Tinnituslu Hastalar Serum Vitamin B12 Düzeylerinin İncelenmesi

Yıl 2026, Cilt: 11 Sayı: 1, 60 - 64, 28.01.2026

Ersin Akçam , Özge Pınarbaşlı Akçam , Soner Taşar

https://doi.org/10.61399/ikcusbfd.1632657

Öz

Amaç: Bu çalışmanın amacı tinnitusu olan hastaların serum Vitamin B12 düzeylerini belirlemek ve Vitamin B12 eksikliği ile tinnitus arasındaki ilişkiyi incelemektir.
Gereç ve Yöntem: Bu çalışmada 50 hastayı (yaş ortalaması: 49,98 S.D.:18,02; 25 kadın 25 erkek) ve kulak patolojisi olmayan 50 sağlıklı gönüllüyü (25 kadın, 25 erkek) değelendirdik. Tüm hasta ve kontrol grubunda genel fizik muayene sonrası laboratuvar kan analizleri ve odyolojik değerlendirmeler yapıldı. Serum Vitamin B12 düzeyi 180 pg/ml altında olan hastalar, Vitamin B12 eksikliği olarak değerlendirmeye alındı. Hasta grubuna odyometrik inceleme yapıldı ve her iki kulak 500-4000 Hz ortalama işitme değerleri hesaplandı.
Bulgular: Hasta grubunda tinnitusun %72 oranında ( %34 sağ, %38 sol) tek taraflı olduğu tespit edildi. %28 oranında ise çift taraflı olduğu tespit edildi. Tinnitusu olan hastaların 16’sı düşük, 34’ü normal Vitamin B12 düzeylerine sahipti. Kontrol grubu Vitamin B12 seviyeleri ile arasında istatiksel olarak anlamlı bir fark tespit edildi (p=0,025)
Sonuç: Bu çalışma, serum Vitamin B12 eksikliğinin tinnitus fizyopatolojisinde rolü olabileceğini göstermektedir. Tinnitus etyolojisi oldukça değişken olması sebebiyle, daha falza çalışmaya ihyitaç duyulmaktadır.

Anahtar Kelimeler

etiyoloji , b12 vitamini eksikliği , odyometri , tinnitus , tinnitus , tinnitus , tinnitus , vitamin b12 , vitamin b12 , vitamin b12 , vitamin b12

Etik Beyan

Afyonkarahisar Sağlık Bilimleri Üniversitesi Girişimsel Olmayan Araştırmalar Etik Kurulu’ ndan 04.10.2024 tarih ve 2024/8 sayılı karar ile etik kurul onayı alındı. Afyonkarahisar Devlet Hastanesi resmi kurum izini alındı.

Examination Of Serum Vitamin B12 Levels in Patients With Tinnitus

Öz

ABSTRACT
Objective: This study aims to determine serum vitamin B12 levels in patients with tinnitus and to examine the relationship between vitamin B12 deficiency and tinnitus.
Material and Methods: In this study, we evaluated 50 patients (mean age: 49.98, S.D.: 18.02; 25 women, 25 men) and 50 healthy volunteers (25 women, 25 men) without ear pathology. After general physical examination, laboratory blood analyses and audiological evaluations were performed in all patient and control groups. Patients with serum vitamin B12 levels below 180 pg/mL were assessed as having a, vitamin B12 deficiency. Audiometric examinations were performed on the patient group, and average hearing values for frequencies ranging from 500 to 4000 Hz in both ears were calculated.
Results: In the patient group, tinnitus was found to be unilateral in 52% of cases (28% on the right, 24% on the left) and bilateral in 48% of cases. Among patients with tinnitus, 16 had low vitamin B12 levels, while 34 had normal vitamin B12 levels. In the control group, vitamin B12 levels were low in 4 individuals and normal in 36 individuals. A statistically significant difference was found between the vitamin B12 levels of the control group and the patient group (p=0.02).
Conclusion: This study shows that serum vitamin B12 deficiency may have a role in the pathophysiology of tinnitus. Since the etiology of tinnitus is quite variable, more studies are needed.
Keywords: Etiology, audiometry, tinnitus, vitamin B12.

Anahtar Kelimeler

tinnitus , tinnitus , tinnitus , etiology , vitamin b12 , vitamin b12 , vitamin b12 , vitamin b12 deficiency , audiometry

Kaynakça

• Hoffman HJ. Epidemiology of tinnitus. In: Tinnitus: Theory and management. 2004:16-41.
• Lanting CP, de Kleine E, van Dijk P. Neural activity underlying tinnitus generation: results from PET and fMRI. Hear Res. 2009;255(1-2):1-13. doi:10.1016/j.heares.2009.06.009
• Edvall NK, Gunan E, Genitsaridi E, et al. Impact of Temporomandibular Joint Complaints on Tinnitus-Related Distress. Front Neurosci. 2019;13:879. doi:10.3389/fnins.2019.00879Çetinkaya MY. Disk hernisi cerrahisi ve hemşirelik bakımı. Türkiye Klinikleri J Surg Nurs-Special Topics. 2015;1(2):100-6.
• Hall CA. Function of vitamin B12 in the central nervous system as revealed by congenital defects. Am J Hematol. 1990 Jun;34(2):121-7. DOI: 10.1002/ajh.2830340208
• Sataloff RT, Roehm PC. Hearing loss. CRC Press; 2024.
• Tunkel DE, Bauer CA, Sun GH, et al. Clinical practice guideline: tinnitus. Otolaryngology Head and Neck Surgery. 2014; 151(2): 1-40.
• Fujimoto C, Yamasoba T. Mitochondria-Targeted Antioxidants for Treatment of Hearing Loss: A Systematic Review. Antioxidants (Basel). 2019 Apr 24;8(4):109. DOI: 10.3390/antiox8040109.
• Jastreboff PJ. Phantom auditory perception (tinnitus): mechanisms of generation and perception. Neurosci Res. 1990 Aug;8(4):221-54. DOI: 10.1016/0168-0102(90)90031-9.
• McKinney CJ, Hazell JWP, Graham RL. An evaluation of the TRT method. In: Proceedings of the sixth international tinnitus seminar. London: Hyperacusis & Tinnitus Centre; 1999. p. 99-105.
• Houston DK, Johnson MA, Nozza RJ, Gunter EW, Shea KJ, Cutler GM, et al. Age-related hearing loss, vitamin B-12, and folate in elderly women. Am J Clin Nutr. 1999 Mar;69(3):564-71. DOI: 10.1093/ajcn/69.3.564.
• Coles RR. Epidemiology of tinnitus: (1) prevalence. J Laryngol Otol Suppl. 1984;9:7-15. DOI: 10.1017/s1755146300090041.
• Sataloff J, Sataloff RT, Lueneburg W. Tinnitus and vertigo in healthy senior citizens without a history of noise exposure. Am J Otol. 1987 Mar;8(2):87-9.
• Heller MF, Bergman M. Tinnitus aurium in normally hearing persons. Ann Otol Rhinol Laryngol. 1953 Mar;62(1):73-83. DOI: 10.1177/000348945306200107.
• Graham JM. Tinnitus in children with hearing loss. Ciba Found Symp. 1981;85:172-92. DOI: 10.1002/9780470720677.ch10.
• Glasgold A, Altmann F. The effect of stapes surgery on tinnitus in otosclerosis. Laryngoscope. 1966 Sep;76(9):1524-32. DOI: 10.1002/lary.5540760904.
• House JW, Brackmann DE. Tinnitus: surgical treatment. Ciba Found Symp. 1981;85:204-16. DOI: 10.1002/9780470720677.ch12.
• Shemesh Z, Attias J, Ornan M, Shapira N, Shahar A. Vitamin B12 deficiency in patients with chronic-tinnitus and noise-induced hearing loss. Am J Otolaryngol. 1993 Mar-Apr;14(2):94-9. DOI: 10.1016/0196-0709(93)90046-a.
• Weir DG, Scott JM. The biochemical basis of the neuropathy in cobalamin deficiency. Baillieres Clin Haematol. 1995 Sep;8(3):479-97. DOI: 10.1016/s0950-3536(05)80217-3.
• Agamanolis DP, Victor M, Harris JW, Hines JD, Chester EM, Kark JA. An ultrastructural study of subacute combined degeneration of the spinal cord in vitamin B12-deficient rhesus monkeys. J Neuropathol Exp Neurol. 1978 May;37(3):273-99. DOI: 10.1097/00005072-197805000-00006
• Krumholz A, Weiss HD, Goldstein PJ, Harris KC. Evoked responses in vitamin B12 deficiency. Ann Neurol. 1981 Apr;9(4):407-9. DOI: 10.1002/ana.410090417.
• Hunter LL, Monson BB, Moore DR, Dhar S, Wright BA, Munro KJ et al. Extended high frequency hearing and speech perception implications in adults and children. Hear Res. 2020 Nov;397:107922. doi: 10.1016/j.heares.2020.107922.
• Hunt A, Harrington D, Robinson S. Vitamin B12 deficiency. BMJ. 2014;349:g5226. Published 2014 Sep 4. doi:10.1136/bmj.g5226
• Stouffer JL, Tyler RS. Characterization of tinnitus by tinnitus patients. J Speech Hear Disord. 1990 Aug;55(3):439-53. DOI: 10.1044/jshd.5503.439
• Sindhusake D, Mitchell P, Newall P, Golding M, Rochtchina E, Rubin G. Prevalence and characteristics of tinnitus in older adults: the Blue Mountains Hearing Study. Int J Audiol. 2003 Jul;42(5):289-94. DOI: 10.3109/14992020309078348.
• Nondahl DM, Cruickshanks KJ, Huang GH, Klein BE, Klein R, Nieto FJ, et al. Tinnitus and its risk factors in the Beaver Dam offspring study. Int J Audiol. 2011 May;50(5):313-20. DOI: 10.3109/14992027.2010.551220.
• Berkiten G, Yildirim G, Topaloglu I, Ugras H. Vitamin B12 levels in patients with tinnitus and effectiveness of vitamin B12 treatment on hearing threshold and tinnitus. B-ENT. 2013;9(2):111-6.
• den Heijer T, Vermeer SE, van Dijk EJ, Prins ND, Koudstaal PJ, Hofman A, et al. Type 2 diabetes and atrophy of medial temporal lobe structures on brain MRI. Diabetologia. 2003 Dec;46(12):1604-10. DOI: 10.1007/s00125-003-1235-0.
• Wright DW, Ritchie JC, Mullins RE, Kellermann AL, Denson DD. Steady-state serum concentrations of progesterone following continuous intravenous infusion in patients with acute moderate to severe traumatic brain injury. J Clin Pharmacol. 2005 Jun;45(6):640-8. DOI: 10.1177/0091270005276201.
• Savage DG, Lindenbaum J. Neurological complications of acquired cobalamin deficiency: clinical aspects. Baillieres Clin Haematol. 1995 Sep;8(3):657-78. DOI: 10.1016/s0950-3536(05)80225-2.