İskemi Reperfüzyon Hasarında Stres ve Hücre Ölümü

Ümmü Gülşen Bozok; Ayşegül Küçük; Mustafa Arslan

doi:10.52827/hititmedj.1008303

İskemi Reperfüzyon Hasarında Stres ve Hücre Ölümü

Öz

İskemi-reperfüzyon hasarı, miyokard enfarktüsü, iskemik inme, akut böbrek hasarı, periferik arter hastalığı, orak hücre anemisi dahil olmak üzere çok çeşitli patolojilerin morbidite ve mortalitesinde rol oynar. İskemide kan akımındaki azalmanın derecesine ve süresine bağlı olarak hücreler metabolik ihtiyaçlarını karşılayamaz. Hızlı reperfüzyon, oksijen açlığı çeken hücrelerin kurtarılması için gerekli olmasına rağmen, hücrede oluşan oksijen paradoksu hücreleri strese sürükler. Reperfüzyon ile birlikte ortaya çıkan stres yanıtı sınırlandırılamazsa hücre ölüm programları aktive olarak hücre ölür. Bu derlemenin amacı iskemi reperfüzyon hasarında rol oynayan hücresel stres mekanizmalarını ve ölüm programlarını tanımlamaktır.

Anahtar Kelimeler

Kaynakça

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Ayrıntılar

Birincil Dil

Türkçe

Konular

Klinik Tıp Bilimleri

Bölüm

Derleme

Yazarlar

Ümmü Gülşen Bozok ^*
0000-0002-2016-7305
Türkiye

Ayşegül Küçük
0000-0001-9316-9574
Türkiye

Mustafa Arslan
0000-0003-4882-5063
Türkiye

Yayımlanma Tarihi

29 Haziran 2022

Gönderilme Tarihi

11 Ekim 2021

Kabul Tarihi

19 Aralık 2021

Yayımlandığı Sayı

Yıl 2022 Cilt: 4 Sayı: 2

DOI

https://doi.org/10.52827/hititmedj.1008303

IZ

https://izlik.org/JA52GK72NW

Kaynak Göster

RIS / Bibtex

APA

Bozok, Ü. G., Küçük, A., & Arslan, M. (2022). İskemi Reperfüzyon Hasarında Stres ve Hücre Ölümü. Hitit Medical Journal, 4(2), 64-73. https://doi.org/10.52827/hititmedj.1008303

AMA

1.Bozok ÜG, Küçük A, Arslan M. İskemi Reperfüzyon Hasarında Stres ve Hücre Ölümü. Hitit Medical Journal. 2022;4(2):64-73. doi:10.52827/hititmedj.1008303

Chicago

Bozok, Ümmü Gülşen, Ayşegül Küçük, ve Mustafa Arslan. 2022. “İskemi Reperfüzyon Hasarında Stres ve Hücre Ölümü”. Hitit Medical Journal 4 (2): 64-73. https://doi.org/10.52827/hititmedj.1008303.

EndNote

Bozok ÜG, Küçük A, Arslan M (01 Haziran 2022) İskemi Reperfüzyon Hasarında Stres ve Hücre Ölümü. Hitit Medical Journal 4 2 64–73.

IEEE

[1]Ü. G. Bozok, A. Küçük, ve M. Arslan, “İskemi Reperfüzyon Hasarında Stres ve Hücre Ölümü”, Hitit Medical Journal, c. 4, sy 2, ss. 64–73, Haz. 2022, doi: 10.52827/hititmedj.1008303.

ISNAD

Bozok, Ümmü Gülşen - Küçük, Ayşegül - Arslan, Mustafa. “İskemi Reperfüzyon Hasarında Stres ve Hücre Ölümü”. Hitit Medical Journal 4/2 (01 Haziran 2022): 64-73. https://doi.org/10.52827/hititmedj.1008303.

JAMA

1.Bozok ÜG, Küçük A, Arslan M. İskemi Reperfüzyon Hasarında Stres ve Hücre Ölümü. Hitit Medical Journal. 2022;4:64–73.

MLA

Bozok, Ümmü Gülşen, vd. “İskemi Reperfüzyon Hasarında Stres ve Hücre Ölümü”. Hitit Medical Journal, c. 4, sy 2, Haziran 2022, ss. 64-73, doi:10.52827/hititmedj.1008303.

Vancouver

1.Ümmü Gülşen Bozok, Ayşegül Küçük, Mustafa Arslan. İskemi Reperfüzyon Hasarında Stres ve Hücre Ölümü. Hitit Medical Journal. 01 Haziran 2022;4(2):64-73. doi:10.52827/hititmedj.1008303