681.
  • Di Lorenzo, C., Dell’Agli, M., Sangıovanni, E., Dos Santos, A., Uberti, F., Moro, E., Bosisio, E. and Restani, P. (2013). Correlation between catechin content and nf-κb ınhibition by ınfusions of green and black tea.Plant Foods for Human Nutrition,68(2), 149-154.
  • Gai, W. T., Yu, D.P., Wang, X.S., and Wang, P.T. (2016). Anti-cancer effect of ursolic acid activates apoptosis through ROCK/PTEN mediated mitochondrial translocation of cofilin-1 in prostate cancer.Oncology Letters, 12(4), 2880-2885.
  • Gali-Muhtasib, H. (2006).Anticancer and medicinal properties of essential oil and extracts of East Mediterranean sage (salvia triloba), Mahmud, T. H. K. and Arjumand, A. (Eds.),Advances in Phytomedicine, (Vol. 2, pp. 169-180). Elsevier.
  • Gülçin, I., Küfrevioǧlu, Ö.İ., Oktay, M. and Büyükokuroǧlu, M.E. (2004). Antioxidant, antimicrobial, antiulcer and analgesic activities of nettle (Urtica dioica L.).Journal of ethnopharmacology, 90(2), 205-215.
  • Jäger, S., Trojan, H., Kopp, T., Laszczyk, M.N. and Scheffler, A. (2009). Pentacyclic triterpene distribution in various plants–rich sources for a new group of multi-potent plant extracts.Molecules,14(6), 2016-2031.
  • Janıcsák, G., Veres, K., Kakasy, A.Z., and Máthé, I. (2006). Study of the oleanolic and ursolic acid contents of some species of the Lamiaceae.Biochemical Systematics and Ecology, 34(5), 392-396.
  • Jesus, J.A., Lago, J.H.G., Laurenti, M.D., Yamamoto, E.S., and Passero, L.F.D.(2015). Antimicrobial activity of oleanolic and ursolic acids: An update.Evidence-based Complementary and Alternative Medicine,1-14.
  • Kaur, G.J., and Arora, D.S.(2010). Bioactive potential of Anethum graveolens, Foeniculum vulgare and Trachyspermum ammi belonging to the family Umbelliferae-Current status.Journal of Medicinal Plants Research,4(2), 087-094.
  • Kim, K.H., Seo, H.S., Choi, H.S., Choi, I.H., Shin, Y.C. and Ko, S.G. (2011). Induction of apoptotic cell death by ursolic acid through mitochondrial death pathway and extrinsic death receptor pathway in MDA-MB-231 cells.Archives of Pharmacal Research,34(8), 1363-1372.
  • Kreydıyyeh, S.I. and Usta, J. (2002). Diuretic effect and mechanism of action of parsley.Journal of ethnopharmacology,79(3) 353-357.
  • Mlyuka, E., Zhang, S., Wang, L., Zheng, Z. and Chen, J. (2016). Characteristics of subcritical water extraction and kinetics of pentacyclic triterpenoids from dry loquat (Eriobotrya japonica) leaves.International Journal of Food Engineering,12(6), 547-555.
  • Oluwatuyı, M., Kaatz, G.W. and Gibbons, S. (2004). Antibacterial and resistance modifying activity of Rosmarinus officinalis.Phytochemistry,65(24), 3249-3254.
  • Opalchenova, G. and Obreshkova, D. (2003). Comparative studies on the activity of basil—an essential oil from Ocimum basilicum L.—against multidrug resistant clinical isolates of the genera Staphylococcus, Enterococcus and Pseudomonas by using different test methods.Journal of Microbiological Methods,54(1), 105-110.
  • Razboršek, M.I., Vončına, D.B., Doleček, V.and Vončına, E. (2007). Determination of major phenolic acids, phenolic diterpenes and triterpenes in rosemary (Rosmarinus officinalis L.) by gas chromatography and mass spectrometry.Acta Chimica Slovenica,54(1), 60-67.
  • Rehman, N.-U., Khan, A.-U., Alkharfy, K. M.and Gilani, A.-H.(2012). Pharmacological basis for the medicinal use of Lepidium sativum in airways disorders.Evidence-Based Complementary and Alternative Medicine.
  • Silva M.G.V., Vieira Í.G.P., Mendes F.N.P., Albuquerque, I.L., Dos Santos R.N., Silva F.O. and Morais S.M. (2008). Variation of ursolic acid content in eight ocimum species from northeastern Brazil.Molecules, 13(10), 2482-2487.
  • Shailajan, S., Hande, H., Singh D. and Tiwari, B. (2014). Estimation of ursolic acid from Urtica dioica L. using validated HPTLC method.Journal of Applied Pharmaceutical Science, 4(5), 092-095.

Türkiye’de yetişen ve yaygın olarak tüketilen bazı bitkilerin ursolik asit içeriklerinin belirlenmesi

Yıl 2022, Cilt: 12 Sayı: 1, 301 - 308, 15.01.2022
https://doi.org/10.17714/gumusfenbil.931509

Öz

Ursolik asit, önemli biyolojik fonksiyonlara sahip olan ve bitkiler aleminde bulunan bir triterpenoid bileşiktir. Bu çalışmada, Anethum graveolens (dereotu), Camellia sinensis L. (yeşil çay), Lepidium sativum L. (tere), Ocimum basilicum L. (fesleğen), Petroselinum crispum L. (maydanoz), Rosmarinus officinalis L. (biberiye), Salvia officinalis L. (adaçayı), Thymus vulgaris L. (kekik) ve Urtica dioica L. (ısırgan)'i kapsayan 9 bitkinin Yüksek Performanslı Sıvı Kromatografi (RP-HPLC-UV) ile ursolik asit içeriği belirlenmiştir. Bitkilerin ursolik asit içerikleri %0.20 ile %7.11 arasında değişmiştir. En yüksek ursolik asit içeriği biberiye ve adaçayında (sırasıyla %7.11±0.20 ve % 6.63 ±0.27), en düşük ursolik asit içeriği ise ısırganda (%0.20±0.10) bulunmuştur. Bu sonuçlar ile Türkiye'de yaygın olarak tüketilen bitkilerin, besleyici değerleri konusundaki bilgilere katkı sağlanılması ve bu bitkilerin fonksiyonel gıda olarak tüketilmelerinin teşvik edilmesi amaçlanmıştır.

Kaynakça

  • Akbay, P., Basaran, A.A., Undeger, U. and Basaran, N. (2003). In vitro immunomodulatory activity of flavonoid glycosides from Urtica dioica L".Phytotherapy research, 17(1), 34-37.
  • AOAC (2000). Official methods of analysis of AOAC International, Gaithersburg, Md., Association of Official Analytical Chemists.
  • Ataie‐Jafari, A., Hosseini, S., Karimi, F. and Pajouhi, M. (2008). Effects of sour cherry juice on blood glucose and some cardiovascular risk factors improvements in diabetic women: A pilot study. Nutrition and Food Science, 38(4), 355-360.
  • Bakırel, T., Bakırel, U., Keleş, O. Ü., Ülgen, S. G. and Yardıbı, H. (2008). In vivo assessment of antidiabetic and antioxidant activities of rosemary (Rosmarinus officinalis) in alloxan-diabetic rabbits.Journal of ethnopharmacology, 116(1),64-73.
  • Bernatonıene, J., Cızauskaıte, U., Ivanauskas, L., Jakstas, V., Kalvenıene, Z. and Kopustınskıene, D. M. (2016). Novel approaches to optimize extraction processes of ursolic, oleanolic and rosmarinic acids from Rosmarinus officinalis leaves.Industrial Crops and Products, 84, 72-79.
  • Bourgeois, C., Leclerc, E.A., Corbin, C., Dossout, J., Serrano, V., Vanier, J-R., Seigneuret, J-M., Auguin, D., Pichon, C., Lainé, E. and Hano, C. (2016). Nettle (Urtica dioica) as source of antioxidant and anti-ageing for cosmetic applications".Comptes rendus Chimie, 19( 9),1090-1100.
  • Chan, E. W. C., Soh, E.Y., Tıe, P.P. and Law, Y.P. (2011). Antioxidant and antibacterial properties of green, black, and herbal teas of Camellia sinensis.Pharmacognosy Research, 3(4), 266-272.
  • Chopade, V., Phatak, A., Upaganlawar, A. and Tankar, A. (2008),"Green tea (Camellia sinensis): Chemistry, traditional, medicinal uses and its pharmacological activities-a review.Pharmacognosy Reviews, 2(3),157-162
  • Cimanga, R. K., Tona, G.L., Mesia, G.K., Kambu, O.K., Bakana, D.P., Kalenda, P.D.T., Penge, A.O., Muyembe, J.-J.T., Totté, J., Pieters, L. and Vlietinck, A. J. (2006). Bioassay-Guided isolation of antimalarial triterpenoid acids from the leaves of Morinda lucida.Pharmaceutical Biology,44(9), 677-681.
  • Di Lorenzo, C., Dell’Agli, M., Sangıovanni, E., Dos Santos, A., Uberti, F., Moro, E., Bosisio, E. and Restani, P. (2013). Correlation between catechin content and nf-κb ınhibition by ınfusions of green and black tea.Plant Foods for Human Nutrition,68(2), 149-154.
  • Gai, W. T., Yu, D.P., Wang, X.S., and Wang, P.T. (2016). Anti-cancer effect of ursolic acid activates apoptosis through ROCK/PTEN mediated mitochondrial translocation of cofilin-1 in prostate cancer.Oncology Letters, 12(4), 2880-2885.
  • Gali-Muhtasib, H. (2006).Anticancer and medicinal properties of essential oil and extracts of East Mediterranean sage (salvia triloba), Mahmud, T. H. K. and Arjumand, A. (Eds.),Advances in Phytomedicine, (Vol. 2, pp. 169-180). Elsevier.
  • Gülçin, I., Küfrevioǧlu, Ö.İ., Oktay, M. and Büyükokuroǧlu, M.E. (2004). Antioxidant, antimicrobial, antiulcer and analgesic activities of nettle (Urtica dioica L.).Journal of ethnopharmacology, 90(2), 205-215.
  • Jäger, S., Trojan, H., Kopp, T., Laszczyk, M.N. and Scheffler, A. (2009). Pentacyclic triterpene distribution in various plants–rich sources for a new group of multi-potent plant extracts.Molecules,14(6), 2016-2031.
  • Janıcsák, G., Veres, K., Kakasy, A.Z., and Máthé, I. (2006). Study of the oleanolic and ursolic acid contents of some species of the Lamiaceae.Biochemical Systematics and Ecology, 34(5), 392-396.
  • Jesus, J.A., Lago, J.H.G., Laurenti, M.D., Yamamoto, E.S., and Passero, L.F.D.(2015). Antimicrobial activity of oleanolic and ursolic acids: An update.Evidence-based Complementary and Alternative Medicine,1-14.
  • Kaur, G.J., and Arora, D.S.(2010). Bioactive potential of Anethum graveolens, Foeniculum vulgare and Trachyspermum ammi belonging to the family Umbelliferae-Current status.Journal of Medicinal Plants Research,4(2), 087-094.
  • Kim, K.H., Seo, H.S., Choi, H.S., Choi, I.H., Shin, Y.C. and Ko, S.G. (2011). Induction of apoptotic cell death by ursolic acid through mitochondrial death pathway and extrinsic death receptor pathway in MDA-MB-231 cells.Archives of Pharmacal Research,34(8), 1363-1372.
  • Kreydıyyeh, S.I. and Usta, J. (2002). Diuretic effect and mechanism of action of parsley.Journal of ethnopharmacology,79(3) 353-357.
  • Mlyuka, E., Zhang, S., Wang, L., Zheng, Z. and Chen, J. (2016). Characteristics of subcritical water extraction and kinetics of pentacyclic triterpenoids from dry loquat (Eriobotrya japonica) leaves.International Journal of Food Engineering,12(6), 547-555.
  • Oluwatuyı, M., Kaatz, G.W. and Gibbons, S. (2004). Antibacterial and resistance modifying activity of Rosmarinus officinalis.Phytochemistry,65(24), 3249-3254.
  • Opalchenova, G. and Obreshkova, D. (2003). Comparative studies on the activity of basil—an essential oil from Ocimum basilicum L.—against multidrug resistant clinical isolates of the genera Staphylococcus, Enterococcus and Pseudomonas by using different test methods.Journal of Microbiological Methods,54(1), 105-110.
  • Razboršek, M.I., Vončına, D.B., Doleček, V.and Vončına, E. (2007). Determination of major phenolic acids, phenolic diterpenes and triterpenes in rosemary (Rosmarinus officinalis L.) by gas chromatography and mass spectrometry.Acta Chimica Slovenica,54(1), 60-67.
  • Rehman, N.-U., Khan, A.-U., Alkharfy, K. M.and Gilani, A.-H.(2012). Pharmacological basis for the medicinal use of Lepidium sativum in airways disorders.Evidence-Based Complementary and Alternative Medicine.
  • Silva M.G.V., Vieira Í.G.P., Mendes F.N.P., Albuquerque, I.L., Dos Santos R.N., Silva F.O. and Morais S.M. (2008). Variation of ursolic acid content in eight ocimum species from northeastern Brazil.Molecules, 13(10), 2482-2487.
  • Shailajan, S., Hande, H., Singh D. and Tiwari, B. (2014). Estimation of ursolic acid from Urtica dioica L. using validated HPTLC method.Journal of Applied Pharmaceutical Science, 4(5), 092-095.
Toplam 26 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Mühendislik
Bölüm Makaleler
Yazarlar

Oscar Zannou Bu kişi benim 0000-0003-1227-1265

Burak İpekci Bu kişi benim 0000-0003-2793-2273

İlkay Koca 0000-0001-6089-8586

Halil İbrahim Odabaş 0000-0001-7111-3852

Yayımlanma Tarihi 15 Ocak 2022
Gönderilme Tarihi 3 Mayıs 2021
Kabul Tarihi 22 Aralık 2021
Yayımlandığı Sayı Yıl 2022 Cilt: 12 Sayı: 1

Kaynak Göster

APA Zannou, O., İpekci, B., Koca, İ., Odabaş, H. İ. (2022). Assessing ursolic acid contents of some commonly consumed herbs grown in Turkey. Gümüşhane Üniversitesi Fen Bilimleri Dergisi, 12(1), 301-308. https://doi.org/10.17714/gumusfenbil.931509