The aim of this study is to examine the mediating role of self-efficacy in the relationship between coronavirus anxiety and suicide probability of university students during the Covid-19 pandemic. 341 university students participated in the study. While analyzing the data, Unpaired t Test, Pearson Product Moment Correlation Analysis and Hierarchical Regression Analysis were used. At the same time, the bootstrapping method was used to examine the role of mediating variable between the dependent variable and independent variable. According to the findings, it was found that self-efficacy plays a partial mediating role in the relationship between coronavirus anxiety and the suicide probability. In addition, it was also found that those who said they became lonely because of coronavirus had higher coronavirus anxiety scores than those who said they were not alone. Finally, it was determined that during the pandemic process, the coronavirus anxiety and suicide probability scores of those who were abused due to pandemic conditions were higher than those who were not. According to results obtained from the study, self-efficacy was found to partially mediate the relationship between coronavirus anxiety and the suicide probability. Accordingly, it was determined that the probability of suicide decreased with increased self-efficacy.