Nodular Lymphoid Hyperplasia of the Gastrointestinal Tract with Selective IgA Deficiency in an Adult Patient: A Case Report

Yıl 2025, Cilt: 7 Sayı: 3, 461 - 464, 13.10.2025

Arzu Hazal Aydın , Mustafa Ergin , Seda Tas Ayçiçek

https://doi.org/10.52827/hititmedj.1567949

Öz

Nodular lymphoid hyperplasia of the gastrointestinal tract is a rare and benign condition which may accompany immunodeficiency. Although being benign, it carries risk for intestinal and extraintestinal lymphoma. There is no specific and definitive treatment for NLH. Thus, treatment is dependent on the management of the associated conditions.
Duodenal and terminal ileal biopsies from a 54-year-old woman with multiple mesenteric lymphadenopathy and gastrointestinal lymphoid hyperplasia revealed nodular lymphoid hyperplasia as well as a paucity of plasma cells.
Based on histopathological findings and laboratory results, a diagnosis of selective IgA deficiency was made.
It is important to evaluate patients with nodular lymphoid hyperplasia for additional histopathological findings due to the association with possible immune deficiency such as absence or scarcity of plasma cells.

Anahtar Kelimeler

selective IgA deficiency , nodular lymphoid hyperplasia , gastrointestinal tract

Selektif IgA eksikliği Olan Erişkin Hastada Gastrointestinal Nodüler Lenfoid Hiperplazi: Olgu Sunumu

Öz

Gastrointestinal kanalın nodüler lenfoid hiperplazisi (NLH) nadir ve benign bir durum olup immün yetmezlikler ile ilişkili olabilir. Benign bir durum olmasına rağmen artmış intestinal ve ekstraintestinal lenfoma riski söz konusudur. NLH’nin tedavisi ilişkili durumların yönetimine bağlıdır.
Multiple mezenterik lenfadenopati ve gastrointestinal traktta diffüz lenfoid hiperplazi tespit edilen 54 yaşında kadın hastada duodenal ve terminal ileum biyopsilerinde nodüler lenfoid hiperplazi yanı sıra plazma hücrelerinde belirgin azalma tespit edilmiştir.
Histopatolojik bulgular ve laboratuvar sonuçları esas alınarak selektif IgA eksikliği tanısı almıştır.
Gastrointestinal trakt biyopsilerinde nodüler lenfoid hiperplazi bulguları izlenen hastalarda ilişkili olabilecek antiteler açısından da değerlendirme önemlidir.

Anahtar Kelimeler

selektif IgA eksikiliği , nodüler lenfoid hiperplazi , gastrointestinal trakt

Kaynakça

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