Antosiyaninin Depresyon Üzerindeki Potansiyel Etkileri: Bir Derleme

Öz

Beslenme, depresyon hastalarında depresyonun önlenmesinde ve semptomlarının azaltılmasında yardımcıdır. Çünkü depresyonun patofizyolojisi incelendiğinde bazı besinlerde eksiklikler görülür. Oksidatif stresin ayrıca hastalığın patofizyolojisine katkıda bulunabilecek inflamasyona neden olduğu bilinmektedir. Antioksidan olduğu bilinen antosiyaninin depresyon üzerindeki etkisi incelenmiştir. Web of Science veritabanında “Antosiyanidin” VEYA “Antosiyanidinler” VEYA “Antosiyanin” VEYA “Leucoantosiyanidinler” VE “depresyon” terimleri taranmış ve bu tarama sonucunda çıkan makaleler incelenmiştir. Tarama sonucunda 71 makale bulunmuş ve özeti incelenmiştir. Uygun görülen 55 makalenin tam metini incelenmiş ve 7 makale dahil edilme kriterlerinin tümünü karşılamıştır. Bu çalışmalara göre, antosiyanin depresyona karşı koruma sağlayabilir ve depresyonun semptomlarını hafifletebilir. Oksidatif stres ve nörogenezdeki bozulma inflamasyonun arkasında yatan mekanizmalardır. Çeşitli insan, hayvan ve in vitro çalışmalar, antosiyaninlerin güçlü anti-enflamatuar ve antioksidan özelliklere sahip olduğunu göstermektedir.

Anahtar Kelimeler

• Antosiyaninler
• depresyon
• antioksidan.

Potential Effects of Anthocyanin on Depression: A Review

Öz

Nutrition is helpful in preventing depression and reducing its symptoms in depressed patients. This is because when the pathophysiology of depression is examined, deficiencies in certain nutrients are observed. Oxidative stress is also known to cause inflammation, which can contribute to the pathophysiology of the disease. We examined the effectiveness of anthocyanin, which is known to be an antioxidant, on depression. Related articles were searched in the Web of Science database. The combinations of the following terms were used for the search: “Anthocyanidin” OR “Anthocyanidins” OR “Anthocyanin” OR “Leucoanthocyanidins” AND “depression”. 71 abstracts were reviewed, 55 full-text articles were examined, and 7 papers met all of the inclusion criteria. According to these studies, anthocyanin may offer protection against depression and can alleviate its symptoms. Oxidative stress and deterioration in neurogenesis are the mechanisms behind inflammation. Various human, animal, and in vitro studies demonstrate that anthocyanins possess strong anti-inflammatory and antioxidant properties.

Anahtar Kelimeler

• Anthocyanins
• depression
• antioxidant

Kaynakça

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