The Relationship between Menopause and Metabolic Syndrome

Öz

Menopause is the permanent cessation of menstruation due to loss of ovarian activity. Increases in the incidence of obesity in menopausal women raise important public health concerns. Metabolic syndrome is a combination of several factors, including hypertension, dyslipidemia, insulin resistance, obesity, and glucose intolerance. Menopause is associated with an increased risk of metabolic syndrome regardless of age. When postmenopausal women's predisposition to metabolic syndrome is evaluated, the presence of metabolic syndrome and its components causes an increase in inflammatory cytokines, making weight control difficult. It has been suggested that this may be caused by the decrease in estrogen levels that naturally occurs during menopause, which plays an important role in many mechanisms that may be related to menopause and metabolic syndrome. Therefore hormone replacement therapy may yield positive results in postmenopausal or ovariectomized women. Physical activity and nutrition are important in preventing metabolic syndrome in postmenopausal women. When the relationship between protein intake and the risk of early menopause was examined in depth, it was seen that the risk of early menopause could be reduced with a diet pattern in which animal protein sources are moderate, and plant protein sources are predominant. In light of this evidence, women can be advised to follow the Mediterranean type of lifestyle model to prevent early menopause and maintain health during menopause. In this review, the relationship between changes in estrogen levels during menopause and metabolic syndrome is summarized in the current literature.

Anahtar Kelimeler

• Abdominal obesity
• nutrition
• menopause
• metabolic syndrome
• estrogen.

Menopoz ve Metabolik Sendrom İlişkisi

Öz

Menopoz, ovaryum aktivitesinin yitirilmesi sonucunda menstrüasyonun kalıcı olarak sonlanmasıdır. Menopozdaki kadınlarda obezitenin görülme sıklığındaki artışlar önemli halk sağlığı endişelerini doğurmaktadır. Metabolik sendrom; kardiyovasküler hastalık ve tip 2 diyabet geliştirme riskini artıran hipertansiyon, dislipidemi, insülin direnci, obezite ve glukoz intoleransı gibi çeşitli faktörlerin bir araya gelmesidir. Menopoz, yaştan bağımsız olarak artan metabolik sendrom riski ile ilişkilidir. Postmenopozal kadınların metabolik sendroma yatkınlıkları değerlendirildiğinde metabolik sendrom ve bileşenlerinin varlığı inflamatuar sitokinlerde artışa sebep olarak ağırlık denetimini zorlaştırmaktadır. Buna menopoz ve metabolik sendromla ilişkili olabilecek birçok mekanizmada önemli rol alan ve menopozda doğal olarak gerçekleşen östrojen düzeylerindeki azalmanın sebep olabileceği, bu nedenle postmenopozal veya ovariektomili kadınlarda hormon replasman tedavisinin olumlu sonuç verebileceği öne sürülmüştür. Postmenopozal kadınlarda metabolik sendromun önlenmesinde fiziksel aktivite ve beslenme büyük öneme sahiptir. Protein alımının erken menopoz riski ile ilişkisine derinlemesine bakıldığında hayvansal protein kaynaklarının ılımlı, bitkisel protein kaynakları ağırlıklı bir beslenme örüntüsüyle erken menopoz riskinin azalabileceği görülmüştür. Bu kanıtlar ışığında kadınlara erken menopozdan korunma ve menopoz döneminde sağlığın korunması için Akdeniz tipi beslenme modelini takip etmeleri önerilebilir. Bu derlemede, menopoz sürecinde östrojen seviyelerindeki değişimin metabolik sendromla ilişkisi güncel literatür doğrultusunda özetlenmiştir.

Anahtar Kelimeler

• Abdominal obezite
• beslenme
• menopoz
• metabolik sendrom
• östrojen.

Kaynakça

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