Psychobiotics and Mental Illness: A Review

Öz

Probiotics are live microorganisms that provide health benefits to the host when administered in adequate amounts and are essential for intestinal health. Probiotic bacteria that have a beneficial effect on mental health when consumed in appropriate amounts are called psychobiotics. In many recent studies, in the pathophysiology of many psychiatric diseases from depression to schizophrenia; intestinal microbiota and intestinal permeability are thought to play a role. The purpose of this review; psychobiotics; To examine the effect on mental illnesses such as depression, anxiety, schizophrenia, attention deficit and hyperactivity disorder. While writing the Psychobiotics and Mental Diseases Review; "Science Direct", "Pubmed" and "Google Scholar" databases and international journals were used and a search was made by typing the keywords "psychobiotics" and "mental diseases" into the search engine and trying to reach all the resources that could be reached between 2008 and 2023. Psychobiotics can be a cost-effective and healthy approach to improving mental health and cognitive behavior. It is recommended that more research be done by increasing the number of subjects in the studies conducted to confirm the assumptions about psychobiotics as an alternative remedy for mental illnesses.

Anahtar Kelimeler

• Anxiety
• Attention Deficit and Hyperactivity Disorder
• Depression
• Mental Illness
• Psychobiotic
• Schizophthenia

Psikobiyotikler ve Ruhsal Hastalıklar: Bir Gözden Geçirme

Öz

Probiyotikler, yeterli miktarlarda uygulandığında konakçıya yarar sağlayan canlı mikroorganizmalardır ve bağırsak sağlığı için çok önemlidirler. Uygun miktarlarda tüketildiğinde ruh sağlığı üzerinde faydalı etkisi olan probiyotik bakterilere ise psikobiyotik denilmektedir. Son zamanlarda yapılan çok sayıda çalışmada, depresyondan şizofreniye kadar birçok psikiyatrik hastalığın patofizyolojisinde; bağırsak mikrobiyotası ve bağırsak geçirgenliğinin rol oynayabileceği ön görülmektedir. Bu derlemenin amacı; psikobiyotiklerin; depresyon, anksiyete, şizofreni, dikkat eksikliği ve hiperaktivite bozukluğu gibi ruhsal hastalıklar üzerindeki etkisini incelemektir. Psikobiyotikler ve Ruhsal Hastalıklar Derlemesi yazılırken; “Science Direct”, “Pubmed” ve “Google Scholar” veri tabanları ve uluslararası dergilerden faydalanılmış ve arama motoruna “psikobiyotikler” ve “ruhsal hastalıklar” anahtar kelimeleri yazılarak ve 2008 ile 2023 yılları arasında ulaşılabilen tüm kaynaklara ulaşılmaya çalışılarak tarama yapılmıştır. Psikobiyotikler, zihinsel sağlığı ve bilişsel davranışları iyileştirmek için uygun maliyetli ve sağlıklı bir yaklaşım olabilmektedir. Ruhsal hastalıklar için alternatif bir çare olan psikobiyotikler hakkındaki varsayımların doğrulaması için yapılan çalışmalardaki denek sayısı artırılarak daha fazla araştırma yapılması önerilmektedir.

Anahtar Kelimeler

• Anksiyete
• Depresyon
• Dikkat Eksikliği ve Hiperaktivite Bozukluğu
• Psikobiyotik
• Ruhsal Hastalıklar
• Şizofreni

Kaynakça

1. AIZAWA, E., TSUJI, H., ASAHARA, T., TAKAHASHI, T., TERAISHI, T., YOSHIDA, S., OTA, M., KOGA, N., HATTORI, K. & KUNUGI, H. (2016). Possible association of Bifidobacterium and Lactobacillus in the gut microbiota of patients with major depressive disorder. Journal of Affective Disorders, 202, 254-257. https://doi.org/10.1016/j.jad.2016.05.038
2. ALLEN, A. P., HUTCH, W., BORRE, Y. E., KENNEDY, P. J., TEMKO, A., BOYLAN, G., MURPHY, E., CRYAN, J. F., DINAN, T. G. & CLARKE, G. (2016). Bifidobacterium longum 1714 as a translational psychobiotic: Modulation of stress, electrophysiology and neurocognition in healthy volunteers. Translational Psychiatry, 6(11). https://doi.org/10.1038/tp.2016.191
3. ANDERSSON, H., TULLBERG, C., AHRNÉ, S., HAMBERG, K., LAZOU AHRÉN, I., MOLIN, G., SONESSON, M. & HÅKANSSON, Å. (2016). Oral Administration of Lactobacillus plantarum 299v Reduces Cortisol Levels in Human Saliva during Examination Induced Stress: A Randomized, Double-Blind Controlled Trial. International Journal of Microbiology, 2016. https://doi.org/10.1155/2016/8469018
4. BARRIO, C., ARIAS-SÁNCHEZ, S. & MARTIN-MONZÓN, I. (2022). The gut microbiota-brain axis, psychobiotics and its influence on brain and behaviour: A systematic review. Psychoneuroendocrinology, 137(October 2021). https://doi.org/10.1016/j.psyneuen.2021.105640
5. BASSO, M., JOHNSTONE, N., KNYTL, P., NAUTA, A., GROENEVELD, A. & COHEN KADOSH, K. (2022). A Systematic Review of Psychobiotic Interventions in Children and Adolescents to Enhance Cognitive Functioning and Emotional Behavior. Nutrients, 14(3). https://doi.org/10.3390/nu14030614
6. BLAKE, K. (T.Y.). Using Psychobiotics to Improve Mood. http://divcomplatform.s3.amazonaws.com/www.integrativepractitioner.com/images/54af851a18c9adcf1b4e7f6d8a6e4d3f.pdf
7. BOONCHOODUANG, N., LOUTHRENOO, O., CHATTIPAKORN, N. & CHATTIPAKORN, S. C. (2020). Possible links between gut – microbiota and attention deficit / hyperactivity disorders in children and adolescents. European Journal of Nutrition, 59(8), 3391-3403. https://doi.org/10.1007/s00394-020-02383-1
8. CARLESSI, A. S., BOTELHO, M. E. M., MANOSSO, L. M., BORBA, L. A., MACIEL, L. R., ANDRADE, N. M., MARTINELLO, N. S., PADILHA, A. P. Z., GENEROSO, C. M., BENCKE, C. V., DE MOURA, A. B., LODETTI, B. F., COLLODEL, A., JOAQUIM, L., BONFANTE, S., BIEHL, E., GENEROSO, J. S., ARENT, C. O., BARICHELLO, T., … RÉUS, G. Z. (2022). Sex differences on the response to antidepressants and psychobiotics following early life stress in rats. Pharmacology Biochemistry and Behavior, 220(July). https://doi.org/10.1016/j.pbb.2022.173468

9. CHENG, L. H., LIU, Y. W., WU, C. C., WANG, S. & TSAI, Y. C. (2019). Psychobiotics in mental health, neurodegenerative and neurodevelopmental disorders. Journal of Food and Drug Analysis, 27(3), 632-648. https://doi.org/10.1016/j.jfda.2019.01.002
10. COHEN KADOSH, K., BASSO, M., KNYTL, P., JOHNSTONE, N., LAU, J. Y. F. & GIBSON, G. R. (2021). Psychobiotic interventions for anxiety in young people: a systematic review and meta-analysis, with youth consultation. Translational Psychiatry, 11(1). https://doi.org/10.1038/s41398-021-01422-7
11. CULPEPPER, T., CHRISTMAN, M. C., NIEVES, C., SPECHT, G. J., ROWE, C. C., SPAISER, S. J., FORD, A. L., DAHL, W. J., GIRARD, S. A. & LANGKAMP-HENKEN, B. (2016). Bifidobacterium bifidum R0071 decreases stress-associated diarrhoea-related symptoms and self-reported stress: A secondary analysis of a randomised trial. Beneficial Microbes, 7(3), 327-336. https://doi.org/10.3920/BM2015.0156
12. DAHIYA, D. & NIGAM, P. S. (2022). Clinical Potential of Microbial Strains, Used in Fermentation for Probiotic Food, Beverages and in Synbiotic Supplements, as Psychobiotics for Cognitive Treatment through Gut–Brain Signaling. Microorganisms, 10(9). https://doi.org/10.3390/microorganisms10091687
13. DEMARTINI, J., PATEL, G. & FANCHER, T. L. (2019). Generalized anxiety disorder. Annals of Internal Medicine, 170(7), ITC49-ITC64. https://doi.org/10.7326/AITC201904020
14. DESBONNET, L., GARRETT, L., CLARKE, G., BIENENSTOCK, J. & DINAN, T. G. (2008). The probiotic Bifidobacteria infantis: An assessment of potential antidepressant properties in the rat. Journal of Psychiatric Research, 43(2), 164-174. https://doi.org/10.1016/j.jpsychires.2008.03.009
15. DICKERSON, F. B., STALLINGS, C., ORIGONI, A., KATSAFANAS, E., SAVAGE, C. L. G., SCHWEINFURTH, L. A. B., GOGA, J., KHUSHALANI, S. & YOLKEN, R. H. (2014). Effect of Probiotic Supplementation on Schizophrenia Symptoms and Association With Gastrointestinal Functioning: A Randomized, Placebo-Controlled Trial. The Primary Care Companion for CNS Disorders, 16(1). https://doi.org/10.4088/PCC.13M01579
16. GHADERI, A., BANAFSHE, H. R., MIRHOSSEINI, N., MORADI, M., KARIMI, M. A., MEHRZAD, F., BAHMANI, F. & ASEMI, Z. (2019). Clinical and metabolic response to vitamin D plus probiotic in schizophrenia patients. BMC Psychiatry, 19(1), 1-10. https://doi.org/10.1186/S12888-019-2059-X/TABLES/4
17. GREENER, M. (2018). News review I Psychobiotics. 22, 9-11.
18. GUALTIERI, P., MARCHETTI, M., CIOCCOLONI, G., DE LORENZO, A., ROMANO, L., CAMMARANO, A., COLICA, C., CONDÒ, R. & DI RENZO, L. (2020). Psychobiotics regulate the anxiety symptoms in carriers of allele A of IL-1 β Gene: A randomized, placebo-controlled clinical trial. Mediators of Inflammation, 2020. https://doi.org/10.1155/2020/2346126
19. HAO, Z., WANG, W., GUO, R. & LIU, H. (2019). Faecalibacterium prausnitzii (ATCC 27766) has preventive and therapeutic effects on chronic unpredictable mild stress-induced depression-like and anxiety-like behavior in rats. Psychoneuroendocrinology, 104(November 2018), 132-142. https://doi.org/10.1016/j.psyneuen.2019.02.025
20. PÄRTTY, A., KALLIOMÄKI, M., WACKLIN, P., SALMINEN, S. & ISOLAURI, E. (2015). A possible link between early probiotic intervention and the risk of neuropsychiatric disorders later in childhood: a randomized trial. 77(6), 823-828. https://doi.org/10.1038/pr.2015.51
21. KARAKULA, H., JUCHNOWICZ, D. VE SZACHTA, P. (2016). Psychobiotics: new possibilities for treatment of affective disorders? Psychobiotyki-nowe możliwości terapii zaburzeń afektywnych? December 2015. https://doi.org/10.17393/fpn.2016.01.005
22. KARINA, T. M.-G., ALESSANDRA, S. M. DO N., TALITA, A. DA A. & SÉRGIO, E. S. (2020). Psychobiotics in daily food against psychiatric disorders. African Journal of Food Science, 14(6), 161-166. https://doi.org/10.5897/ajfs2020.1927
23. KIM, C. S., CHA, L., SIM, M., JUNG, S., CHUN, W. Y., BAIK, H. W. & SHIN, D. M. (2021). Probiotic supplementation improves cognitive function and mood with changes in gut microbiota in community- dwelling older adults: A randomized, double-blind, placebo-controlled, multicenter trial. Journals of Gerontology - Series A Biological Sciences and Medical Sciences, 76(1), 32-40. https://doi.org/10.1093/GERONA/GLAA090
24. LIU, Y. W., LIU, W. H., WU, C. C., JUAN, Y. C., WU, Y. C., TSAI, H. P., WANG, S. & TSAI, Y. C. (2016). Psychotropic effects of Lactobacillus plantarum PS128 in early life-stressed and naïve adult mice. Brain Research, 1631, 1-12. https://doi.org/10.1016/j.brainres.2015.11.018
25. MISERA, A., LIŚKIEWICZ, P., ŁONIEWSKI, I., SKONIECZNA-ŻYDECKA, K. & SAMOCHOWIEC, J. (2021). Effect of psychobiotics on psychometric tests and inflammatory markers in major depressive disorder: Meta-analysis of randomized controlled trials with meta-regression. Pharmaceuticals, 14(10). https://doi.org/10.3390/ph14100952
26. MISRA, S. & MOHANTY, D. (2019). Psychobiotics: A new approach for treating mental illness? Critical Reviews in Food Science and Nutrition, 59(8), 1230-1236. https://doi.org/10.1080/10408398.2017.1399860
27. MOLUDI, J., ALIZADEH, M., MOHAMMADZAD, M. H. S. & DAVARI, M. (2019). The Effect of Probiotic Supplementation on Depressive Symptoms and Quality of Life in Patients after Myocardial Infarction: Results of a Preliminary Double-Blind Clinical Trial. Psychosomatic Medicine, 81(9), 770-777. https://doi.org/10.1097/PSY.0000000000000749
28. MORSHEDI, M., VALENLIA, K. B., HOSSEINIFARD, E. S., SHAHABI, P., ABBASI, M. M., GHORBANI, M., BARZEGARI, A., SADIGH-ETEGHAD, S. & SAGHAFI-ASL, M. (2018). Beneficial psychological effects of novel psychobiotics in diabetic rats: the interaction among the gut, blood, and amygdala. Journal of Nutritional Biochemistry, 57, 145-152. https://doi.org/10.1016/j.jnutbio.2018.03.022
29. MUNAWAR, N., AHSAN, K., MUHAMMAD, K., AHMAD, A., ANWAR, M. A., SHAH, I., AMERI, A. K. A. & MUGHAIRBI, F. A. (2021). Hidden role of gut microbiome dysbiosis in schizophrenia: Antipsychotics or psychobiotics as therapeutics? International Journal of Molecular Sciences, 22(14). https://doi.org/10.3390/ijms22147671
30. NIU, Y., LIANG, S., WANG, T., HU, X., LI, W., WU, X. & JIN, F. (2020). Pre-Gestational intake of Lactobacillus helveticus NS8 has anxiolytic effects in adolescent Sprague Dawley offspring. Brain and Behavior, 10(9), 1-13. https://doi.org/10.1002/brb3.1714
31. PALEPU, M. S. K. & DANDEKAR, M. P. (2022). Remodeling of microbiota gut-brain axis using psychobiotics in depression. European Journal of Pharmacology, 931(July), 175171. https://doi.org/10.1016/j.ejphar.2022.175171
32. PELSSER, L. M. J., TOORMAN, J., PEREIRA, R. R. & BUITELAAR, J. K. (2009). A randomised controlled trial into the effects of food on ADHD. 12-19. https://doi.org/10.1007/s00787-008-0695-7
33. PINTO-SANCHEZ, M. I., HALL, G. B., GHAJAR, K., NARDELLI, A., BOLINO, C., LAU, J. T., MARTIN, F. P., COMINETTI, O., WELSH, C., RIEDER, A., TRAYNOR, J., GREGORY, C., DE PALMA, G., PIGRAU, M., FORD, A. C., MACRI, J., BERGER, B., BERGONZELLI, G., SURETTE, M. G., … BERCIK, P. (2017). Probiotic Bifidobacterium longum NCC3001 Reduces Depression Scores and Alters Brain Activity: A Pilot Study in Patients With Irritable Bowel Syndrome. Gastroenterology, 153(2), 448-459.e8. https://doi.org/10.1053/j.gastro.2017.05.003
34. RIGGS, D. S. (2009). Treatment of Anxiety Disorders. Living and Surviving in Harm’s Way: A Psychological Treatment Handbook for Pre- and Post-Deployment of Military Personnel, 2017, 211-237. https://doi.org/10.4324/9780203893906-21
35. ROMIJN, A. R., RUCKLIDGE, J. J., KUIJER, R. G. & FRAMPTON, C. (2017). A double-blind, randomized, placebo-controlled trial of Lactobacillus helveticus and Bifidobacterium longum for the symptoms of depression. Australian and New Zealand Journal of Psychiatry, 51(8), 810-821. https://doi.org/10.1177/0004867416686694
36. ROSS, K. (2023). Psychobiotics: Are they the future intervention for managing depression and anxiety? A literature review. Explore, August 2022. https://doi.org/10.1016/j.explore.2023.02.007
37. RUDZKI, L., OSTROWSKA, L., PAWLAK, D., MAŁUS, A., PAWLAK, K., WASZKIEWICZ, N. & SZULC, A. (2019). Probiotic Lactobacillus Plantarum 299v decreases kynurenine concentration and improves cognitive functions in patients with major depression: A double-blind, randomized, placebo controlled study. Psychoneuroendocrinology, 100(March 2018), 213-222. https://doi.org/10.1016/j.psyneuen.2018.10.010
38. SHARMA, H. & BAJWA, J. (2022). Approach of probiotics in mental health as a psychobiotics. Archives of Microbiology, 204(1), 1-7. https://doi.org/10.1007/s00203-021-02622-x
39. SHARMA, R., GUPTA, D., MEHROTRA, R. & MAGO, P. (2021). Psychobiotics: The Next-Generation Probiotics for the Brain. Current Microbiology, 78(2), 449-463. https://doi.org/10.1007/s00284-020-02289-5
40. SINN, N. (2008). Nutritional and dietary influences on attention deficit hyperactivity disorder. 66(10), 558-568. https://doi.org/10.1111/j.1753-4887.2008.00107.x
41. SKOWRON, K., BUDZYŃSKA, A., WIKTORCZYK-KAPISCHKE, N., CHOMACKA, K., GRUDLEWSKA-BUDA, K., WILK, M., WAŁECKA-ZACHARSKA, E., ANDRZEJEWSKA, M. & GOSPODAREK-KOMKOWSKA, E. (2022). The Role of Psychobiotics in Supporting the Treatment of Disturbances in the Functioning of the Nervous System—A Systematic Review. International Journal of Molecular Sciences, 23(14). https://doi.org/10.3390/ijms23147820
42. SMITH, K. S., GREENE, M. W., BABU, J. R. & FRUGÉ, A. D. (2021). Psychobiotics as treatment for anxiety, depression, and related symptoms: a systematic review. Nutritional Neuroscience, 24(12), 963-977. https://doi.org/10.1080/1028415X.2019.1701220
43. SZOPINSKA-TOKOV, J., DAM, S., NAAIJEN, J., KONSTANTI, P., BLOEMENDAAL, M., AARTS, E. & VASQUEZ, A. A. (2020). Investigating the Gut Microbiota Composition of Individuals with Attention-Deficit / Hyperactivity Disorder and Association with Symptoms.
44. TIAN, P., O’RIORDAN, K. J., LEE, Y. K., WANG, G., ZHAO, J., ZHANG, H., CRYAN, J. F. & CHEN, W. (2020). Towards a psychobiotic therapy for depression: Bifidobacterium breve CCFM1025 reverses chronic stress-induced depressive symptoms and gut microbial abnormalities in mice. Neurobiology of Stress, 12(November 2019), 100216. https://doi.org/10.1016/j.ynstr.2020.100216
45. TILLISCH, K., LABUS, J., KILPATRICK, L., JIANG, Z., STAINS, J., EBRAT, B., GUYONNET, D., LEGRAIN-RASPAUD, S., TROTIN, B., NALIBOFF, B. & MAYER, E. A. (2013). Consumption of fermented milk product with probiotic modulates brain activity. Gastroenterology, 144(7), 1394-1401.e4. https://doi.org/10.1053/j.gastro.2013.02.043
46. TOMASIK, J., YOLKEN, R. H., BAHN, S. & DICKERSON, F. B. (2015). Immunomodulatory Effects of Probiotic Supplementation in Schizophrenia Patients: A Randomized, Placebo-Controlled Trial. Biomarker Insights, 10, 47-54. https://doi.org/10.4137/BMI.S22007/FORMAT/EPUB
47. TREMBLAY, A., LINGRAND, L., MAILLARD, M., FEUZ, B. & TOMPKINS, T. A. (2021). The effects of psychobiotics on the microbiota-gut-brain axis in early-life stress and neuropsychiatric disorders. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 105(September 2020), 110142. https://doi.org/10.1016/j.pnpbp.2020.110142
48. TRIAL, P., KWARTA, P., CYBULA, M., KARBOWNIK, M. S., KR, J., KOWALCZYK, E., PIETRAS, T., SZEMRAJ, J. & WIKTOROWSKA-OWCZAREK, A. (2020). nutrients E ff ect of Supplementation with Saccharomyces Boulardii on Academic Examination Performance and Related Stress in Healthy Medical Students : A.
49. TRZECIAK, P. & HERBET, M. (2021). Role of the intestinal microbiome, intestinal barrier and psychobiotics in depression. Nutrients, 13(3), 1-27. https://doi.org/10.3390/nu13030927
50. ZAGÓRSKA, A., MARCINKOWSKA, M., JAMROZIK, M., WIŚNIOWSKA, B. & PAŚKO, P. (2020). From probiotics to psychobiotics - The gut-brain axis in psychiatric disorders. Beneficial Microbes, 11(8), 717-732. https://doi.org/10.3920/BM2020.0063
51. ZHU, H., TIAN, P., ZHAO, J., ZHANG, H., WANG, G. & CHEN, W. (2022). A psychobiotic approach to the treatment of depression: A systematic review and meta-analysis. Journal of Functional Foods, 91(February), 104999. https://doi.org/10.1016/j.jff.2022.104999