Yıl 2019, Cilt 8 , Sayı 3, Sayfalar 237 - 244 2019-09-30

Protective Effects of Chromium Picolinate on Indomethacin-Induced Stomach Ulcer in the Rat
Sıçanlarda İndometazin İle İndüklenen Mide Ülseri Üzerine Krom Pikolinatın Koruyucu Etkileri

Gözde ATİLA USLU [1] , Hamit USLU [2]


In the present study, it was aimed to investigate the protective effects of chromium picolinate (Crpic) on gastric lesions induced by indomethacine, one of the non-steroid anti-inflammatory drugs. Forty female Sprague-Dawley rats were used in this research. The rats were equally divided into four groups, namely Control (C), Chromium Picolinate + Indomethacine (Crpic+IND), Indomethacine (IND) and Pantoprazole + Indomethacine (PAN+IND). Respectively the group I was given Dimethyl Sulfoxide (DMSO) only, the group II was given 300 μg/kg Crpic, group III was given (DMSO) and the group IV was given 5 mg/kg pantoprazole orally. On the 11th day of the study, a single dose of 100 mg/kg indomethacine was administered orally to the II, III and IV groups. C-reactive protein (CRP) levels was higher than the control group IND group (I-III p<0.001, I-II, IV p<0.05). However, significant decreases were observed in the Crpic and pantoprazole groups compared to the group treated with indomethacine alone (p<0.01). Cyclooxygenase-2 (COX-2) levels were increased by indomethacine administration (p<0.001), whereas Crpic (p<0.001) and pantoprazole (p<0.01) applications significantly decreased. Tumor necrosis factor-alpha (TNF-α) (p<0.05) and interleukin-6 (IL-6) (p<0.01), levels increased significantly in İND group. There were some decreases in TNF-α and IL-6 levels in chromium picolinate and pantoprazole groups, but these decreases were not significant. As a result; it has been found that chromium picolinate significantly reduces COX-2 and CRP levels, which play an important role in the pathogenesis of inflammation. Furthermore, it was determined that chromium picolinate was very effective in preventing indomethacin-induced gastric lesions. 

Bu çalışmada, nonsteroid anti-inflamatuar ilaçlardan biri olan indometazin ile indüklenen gastrik lezyonlar üzerine krom pikolinatın (Crpic) koruyucu etkilerinin araştırılması amaçlandı. Araştırmada 40 adet dişi Sprague-Dawley sıçan kullanıldı. Sıçanlar eşit olarak dört gruba ayrıldı, Kontrol (K), Krom pikolinat + İndomethazin (Crpic+İND), İndomethazin (İND) and Pantoprazol + İndomethazin (PAN+İND). Sırasıyla I gruba sadece Di-metil sülfoksit (DMSO) verildi, grup II'ye 300 µg/kg Crpic verildi, grup III'e DMSO verildi ve IV grubuna 5 mg/kg pantoprazol verildi. Çalışmanın 11. gününde, II, III ve IV gruplarına tek doz 100 mg/kg indometazin oral olarak verildi. C-reaktif protein (CRP) düzeyleri, İND grubunda kontrol grubuna göre daha yüksekti (I-III p<0,001, I-II, IV p<0,05). Ancak Crpic ve pantoprazol gruplarında tek başına indometazin ile tedavi edilen gruba göre anlamlı düşüşler gözlendi (p<0,01). Siklooksijenaz-2 (COX-2) düzeyleri indometazin uygulaması ile artarken (p<0,001) Crpic (p<0,001) ve pantoprazol (p<0,01) uygulamalarıyla anlamlı olarak azaldı. Tümör nekrozis faktör-alfa (TNF-α) (p<0,05) ve interlökin-6 (IL-6) (p<0,01) seviyeleri, İND grubunda önemli ölçüde artmıştır. Krom pikolinat ve pantoprazol gruplarında TNF-α ve IL-6 düzeylerinde bazı düşüşler vardı, ancak bu düşüşler anlamlı değildi. Sonuç olarak; Krom pikolinatın, inflamasyonun patogenezinde önemli bir rol oynayan COX-2 ve CRP seviyelerini önemli ölçüde azalttığı bulunmuştur. Ayrıca krom pikolinatın indometazin ile indüklenen gastrik lezyonları önlemede oldukça etkili olduğu belirlendi. 

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Birincil Dil tr
Konular Sağlık Bilimleri ve Hizmetleri
Bölüm Araştırma Makaleleri
Yazarlar

Orcid: 0000-0002-2328-9164
Yazar: Gözde ATİLA USLU (Sorumlu Yazar)
Kurum: KAFKAS ÜNİVERSİTESİ VETERİNER FAKÜLTESİ
Ülke: Turkey


Orcid: 0000-0002-3974-5814
Yazar: Hamit USLU
Kurum: KAFKAS ÜNİVERSİTESİ ATATÜRK SAĞLIK HİZMETLERİ MESLEK YÜKSEKOKULU

Tarihler

Yayımlanma Tarihi : 30 Eylül 2019

Bibtex @araştırma makalesi { gumussagbil446046, journal = {Gümüşhane Üniversitesi Sağlık Bilimleri Dergisi}, issn = {}, eissn = {2146-9954}, address = {}, publisher = {Gümüşhane Üniversitesi}, year = {2019}, volume = {8}, pages = {237 - 244}, doi = {}, title = {Sıçanlarda İndometazin İle İndüklenen Mide Ülseri Üzerine Krom Pikolinatın Koruyucu Etkileri}, key = {cite}, author = {ATİLA USLU, Gözde and USLU, Hamit} }
APA ATİLA USLU, G , USLU, H . (2019). Sıçanlarda İndometazin İle İndüklenen Mide Ülseri Üzerine Krom Pikolinatın Koruyucu Etkileri. Gümüşhane Üniversitesi Sağlık Bilimleri Dergisi , 8 (3) , 237-244 . Retrieved from https://dergipark.org.tr/tr/pub/gumussagbil/issue/48952/446046
MLA ATİLA USLU, G , USLU, H . "Sıçanlarda İndometazin İle İndüklenen Mide Ülseri Üzerine Krom Pikolinatın Koruyucu Etkileri". Gümüşhane Üniversitesi Sağlık Bilimleri Dergisi 8 (2019 ): 237-244 <https://dergipark.org.tr/tr/pub/gumussagbil/issue/48952/446046>
Chicago ATİLA USLU, G , USLU, H . "Sıçanlarda İndometazin İle İndüklenen Mide Ülseri Üzerine Krom Pikolinatın Koruyucu Etkileri". Gümüşhane Üniversitesi Sağlık Bilimleri Dergisi 8 (2019 ): 237-244
RIS TY - JOUR T1 - Sıçanlarda İndometazin İle İndüklenen Mide Ülseri Üzerine Krom Pikolinatın Koruyucu Etkileri AU - Gözde ATİLA USLU , Hamit USLU Y1 - 2019 PY - 2019 N1 - DO - T2 - Gümüşhane Üniversitesi Sağlık Bilimleri Dergisi JF - Journal JO - JOR SP - 237 EP - 244 VL - 8 IS - 3 SN - -2146-9954 M3 - UR - Y2 - 2019 ER -
EndNote %0 Gümüşhane Üniversitesi Sağlık Bilimleri Dergisi Sıçanlarda İndometazin İle İndüklenen Mide Ülseri Üzerine Krom Pikolinatın Koruyucu Etkileri %A Gözde ATİLA USLU , Hamit USLU %T Sıçanlarda İndometazin İle İndüklenen Mide Ülseri Üzerine Krom Pikolinatın Koruyucu Etkileri %D 2019 %J Gümüşhane Üniversitesi Sağlık Bilimleri Dergisi %P -2146-9954 %V 8 %N 3 %R %U
ISNAD ATİLA USLU, Gözde , USLU, Hamit . "Sıçanlarda İndometazin İle İndüklenen Mide Ülseri Üzerine Krom Pikolinatın Koruyucu Etkileri". Gümüşhane Üniversitesi Sağlık Bilimleri Dergisi 8 / 3 (Eylül 2019): 237-244 .
AMA ATİLA USLU G , USLU H . Sıçanlarda İndometazin İle İndüklenen Mide Ülseri Üzerine Krom Pikolinatın Koruyucu Etkileri. Gümüşhane Üniversitesi Sağlık Bilimleri Dergisi. 2019; 8(3): 237-244.
Vancouver ATİLA USLU G , USLU H . Sıçanlarda İndometazin İle İndüklenen Mide Ülseri Üzerine Krom Pikolinatın Koruyucu Etkileri. Gümüşhane Üniversitesi Sağlık Bilimleri Dergisi. 2019; 8(3): 244-237.