Determination of the Efficacy of Fenbendazol+Pyrantel Pamoate and Praziquantel Combination in Naturally Infected Cats with Toxocara cati

Abstract

This study aimed to determine the efficacy of fenbendazole (50 mg/kg), pyrantel pamoate (20 mg/kg), and praziquantel (5 mg/kg) combination in cats which naturally infected with Toxocara cati. The feces taken from animals brought to the clinic and suspected of infection were examined by the saltwater flotation method. Then, the Mc Master method was applied to determine the infection burden in cats positive for T. cati. Ten cats with 250 or more eggs per gram stool (EPG) were included in the study. Before the treatment, feces were taken from these cats. EPG values were determined. The combination of fenbendazole + pyrantel pamoate and praziquantel in tablet form was given orally. The cats were housed in a separate compartment in the clinic and kept under observation during the study. On the 7th, 14th, and 21st days after the treatment, feces were retaken from these cats, and EPG values were determined. No T. cati eggs were found in the feces of eight of ten treated cats on days 7, 14, and 21. However, eggs were found in the stool examination performed on the 14th and 21st days in one cat and every three sampling days after the treatment in one cat. The drug’s effectiveness was found to be over 98% in all sampling times after treatment (7, 14, 21). However, the detection of parasite eggs in the feces of two cats should not be ignored. For this reason, 7-14 days after the treatment with this anthelmintic combination, a fecal examination should be performed to observe the effectiveness of the treatment. If necessary, the treatment should be repeated.

Keywords

• Cat
• Efficacy
• Fenbendazole
• Praziquantel
• Pyrantel pamoate
• Toxacara cati

Toxocara cati ile Doğal Enfekte Kedilerde Fenbendazol+Pyrantel Pamoate ve Praziquantel Kombinasyonunun Etkinliğinin Belirlenmesi

Abstract

Bu çalışmada Toxocara cati ile doğal enfekte kedilerde fenbendazol (50 mg/kg), pyrantel pamoate (20 mg/kg) ve praziquantel (5 mg/kg) kombinasyonunun etkinliğinin belirlenmesi amaçlanmıştır. Çalışmaya dahil edilecek kedilerin belirlenebilmesi amacıyla kliniğe getirilen ve enfeksiyondan şüphelenilen hayvanlardan alınan dışkılar önce doymuş tuzlu su flotasyon yöntemiyle incelenmiştir. Daha sonra T. cati yönünden pozitif bulunan kedilerdeki enfeksiyon yükünü belirlemek için Mc Master yöntemi uygulanmıştır. Gram dışkıdaki yumurta sayısı (EPG) 250 ve üzeri olan toplam 10 kedi çalışmaya dahil edilmiştir. Tedavi öncesinde bu kedilerden dışkı alınarak EPG değerleri belirlenmiş ve canlı ağırlıklarına göre tablet formundaki fenbendazol+ pyrantel pamoate ve praziquantel kombinasyonu oral yolla verilmiştir. Kediler çalışma süresince klinikte ayrı bir bölmede barındırılmış ve gözlem altına alınmıştır. Tedaviden sonraki 7, 14 ve 21. günlerde bu kedilerden tekrar dışkı alınarak EPG değerleri belirlenmiştir. Tedavi edilen on kediden sekizinin dışkılarında 7, 14 ve 21. günlerde T. cati yumurtalarına rastlanılmamıştır. Ancak bir kedide 14 ve 21. günlerde, bir kedide de tedavi sonrasındaki her üç örnekleme gününde yapılan dışkı muayenesinde yumurtalara rastlanmıştır. Tedaviden sonraki örnekleme zamanlarının hepsinde de (7, 14, 21) ilacın etkinliği %98’in üzerinde bulunmuştur. Bununla birlikte iki kedinin dışkısında parazit yumurtalarının tespit edilmiş olması göz ardı edilmemelidir. Bu nedenle bu antihelmintik kombinasyonuyla yapılacak olan tedavilerinden 7-14 gün sonra dışkı muayenesi yapılarak tedavinin etkinliği gözlenmeli ve gerekirse tedavi tekrarlanmalıdır.

Keywords

• Toxocara cati
• fenbendazol
• pyrantel pomat
• praziquantel
• kedi
• etkinlik

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