Vitamin B12 Eksiliğinde Hastalarda Ortalama Trombosit Volümün Değerlendirilmesi
Yıl 2014,
Cilt: 11 Sayı: 3, 253 - 256, 15.12.2014
Mahmut Abuhandan
Hüseyin Gümüş
Abdullah Solmaz
Bülent Güzel
Öz
Amaç: Bu çalışmada vitamin B12 eksiliği olan çocuklarda Ortalama Trombosit Volümünün
değerlendirilmesi amaçlandı.
Metaryal ve metod: Vitamin B eksikliği tanısı alan 68 hasta ile 54 sağlıklı kontrol grubu çalışmaya alındı. 12
Hasta ve kontrol grubunun Ortalama Trombosit Volümü ve trombosit sayıları değerlendirildi. Vitamin B12
düzeyi 200 pg/Laltında eksiklik olarak kabul edildi.
Bulgular: Çalışmaya alınan vitamin B eksikliği olan hastaların ortalama trombosit volümü değerleri (7.09 12
± 1.1 fl) ile sağlıklı kontrol grubun ortalama değerleri (6.52 ± 0.7 fl) karşılaştırıldığında istatistiksel olarak
anlamlı derecede yüksek bulunurken (p=0.001), trombosit sayısı açısında istatistiksel olarak anlamlı bir fark
bulunmadı (p>0.05).
Sonuç: Rutin tam kan sayımında ortalama trombosit volümü değerlerine bakarak vitamin B eksikliği 12
yakalanmasının mümkün olabileceğini düşündürmektedir.
Kaynakça
- 1) Fenech M. Chromosomal damage rate, aging, and
diet. Ann N YAcad Sci, 1998. 854: 23-36.
2) Wilson A, Platt R, Wu Q, Leclerc D, Christensen
B, et al. A common variant in methionine synthase
reductase combined with low cobalamin (vitamin B12)
increases risk for spina bifida. Mol Genet Metab, 1999.
67(4): 317-23.
3) Roschitz B, Plecko B, Huemer M, ark. Nutritional
infantile vitamin B12 deficiency: pathobiochemical
considerations in seven patients. Arch Dis Child Fetal
Neonatal Ed 2005;90:281-2.
4) Brocadello F, Levedianos G, Piccione F, Manara
R, Pesenti FF. Irreversible subacute sclerotic combined
degeneration of the spinal cord in a vegan subject.
Nutrition 2007;23(7-8):622-4.
5) Elzey BD, Tian J, Jensen RJ, Swanson AK, Lees
JR, Lentz SR, Stein CS, Nieswandt B, Wang Y, Davidson
BL, Ratliff TL. Platelet-mediated modulation of
adaptive immunity. A communication link between
innate and adaptive immune compartments. Immunity.
2003;19(1):9-19
6) Bath PM, Butterworth RJ. Platelet size:
measurement, physiology and vascular disease. Blood
Coagul Fibrinolysis. 1996; 7(2):157-61.
7) Sharp DS, Benowitz NL, Bath PM, Martin JF,
Beswick AD, Elwood PC. Cigarette smoking sensitizes
and desensitizes impedance-measured ADP-induced
platelet aggregation in whole blood. Thromb Haemost.
1995; 74(2):730-5.
8) Uysal P, Tuncel T, Olmez D, Babayigit A,
Karaman O, Uzuner N. The role of mean platelet volume
predicting acute exacerbations of cystic fibrosis in
children. Ann Thorac Med. 2011; 6(4): 227-30.
9) Yüksel O, Helvaci K, Başar O, Köklü S, Caner S,
Helvaci N, Abayli E, Altiparmak E. An overlooked
indicator of disease activity in ulcerative colitis: mean
platelet volume. Platelets. 2009; 20(4): 277-81.
10) Yazici S, Yazici M, Erer B, Erer B, Calik Y, Ozhan
H, Ataoglu S. The platelet indices in patients with
rheumatoid arthritis: mean platelet volume reflects
disease activity. Platelets. 2010; 21(2): 122-5.
11) Makay B, Türkyilmaz Z, Unsal E. Mean platelet
volume in children with familial Mediterranean fever.
Clin Rheumatol. 2009; 28(8): 975-8.
12) Oncel MY, Ozdemir R, Yurttutan S, Canpolat FE,
Erdeve O, Oguz SS, Uras N, Dilmen U. Mean platelet
volume in neonatal sepsis. J Clin Lab Anal. 2012 ; 26(6):
493-6.
13) Karadag-Oncel E, Ozsurekci Y, Kara A, Karahan S,
Cengiz AB, Ceyhan M. The value of mean platelet
volume in the determination of community acquired
pneumonia in children. Ital J Pediatr. 2013; 8;39:16.
14) Catal F, Bavbek N, Bayrak O, Uz E, Isik B, Karabel
M, Degirmencioglu H, Mete E, Akcay A. Platelet
parameters in children with upper urinary tract infection:
is there a specific response? Ren Fail. 2008;30(4):377-81.
15) Snow CF. Laboratory diagnosis of vitamin B12 and
folate deficiency. Arch Intern Med. 1999; 159: 1289-
1298.
16) Drabick JJ, Davis BJ, Byrd JC. Concurrent
pernicious anemia and myelodisplastic syndrome. Ann
Hemato. 2001;80:243-245.
17) Toh BH, van Driel IR, Gleeson PA. Pernisious
anemia. N Eng J Med. 1997;337:1441-1448.
18) Zaki MM. Parasite Platelet Interactions. PUJ;
2011, 4(2): 127-136.
19) Flad, HD, Brandt E. Platelet-derived chemokines:
Pathophysiology and therapeutic aspects. Cell Mol Life
Sci; 2010, 67 (14):2363-86.
20) Tschoepe D, Roesen P, Esser J, Schwippert B,
Nieuwenhuis HK, Kehrel B, Gries FA. Large platelets
circulate in an activated state in diabetes mellitus. Semin
Thromb Hemost. 1991;17(4):433-8.
21) Zuberi BF, Akhtar N, Afsar S. Comparison of mean
platelet volume in patients with diabetes mellitus, impaired
fasting glucose and non-diabetic subjects. Singapore Med J.
2008; 49(2):114-6.
22) Martin JF, Bath PM, Burr ML. Influence of platelet
size on outcome after myocardial infarction. Lancet.
1991;338(8780):1409-11.
23) Ghahremanfard F, Asghari N, Ghorbani R, Samaei A,
Ghomi H, Tamadon M. The relationship between mean
platelet volume and severity of acute ischemic brain stroke.
Neurosciences (Riyadh). 2013;18(2):147-51.
24) Kario K, Matsuo T, Nakao K. Cigarette smoking
increases the mean platelet volume in elderly patients with
risk factors for atherosclerosis. Clin Lab Haematol.
1992;14(4):281-7.
25) Bath PM, Missouris CG, Buckenham T, MacGregor
GA. Increased platelet volume and platelet mass in patients
with atherosclerotic renal artery stenosis. Clin Sci (Lond).
1994;87(2):253-7.
26) Icli A, Aksoy F, Dogan A, Arslan A, Akcay S, Yücel
H, Ersoy I, Gorgulu O. Increased Mean Platelet Volume in
Hypertrophic Cardiomyopathy. Angiology. 2013. [Epub
ahead of print] PubMed PMID: 23564022.
27) Oztürk ZA, Dag MS, Kuyumcu ME, Cam H, Yesil Y,
Yilmaz N, Aydinli M, Kadayifci A, Kepekci Y. Could
platelet indices be new biomarkers for inflammatory bowel
diseases? Eur Rev Med Pharmacol Sci. 2013;17(3):334-41.
28) Liu R, Gao F, Huo J, Yi Q. Study on the relationship
between mean platelet volume and platelet distribution
width with coronary artery lesion in children with Kawasaki
disease. Platelets. 2012;23(1):11-6.
29) Babior BM, Bunn HF. Megaloblastic anemias, In:
Braunwald E, Fauci AS, Kasper DL, Hauser SL, Longo DL,
Jameson JL, Editors. Harrison's Principles of Internal
Medicine. Section 2. Disorders of hematopoiesis, 15th ed.
New York. McGraw-Hill Companies 2003; 674-680.
Assessment Of Mean Platelet Volume In Patients Deficiency Vitamin B12
Yıl 2014,
Cilt: 11 Sayı: 3, 253 - 256, 15.12.2014
Mahmut Abuhandan
Hüseyin Gümüş
Abdullah Solmaz
Bülent Güzel
Öz
Objectıve: In this study, we aimed to evaluate mean Platelet Volume (MPV) at children with vitamin B12
deficiency.
Material and method: 68 patients with the diagnosis of vitamin B12 deficiency and 54 healthy children as a
control group were enrolled to study. MPVand platelet counts were evaluated at patients and control groups.
Vitamin B12 level under of 200 pg / Lwere considered to be insufficiency.
Results: İn the study vitamin B12 deficiency patients of mean platelet volume values compared to the
healthy (7.09 ± 1.1 fl) control group (6.52 ± 0.7 fl) was statistically significantly higher mean values
(p=0.001), and platelet count were not statistically significant (p> 0.05).
Conclusions: This study suggests that for the diagnosis of patients with vitamin B12 deficiency may be
indication by looking the values of mean platelet volume in routine complete blood count.
Kaynakça
- 1) Fenech M. Chromosomal damage rate, aging, and
diet. Ann N YAcad Sci, 1998. 854: 23-36.
2) Wilson A, Platt R, Wu Q, Leclerc D, Christensen
B, et al. A common variant in methionine synthase
reductase combined with low cobalamin (vitamin B12)
increases risk for spina bifida. Mol Genet Metab, 1999.
67(4): 317-23.
3) Roschitz B, Plecko B, Huemer M, ark. Nutritional
infantile vitamin B12 deficiency: pathobiochemical
considerations in seven patients. Arch Dis Child Fetal
Neonatal Ed 2005;90:281-2.
4) Brocadello F, Levedianos G, Piccione F, Manara
R, Pesenti FF. Irreversible subacute sclerotic combined
degeneration of the spinal cord in a vegan subject.
Nutrition 2007;23(7-8):622-4.
5) Elzey BD, Tian J, Jensen RJ, Swanson AK, Lees
JR, Lentz SR, Stein CS, Nieswandt B, Wang Y, Davidson
BL, Ratliff TL. Platelet-mediated modulation of
adaptive immunity. A communication link between
innate and adaptive immune compartments. Immunity.
2003;19(1):9-19
6) Bath PM, Butterworth RJ. Platelet size:
measurement, physiology and vascular disease. Blood
Coagul Fibrinolysis. 1996; 7(2):157-61.
7) Sharp DS, Benowitz NL, Bath PM, Martin JF,
Beswick AD, Elwood PC. Cigarette smoking sensitizes
and desensitizes impedance-measured ADP-induced
platelet aggregation in whole blood. Thromb Haemost.
1995; 74(2):730-5.
8) Uysal P, Tuncel T, Olmez D, Babayigit A,
Karaman O, Uzuner N. The role of mean platelet volume
predicting acute exacerbations of cystic fibrosis in
children. Ann Thorac Med. 2011; 6(4): 227-30.
9) Yüksel O, Helvaci K, Başar O, Köklü S, Caner S,
Helvaci N, Abayli E, Altiparmak E. An overlooked
indicator of disease activity in ulcerative colitis: mean
platelet volume. Platelets. 2009; 20(4): 277-81.
10) Yazici S, Yazici M, Erer B, Erer B, Calik Y, Ozhan
H, Ataoglu S. The platelet indices in patients with
rheumatoid arthritis: mean platelet volume reflects
disease activity. Platelets. 2010; 21(2): 122-5.
11) Makay B, Türkyilmaz Z, Unsal E. Mean platelet
volume in children with familial Mediterranean fever.
Clin Rheumatol. 2009; 28(8): 975-8.
12) Oncel MY, Ozdemir R, Yurttutan S, Canpolat FE,
Erdeve O, Oguz SS, Uras N, Dilmen U. Mean platelet
volume in neonatal sepsis. J Clin Lab Anal. 2012 ; 26(6):
493-6.
13) Karadag-Oncel E, Ozsurekci Y, Kara A, Karahan S,
Cengiz AB, Ceyhan M. The value of mean platelet
volume in the determination of community acquired
pneumonia in children. Ital J Pediatr. 2013; 8;39:16.
14) Catal F, Bavbek N, Bayrak O, Uz E, Isik B, Karabel
M, Degirmencioglu H, Mete E, Akcay A. Platelet
parameters in children with upper urinary tract infection:
is there a specific response? Ren Fail. 2008;30(4):377-81.
15) Snow CF. Laboratory diagnosis of vitamin B12 and
folate deficiency. Arch Intern Med. 1999; 159: 1289-
1298.
16) Drabick JJ, Davis BJ, Byrd JC. Concurrent
pernicious anemia and myelodisplastic syndrome. Ann
Hemato. 2001;80:243-245.
17) Toh BH, van Driel IR, Gleeson PA. Pernisious
anemia. N Eng J Med. 1997;337:1441-1448.
18) Zaki MM. Parasite Platelet Interactions. PUJ;
2011, 4(2): 127-136.
19) Flad, HD, Brandt E. Platelet-derived chemokines:
Pathophysiology and therapeutic aspects. Cell Mol Life
Sci; 2010, 67 (14):2363-86.
20) Tschoepe D, Roesen P, Esser J, Schwippert B,
Nieuwenhuis HK, Kehrel B, Gries FA. Large platelets
circulate in an activated state in diabetes mellitus. Semin
Thromb Hemost. 1991;17(4):433-8.
21) Zuberi BF, Akhtar N, Afsar S. Comparison of mean
platelet volume in patients with diabetes mellitus, impaired
fasting glucose and non-diabetic subjects. Singapore Med J.
2008; 49(2):114-6.
22) Martin JF, Bath PM, Burr ML. Influence of platelet
size on outcome after myocardial infarction. Lancet.
1991;338(8780):1409-11.
23) Ghahremanfard F, Asghari N, Ghorbani R, Samaei A,
Ghomi H, Tamadon M. The relationship between mean
platelet volume and severity of acute ischemic brain stroke.
Neurosciences (Riyadh). 2013;18(2):147-51.
24) Kario K, Matsuo T, Nakao K. Cigarette smoking
increases the mean platelet volume in elderly patients with
risk factors for atherosclerosis. Clin Lab Haematol.
1992;14(4):281-7.
25) Bath PM, Missouris CG, Buckenham T, MacGregor
GA. Increased platelet volume and platelet mass in patients
with atherosclerotic renal artery stenosis. Clin Sci (Lond).
1994;87(2):253-7.
26) Icli A, Aksoy F, Dogan A, Arslan A, Akcay S, Yücel
H, Ersoy I, Gorgulu O. Increased Mean Platelet Volume in
Hypertrophic Cardiomyopathy. Angiology. 2013. [Epub
ahead of print] PubMed PMID: 23564022.
27) Oztürk ZA, Dag MS, Kuyumcu ME, Cam H, Yesil Y,
Yilmaz N, Aydinli M, Kadayifci A, Kepekci Y. Could
platelet indices be new biomarkers for inflammatory bowel
diseases? Eur Rev Med Pharmacol Sci. 2013;17(3):334-41.
28) Liu R, Gao F, Huo J, Yi Q. Study on the relationship
between mean platelet volume and platelet distribution
width with coronary artery lesion in children with Kawasaki
disease. Platelets. 2012;23(1):11-6.
29) Babior BM, Bunn HF. Megaloblastic anemias, In:
Braunwald E, Fauci AS, Kasper DL, Hauser SL, Longo DL,
Jameson JL, Editors. Harrison's Principles of Internal
Medicine. Section 2. Disorders of hematopoiesis, 15th ed.
New York. McGraw-Hill Companies 2003; 674-680.